Agrophyllin 77mg/23mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Very fast, irregular, or pounding heartbeat
- Persistent vomiting or severe stomach pain
- Severe restlessness, confusion, or agitation
- Seizure or loss of consciousness
- Chest pain or difficulty breathing that is getting worse
- Swelling of the face, lips, or throat
- Fainting or severe dizziness
If experiencing severe symptoms, call emergency services immediately.
What is agrophyllin 77mg/23mg tablet used for?
This medicine is an oral bronchodilator tablet containing etofylline 77 mg and theophylline 23 mg. It is used to relax the airways and make breathing easier in conditions such as bronchial asthma and chronic obstructive pulmonary disease. It must be taken only under medical supervision because the safe dose range is narrow.
- Generic Name: Etofylline + Theophylline
- Manufacturer: Agron Remedies Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 agrophyllin 77mg/23mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एटोफिलिन 77 मिलीग्राम और थियोफिलिन 23 मिलीग्राम का मिश्रण है, जो मिथाइलज़ैंथिन वर्ग का ब्रोंकोडाइलेटर है। इसका उपयोग अस्थमा और क्रॉनिक ऑब्सट्रक्टिव पल्मोनरी डिजीज़ जैसी स्थितियों में सांस की नली को खोलने और सांस लेने में आसानी देने के लिए किया जाता है। यह दवा घरघराहट, सांस फूलने और छाती में जकड़न को कम करने में मदद करती है। इसे डॉक्टर की सलाह के बिना शुरू या बंद नहीं करना चाहिए, क्योंकि इसकी सुरक्षित खुराक की सीमा कम है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में जी मिचलाना, उल्टी, पेट में असहजता, सिरदर्द, बेचैनी, नींद न आना और धड़कन तेज होना शामिल हैं। कुछ लोगों में हाथ-पैर कांपना या बार-बार पेशाब आना भी देखा जा सकता है। गंभीर दुष्प्रभाव कम होते हैं, लेकिन धड़कन अनियमित होना, दौरा पड़ना, गंभीर एलर्जी या थियोफिलिन के स्तर के बढ़ने के लक्षण जैसे लगातार उल्टी और बहुत तेज धड़कन हो सकते हैं। ऐसे लक्षण दिखने पर तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को केवल योग्य डॉक्टर की सलाह से ही लें और खुराक में कोई बदलाव खुद न करें। गोली को एक गिलास पानी के साथ, भोजन के साथ या भोजन के तुरंत बाद लें, जिससे पेट की परेशानी कम हो सके। चाय, कॉफी, कोला और एनर्जी ड्रिंक का सेवन सीमित करें, क्योंकि कैफीन इस दवा के प्रभाव को बढ़ा सकता है। कोई भी नई दवा शुरू करने से पहले अपने डॉक्टर या फार्मासिस्ट से सलाह लें। दवा को मूल पैकेट में, ठंडी और सूखी जगह पर, धूप से दूर और बच्चों की पहुंच से बाहर रखें।
💊 agrophyllin 77mg/23mg tablet Uses & Benefits
[{"condition":"Bronchial asthma","description":"Used to relax bronchial smooth muscle and improve airflow in patients with reversible airway obstruction.","evidence":"Established for methylxanthine bronchodilators"},{"condition":"Chronic obstructive pulmonary disease (COPD)","description":"May help reduce breathlessness and wheezing in selected patients with chronic airflow limitation.","evidence":"Established for methylxanthine bronchodilators"},{"condition":"Chronic bronchitis with bronchospasm","description":"Can be used as part of a treatment plan when bronchospasm contributes to breathing difficulty.","evidence":"Limited to supportive use"}]
Off-label uses: [{"condition":"Apnea of prematurity","description":"Methylxanthines are used in newborns for this purpose, but this specific combination tablet is not intended for that use.","evidence":"Established for caffeine or theophylline in neonatal units, not for this product"}]
Primary treatment for: Reversible obstructive airway disease such as bronchial asthma
Also treats: Chronic obstructive pulmonary disease, Chronic bronchitis with bronchospasm
📋 Drug Information
| Generic Name(s) | Etofylline + Theophylline |
| Brand Name | Asmaphylin M 231mg/69mg/10mg Tablet SR |
| Manufacturer | Agron Remedies Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | Xanthine bronchodilator |
| Route of Administration | Oral |
| Storage | Store below 30°C in a dry place, away from direct sunlight and moisture. Keep the tablets in their original container and out of the reach of children. |
| Shelf Life | Not established from the available information. Check the expiry date printed on the pack and do not use the medicine after that date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Etofylline and theophylline are methylxanthine derivatives that relax bronchial smooth muscle and reduce airway resistance. They inhibit phosphodiesterase enzymes, which increases cyclic AMP inside airway smooth muscle cells and leads to relaxation. They also block adenosine receptors, which contributes to bronchodilation and to some of the stimulant effects on the heart and central nervous system. The combined effect is widening of the airways, improved airflow, and easier breathing in patients with reversible obstruction.
