Dayclazide Total 60mg/15mg/500mg Tablet SR: Comprehensive Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Severe hypoglycemia (confusion, seizures, loss of consciousness)
- Symptoms of lactic acidosis (muscle pain, difficulty breathing, extreme fatigue)
- Signs of heart failure (rapid weight gain, swelling in legs, shortness of breath)
- Yellowing of skin or eyes (jaundice)
- Blood in urine or painful urination
- Severe abdominal pain with nausea and vomiting
If experiencing severe symptoms, call emergency services immediately.
What is prizide mp 60mg/15mg/500mg tablet used for?
This medicine is a combination of gliclazide, pioglitazone, and metformin used to treat type 2 diabetes. It lowers blood sugar by increasing insulin release, improving insulin sensitivity, and reducing liver glucose production. It is taken orally once daily with a meal.
- Generic Name: Gliclazide (60mg) + Pioglitazone (15mg)
- Manufacturer: Primus Remedies Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 prizide mp 60mg/15mg/500mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा टाइप 2 डायबिटीज (मधुमेह) के इलाज के लिए इस्तेमाल की जाती है। इसमें ग्लिक्लाजाइड, पियोग्लिटाजोन और मेटफॉर्मिन तीनों मिलाकर ब्लड शुगर को कंट्रोल करते हैं। यह दवा शरीर में इंसुलिन का स्तर बढ़ाती है, इंसुलिन के प्रति संवेदनशीलता सुधारती है और लिवर में ग्लूकोज बनना कम करती है। इसे डॉक्टर की सलाह पर ही लेना चाहिए और खाने के साथ लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में कम ब्लड शुगर (हाइपोग्लाइसीमिया), जी मिचलाना, दस्त, पेट दर्द, वजन बढ़ना और सिरदर्द शामिल हैं। गंभीर दुष्प्रभावों में लैक्टिक एसिडोसिस, दिल की विफलता, लिवर की समस्या और ब्लैडर कैंसर का खतरा शामिल है। अगर आपको मांसपेशियों में दर्द, सांस लेने में तकलीफ, पैरों में सूजन या पेशाब में खून जैसे लक्षण दिखें तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को हमेशा डॉक्टर के बताए अनुसार ही लें। खुराक बदलने या बंद करने से पहले डॉक्टर से सलाह लें। इसे खाने के साथ लें ताकि पेट की परेशानी और लो शुगर का खतरा कम हो। अपने ब्लड शुगर की नियमित जांच करें। शराब का सेवन न करें क्योंकि इससे लैक्टिक एसिडोसिस और हाइपोग्लाइसीमिया का खतरा बढ़ सकता है। अगर आप गर्भवती हैं, स्तनपान करा रही हैं या कोई अन्य दवा ले रही हैं तो डॉक्टर को बताएं।
💊 prizide mp 60mg/15mg/500mg tablet Uses & Benefits
[{"condition":"Type 2 diabetes mellitus","description":"Used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes who are not adequately controlled on monotherapy or other combinations.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Polycystic ovary syndrome (PCOS)","description":"Pioglitazone component may be used off-label to improve insulin sensitivity in women with PCOS, but this combination is not standard and requires specialist supervision.","evidence":"Limited"}]
Primary treatment for: Type 2 diabetes mellitus
Also treats: Insulin resistance, Metabolic syndrome
📋 Drug Information
| Generic Name(s) | Gliclazide (60mg) + Pioglitazone (15mg) |
| Brand Name | prizide mp 60mg/15mg/500mg tablet |
| Manufacturer | Primus Remedies Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI DIABETIC |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines three active ingredients with complementary mechanisms. Gliclazide, a sulfonylurea, binds to ATP-sensitive potassium channels on pancreatic beta cells, causing depolarization and increased insulin secretion. Pioglitazone, a thiazolidinedione, activates peroxisome proliferator-activated receptor gamma (PPAR-γ), leading to increased insulin sensitivity in adipose tissue, skeletal muscle, and liver. Metformin, a biguanide, reduces hepatic glucose production, decreases intestinal glucose absorption, and improves peripheral insulin sensitivity. The combined effect lowers fasting and postprandial blood glucose levels.
Mechanism Steps
💡 How to Take prizide mp 60mg/15mg/500mg tablet
Strength: Sustained-release tablet containing gliclazide 60 mg, pioglitazone 15 mg, and metformin hydrochloride 500 mg.
