Amitant Kit (Aprepitant 125 mg + 12 mg): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of the face, lips, tongue, or throat
- Difficulty breathing or wheezing
- Widespread rash, blistering, or peeling skin
- Severe dizziness or fainting
- Unusual tiredness or weakness that does not go away
- Yellowing of the skin or eyes
- Severe abdominal pain or persistent vomiting
If experiencing severe symptoms, call emergency services immediately.
What is amitant kit used for?
This medicine is a prescription kit containing two strengths of aprepitant, an NK1 receptor antagonist used to prevent nausea and vomiting caused by chemotherapy or surgery. It works by blocking substance P in the brain and gut. It is taken by mouth exactly as directed by your doctor.
- Generic Name: Aprepitant (12mg) + Aprepitant (125mg)
- Manufacturer: Aureate Healthcare Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 amitant kit के बारे में (Hindi Summary)
उपयोग: यह दवा एप्रेपिटेंट नामक सक्रिय तत्व की दो शक्तियों का एक किट है, जिसका उपयोग कीमोथेरेपी या सर्जरी के कारण होने वाली मतली और उल्टी को रोकने के लिए किया जाता है। यह मस्तिष्क और आंत में एक विशेष रिसेप्टर को ब्लॉक करके काम करती है, जिससे उल्टी की प्रवृत्ति कम होती है। यह दवा मुँह से ली जाती है और डॉक्टर के निर्देशानुसार ही लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में थकान, सिरदर्द, कब्ज, दस्त, भूख न लगना और हिचकी शामिल हो सकते हैं। ये आमतौर पर हल्के होते हैं और अपने आप ठीक हो जाते हैं। कभी-कभी गंभीर एलर्जी प्रतिक्रिया हो सकती है, जैसे चेहरे, होंठ, जीभ या गले में सूजन, साँस लेने में कठिनाई, या त्वचा पर चकत्ते। ऐसा होने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें, क्योंकि सही समय पर लेना बहुत जरूरी है। कैप्सूल को पानी के साथ पूरा निगलें। अपने डॉक्टर को अपनी सभी दवाओं के बारे में बताएं, क्योंकि यह कई दवाओं के साथ प्रतिक्रिया कर सकती है। इस दवा के साथ शराब न लें। यदि आप गर्भवती हैं, गर्भधारण की योजना बना रही हैं या स्तनपान करा रही हैं, तो डॉक्टर से सलाह लें। दवा को ठंडी, सूखी जगह पर, धूप से दूर, बच्चों की पहुंच से बाहर रखें।
💊 amitant kit Uses & Benefits
[{"condition":"Prevention of chemotherapy-induced nausea and vomiting (CINV)","description":"Used as part of a combination regimen to prevent acute and delayed nausea and vomiting in adults receiving highly or moderately emetogenic chemotherapy.","evidence":"Well-established"},{"condition":"Prevention of postoperative nausea and vomiting (PONV)","description":"May be used to reduce the risk of nausea and vomiting after surgery in appropriate patients.","evidence":"Established"}]
Off-label uses: [{"condition":"Refractory nausea and vomiting from other causes","description":"Occasionally used off-label for severe nausea and vomiting not related to chemotherapy or surgery, based on clinician judgment.","evidence":"Limited"}]
Primary treatment for: Chemotherapy-induced nausea and vomiting
Also treats: Postoperative nausea and vomiting
📋 Drug Information
| Generic Name(s) | Aprepitant (12mg) + Aprepitant (125mg) |
| Brand Name | amitant kit |
| Manufacturer | Aureate Healthcare Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep in the original packaging, away from moisture and direct sunlight. Do not refrigerate unless instructed. |
| Shelf Life | The shelf life is typically 24 months from the date of manufacture. Check the expiry date on the pack before use. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Aprepitant is a selective antagonist of the neurokinin-1 (NK1) receptor. Substance P is a natural chemical that binds to NK1 receptors in the brain and gastrointestinal tract and can trigger nausea and vomiting. By blocking these receptors, aprepitant reduces the vomiting reflex and helps prevent nausea and vomiting caused by chemotherapy and surgery. This medicine provides two strengths of aprepitant in one kit so that the clinician can give the appropriate dose at the appropriate time.
Mechanism Steps
💡 How to Take amitant kit
Strength: Kit containing aprepitant 125 mg and aprepitant 12 mg immediate-release capsules
Dosage Information
| Adult Dosage | The dose and timing of this medicine depend on the reason it is being given and on other medicines you take. For prevention of chemotherapy-induced nausea and vomiting, a common regimen is 125 mg on day 1 and 80 mg once daily on days 2 and 3, often combined with other anti-emetics. For prevention of postoperative nausea and vomiting, a single 40 mg dose may be used. This kit contains 125 mg and 12 mg components, so the exact number of capsules and timing must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and other medicines. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is required for elderly patients based on age alone. However, because older adults may have reduced liver or kidney function or take other medicines, the dose should be individualized by a qualified clinician. |
| Renal Impairment | No dose adjustment is needed for mild to moderate kidney impairment. For severe kidney impairment or patients on dialysis, use with caution and individualize the dose as advised by a qualified clinician. |
| Hepatic Impairment | For mild to moderate liver impairment, no dose adjustment is usually needed. For severe liver impairment, use with caution and individualize the dose as advised by a qualified clinician. |
| Maximum Daily Dose | The maximum daily dose depends on the indication and should not exceed the dose prescribed by your clinician. For chemotherapy-induced nausea and vomiting, the usual maximum is 125 mg on day 1 and 80 mg on subsequent days. For postoperative nausea and vomiting, a single 40 mg dose is typical. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of amitant kit
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Rifampicin | Major | |
| St. John's wort | Major | |
| Ketoconazole | Moderate | |
| Diltiazem | Moderate | |
| Paroxetine | Moderate | |
| Oral contraceptives | Minor | |
| Tolbutamide | Minor | |
| Midazolam | Moderate | |
| Dexamethasone | Moderate |
🚨 Major Interactions
- Warfarin
- Rifampicin
- St. John's wort
⚡ Moderate Interactions
- Ketoconazole
- Diltiazem
- Paroxetine
🍷 Alcohol Interaction
Alcohol may increase dizziness, drowsiness, and tiredness while taking this medicine. It is best to avoid alcohol during treatment, especially if you are also taking other medicines that cause drowsiness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Allergy to aprepitant or any ingredient in the kit","Use with rifampicin, St. John's wort, or certain other medicines that strongly affect liver enzymes","Severe liver disease without medical supervision"]
⚠️ Warnings & Precautions
["Tell your doctor about all medicines you take, including herbal products.","Avoid alcohol while taking this medicine.","Use with caution in liver disease.","Use with caution in kidney disease.","Do not use if pregnant or breastfeeding without medical advice.","Keep out of reach of children.","Do not share this medicine with others."]
