Ancount Injection (Filgrastim 300 mcg): Comprehensive Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Left upper abdominal pain or shoulder tip pain
- Difficulty breathing or rapid breathing
- Swelling of the face, lips, or throat
- Severe bone pain unrelieved by over-the-counter painkillers
- Signs of infection such as fever, chills, or sore throat
- Unusual bleeding or bruising
- Decreased urine output or swelling in the legs
If experiencing severe symptoms, call emergency services immediately.
What is ancount injection used for?
Ancount injection contains Filgrastim 300 mcg, a colony-stimulating factor used to increase white blood cell counts in patients with neutropenia caused by chemotherapy, chronic neutropenia, or bone marrow transplantation. It is given intravenously or subcutaneously under medical supervision.
- Generic Name: Filgrastim
- Manufacturer: Aureate Healthcare Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ancount injection के बारे में (Hindi Summary)
उपयोग: यह दवा फिलग्रास्टिम 300 माइक्रोग्राम इंजेक्शन के रूप में उपलब्ध है। यह मुख्य रूप से कीमोथेरेपी के कारण होने वाले न्यूट्रोपेनिया (सफेद रक्त कोशिकाओं की कमी) के इलाज के लिए दी जाती है। यह शरीर में न्यूट्रोफिल नामक श्वेत रक्त कोशिकाओं का उत्पादन बढ़ाकर संक्रमण से लड़ने में मदद करती है। इसका उपयोग गंभीर क्रोनिक न्यूट्रोपेनिया, अस्थि मज्जा प्रत्यारोपण और स्टेम सेल संग्रह के दौरान भी किया जाता है। यह दवा केवल डॉक्टर की देखरेख में इंजेक्शन द्वारा दी जाती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में हड्डियों में दर्द, सिरदर्द, थकान, मतली और इंजेक्शन लगाने की जगह पर लालिमा या सूजन शामिल हैं। गंभीर दुष्प्रभावों में प्लीहा का फटना, सांस लेने में कठिनाई, एलर्जी प्रतिक्रिया और केशिका रिसाव सिंड्रोम हो सकते हैं। यदि आपको तेज दर्द, सांस लेने में परेशानी या चेहरे पर सूजन हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल योग्य स्वास्थ्य पेशेवर की देखरेख में ही दी जानी चाहिए। बिना प्रशिक्षण के स्वयं इंजेक्शन न लगाएं। नियमित रक्त परीक्षण कराते रहें। यदि आपको सिकल सेल रोग, हृदय या फेफड़ों की बीमारी है तो डॉक्टर को बताएं। संक्रमण से बचने के लिए भीड़-भाड़ वाली जगहों से बचें। इस दवा को 2°C से 8°C के बीच रेफ्रिजरेटर में रखें और जमने न दें।
💊 ancount injection Uses & Benefits
[{"condition":"Chemotherapy-induced neutropenia","description":"Reduces the duration of neutropenia and the incidence of infection in patients receiving myelosuppressive chemotherapy.","evidence":"Well-established"},{"condition":"Severe chronic neutropenia","description":"Used to manage severe chronic neutropenia, including congenital, cyclic, and idiopathic neutropenia.","evidence":"Well-established"},{"condition":"Bone marrow transplantation","description":"Accelerates neutrophil recovery after bone marrow transplantation.","evidence":"Well-established"},{"condition":"Peripheral blood stem cell mobilization","description":"Mobilizes hematopoietic stem cells into the peripheral blood for collection and subsequent transplantation.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Myelodysplastic syndromes","description":"Sometimes used off-label to treat neutropenia associated with myelodysplastic syndromes.","evidence":"Limited"},{"condition":"Aplastic anemia","description":"May be used off-label in some cases of aplastic anemia to stimulate neutrophil production.","evidence":"Limited"}]
Primary treatment for: Chemotherapy-induced neutropenia
Also treats: Severe chronic neutropenia, Bone marrow transplantation, Peripheral blood stem cell mobilization
📋 Drug Information
| Generic Name(s) | Filgrastim |
| Brand Name | Axokine Injection |
| Manufacturer | Aureate Healthcare Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Granulocyte-colony stimulating factor (G-CSF) |
| Route of Administration | Intravenous (IV) infusion or subcutaneous injection. The route specified for this product is intravenous |
| Storage | Store in the refrigerator at 2°C to 8°C (36°F to 46°F). Do not freeze. Keep the vial in the original carton to protect from light. Do not shake. Before use, allow the vial to reach room temperature for 30 minutes. Do not use if the solution is discolored or contains particulate matter. |
| Shelf Life | The shelf life of this medicine is typically 24 months from the date of manufacture when stored under recommended conditions. Refer to the product label for the exact expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Filgrastim binds to specific cell surface receptors on hematopoietic cells, particularly neutrophil precursors, and stimulates their proliferation, differentiation, and activation. This leads to an increased production of neutrophils from the bone marrow and enhanced functional activity of mature neutrophils, such as phagocytosis and antibody-dependent cell-mediated cytotoxicity.
