agrophyllin 77mg/23mg tablet

4.5 (15 reviews)

Etofylline (77mg) Theophylline (23mg)

🏭 Agron Remedies Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is agrophyllin 77mg/23mg tablet used for?

Asmaphylin M 231mg/69mg/10mg Tablet SR (Etofylline + Theophylline) is used to treat RESPIRATORY. It contains Etofylline (77mg) + Theophylline (23mg), which Inhibits phosphodiesterase, increasing cAMP; antagonizes adenosine receptors; en. Always consult your doctor before use. Take as prescribed.

Generic Name: Etofylline + Theophylline
Manufacturer: Agron Remedies Pvt Ltd
Form: Allopathy
Pregnancy Category: C
Prescription Required: Yes

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 agrophyllin 77mg/23mg tablet Uses & Benefits

Bronchial asthma, chronic obstructive pulmonary disease (COPD), and other respiratory conditions with bronchospasm.

Off-label uses: Apnea of prematurity, Postoperative respiratory depression

📋 Drug Information

Generic Name(s)	Etofylline + Theophylline
Brand Name	Asmaphylin M 231mg/69mg/10mg Tablet SR
Manufacturer	Agron Remedies Pvt Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	RESPIRATORY
Action Class	Xanthine bronchodilator
Route of Administration	Oral
Storage	Store at room temperature (20-25°C), protect from moisture and light.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionWell absorbed orally; sustained-release formulation provides prolonged absorption.

DistributionDistributes widely; crosses placenta and enters breast milk.

Protein BindingApproximately 40% for theophylline; etofylline binding not well defined.

MetabolismHepatic via CYP1A2, CYP2E1, and CYP3A4; etofylline is a prodrug converted to theophylline.

Half-LifeTheophylline: 3-12 hours (adults), longer in neonates and with hepatic impairment.

ExcretionRenal (primarily as metabolites; 10% unchanged theophylline).

BioavailabilityNearly 100% for oral theophylline; sustained-release formulation may have slightly lower bioavailabi

Onset of Action30-60 minutes (immediate release); sustained release: 1-2 hours.

Peak Plasma TimeSustained release: 4-8 hours.

Duration of Action12-24 hours (sustained release).

How It Works

Inhibits phosphodiesterase, increasing cAMP; antagonizes adenosine receptors; enhances mucociliary clearance.

Mechanism Steps

1Inhibition of phosphodiesterase (PDE) enzymes, leading to increased intracellular cyclic AMP (cAMP).

2Antagonism of adenosine receptors (A1 and A2), reducing bronchoconstriction and inflammation.

3Enhanced mucociliary clearance by increasing ciliary beat frequency.

💡 How to Take agrophyllin 77mg/23mg tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of agrophyllin 77mg/23mg tablet

✅ Common Side Effects

Nausea
Vomiting
Headache
Insomnia
Nervousness
Tachycardia

🚨 Serious Side Effects

Seizures
Arrhythmias
Severe hypotension
Respiratory arrest

⚠️ Rare Side Effects

Hyperglycemia
Hypokalemia
Rhabdomyolysis
Allergic reactions

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Cimetidine	Major	Decreased theophylline clearance, increased toxicity risk.
Ciprofloxacin	Major	Increased theophylline levels, risk of seizures.
Erythromycin	Major	Increased theophylline levels, toxicity.
Fluvoxamine	Major	Markedly increased theophylline levels.
Methotrexate	Major	Increased theophylline levels.
Propranolol	Major	Reduced theophylline clearance, antagonism of bronchodilation.
Carbamazepine	Moderate	Decreased theophylline levels.
Phenytoin	Moderate	Decreased theophylline levels.
Rifampin	Moderate	Decreased theophylline levels.
Smoking	Moderate	Increased theophylline metabolism, reduced efficacy.
St. John's Wort	Moderate	Decreased theophylline levels.
Allopurinol	Minor	Slight increase in theophylline levels.
Benzodiazepines	Minor	Possible additive CNS depression.
Disulfiram	Minor	Decreased theophylline clearance.
Interferon	Minor	Decreased theophylline clearance.
Verapamil	Minor	Increased theophylline levels.

🚨 Major Interactions

Cimetidine
Ciprofloxacin
Erythromycin
Fluvoxamine
Methotrexate
Propranolol

⚡ Moderate Interactions

Carbamazepine
Phenytoin
Rifampin
Smoking (tobacco/marijuana)
St. John's Wort

ℹ️ Minor Interactions

Allopurinol
Benzodiazepines
Disulfiram
Interferon
Verapamil

🍽️ Food Interactions

High-fat meals may delay absorption; charcoal-broiled foods increase metabolism; caffeine-containing foods may increase side effects.

🍷 Alcohol Interaction

Alcohol may increase theophylline metabolism and reduce efficacy; also may increase risk of seizures.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to xanthines, active peptic ulcer, seizure disorders (unless controlled), severe cardiac arrhythmias.

📊 Monitoring Parameters

Serum theophylline levels (therapeutic range 10-20 mcg/mL), heart rate, respiratory rate, CNS symptoms.

🤱 Lactation Safety

Use with caution; theophylline excreted in breast milk; may cause irritability in infants.

💊 Overdose Management

Activated charcoal, supportive care, monitoring of serum theophylline levels; severe cases may require hemodialysis.

⏰ Missed Dose

Take as soon as remembered unless near next dose; do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

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⭐ User Reviews

Verified User Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Regular Customer Jul 10, 2026

Found this to be a helpful product. Good results.

Happy Patient Jul 10, 2026