azactiv 100mg injection - Azacitidine (100mg) medicine

Azactiv 100mg Injection - Uses, Price, Side Effects

4.5 (15 reviews)
Azacitidine (100mg)
๐Ÿญ Glenmark Pharmaceuticals Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Aug 21, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Aug 21, 2026

What is azactiv 100mg injection used for?

Azactiv 100mg Injection contains Azacitidine, a chemotherapy drug used to treat myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). It works by inhibiting DNA methylation, which helps restore normal cell growth and differentiation. Administered subcutaneously or intravenously, it is typically given for 7 days per cycle.

  • Generic Name: Azacitidine
  • Manufacturer: Glenmark Pharmaceuticals Ltd
  • Form: Allopathy
  • Pregnancy Category: D
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

๐Ÿ’Š azactiv 100mg injection Uses & Benefits

Myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), chronic myelomonocytic leukemia (CMML).

Off-label uses: Chronic myeloid leukemia (CML), solid tumors (investigational).

๐Ÿ“‹ Drug Information

Generic Name(s)Azacitidine
Brand NameAzadine Injection
ManufacturerGlenmark Pharmaceuticals Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI NEOPLASTICS
Action ClassAntimetabolites
Route of AdministrationSubcutaneous injection or intravenous infusion.
StorageStore at 25ยฐC (77ยฐF); excursions permitted to 15-30ยฐC (59-86ยฐF). Protect from light.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed after subcutaneous administration; peak plasma concentration achieved within 30 minutes.
DistributionWidely distributed into body tissues, including bone marrow; crosses the blood-brain barrier.
Protein BindingApproximately 10-15% bound to plasma proteins.
MetabolismPrimarily metabolized by cytidine deaminase to inactive metabolites; also undergoes spontaneous hydrolysis.
Half-LifeApproximately 4 hours (subcutaneous); 1-2 hours (intravenous).
ExcretionPrimarily excreted in urine (85% as metabolites, <10% unchanged).
BioavailabilityApproximately 89% after subcutaneous administration.
Onset of ActionWithin 1-2 weeks of therapy.
Peak Plasma Time30 minutes (subcutaneous); end of infusion (intravenous).
Duration of ActionVariable; effects on hematopoiesis persist for weeks.

How It Works

Incorporates into DNA and RNA, inhibiting DNA methyltransferase, leading to hypomethylation and re-expression of silenced tumor suppressor genes.

Mechanism Steps

1Azacitidine is taken up by cells and phosphorylated to azacitidine triphosphate.
2Incorporates into RNA, disrupting RNA metabolism and protein synthesis.
3Incorporates into DNA, inhibiting DNA methyltransferase (DNMT1).

๐Ÿ’ก How to Take azactiv 100mg injection

Follow your doctor's prescription exactly.

Dosage Timeline

๐ŸŒ… Morning โœ… โ˜€๏ธ Afternoon โŒ ๐ŸŒ† Evening โŒ ๐ŸŒ™ Night โŒ

โš ๏ธ Side Effects of azactiv 100mg injection

โœ… Common Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Fatigue
  • Fever
  • Anemia
  • Thrombocytopenia
  • Neutropenia
  • Injection site reactions

๐Ÿšจ Serious Side Effects

  • Severe myelosuppression
  • Hepatic failure
  • Renal toxicity
  • Tumor lysis syndrome
  • Cardiac arrhythmias

โš ๏ธ Rare Side Effects

  • Interstitial lung disease
  • Sweet's syndrome
  • Differentiation syndrome
  • Hemorrhagic cystitis

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Warfarin Major Increased bleeding risk
Cytarabine Moderate Increased risk of myelosuppression
Rifampin Moderate Reduced azacitidine efficacy

๐Ÿšจ Major Interactions

  • Cytarabine
  • Ribavirin
  • Gemcitabine

โšก Moderate Interactions

  • Valproic acid
  • Hydralazine
  • Procainamide

โ„น๏ธ Minor Interactions

  • Acetaminophen
  • Cimetidine
  • Ranitidine

๐Ÿฝ๏ธ Food Interactions

No significant food interactions reported.

๐Ÿท Alcohol Interaction

Avoid alcohol; may increase hepatotoxicity risk.

๐Ÿ›ก๏ธ Safety & Warnings

Liver
Moderate
Kidney
Moderate
Heart
Low
Pregnancy
Category D

๐Ÿšซ Contraindications

Hypersensitivity to azacitidine or mannitol; advanced malignant hepatic tumors; pregnancy.

๐Ÿ“Š Monitoring Parameters

Complete blood count (CBC) with differential, liver function tests, renal function tests, serum electrolytes.

๐Ÿคฑ Lactation Safety

Contraindicated; discontinue breastfeeding during therapy.

๐Ÿ’Š Overdose Management

No specific antidote; supportive care with monitoring of hematologic parameters and organ function.

โฐ Missed Dose

If a dose is missed, administer as soon as possible; do not double the next dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 21, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for azactiv 100mg injection

View All

Alternative brands with exact same active ingredient (Azacitidine (100mg)):

Medical Note: Always consult your doctor before switching medications.

โญ User Reviews

Regular Customer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Happy Patient Jul 10, 2026

Effective and reliable. Worked as expected.

Regular Customer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Trusted Reviewer Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Regular Customer Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

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