Mechanism Steps
💡 How to Take ancount injection
Strength: Filgrastim 300 mcg in a single-use vial for injection.
Dosage Information
| Adult Dosage | The dose of this medicine must be individualized by a qualified clinician based on the indication, patient's age, weight, renal and hepatic function, and response to therapy. For chemotherapy-induced neutropenia, the usual adult dose is 5 mcg/kg per day as a single subcutaneous injection or intravenous infusion, starting at least 24 hours after chemotherapy. For severe chronic neutropenia, the starting dose is 6 mcg/kg twice daily. For stem cell mobilization, the dose is 10 mcg/kg per day. Do not self-administer; follow your doctor's instructions exactly. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Clinical studies of Filgrastim did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. |
| Renal Impairment | No specific dose adjustment is recommended for patients with renal impairment. However, Filgrastim is excreted by the kidneys, and caution should be exercised in patients with severe renal impairment. Monitor closely. |
| Hepatic Impairment | No specific dose adjustment is recommended for patients with hepatic impairment. However, Filgrastim is metabolized in the liver, and caution should be exercised in patients with severe hepatic impairment. Monitor closely. |
| Maximum Daily Dose | The maximum daily dose has not been established. Doses up to 100 mcg/kg per day have been used in clinical trials. Dose must be individualized by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ancount injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Cyclophosphamide | Major | |
| Doxorubicin | Major | |
| Lithium | Moderate | |
| Sargramostim | Moderate |
🚨 Major Interactions
- Chemotherapy agents (e.g., cyclophosphamide, doxorubicin)
- Lithium
⚡ Moderate Interactions
- Other colony-stimulating factors (e.g., sargramostim)
🍷 Alcohol Interaction
There is no known direct interaction between alcohol and Filgrastim. However, alcohol may suppress bone marrow function and worsen neutropenia, so it is advisable to avoid alcohol while receiving this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to Filgrastim or any component of the formulation","Concurrent use with chemotherapy within 24 hours before or after administration","Patients with sickle cell disease (may precipitate severe vaso-occlusive crisis)"]
⚠️ Warnings & Precautions
["Splenic rupture: Rare but serious. Monitor for left upper abdominal or shoulder pain.","Acute respiratory distress syndrome (ARDS): Monitor for respiratory symptoms.","Serious allergic reactions: Discontinue immediately if anaphylaxis occurs.","Capillary leak syndrome: Monitor for hypotension, edema, and hemoconcentration.","Leukocytosis: Monitor white blood cell count and adjust dose as needed.","Thrombocytopenia: Monitor platelet count.","Sickle cell disease: May precipitate severe vaso-occlusive crisis. Use with caution.","Myelodysplastic syndromes: May increase risk of progression to acute myeloid leukemia.","Glomerulonephritis: Has been reported in patients receiving Filgrastim. Monitor for hematuria and proteinuria."]
🤱 Lactation Safety
It is not known whether Filgrastim is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
💊 Overdose Management
Overdose of Filgrastim may result in leukocytosis and bone pain. There is no specific antidote. Treatment should be symptomatic and supportive. Monitor white blood cell count and provide appropriate care. In case of accidental overdose, contact a poison control center or emergency room immediately.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up. If you are unsure, consult your healthcare provider.
Additional Safety Advice
This medicine must only be administered under the supervision of a qualified healthcare professional. Do not self-administer unless you have been trained and instructed by your doctor. Regular blood tests are required to monitor your white blood cell count and platelet levels. Inform your doctor if you have a history of sickle cell disease, heart problems, or lung disease. Avoid close contact with people who have infections, as your immune system may be compromised. Do not receive any live vaccines while on this medicine without consulting your doctor. If you experience severe bone pain, difficulty breathing, or swelling of the face or throat, seek emergency medical help immediately. Store this medicine in the refrigerator at 2°C to 8°C, and do not freeze. Keep it out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to the side effects of Filgrastim, particularly bone pain and fatigue. Dose selection should be cautious, and monitoring should be more frequent. No specific dose adjustment is recommended based on age alone, but individual factors should be considered.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before starting this medicine. Filgrastim is Pregnancy Category C and should be used during pregnancy only if clearly needed. Effective contraception should be used during treatment.
