aekil plus tablet - Caffeine (50mg) + Paracetamol (650mg) medicine

Algina Plus 50mg/650mg Tablet: Complete Information

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🏭 Agron Remedies Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 16, 2026
⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for Paracetamol; Caffeine as adjuvant has good evidence for headache.
Reviewed by
SaathiMed Expert Panel | Oct 16, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Yellowing of skin or eyes
  • Severe abdominal pain
  • Blood in vomit or stool
  • Difficulty breathing or swelling of face, lips, or throat
  • Decreased urine output
  • Unusual bleeding or bruising
  • Persistent high fever

If experiencing severe symptoms, call emergency services immediately.

What is aekil plus tablet used for?

This medicine is a combination of Paracetamol 650 mg and Caffeine 50 mg used for relief of mild to moderate pain and fever. It works by reducing pain and fever through Paracetamol, while Caffeine enhances the pain-relieving effect. It is taken orally, usually 1 tablet every 4-6 hours as needed, not exceeding 6 tablets in 24 hours.

  • Generic Name: Paracetamol + Caffeine
  • Manufacturer: Agron Remedies Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 aekil plus tablet के बारे में (Hindi Summary)

उपयोग: यह दवा पैरासिटामोल और कैफीन का संयोजन है, जिसका उपयोग हल्के से मध्यम दर्द और बुखार के इलाज के लिए किया जाता है। यह सिरदर्द, माइग्रेन, दांत दर्द, मांसपेशियों में दर्द, मासिक धर्म में होने वाले दर्द और सर्दी-जुकाम से जुड़े दर्द में राहत देती है।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, पेट में असुविधा, बेचैनी, अनिद्रा और घबराहट शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अत्यधिक मात्रा में लेने पर लिवर को नुकसान हो सकता है। किसी भी गंभीर लक्षण पर तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। निर्धारित मात्रा से अधिक न लें। शराब का सेवन न करें क्योंकि इससे लिवर को नुकसान का खतरा बढ़ जाता है। पैरासिटामोल युक्त अन्य दवाओं के साथ इसका सेवन न करें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 aekil plus tablet Uses & Benefits

[{"condition":"Headache","description":"Relieves mild to moderate headache, including tension-type headache.","evidence":"Well-established"},{"condition":"Migraine","description":"Provides relief from migraine pain; caffeine enhances the analgesic effect.","evidence":"Well-established"},{"condition":"Toothache","description":"Temporary relief of dental pain until definitive treatment can be obtained.","evidence":"Well-established"},{"condition":"Musculoskeletal pain","description":"Relieves muscle aches, back pain, and joint pain.","evidence":"Well-established"},{"condition":"Menstrual cramps","description":"Reduces pain associated with dysmenorrhea.","evidence":"Well-established"},{"condition":"Fever","description":"Reduces fever due to its Paracetamol content.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Post-operative pain","description":"Sometimes used as an adjunct for mild post-operative pain.","evidence":"Limited"},{"condition":"Osteoarthritis pain","description":"May be used for short-term relief of osteoarthritis pain.","evidence":"Limited"}]

Primary treatment for: Pain and fever

Also treats: Headache, Migraine, Toothache, Musculoskeletal pain, Dysmenorrhea

📋 Drug Information

Generic Name(s)Paracetamol + Caffeine
Brand NameAnacin Tablet
ManufacturerAgron Remedies Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action ClassAnalgesic and Antipyretic
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep out of reach of children.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food or milk to reduce stomach upset.
2
Do not exceed the recommended dose of 6 tablets in 24 hours.
3
Avoid alcohol while taking this medicine to prevent liver damage.
4
Do not take other Paracetamol-containing products simultaneously.
5
Consult your doctor if pain persists beyond 5 days or fever beyond 3 days.
6
Be aware that Caffeine may cause insomnia; avoid taking close to bedtime.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Headache
This medicine is commonly used for headache relief.
Likely Use
✅
Fever
Paracetamol reduces fever.
Likely Use
❌
Severe chest pain
This medicine is not for severe chest pain; seek emergency care.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionParacetamol is rapidly and almost completely absorbed from the gastrointestinal tract. Caffeine is also rapidly absorbed. Food may delay absorption slightly.
DistributionParacetamol distributes widely into body tissues; it crosses the placenta and is excreted in breast milk. Caffeine distributes throughout body fluids and crosses the blood-brain barrier and placenta.
Protein BindingParacetamol: Approximately 10-25% bound to plasma proteins. Caffeine: Approximately 15-25% bound to plasma proteins.
MetabolismParacetamol is metabolized in the liver primarily by glucuronidation and sulfation, with a small fraction via CYP2E1 to N-acetyl-p-benzoquinone imine (NAPQI), which is detoxified by glutathione. Caffeine is metabolized in the liver by CYP1A2 to paraxanthine, theobromine, and theophylline.
Half-LifeParacetamol: 2-3 hours. Caffeine: 3-7 hours.
ExcretionParacetamol metabolites are excreted primarily in urine. Caffeine metabolites are excreted in urine.
BioavailabilityParacetamol: 80-100%. Caffeine: Approximately 99%.
Onset of ActionParacetamol: 30-60 minutes. Caffeine: 15-45 minutes.
Peak Plasma TimeParacetamol: 0.5-2 hours. Caffeine: 0.5-2 hours.
Duration of ActionParacetamol: 4-6 hours. Caffeine: 3-5 hours.

