Avazide 60mg Tablet XR: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe hypoglycemia with confusion, seizures, or loss of consciousness.
- Signs of blood disorders: sudden fever, sore throat, mouth ulcers, unusual bleeding, or bruising.
- Yellowing of skin or eyes, dark urine, or severe abdominal pain.
- Severe skin rash with blisters or peeling.
- Persistent vomiting or diarrhea leading to dehydration.
- Chest pain, shortness of breath, or irregular heartbeat.
If experiencing severe symptoms, call emergency services immediately.
What is glicla 60mg tablet used for?
This medicine is an extended-release tablet containing gliclazide 60 mg, used to treat type 2 diabetes by stimulating insulin release from the pancreas. It is taken once daily with breakfast and must be swallowed whole.
- Generic Name: Gliclazide (60mg)
- Manufacturer: Orchid Chemicals & Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 glicla 60mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा टाइप 2 डायबिटीज (मधुमेह) के इलाज के लिए इस्तेमाल की जाती है। यह शरीर में इंसुलिन का स्तर बढ़ाकर ब्लड शुगर को कंट्रोल करने में मदद करती है। इसे डॉक्टर की सलाह के अनुसार नाश्ते के साथ एक बार लेना चाहिए। यह दवा उन लोगों के लिए नहीं है जिन्हें टाइप 1 डायबिटीज है, या जिनके किडनी या लिवर की बीमारी गंभीर है।
साइड इफेक्ट्स: आम दुष्प्रभावों में लो ब्लड शुगर (हाइपोग्लाइसीमिया), वजन बढ़ना, जी मिचलाना और पेट में हल्की परेशानी शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन इनमें गंभीर हाइपोग्लाइसीमिया, खून की बीमारियां, और त्वचा पर गंभीर एलर्जी शामिल हो सकती हैं। अगर आपको कम ब्लड शुगर के लक्षण महसूस हों, तो तुरंत मीठा खाएं और डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को हमेशा डॉक्टर के बताए अनुसार ही लें। इसे नाश्ते के साथ रोज एक ही समय पर लें। गोली को पूरा निगलें, चबाएं या तोड़ें नहीं। हाइपोग्लाइसीमिया से बचने के लिए हमेशा अपने पास ग्लूकोज या मिठाई रखें। शराब का सेवन न करें क्योंकि इससे ब्लड शुगर अचानक गिर सकता है। अपने डॉक्टर को अन्य दवाओं के बारे में बताएं। नियमित रूप से ब्लड शुगर की जांच कराएं।
💊 glicla 60mg tablet Uses & Benefits
[{"condition":"Type 2 diabetes mellitus","description":"Used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes.","evidence":"Well-established"}]
Off-label uses: []
Primary treatment for: Type 2 diabetes mellitus
Also treats: Metabolic syndrome, Obesity
📋 Drug Information
| Generic Name(s) | Gliclazide (60mg) |
| Brand Name | glicla 60mg tablet |
| Manufacturer | Orchid Chemicals & Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI DIABETIC |
| Action Class | Sulfonylureas (Insulin Secretogogues) |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from moisture and light. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | The World Health Organization (WHO) recommends sulfonylureas like gliclazide as second-line therapy after metformin for type 2 diabetes when glycemic targets are not met. However, guidelines should be individualized. |
| ICMR Guideline | The Indian Council of Medical Research (ICMR) guidelines for type 2 diabetes recommend gliclazide as an option for monotherapy or combination therapy based on patient-specific factors. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Gliclazide belongs to the sulfonylurea class of antidiabetic drugs. It binds to specific receptors on the ATP-sensitive potassium channels (SUR1) on pancreatic beta-cell membranes. This binding closes the potassium channels, leading to depolarization of the beta-cell membrane. The depolarization opens voltage-gated calcium channels, causing an influx of calcium ions. The increased intracellular calcium triggers the release of insulin from preformed granules. Additionally, gliclazide may enhance peripheral insulin sensitivity and reduce hepatic glucose production. The extended-release formulation provides a gradual release of the drug, leading to more stable blood levels and a lower risk of hypoglycemia compared to immediate-release formulations.
Mechanism Steps
💡 How to Take glicla 60mg tablet
Strength: Extended-release tablet, 60 mg.