🏥 Post-Surgery Considerations
If you have recently undergone surgery, inform your surgeon and anesthesiologist that you are receiving Filgrastim. It may affect blood counts and healing. Your doctor will determine the appropriate timing for administration around surgery.
🦷 Dental Procedures
Inform your dentist that you are receiving Filgrastim, as it may affect your white blood cell count and increase the risk of infection. Your dentist may recommend postponing non-urgent dental procedures until your blood counts recover.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While on this medicine, you may experience fatigue and bone pain. Avoid strenuous exercise if you feel unwell. Light activities like walking may be beneficial, but consult your doctor before starting any exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue and bone pain, which can affect your ability to work or perform daily activities. If you experience dizziness or severe fatigue, avoid driving or operating heavy machinery. Discuss with your employer if you need flexible working arrangements during treatment.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Your doctor will determine when to stop based on your blood counts and clinical response. If you experience serious side effects, contact your doctor immediately; they may adjust or discontinue the treatment.
📅 Long-Term Use Effects
Long-term use of Filgrastim may be associated with an increased risk of myelodysplastic syndromes and acute myeloid leukemia in patients with severe chronic neutropenia. Regular monitoring of blood counts and clinical assessment is necessary. Bone pain may persist but can be managed. Patients should be monitored for splenic rupture and other serious adverse effects. The need for continued therapy should be reassessed periodically.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A longer-acting form of G-CSF that requires less frequent dosing.
Evidence: Well-establishedA GM-CSF that stimulates both neutrophils and macrophages.
Evidence: Well-establishedUsed to prevent infections in neutropenic patients, but does not increase white blood cell count.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should not be administered while on this medicine due to the potential for severe infections. Inactivated vaccines may be given, but the immune response may be reduced. Consult your doctor before receiving any vaccinations.
📦 Storage Guide
✅ DO
Store in the refrigerator at 2°C to 8°C
❌ DON'T
Do not freeze
✅ DO
Keep in the original carton to protect from light
❌ DON'T
Do not expose to direct sunlight
✅ DO
Allow to reach room temperature before injection
❌ DON'T
Do not shake the vial
✅ DO
Check for particles or discoloration before use
❌ DON'T
Do not use if the solution is cloudy or contains particles
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging with the prescription label. Keep it in a cool, insulated bag with ice packs to maintain the temperature between 2°C and 8°C. Do not freeze. Carry a copy of your prescription and a letter from your doctor explaining the medical need for the injection. Check airline regulations for carrying injectable medicines and sharps. If crossing time zones, consult your doctor about adjusting the dosing schedule. Always declare the medication at customs if required.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: An increase in neutrophil count is typically seen within 24 hours, with a peak effect after 3 to 5 days of daily dosing.
A: Yes, but only if you have been trained by a healthcare professional to administer subcutaneous injections safely.
A: Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: Filgrastim is Pregnancy Category C. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult your doctor.
A: Store in the refrigerator at 2°C to 8°C. Do not freeze. Keep in the original carton to protect from light.
🤔 Common Patient Concerns
🔄 Substitutes for ancount injection
View AllAlternative brands with exact same active ingredient:
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granfill 300mcg injectionSamarth Life Sciences Pvt Ltd ₹375.00 66.9% CHEAPER
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neukine 300mcg injectionIntas Pharmaceuticals Ltd ₹587.55 48.2% CHEAPER
-
grafeel injectionDr Reddy's Laboratories Ltd ₹724.31 36.1% CHEAPER
-
grastim injectionDr Reddy's Laboratories Ltd ₹736.91 35% CHEAPER
-
imumax 300mcg injectionAbbott ₹1,086.23 4.2% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Filgrastim can be used to treat active infections.
Fact: Filgrastim is not an antibiotic and does not treat active infections. It helps prevent infections by increasing white blood cell counts. - Myth: Filgrastim is safe to use without medical supervision.
Fact: Filgrastim must only be used under the supervision of a qualified healthcare professional due to serious risks. - Myth: Filgrastim can be taken orally.
Fact: Filgrastim is a protein and would be digested if taken orally. It must be given by injection.
🔄 Alternative Options
Generic Alternatives
- Filgrastim (generic)
Brand Alternatives
- Neupogen
- Zarxio
- Nivestym
- Fulphila
- Udenyca
- Ziextenzo