How It Works

This medicine combines two active ingredients. Paracetamol acts primarily in the central nervous system by inhibiting prostaglandin synthesis, which reduces pain and fever. Caffeine is a methylxanthine that blocks adenosine receptors, leading to vasoconstriction and enhanced analgesic effects. Together, they provide more effective pain relief than Paracetamol alone.

Mechanism Steps

1
Paracetamol action: Paracetamol inhibits prostaglandin synthesis in the central nervous system, reducing pain perception and fever.
2
Caffeine action: Caffeine blocks adenosine receptors, causing vasoconstriction and increasing the release of certain neurotransmitters, which enhances the analgesic effect.
3
Synergistic effect: The combination provides greater pain relief than either agent alone, particularly for headache and migraine.

💡 How to Take aekil plus tablet

Strength: Tablet containing Caffeine 50 mg and Paracetamol 650 mg.

1Take this medicine orally with a glass of water.
2Swallow the tablet whole; do not crush or chew.
3Take with food or milk to reduce stomach upset.
4Do not exceed the recommended dose.
5Follow your doctor's instructions carefully.

Dosage Information

Adult DosageThe usual adult dose is 1 tablet every 4 to 6 hours as needed for pain or fever, not to exceed 6 tablets in 24 hours. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of Caffeine and Paracetamol. Use with caution and consult a doctor for appropriate dosing.
Renal ImpairmentUse with caution in patients with renal impairment. Consult a doctor for dose adjustment.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose reduction or avoidance may be necessary. Consult a doctor.
Maximum Daily DoseMaximum 6 tablets in 24 hours for adults. Do not exceed 4000 mg of Paracetamol per day from all sources.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals or snacks
Reduces stomach upset.
Grapefruit
Avoid large amounts
May increase caffeine levels.
Caffeine-containing beverages
Limit
May increase caffeine side effects.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of aekil plus tablet

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food or milk to reduce nausea. Consult doctor if persistent.
Insomnia (Common (5-10%))
Avoid taking close to bedtime. Consult doctor if severe.
Restlessness (Common (5-10%))
Usually temporary. Reduce caffeine intake from other sources.
Stomach discomfort (Common (5-10%))
Take with food. Consult doctor if persists.

🚨 Serious Side Effects

Severe liver injury (Rare (<0.1%))
Seek immediate medical attention if you experience yellowing of skin or eyes, dark urine, or severe abdominal pain.
Allergic reactions (Rare (<0.1%))
Seek emergency help if you notice rash, itching, swelling of face, lips, or throat, or difficulty breathing.
Severe skin reactions (Very rare (<0.01%))
Stop the medicine and seek immediate medical attention if you develop blistering, peeling, or rash.

⚠️ Rare Side Effects

Blood disorders
Report unusual bleeding or bruising to your doctor.
Pancreatitis
Seek medical attention if you experience severe abdominal pain radiating to the back.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Alcohol Major
Carbamazepine Moderate
Phenytoin Moderate
Rifampicin Moderate
Fluconazole Moderate
Ketoconazole Moderate
Oral contraceptives Minor
Cimetidine Minor
Other Paracetamol products Major

🚨 Major Interactions

  • Warfarin
  • Alcohol
  • Other Paracetamol-containing products

⚡ Moderate Interactions

  • Carbamazepine, phenytoin, rifampicin
  • Fluconazole, ketoconazole

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol increases the risk of liver damage from Paracetamol and may worsen stomach irritation.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to Paracetamol or Caffeine","Severe liver disease","Severe kidney disease","Alcoholism"]

⚠️ Warnings & Precautions

["Do not exceed the recommended dose.","Avoid alcohol.","Do not use with other Paracetamol-containing products.","Consult doctor if pain persists beyond 5 days or fever beyond 3 days.","Use with caution in patients with liver or kidney disease.","May cause insomnia; avoid taking close to bedtime."]

🤱 Lactation Safety

Paracetamol and caffeine are excreted in breast milk in small amounts. Generally considered compatible with breastfeeding, but consult your doctor.