Mechanism Steps
💡 How to Take agrophyllin 77mg/23mg tablet
Strength: Each tablet contains etofylline 77 mg and theophylline 23 mg.
Dosage Information
| Adult Dosage | The dose of this medicine must be individualized by a qualified clinician based on the indication, age, weight, kidney function, liver function, and response to treatment. It is usually taken by mouth with or just after food, and the frequency may be once or more times a day depending on the prescription. Do not change the dose or frequency without medical advice. Because the safe dose range is narrow, your doctor may adjust the dose or arrange blood tests to check the level of the medicine in your body. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Older adults may be more sensitive to the effects of this medicine and may need a lower dose or more careful monitoring. The dose must be individualized by a qualified clinician based on kidney function, liver function, heart function, and other medicines being taken. |
| Renal Impairment | Kidney disease can reduce the removal of this medicine from the body. The dose must be individualized by a qualified clinician based on kidney function, and monitoring may be needed. |
| Hepatic Impairment | Liver disease can reduce the breakdown of this medicine and increase the risk of toxicity. The dose must be individualized by a qualified clinician based on liver function, and monitoring may be needed. |
| Maximum Daily Dose | Not established from the available information. The maximum daily dose must be determined by a qualified clinician for each patient. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of agrophyllin 77mg/23mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ciprofloxacin | Major | |
| Erythromycin | Major | |
| Cimetidine | Major | |
| Ritonavir | Major | |
| Phenytoin | Moderate | |
| Rifampicin | Moderate | |
| Beta-blockers | Moderate | |
| Loop diuretics | Moderate | |
| Caffeine | Minor | |
| Oral contraceptives | Minor |
🚨 Major Interactions
- Ciprofloxacin
- Erythromycin
- Cimetidine
- Ritonavir
⚡ Moderate Interactions
- Phenytoin
- Rifampicin
- Beta-blockers
- Loop diuretics
🍷 Alcohol Interaction
Alcohol may add to the central nervous system and heart effects of this medicine and can increase stomach irritation. It is best to avoid alcohol while taking this medicine unless a doctor has said it is safe.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy or hypersensitivity to etofylline, theophylline, or any component of this medicine","Active peptic ulcer disease","Certain serious heart rhythm disorders, unless a specialist has approved use","Uncontrolled seizure disorder, unless a specialist has approved use","Children below the age recommended by the prescribing clinician for this specific product"]
⚠️ Warnings & Precautions
["The safe dose range of methylxanthines is narrow, so take only the dose prescribed by your doctor.","Tell your doctor if you have heart disease, liver disease, kidney disease, an overactive thyroid, or a history of seizures.","Avoid caffeine-containing drinks because they can add to the stimulating effects.","Do not start or stop other medicines without checking with your doctor or pharmacist.","Report persistent vomiting, severe restlessness, a very fast heartbeat, or fainting immediately.","Keep all follow-up appointments so that your response to treatment can be reviewed."]
🤱 Lactation Safety
Theophylline passes into breast milk and may cause irritability or poor sleep in a breastfed baby. Breastfeeding while taking this medicine should only be done after discussing the risks and benefits with a qualified clinician.
💊 Overdose Management
An overdose of this medicine can cause severe nausea, vomiting, restlessness, a very fast or irregular heartbeat, seizures, and low blood pressure. If an overdose is suspected, seek emergency medical care immediately. Do not try to treat the overdose at home. Treatment in hospital may include stopping the medicine, monitoring the heart and breathing, giving activated charcoal if appropriate, and providing supportive care. Theophylline blood levels may be measured to guide treatment.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember, unless it is almost time for the next dose. If it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure what to do, contact your doctor or pharmacist.
Additional Safety Advice
Take this medicine only under the supervision of a qualified clinician, and never change the dose without medical advice. Swallow the tablet with a full glass of water, preferably with or just after food, to reduce stomach upset. Avoid drinking large amounts of coffee, tea, cola, or energy drinks because caffeine can add to the stimulating effects of this medicine. Do not start or stop any other medicine, including over-the-counter remedies, without checking with your doctor or pharmacist. Tell your doctor if you have heart disease, liver disease, kidney disease, an overactive thyroid, or a history of seizures. Keep all follow-up appointments so that your response to treatment and any need for blood tests can be reviewed. Store the tablets in their original packaging, away from moisture and direct sunlight, and keep them out of the reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults may be more sensitive to the effects of this medicine and may have reduced kidney or liver function, which can increase the risk of side effects. The dose must be individualized by a qualified clinician, and monitoring for fast heartbeat, restlessness, and other side effects is important.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy or are pregnant, talk to your doctor before using this medicine. The risks and benefits must be weighed for each individual, and alternative treatments may be considered. Do not start or stop this medicine without medical advice.