🤱 Lactation Safety
It is not known whether aprepitant passes into breast milk. Because many medicines do pass into breast milk, breastfeeding is not recommended while taking this medicine unless your doctor advises otherwise.
💊 Overdose Management
If you take too much of this medicine, contact your doctor or go to the nearest emergency room right away. Symptoms of overdose may include severe drowsiness, dizziness, or unusual tiredness. Treatment is supportive and based on symptoms.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. Follow the specific instructions given by your healthcare team.
Additional Safety Advice
Take this medicine exactly as your doctor or nurse instructs, because the timing of each component is important for it to work properly. Swallow the capsules whole with a little water unless your clinician tells you otherwise. Do not take more than the prescribed amount, and do not share this medicine with anyone else. Tell your doctor about all other medicines you take, including prescription, over-the-counter, herbal, and vitamin products, because aprepitant can interact with several common medicines. Avoid alcohol while using this medicine, as it may increase dizziness and drowsiness. If you are pregnant, planning pregnancy, or breastfeeding, talk to your doctor before using this medicine. Keep the kit in its original packaging, store it at room temperature away from moisture and direct sunlight, and keep it out of reach of children. If you miss a dose, follow the instructions given by your healthcare team rather than guessing.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults may be more sensitive to the side effects of this medicine, such as tiredness and dizziness. They may also have reduced liver or kidney function or take other medicines, so the dose should be individualized by a qualified clinician.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, talk to your doctor before using this medicine. It is not recommended during pregnancy unless clearly needed. Your doctor can help you weigh the benefits and risks.
🏥 Post-Surgery Considerations
This medicine may be used before surgery to prevent postoperative nausea and vomiting. After surgery, follow your doctor's instructions for taking any remaining doses. Report any unusual symptoms to your healthcare team.
🦷 Dental Procedures
If you are scheduled for a dental procedure, tell your dentist about all medicines you take, including this one. There are no specific restrictions, but your dentist may want to coordinate with your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Mild exercise such as walking may help with overall well-being, but avoid strenuous activity if you feel tired, dizzy, or weak. Listen to your body and rest when needed.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause tiredness or dizziness in some people. If you feel drowsy, avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their daily activities, but it is important to rest when needed, especially after chemotherapy or surgery.
🛑 When to Stop This Medicine
Do not stop taking this medicine without talking to your doctor. It is usually taken for a short, fixed period. If you experience severe side effects or an allergic reaction, stop the medicine and seek medical help immediately. Your doctor will decide if any change is needed.
📅 Long-Term Use Effects
This medicine is usually taken for a short period, such as a few days around chemotherapy or a single dose before surgery. Long-term effects are not well established because it is not intended for prolonged use. If you need to take it for a longer time, your doctor may monitor your liver function and other parameters.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Medicines such as ondansetron or dexamethasone may be used alone or in combination with this medicine.
Evidence: Well-establishedRelaxation techniques, acupuncture, and dietary changes may help reduce nausea in some people.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are receiving chemotherapy or have a weakened immune system, talk to your doctor about the timing of any vaccinations.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label clearly visible. Bring a copy of your prescription and a doctor's note explaining why you need it, especially for international travel. Store it in your carry-on luggage to avoid extreme temperatures in checked baggage. If you are crossing time zones, ask your doctor how to adjust the timing of your doses. Keep it away from direct sunlight and moisture during travel.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working after it is absorbed, with peak levels reached in about 4 hours. It is taken before chemotherapy or surgery to prevent nausea and vomiting.
A: Yes, but some medicines can interact with it. Always tell your doctor about all medicines you take, including prescription, over-the-counter, and herbal products.
A: It is not recommended during pregnancy unless clearly needed. Consult your doctor if you are pregnant or planning pregnancy.
A: Take it as soon as you remember if it is not almost time for your next dose. If it is almost time, skip the missed dose and continue with your regular schedule. Do not double dose.
A: It is best to avoid alcohol because it can increase drowsiness and dizziness.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can be taken after nausea starts to stop it quickly.
Fact: This medicine is used to prevent nausea and vomiting and works best when taken before chemotherapy or surgery as directed. - Myth: This medicine is a pain reliever.
Fact: This medicine is an anti-nausea medicine and does not relieve pain. - Myth: It is safe to take extra doses if nausea is severe.
Fact: Taking more than prescribed can increase side effects and is not recommended. Follow your doctor's instructions exactly.
🔄 Alternative Options
Generic Alternatives
- Aprepitant
Brand Alternatives
- Emend