azaplast injection - Azacitidine (100mg) medicine

azaplast injection

4.6 (18 reviews)
Azacitidine (100mg)
๐Ÿญ RPG Life Sciences Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Aug 21, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Aug 21, 2026

What is azaplast injection used for?

Azadine Injection (Azacitidine) is used to treat ANTI NEOPLASTICS. It contains Azacitidine (100mg), which Incorporates into DNA and RNA, inhibiting DNA methyltransferase, leading to hypo. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Azacitidine
  • Manufacturer: RPG Life Sciences Ltd
  • Form: Allopathy
  • Pregnancy Category: D
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

๐Ÿ’Š azaplast injection Uses & Benefits

Myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), chronic myelomonocytic leukemia (CMML).

Off-label uses: Chronic myeloid leukemia (CML), solid tumors (investigational).

๐Ÿ“‹ Drug Information

Generic Name(s)Azacitidine
Brand NameAzadine Injection
ManufacturerRPG Life Sciences Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI NEOPLASTICS
Action ClassAntimetabolites
Route of AdministrationSubcutaneous injection or intravenous infusion.
StorageStore at 25ยฐC (77ยฐF); excursions permitted to 15-30ยฐC (59-86ยฐF). Protect from light.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed after subcutaneous administration; peak plasma concentration achieved within 30 minutes.
DistributionWidely distributed into body tissues, including bone marrow; crosses the blood-brain barrier.
Protein BindingApproximately 10-15% bound to plasma proteins.
MetabolismPrimarily metabolized by cytidine deaminase to inactive metabolites; also undergoes spontaneous hydrolysis.
Half-LifeApproximately 4 hours (subcutaneous); 1-2 hours (intravenous).
ExcretionPrimarily excreted in urine (85% as metabolites, <10% unchanged).
BioavailabilityApproximately 89% after subcutaneous administration.
Onset of ActionWithin 1-2 weeks of therapy.
Peak Plasma Time30 minutes (subcutaneous); end of infusion (intravenous).
Duration of ActionVariable; effects on hematopoiesis persist for weeks.

How It Works

Incorporates into DNA and RNA, inhibiting DNA methyltransferase, leading to hypomethylation and re-expression of silenced tumor suppressor genes.

Mechanism Steps

1Azacitidine is taken up by cells and phosphorylated to azacitidine triphosphate.
2Incorporates into RNA, disrupting RNA metabolism and protein synthesis.
3Incorporates into DNA, inhibiting DNA methyltransferase (DNMT1).

๐Ÿ’ก How to Take azaplast injection

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of azaplast injection

โœ… Common Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Fatigue
  • Fever
  • Anemia
  • Thrombocytopenia
  • Neutropenia
  • Injection site reactions

๐Ÿšจ Serious Side Effects

  • Severe myelosuppression
  • Hepatic failure
  • Renal toxicity
  • Tumor lysis syndrome
  • Cardiac arrhythmias

โš ๏ธ Rare Side Effects

  • Interstitial lung disease
  • Sweet's syndrome
  • Differentiation syndrome
  • Hemorrhagic cystitis

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Cytarabine Major Increased risk of myelosuppression
Ribavirin Major Reduced azacitidine efficacy
Gemcitabine Major Additive myelosuppression
Valproic acid Moderate Increased risk of hepatotoxicity
Hydralazine Moderate Increased risk of myelodysplasia
Procainamide Moderate Increased risk of myelodysplasia
Acetaminophen Minor Possible increased hepatotoxicity
Cimetidine Minor Possible increased azacitidine levels
Ranitidine Minor Possible increased azacitidine levels

๐Ÿšจ Major Interactions

  • Cytarabine
  • Ribavirin
  • Gemcitabine

โšก Moderate Interactions

  • Valproic acid
  • Hydralazine
  • Procainamide

โ„น๏ธ Minor Interactions

  • Acetaminophen
  • Cimetidine
  • Ranitidine

๐Ÿฝ๏ธ Food Interactions

No significant food interactions reported.

๐Ÿท Alcohol Interaction

Avoid alcohol; may increase hepatotoxicity risk.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to azacitidine or mannitol; advanced malignant hepatic tumors; pregnancy.

๐Ÿ“Š Monitoring Parameters

Complete blood count (CBC) with differential, liver function tests, renal function tests, serum electrolytes.

๐Ÿคฑ Lactation Safety

Contraindicated; discontinue breastfeeding during therapy.

๐Ÿ’Š Overdose Management

No specific antidote; supportive care with monitoring of hematologic parameters and organ function.

โฐ Missed Dose

If a dose is missed, administer as soon as possible; do not double the next dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 21, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for azaplast injection

View All

Alternative brands with exact same active ingredient (Azacitidine (100mg)):

Medical Note: Always consult your doctor before switching medications.

โญ User Reviews

Verified User Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Verified User Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Regular Customer Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Regular Customer Jul 10, 2026

Found this to be a helpful product. Good results.

Regular Customer Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

๐Ÿ˜Š Was this information helpful?

Browse Medicines A-Z

Search our extensive medical database alphabetically.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Back to Medicines Directory