Dosage Information
| Adult Dosage | The usual starting dose is one tablet once daily with the evening meal. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and glycemic control. The maximum daily dose is one tablet of this strength. Do not exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. Dose should be individualized by a clinician, with careful monitoring of renal function and blood glucose. |
| Renal Impairment | Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73 m²). In mild to moderate renal impairment, dose adjustment or alternative therapy may be required. Consult a clinician. |
| Hepatic Impairment | Contraindicated in severe hepatic impairment. In mild to moderate hepatic impairment, use with caution and monitor liver function. Dose adjustment may be needed. |
| Maximum Daily Dose | One tablet of this strength per day, unless otherwise prescribed by a clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of prizide mp 60mg/15mg/500mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Alcohol | Major | |
| Contrast media | Major | |
| Diuretics | Major | |
| Beta-blockers | Moderate | |
| Corticosteroids | Moderate | |
| Rifampicin | Moderate | |
| Gemfibrozil | Moderate | |
| ACE inhibitors | Minor | |
| MAO inhibitors | Minor | |
| Cationic drugs | Moderate |
🚨 Major Interactions
- Alcohol
- Contrast media (iodinated)
- Diuretics
- Cationic drugs (e.g., amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, vancomycin)
⚡ Moderate Interactions
- Beta-blockers
- Corticosteroids
- Rifampicin
- Gemfibrozil
🍷 Alcohol Interaction
Alcohol increases the risk of lactic acidosis and hypoglycemia. Avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Type 1 diabetes mellitus","Diabetic ketoacidosis","Severe renal impairment (eGFR
⚠️ Warnings & Precautions
["Lactic acidosis: rare but serious; discontinue if suspected.","Heart failure: pioglitazone may cause fluid retention; monitor for signs.","Hypoglycemia: risk increased with sulfonylurea; educate patient.","Renal impairment: metformin dose adjustment required.","Liver disease: monitor liver enzymes; discontinue if injury suspected.","Bladder cancer: long-term pioglitazone use may increase risk.","Bone fractures: pioglitazone may increase risk, especially in women.","Macular edema: report vision changes.","Alcohol: avoid due to increased risk of lactic acidosis."]
🤱 Lactation Safety
Not established from the available information. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose may cause severe hypoglycemia and lactic acidosis. Seek immediate medical attention. Treatment includes supportive care, glucose administration for hypoglycemia, and hemodialysis for metformin overdose if indicated.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without medical advice. Take the tablet with a meal to reduce stomach upset and lower the risk of hypoglycemia. Monitor your blood sugar levels regularly as advised. Carry a fast-acting source of sugar, such as glucose tablets or candy, to treat low blood sugar episodes. Inform your doctor if you have kidney, liver, or heart problems, or if you are pregnant, planning pregnancy, or breastfeeding. Avoid excessive alcohol consumption as it can increase the risk of lactic acidosis and hypoglycemia. Tell your healthcare provider about all other medicines, supplements, or herbal products you are taking. Attend regular check-ups for kidney function, liver enzymes, and blood counts. Report any unusual symptoms such as persistent nausea, muscle pain, difficulty breathing, or swelling promptly.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of hypoglycemia and renal impairment. Dose should be individualized and renal function monitored regularly.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy. If you are planning pregnancy, consult your doctor to switch to a safer alternative and optimize blood sugar control before conception.
🏥 Post-Surgery Considerations
Metformin should be temporarily discontinued before surgery and restarted after 48 hours once renal function is normal. Consult your surgeon and physician.
🦷 Dental Procedures
Inform your dentist about this medicine. Hypoglycemia risk may require adjusting meal timing around dental procedures. Maintain good oral hygiene.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise can lower blood sugar; monitor levels before and after exercise. Adjust carbohydrate intake and medication as advised by your doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause hypoglycemia, which can affect driving or operating machinery. Be cautious until you know how it affects you. Carry a sugar source at all times.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience serious side effects like lactic acidosis or heart failure symptoms, seek immediate medical advice; your doctor may discontinue it.
📅 Long-Term Use Effects
Long-term use may increase the risk of bladder cancer, bone fractures, and heart failure due to pioglitazone. Metformin can cause vitamin B12 deficiency. Regular monitoring of kidney function, liver enzymes, and blood counts is essential. Periodic review of the risk-benefit ratio is advised.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet and exercise are foundational for managing type 2 diabetes.
Evidence: Well-establishedDPP-4 inhibitors, SGLT2 inhibitors, or GLP-1 receptor agonists may be alternatives.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are established. Maintain routine vaccinations as advised for diabetes patients.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture. If traveling across time zones, consult your doctor about adjusting the timing. Keep enough supply for the entire trip and carry it in your hand luggage. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts lowering blood sugar within days, but full effects on HbA1c may take 2-3 months.
A: It is contraindicated in severe kidney disease. Your doctor will adjust the dose or choose an alternative based on your kidney function.
A: Take fast-acting sugar like glucose tablets or candy immediately. If symptoms persist, seek medical help.
🤔 Common Patient Concerns
🔄 Substitutes for prizide mp 60mg/15mg/500mg tablet
View AllAlternative brands with exact same active ingredient:
-
glizid total p 15 tablet srPanacea Biotec Ltd ₹100.20 0.1% CHEAPER
-
gliclize total 60mg/15mg/500mg tablet srJohnlee Pharmaceuticals Pvt Ltd ₹101.25 0.9% COSTLIER
-
reclimet-pg 60 tablet srDr Reddy's Laboratories Ltd ₹112.25 11.9% COSTLIER
-
dayclazide total 60mg/15mg/500mg tablet srDaylon Healthcare ₹112.50 12.2% COSTLIER
-
carryl mp 60mg/15mg/500mg tablet sr4Care Lifescience Pvt Ltd ₹120.00 19.6% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure diabetes.
Fact: This medicine helps manage blood sugar but does not cure diabetes. Lifestyle changes and ongoing medical care are essential. - Myth: I can stop taking this medicine once my sugar is normal.
Fact: Stopping without medical advice can cause blood sugar to rise again. Always consult your doctor before stopping. - Myth: This medicine can be taken without food.
Fact: It should be taken with a meal to reduce stomach upset and risk of low blood sugar.
🔄 Alternative Options
Generic Alternatives
- Gliclazide + Pioglitazone + Metformin sustained-release tablets (various manufacturers)