Azadine Injection (Azacitidine 100 mg): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Fever above 38°C (100.4°F) or chills
- Unusual bleeding or bruising
- Shortness of breath or difficulty breathing
- Severe abdominal pain
- Yellowing of skin or eyes
- Decreased urine output
- Severe allergic reaction (rash, swelling, difficulty breathing)
If experiencing severe symptoms, call emergency services immediately.
What is azactiv 100mg injection used for?
Azacitidine injection is a chemotherapy medicine used to treat myelodysplastic syndromes and acute myeloid leukemia. It works by helping the bone marrow produce normal blood cells and slowing the growth of abnormal cells. It is given intravenously by a healthcare professional.
- Generic Name: Azacitidine
- Manufacturer: Glenmark Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 azactiv 100mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा एक प्रिस्क्रिप्शन इंजेक्शन है जिसका उपयोग माइलोडिसप्लास्टिक सिंड्रोम और तीव्र माइलॉयड ल्यूकेमिया जैसे रक्त कैंसर के इलाज के लिए किया जाता है। यह असामान्य रक्त कोशिकाओं की वृद्धि को धीमा करती है और अस्थि मज्जा को सामान्य रक्त कोशिकाएं बनाने में मदद करती है। यह दवा डॉक्टर द्वारा नस के माध्यम से दी जाती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, दस्त, कब्ज, थकान, बुखार और इंजेक्शन स्थल पर प्रतिक्रिया शामिल हैं। गंभीर दुष्प्रभावों में रक्त कोशिकाओं की कमी, संक्रमण, रक्तस्राव, यकृत और गुर्दे की समस्याएं शामिल हो सकती हैं। किसी भी असामान्य लक्षण की तुरंत डॉक्टर को सूचना दें।
सुरक्षा सलाह: यह दवा केवल योग्य कैंसर विशेषज्ञ की देखरेख में दी जानी चाहिए। नियमित रक्त परीक्षण आवश्यक हैं। संक्रमण से बचने के लिए सावधानी बरतें। गर्भवती महिलाओं को यह दवा नहीं लेनी चाहिए। शराब का सेवन न करें। डॉक्टर से परामर्श के बिना कोई अन्य दवा न लें।
💊 azactiv 100mg injection Uses & Benefits
[{"condition":"Myelodysplastic syndromes (MDS)","description":"Used to treat adults with myelodysplastic syndromes, including refractory anemia with excess blasts, chronic myelomonocytic leukemia, and other subtypes.","evidence":"Well-established"},{"condition":"Acute myeloid leukemia (AML)","description":"Used for the treatment of adults with acute myeloid leukemia, particularly in older patients or those who cannot tolerate intensive chemotherapy.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Chronic myelomonocytic leukemia (CMML)","description":"Sometimes used off-label for chronic myelomonocytic leukemia, a condition that overlaps with MDS.","evidence":"Limited"},{"condition":"Relapsed or refractory AML","description":"May be used off-label in some patients with relapsed or refractory acute myeloid leukemia.","evidence":"Limited"}]
Primary treatment for: Myelodysplastic syndromes
Also treats: Acute myeloid leukemia, Chronic myelomonocytic leukemia
📋 Drug Information
| Generic Name(s) | Azacitidine |
| Brand Name | Azadine Injection |
| Manufacturer | Glenmark Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Antimetabolites |
| Route of Administration | Intravenous (IV) infusion. This medicine is administered by a healthcare professional |
| Storage | Store unopened vials at 20°C to 25°C (68°F to 77°F). Excursions permitted to 15°C to 30°C (59°F to 86°F). Store in original carton to protect from light. After reconstitution, the solution should be stored as directed by the pharmacy and used within the specified time. |
| Shelf Life | Refer to the product packaging for the expiration date. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Azacitidine is a pyrimidine nucleoside analog that exerts its effects by incorporating into DNA and RNA. In DNA, it inhibits DNA methyltransferase, leading to hypomethylation of DNA and reactivation of silenced genes, including tumor suppressor genes. In RNA, it interferes with protein synthesis and can induce cellular differentiation and apoptosis of abnormal hematopoietic cells. This dual mechanism helps restore normal hematopoiesis and slows the proliferation of malignant cells.
Mechanism Steps
💡 How to Take azactiv 100mg injection
Strength: Azacitidine 100 mg powder for injection (intravenous use).
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is determined by the treating oncologist based on the specific condition being treated, the patient's blood counts, and overall health. For myelodysplastic syndromes, a common regimen is 75 mg/m² given intravenously once daily for 7 days every 4 weeks. For acute myeloid leukemia, the dose may be 75 mg/m² daily for 7 days every 4 weeks. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. Dose selection should be cautious, and monitoring of blood counts, liver, and kidney function is recommended. No specific dose adjustment is established solely based on age. |
| Renal Impairment | Patients with severe renal impairment may require dose adjustment. Monitor kidney function closely. Consult the prescribing oncologist for specific dosing. |
| Hepatic Impairment | Patients with severe hepatic impairment may require dose adjustment. Monitor liver function closely. Consult the prescribing oncologist for specific dosing. |
| Maximum Daily Dose | The maximum daily dose is not established from available information. Dosing is individualized by the treating oncologist. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of azactiv 100mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Live vaccines | Major | |
| Myelosuppressive agents | Major | |
| NSAIDs | Moderate | |
| Anticoagulants | Moderate | |
| Alcohol | Moderate |
🚨 Major Interactions
- Live vaccines
- Myelosuppressive agents (e.g., chemotherapy, radiation)
⚡ Moderate Interactions
- NSAIDs (e.g., ibuprofen, naproxen)
- Anticoagulants (e.g., warfarin, heparin)
🍷 Alcohol Interaction
Alcohol should be avoided during treatment with this medicine because it can increase the risk of liver problems and bleeding, and may worsen side effects such as nausea and fatigue.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to azacitidine or any component of the formulation","Pregnancy","Breastfeeding","Severe liver disease","Severe kidney disease"]
⚠️ Warnings & Precautions
["This medicine can cause severe myelosuppression; monitor blood counts regularly.","May cause fetal harm; use effective contraception.","Avoid live vaccines during treatment.","May cause liver and kidney toxicity; monitor function tests.","May cause tumor lysis syndrome; monitor electrolytes and uric acid.","May cause severe allergic reactions; seek immediate help if symptoms occur.","Patients with pre-existing liver or kidney disease may require dose adjustments."]