🏥 Post-Surgery Considerations
Tell your surgeon and anesthesiologist that you are taking this medicine before any surgery. Methylxanthines can affect heart rate and interact with some medicines used during anesthesia, so your treatment may need to be reviewed before and after surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It can cause a fast heartbeat and restlessness, and it may interact with some medicines used in dentistry. Your dentist may need to consult your doctor before the procedure.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Gentle exercise can be helpful for lung health, but avoid very strenuous activity if you feel breathless, dizzy, or have a fast heartbeat. Warm up slowly and stop if you develop chest pain, severe breathlessness, or palpitations. Ask your doctor about any exercise restrictions based on your heart and lung condition.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause restlessness, dizziness, or a fast heartbeat in some people. Avoid driving or operating heavy machinery until you know how it affects you. If your work involves heights, heavy machinery, or safety-sensitive tasks, discuss with your doctor whether it is safe to continue while taking this medicine.
🛑 When to Stop This Medicine
Do not stop this medicine on your own. If you develop serious side effects such as an irregular heartbeat, seizures, or a severe allergic reaction, seek immediate medical help and follow your doctor's advice about stopping. Your doctor may stop or change the medicine if your condition improves, if side effects occur, or if another treatment is more suitable.
📅 Long-Term Use Effects
Long-term use of this medicine requires regular medical review because the safe dose range is narrow and side effects can increase over time. Your doctor may check your heart rate, breathing, and sometimes the level of the medicine in your blood. Long-term use should be reassessed periodically to make sure the benefits continue to outweigh the risks. Do not stop the medicine suddenly without medical advice, because your breathing symptoms may worsen.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Inhaled medicines such as salbutamol or ipratropium can deliver bronchodilation directly to the lungs and are often preferred for quick relief.
Evidence: Well-establishedThese reduce airway inflammation and are commonly used for long-term control of asthma.
Evidence: Well-establishedA structured program of exercise, education, and breathing techniques can improve quality of life in chronic lung disease.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
People with chronic lung diseases such as asthma or COPD should discuss recommended vaccinations, including influenza and pneumococcal vaccines, with their doctor. There is no specific interaction between this medicine and vaccines, but vaccination helps prevent infections that can worsen breathing problems.
📦 Storage Guide
✅ DO
Store below 30°C in a dry place.
❌ DON'T
Do not store in a hot or humid place.
✅ DO
Keep the tablets in their original container.
❌ DON'T
Do not transfer them to unmarked containers.
✅ DO
Keep away from direct sunlight.
❌ DON'T
Do not store in the bathroom cabinet.
✅ DO
Keep out of the reach of children.
❌ DON'T
Do not use after the expiry date.
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with the prescription label visible. Bring a copy of your prescription and a doctor's letter if you are travelling internationally, because some countries have strict rules about prescription medicines. Keep the tablets in a cool, dry place during travel and avoid leaving them in a hot car or in direct sunlight. If you are crossing time zones, ask your doctor how to adjust the timing of your doses. Carry enough medicine for the whole trip and a little extra in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The onset of bronchodilation after oral methylxanthine therapy is usually within 30 to 60 minutes, but the exact onset for this specific combination is not established from the available information. Follow your doctor's advice and report if your breathing does not improve.
A: Yes, taking this medicine with or just after food is often recommended to reduce stomach upset. Follow the instructions given by your doctor or pharmacist.
A: If you miss a dose, take it as soon as you remember unless it is almost time for the next dose. If it is almost time, skip the missed dose and continue with your regular schedule. Do not take a double dose.
A: It is best to avoid alcohol while taking this medicine unless a doctor has said it is safe, because alcohol can add to the central nervous system and heart effects.
🤔 Common Patient Concerns
🔄 Substitutes for agrophyllin 77mg/23mg tablet
View AllAlternative brands with exact same active ingredient:
-
zeriphylline tabletHealthy Life Pharma Pvt Ltd ₹2.22 0.9% CHEAPER
-
graphyllin tabletGracure Pharmaceuticals Ltd ₹2.50 11.6% COSTLIER
-
euroder 77mg/23mg tabletEuro Biogenics ₹3.20 42.9% COSTLIER
-
deripen 77mg/23mg tabletMorepen Laboratories Ltd ₹4.22 88.4% COSTLIER
-
dericip 77mg/23mg tabletCipla Ltd ₹5.92 164.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken whenever breathing feels difficult without a prescription.
Fact: This medicine is a prescription bronchodilator with a narrow safe dose range and must only be used under medical supervision. - Myth: More of this medicine will always give better relief.
Fact: Taking more than the prescribed dose can cause serious side effects such as irregular heart rhythms and seizures. - Myth: Coffee and energy drinks are safe with this medicine.
Fact: Caffeine can add to the stimulating effects and increase the risk of a fast heartbeat and restlessness.
🔄 Alternative Options
Generic Alternatives
- Etofylline and theophylline combination tablets from other manufacturers
- Theophylline tablets
- Etofylline tablets
Brand Alternatives
- Agrophyllin 77mg/23mg tablet