amitant-iv injection

4.6 (16 reviews)

Fosaprepitant (150mg)

🏭 Aureate Healthcare Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 21, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 21, 2026

What is amitant-iv injection used for?

Amitant-IV Injection (Fosaprepitant) is used to treat GASTRO INTESTINAL. It contains Fosaprepitant (150mg), which Fosaprepitant is a prodrug of aprepitant, which is a selective high-affinity ant. Always consult your doctor before use. Take as prescribed.

Generic Name: Fosaprepitant
Manufacturer: Aureate Healthcare Pvt Ltd
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 amitant-iv injection Uses & Benefits

Prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) associated with highly emetogenic chemotherapy; prevention of postoperative nausea and vomiting (PONV).

Off-label uses: Treatment of pruritus; prevention of nausea and vomiting in other settings (e.g., radiation therapy).

📋 Drug Information

Generic Name(s)	Fosaprepitant
Brand Name	Amitant-IV Injection
Manufacturer	Aureate Healthcare Pvt Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	GASTRO INTESTINAL
Action Class	NK1 Antagonists
Route of Administration	Intravenous infusion over 15-30 minutes.
Storage	Store at 20-25°C (68-77°F); protect from light; reconstituted solution stable for 24 hours at room temperature.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionIntravenous administration results in complete bioavailability as it is directly delivered into the bloodstream.

DistributionWidely distributed in tissues; crosses the blood-brain barrier.

Protein Binding>95% bound to plasma proteins.

MetabolismRapidly converted to aprepitant by ubiquitous phosphatases; aprepitant is metabolized primarily by CYP3A4, with minor contributions from CYP1A2 and CYP2C19.

Half-LifeApproximately 9-13 hours for aprepitant.

ExcretionPrimarily excreted in feces (about 80%) and urine (about 20%) as metabolites.

Bioavailability100% (intravenous).

Onset of ActionRapid; within 30 minutes.

Peak Plasma TimeImmediately after infusion completion.

Duration of ActionUp to 48 hours for prevention of chemotherapy-induced nausea and vomiting.

How It Works

Fosaprepitant is a prodrug of aprepitant, which is a selective high-affinity antagonist of the human substance P/neurokinin 1 (NK1) receptor.

Mechanism Steps

1Fosaprepitant is administered intravenously and rapidly converted to aprepitant by phosphatases.

2Aprepitant crosses the blood-brain barrier and binds with high affinity to NK1 receptors in the central nervous system.

3By blocking substance P from binding to NK1 receptors, aprepitant inhibits the emetic reflex.

💡 How to Take amitant-iv injection

Follow your doctor's prescription exactly.

⚠️ Side Effects of amitant-iv injection

✅ Common Side Effects

Fatigue
Constipation
Diarrhea
Headache
Hiccups
Anorexia

🚨 Serious Side Effects

Hypersensitivity reactions (anaphylaxis, urticaria)
Stevens-Johnson syndrome
Angioedema

⚠️ Rare Side Effects

Elevated liver enzymes
Bradycardia
Confusion

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Warfarin	Major	Decreased INR; reduced anticoagulant effect.
Oral contraceptives	Major	Reduced contraceptive efficacy.
Midazolam	Major	Increased midazolam exposure; risk of prolonged sedation.
Rifampin	Major	Reduced aprepitant exposure; decreased efficacy.
Ketoconazole	Moderate	Increased aprepitant exposure.
Dexamethasone	Minor	Increased dexamethasone exposure.

🚨 Major Interactions

Warfarin
Oral contraceptives
CYP3A4 substrates (e.g., midazolam, pimozide, ergot alkaloids)
CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin)

⚡ Moderate Interactions

CYP2C9 substrates (e.g., tolbutamide, warfarin)
CYP2C19 substrates (e.g., omeprazole)
CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)

ℹ️ Minor Interactions

Dexamethasone
Methylprednisolone

🍽️ Food Interactions

No significant food interactions.

🍷 Alcohol Interaction

May increase CNS depression; avoid concurrent use.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to fosaprepitant, aprepitant, or any component; concurrent use with pimozide.

📊 Monitoring Parameters

Monitor for signs of hypersensitivity; liver function tests if prolonged use; INR in patients on warfarin.

🤱 Lactation Safety

Not recommended; unknown if excreted in human milk.

💊 Overdose Management

No specific antidote; supportive care; dialysis unlikely to be effective due to high protein binding.

⏰ Missed Dose

Not applicable for single-dose IV regimen; if used in multi-day regimen, administer as soon as remembered if within 12 hours.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 21, 2026

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🔄 Substitutes for amitant-iv injection

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Alternative brands with exact same active ingredient (Fosaprepitant (150mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Certified Buyer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Happy Patient Jul 10, 2026

Good quality medicine. Satisfied with the outcome.