🤱 Lactation Safety
It is not known whether azacitidine passes into breast milk. Because of the potential for serious adverse reactions in nursing infants, breastfeeding should be discontinued during treatment and for at least 1 week after the last dose.
💊 Overdose Management
There is no specific antidote for overdose. In case of overdose, discontinue the medicine and provide supportive care. Monitor blood counts, liver and kidney function closely. Contact a poison control center or emergency department immediately.
⏰ Missed Dose
If a dose is missed, contact your healthcare provider as soon as possible. Do not double the dose to catch up. The dosing schedule should be adjusted by the treating oncologist.
Additional Safety Advice
This medicine must be given under the supervision of a qualified oncologist. Regular blood tests are required to monitor blood counts, liver function, and kidney function. Patients should avoid close contact with people who have infections and should practice good hand hygiene. Women of childbearing age should use effective contraception during treatment and for a period after the last dose. Men should also use contraception. This medicine may cause fatigue or dizziness; patients should avoid driving or operating machinery until they know how it affects them. Do not receive any live vaccines without consulting the doctor. Inform your doctor about all other medicines, including over-the-counter drugs and herbal supplements.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to side effects such as myelosuppression, infections, and fatigue. Close monitoring of blood counts, liver, and kidney function is recommended. Dose adjustments may be necessary based on tolerability.
🤰 Pregnancy Planning (TTC)
This medicine can cause fetal harm. Women of childbearing potential should use effective contraception during treatment and for at least 6 months after the last dose. Men should also use contraception. If you are planning pregnancy, consult your doctor before starting treatment.
🏥 Post-Surgery Considerations
This medicine may increase the risk of bleeding and infection after surgery. Inform your surgeon and anesthesiologist about your treatment. Your doctor may recommend delaying surgery or adjusting the treatment schedule.
🦷 Dental Procedures
Inform your dentist about your treatment with this medicine. Due to increased risk of bleeding and infection, dental procedures may need to be postponed or performed with precautions. Consult your doctor before any dental work.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Patients should avoid strenuous exercise during treatment due to fatigue and increased risk of bleeding. Light activities like walking are encouraged if tolerated. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue, dizziness, and increased risk of infection, which can affect your ability to work or drive. Avoid driving or operating machinery until you know how this medicine affects you. Discuss work accommodations with your employer if needed.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Treatment duration is determined by your oncologist based on your response and side effects. If you experience severe side effects, contact your doctor immediately; they may adjust or stop the treatment.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to persistent low blood counts, increased risk of infections, and bleeding. Regular monitoring of blood counts, liver, and kidney function is essential. Some patients may develop resistance to the medicine over time. Long-term effects on fertility are not fully known. Patients should be monitored for secondary cancers.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Blood transfusions, antibiotics, and growth factors can help manage symptoms.
Evidence: Well-establishedFor eligible patients, stem cell transplant may be curative.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided during treatment with this medicine due to the risk of infection. Inactivated vaccines may be given, but their effectiveness may be reduced. Consult your doctor before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original carton to protect from light
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature, away from direct sunlight. If traveling across time zones, consult your doctor about adjusting the dosing schedule. Check customs regulations for carrying prescription medications. Always carry a medical alert card stating your condition and treatment.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: It may take several weeks to months of treatment to see improvement in blood counts. Your doctor will monitor your progress with regular blood tests.
A: No, this medicine must be given by a healthcare professional in a clinic or hospital setting.
A: Contact your healthcare provider as soon as possible. Do not double the dose.
A: No, this medicine can harm the unborn baby. Use effective contraception during treatment.
🤔 Common Patient Concerns
🔄 Substitutes for azactiv 100mg injection
View AllAlternative brands with exact same active ingredient:
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hemazide injectionCadila Pharmaceuticals Ltd ₹2,343.75 3.5% CHEAPER
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azatend injectionZydus Cadila ₹2,625.00 8% COSTLIER
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myaza injectionMylan Pharmaceuticals Pvt Ltd ₹3,000.00 23.5% COSTLIER
-
azaplast injectionRPG Life Sciences Ltd ₹3,162.19 30.1% COSTLIER
-
azafab 100mg injectionPanacea Biotec Ltd ₹3,716.59 52.9% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Azacitidine is a cure for all blood cancers.
Fact: Azacitidine is used for specific types of blood disorders and is not a cure for all cancers. It helps control the disease and improve blood counts. - Myth: Azacitidine can be taken at home.
Fact: Azacitidine must be given by a healthcare professional in a clinic or hospital setting. - Myth: Azacitidine has no side effects.
Fact: Azacitidine can cause significant side effects, including low blood counts, infections, and bleeding.
🔄 Alternative Options
Generic Alternatives
- Azacitidine
Brand Alternatives
- Azadine