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azafect 100mg injection - Azacitidine (100mg) medicine

Azafect 100mg Injection - Uses, Price, Side Effects

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Azacitidine (100mg)
๐Ÿญ Aureate Healthcare Pvt Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 29, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Jun 29, 2026

What is azafect 100mg injection used for?

Azafect 100mg Injection contains Azacitidine, a chemotherapy drug used to treat myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). It works by inhibiting DNA methyltransferase, which helps restore normal growth control in cancer cells. It is administered subcutaneously or intravenously under medical supervision.

  • Generic Name: Azacitidine
  • Manufacturer: Aureate Healthcare Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: D
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

๐Ÿ’Š azafect 100mg injection Uses & Benefits

Myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), chronic myelomonocytic leukemia (CMML).

Off-label uses: Chronic myeloid leukemia (CML), solid tumors (investigational).

๐Ÿ“‹ Drug Information

Generic Name(s)Azacitidine
Brand NameAzadine Injection
ManufacturerAureate Healthcare Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI NEOPLASTICS
Action ClassAntimetabolites
Route of AdministrationSubcutaneous injection or intravenous infusion.
StorageStore at 25ยฐC (77ยฐF); excursions permitted to 15-30ยฐC (59-86ยฐF). Protect from light.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed after subcutaneous administration; peak plasma concentration achieved within 30 minutes.
DistributionWidely distributed into body tissues, including bone marrow; crosses the blood-brain barrier.
Protein BindingApproximately 10-15% bound to plasma proteins.
MetabolismPrimarily metabolized by cytidine deaminase to inactive metabolites; also undergoes spontaneous hydrolysis.
Half-LifeApproximately 4 hours (subcutaneous); 1-2 hours (intravenous).
ExcretionPrimarily excreted in urine (85% as metabolites, <10% unchanged).
BioavailabilityApproximately 89% after subcutaneous administration.
Onset of ActionWithin 1-2 weeks of therapy.
Peak Plasma Time30 minutes (subcutaneous); end of infusion (intravenous).
Duration of ActionVariable; effects on hematopoiesis persist for weeks.

How It Works

Incorporates into DNA and RNA, inhibiting DNA methyltransferase, leading to hypomethylation and re-expression of silenced tumor suppressor genes.

Mechanism Steps

1Azacitidine is taken up by cells and phosphorylated to azacitidine triphosphate.
2Incorporates into RNA, disrupting RNA metabolism and protein synthesis.
3Incorporates into DNA, inhibiting DNA methyltransferase (DNMT1).

๐Ÿ’ก How to Take azafect 100mg injection

Follow your doctor's prescription exactly.

Dosage Timeline

๐ŸŒ… Morning โœ… โ˜€๏ธ Afternoon โŒ ๐ŸŒ† Evening โœ… ๐ŸŒ™ Night โŒ

โš ๏ธ Side Effects of azafect 100mg injection

โœ… Common Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Fatigue
  • Fever
  • Anemia
  • Thrombocytopenia
  • Neutropenia
  • Injection site reactions

๐Ÿšจ Serious Side Effects

  • Severe myelosuppression
  • Hepatic failure
  • Renal toxicity
  • Tumor lysis syndrome
  • Cardiac arrhythmias

โš ๏ธ Rare Side Effects

  • Interstitial lung disease
  • Sweet's syndrome
  • Differentiation syndrome
  • Hemorrhagic cystitis

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Warfarin Major Increased bleeding risk
Allopurinol Moderate Increased risk of azacitidine toxicity
Live vaccines Major Risk of disseminated infection

๐Ÿšจ Major Interactions

  • Cytarabine
  • Ribavirin
  • Gemcitabine

โšก Moderate Interactions

  • Valproic acid
  • Hydralazine
  • Procainamide

โ„น๏ธ Minor Interactions

  • Acetaminophen
  • Cimetidine
  • Ranitidine

๐Ÿฝ๏ธ Food Interactions

No significant food interactions reported.

๐Ÿท Alcohol Interaction

Avoid alcohol; may increase hepatotoxicity risk.

๐Ÿ›ก๏ธ Safety & Warnings

Liver
Moderate
Kidney
Moderate
Heart
Low
Pregnancy
Category D

๐Ÿšซ Contraindications

Hypersensitivity to azacitidine or mannitol; advanced malignant hepatic tumors; pregnancy.

๐Ÿ“Š Monitoring Parameters

Complete blood count (CBC) with differential, liver function tests, renal function tests, serum electrolytes.

๐Ÿคฑ Lactation Safety

Contraindicated; discontinue breastfeeding during therapy.

๐Ÿ’Š Overdose Management

No specific antidote; supportive care with monitoring of hematologic parameters and organ function.

โฐ Missed Dose

If a dose is missed, administer as soon as possible; do not double the next dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 29, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for azafect 100mg injection

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Alternative brands with exact same active ingredient (Azacitidine (100mg)):

Medical Note: Always consult your doctor before switching medications.

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