azr tablet - Azathioprine (50mg) medicine

azr tablet

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๐Ÿญ Ipca Laboratories Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Sep 21, 2026
๐Ÿคฐ Pregnancy Category A ๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
12 min read
Reviewed by
SaathiMed Expert Panel | Sep 21, 2026

What is azr tablet used for?

This medicine contains Azathioprine (50mg) and is used to treat ANTI NEOPLASTICS. Azathioprine is a purine analog that inhibits DNA and RNA synthesis, suppressing immune cell prolife. Always consult your doctor before use.

  • Generic Name: Azathioprine
  • Manufacturer: Ipca Laboratories Ltd
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

๐Ÿ’Š azr tablet Uses & Benefits

Prevention of organ transplant rejection, rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease (Crohn's disease, ulcerative colitis), autoimmune hepatitis.

Off-label uses: Behรงet's disease, myasthenia gravis, pemphigus vulgaris, atopic dermatitis, multiple sclerosis.

๐Ÿ“‹ Drug Information

Generic Name(s)Azathioprine
Brand NameAzoran Tablet
ManufacturerIpca Laboratories Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI NEOPLASTICS
Action ClassImmunosuppressant- Purine analogs
Route of AdministrationOral
StorageStore at room temperature (20-25ยฐC), protect from light and moisture.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionWell absorbed orally, approximately 50% bioavailability.
DistributionDistributes widely into body tissues, including liver and kidneys.
Protein BindingApproximately 30% bound to plasma proteins.
MetabolismMetabolized in the liver to 6-mercaptopurine (active) and other metabolites via xanthine oxidase and TPMT.
Half-LifeApproximately 5 hours for azathioprine; 3-5 hours for 6-mercaptopurine.
ExcretionPrimarily renal excretion of metabolites; small amount unchanged in urine.
BioavailabilityApproximately 50% (oral).
Onset of ActionDelayed; clinical effects may take weeks to months.
Peak Plasma Time1-2 hours after oral administration.
Duration of ActionProlonged; effects persist for weeks after discontinuation.

How It Works

Azathioprine is a purine analog that inhibits DNA and RNA synthesis, suppressing immune cell proliferation.

Mechanism Steps

1Azathioprine is converted to 6-mercaptopurine (6-MP) in the liver.
26-MP is metabolized to 6-thioguanine nucleotides (6-TGNs) via hypoxanthine-guanine phosphoribosyltransferase (HGPRT).
36-TGNs incorporate into DNA and RNA, inhibiting purine synthesis.
4This disrupts nucleic acid synthesis and cell division, particularly in rapidly dividing cells like lymphocytes.
5Suppression of T-cell and B-cell proliferation leads to immunosuppression.

๐Ÿ’ก How to Take azr tablet

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of azr tablet

โœ… Common Side Effects

Nausea
Vomiting
Diarrhea
Leukopenia
Anemia
Thrombocytopenia
Increased liver enzymes

๐Ÿšจ Serious Side Effects

Severe bone marrow suppression
Hepatotoxicity
Pancreatitis
Serious infections
Lymphoma
Skin cancer

โš ๏ธ Rare Side Effects

Pulmonary fibrosis
Venocclusive disease of liver
Alopecia
Rash
Arthralgia
Hypersensitivity reactions

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

Drug Severity Effect
Allopurinol Major Increased azathioprine toxicity; reduce dose.
Warfarin Major Decreased anticoagulant effect; monitor INR.
Ribavirin Major Increased myelosuppression risk.
Febuxostat Major Increased azathioprine levels; avoid.
Co-trimoxazole Major Increased myelosuppression risk.
ACE inhibitors Moderate Increased risk of anemia and leukopenia.
Methotrexate Moderate Increased hepatotoxicity risk.
Cyclosporine Moderate Increased immunosuppression; monitor.
Infliximab Moderate Increased infection risk.
Mycophenolate Moderate Increased immunosuppression; monitor.
Antacids Minor Decreased absorption; separate by 2 hours.
Oral contraceptives Minor Possible reduced efficacy of contraceptives.
Cimetidine Minor Increased azathioprine levels.
Furosemide Minor Possible increased toxicity.
Indomethacin Minor Increased myelosuppression risk.

๐Ÿšจ Major Interactions

  • Allopurinol
  • Warfarin
  • Ribavirin
  • Febuxostat
  • Co-trimoxazole

โšก Moderate Interactions

  • ACE inhibitors
  • Methotrexate
  • Cyclosporine
  • Infliximab
  • Mycophenolate

๐Ÿท Alcohol Interaction

Alcohol may increase hepatotoxicity risk; avoid or limit.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to azathioprine, severe infections, pregnancy (unless essential), lactation, severe bone marrow suppression.

๐Ÿคฑ Lactation Safety

Not recommended; excreted in breast milk; may cause immunosuppression in infant.

๐Ÿ’Š Overdose Management

Induce vomiting or gastric lavage; monitor for myelosuppression; supportive care; consider hemodialysis.

โฐ Missed Dose

Take as soon as remembered unless near next dose; do not double dose.

๐Ÿ”„ Substitutes for azr tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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