💊 Overdose Management

Overdose of Paracetamol can cause severe liver damage. Symptoms may include nausea, vomiting, abdominal pain, and yellowing of skin. Seek immediate medical attention. Treatment includes activated charcoal, N-acetylcysteine, and supportive care. Caffeine overdose may cause restlessness, palpitations, and insomnia; treatment is supportive.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Additional Safety Advice

General Safety

Take this medicine exactly as directed by your doctor. Do not exceed the recommended dose or duration of treatment. Avoid consuming alcohol while taking this medicine as it increases the risk of liver damage. Do not take other products containing Paracetamol simultaneously to prevent overdose. Inform your doctor if you have liver or kidney disease, or if you are pregnant or breastfeeding. Keep out of reach of children. Store in a cool, dry place away from direct sunlight.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the effects of Caffeine and Paracetamol. Use with caution and consult a doctor for appropriate dosing.

🤰 Pregnancy Planning (TTC)

Consult your doctor before taking this medicine if you are planning pregnancy or are pregnant. Paracetamol is generally considered safe, but caffeine intake should be limited.

🏥 Post-Surgery Considerations

This medicine may be used for mild post-operative pain, but consult your surgeon before use, especially if you are on other medications.

🦷 Dental Procedures

This medicine can provide temporary relief for dental pain. Inform your dentist if you are taking it before any dental procedure.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce stress on joints.
🥗
Stay hydrated by drinking plenty of water.
😴
Get adequate sleep to help your body recover.
💧
Manage stress through relaxation techniques.
🧘
Avoid excessive caffeine intake from other sources.

🏋️ Exercise Considerations

Moderate exercise is generally safe while taking this medicine. However, if you experience dizziness or restlessness, avoid strenuous activities until you know how the medicine affects you.

🥗 Diet Recommendations

Include fruits and vegetables rich in antioxidants.
Limit processed foods and added sugars.
Stay well hydrated.
Avoid alcohol.

💼 Impact on Daily Work & Life

This medicine may cause restlessness or insomnia in some individuals. If you experience these effects, avoid driving or operating heavy machinery until you know how it affects you.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if your symptoms do not improve within 5 days for pain or 3 days for fever, or if you experience any severe side effects.

📅 Long-Term Use Effects

Long-term use of this medicine should be avoided unless prescribed by a doctor. Prolonged high-dose use of Paracetamol can increase the risk of liver and kidney damage. Regular monitoring of liver and kidney function may be required if used for extended periods.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Physical therapy

Can help manage chronic pain conditions.

Evidence: Well-established
Relaxation techniques

May help reduce tension headaches.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

This medicine does not interact with vaccines. However, if you have a fever, consult your doctor before vaccination.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing intervals as advised by your doctor. Check customs regulations for carrying medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old woman with tension headaches
She often experienced headaches due to work stress. Her doctor prescribed this medicine. She took one tablet with food when the headache started and found relief within 30 minutes. She was advised not to take more than 3 tablets a day and to avoid caffeine in the evening.
💡 Lesson: Taking the medicine early and with food improves effectiveness and reduces stomach upset.
👤 A 50-year-old man with dental pain
He had severe toothache before a dental procedure. He took this medicine as prescribed and experienced significant pain relief. He was cautioned not to exceed the dose and to avoid alcohol. He also scheduled a dental appointment for definitive treatment.
💡 Lesson: This medicine provides temporary relief but does not treat the underlying cause; dental care is essential.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts working within 30-60 minutes after oral intake.

Q: Can I take it on an empty stomach?

A: It is best taken with food to reduce stomach upset.

Q: Is it safe for children?

A: It is not recommended for children under 12 years without medical advice.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for aekil plus tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure all types of pain.
    Fact: It is effective for mild to moderate pain but not for severe pain or pain from serious conditions.
  • Myth: It is safe to take with alcohol.
    Fact: Alcohol increases the risk of liver damage and should be avoided.
  • Myth: More tablets mean faster relief.
    Fact: Exceeding the dose can cause serious liver damage. Always follow the recommended dose.

🔄 Alternative Options

Generic Alternatives

  • Paracetamol 650 mg + Caffeine 50 mg tablet

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Paracetamol 650 mg + Caffeine 50 mg","uses":"Pain and fever","notes":"Caffeine enhances analgesia"},{"medicine":"Paracetamol 650 mg","composition":"Paracetamol 650 mg","uses":"Pain and fever","notes":"No caffeine"},{"medicine":"Ibuprofen 400 mg","composition":"Ibuprofen 400 mg","uses":"Pain, fever, inflammation","notes":"NSAID, different side effect profile"}]

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