Dosage Information
| Adult Dosage | The usual starting dose of this medicine is 30 mg once daily with breakfast, and the dose may be increased to 60 mg once daily as needed based on blood glucose levels. The maximum recommended dose is 120 mg once daily. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and concomitant medications. Swallow the tablet whole with a glass of water; do not crush or chew. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the hypoglycemic effects of gliclazide. Start with a lower dose (30 mg once daily) and titrate slowly based on blood glucose monitoring. Renal function should be assessed before initiating therapy. |
| Renal Impairment | In patients with mild to moderate renal impairment (eGFR 30-59 mL/min), use with caution and monitor blood glucose closely. In severe renal impairment (eGFR < 30 mL/min), gliclazide is contraindicated. Dose adjustment is required based on renal function. |
| Hepatic Impairment | In patients with mild to moderate hepatic impairment, use with caution and monitor liver function. In severe hepatic impairment, gliclazide is contraindicated. Dose adjustment may be necessary. |
| Maximum Daily Dose | 120 mg per day. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of glicla 60mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Miconazole | Major | |
| Phenylbutazone | Major | |
| Alcohol | Major | |
| Beta-blockers | Moderate | |
| ACE inhibitors | Moderate | |
| Thiazide diuretics | Moderate | |
| Corticosteroids | Moderate | |
| Warfarin | Moderate | |
| Antacids | Minor | |
| Cholestyramine | Minor |
🚨 Major Interactions
- Miconazole
- Phenylbutazone
- Alcohol
⚡ Moderate Interactions
- Beta-blockers
- ACE inhibitors
- Diuretics (thiazides)
- Corticosteroids
- Warfarin
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. It can cause a sudden drop in blood sugar (hypoglycemia) and may trigger a disulfiram-like reaction with symptoms like flushing, nausea, and palpitations. If you choose to drink alcohol, do so only in moderation and always with food, and monitor your blood sugar closely.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Type 1 diabetes mellitus","Diabetic ketoacidosis","Severe renal impairment (eGFR < 30 mL/min)","Severe hepatic impairment","Known hypersensitivity to gliclazide or other sulfonylureas","Pregnancy and breastfeeding","Concomitant use with miconazole"]
⚠️ Warnings & Precautions
["Risk of hypoglycemia, especially in elderly, malnourished, or patients with renal/hepatic impairment.","Alcohol may increase the risk of hypoglycemia.","May cause weight gain.","Not recommended for use in children.","Use with caution in patients with G6PD deficiency (risk of hemolytic anemia).","May increase cardiovascular risk in patients with coronary artery disease.","Do not crush or chew the extended-release tablet.","Regular monitoring of blood glucose and HbA1c is essential."]
🤱 Lactation Safety
Gliclazide is excreted in breast milk in small amounts. It is not recommended during breastfeeding due to the potential risk of hypoglycemia in the infant. Consult your doctor for alternative treatments if you are breastfeeding.
💊 Overdose Management
Overdose of gliclazide can cause severe hypoglycemia, which may lead to seizures, coma, or death. If overdose is suspected, seek emergency medical attention immediately. Treatment includes administration of glucose (oral or intravenous) and monitoring of blood glucose and vital signs. In severe cases, glucagon may be administered. Hemodialysis is not effective for removing gliclazide.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember if it is less than 12 hours since the missed dose. If more than 12 hours have passed, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. Monitor your blood sugar more frequently on the day of a missed dose.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without medical advice. Take the tablet with breakfast at the same time each day to maintain steady blood sugar control. Swallow the tablet whole with a glass of water; do not crush, chew, or break it. Carry a source of fast-acting sugar with you at all times in case of hypoglycemia. Avoid skipping meals, as this increases the risk of low blood sugar. Limit alcohol consumption because it can unpredictably affect blood sugar levels. Inform your doctor about all other medicines, supplements, and herbal products you are taking. Regularly monitor your blood sugar as advised and keep all follow-up appointments. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before using this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of hypoglycemia due to reduced renal function and other comorbidities. Start with a lower dose and monitor blood sugar closely. Regular assessment of kidney function is recommended.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy. If you are planning pregnancy, consult your doctor to switch to insulin or another safe alternative before conception. Good blood sugar control before and during pregnancy is crucial for the health of both mother and baby.
🏥 Post-Surgery Considerations
After surgery, blood sugar levels can fluctuate. Your doctor may adjust your diabetes medicine, including this medicine, based on your blood sugar levels and overall condition. Monitor closely and follow your healthcare team's instructions.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. Dental procedures can cause stress and affect blood sugar. Eat normally before your appointment unless instructed otherwise. Monitor your blood sugar and carry glucose tablets.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise can lower blood sugar levels. If you exercise vigorously, monitor your blood sugar before, during, and after exercise. Carry a source of fast-acting sugar with you. Adjust your medicine dose only under your doctor's guidance.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause low blood sugar, which can affect your ability to drive or operate machinery. Do not drive if you feel symptoms of hypoglycemia. Take regular breaks and eat meals on time. Inform your employer about your condition and emergency contacts.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or your blood sugar is consistently low, your doctor may adjust or stop the medicine. Always follow your doctor's advice.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to weight gain and an increased risk of hypoglycemia. Regular monitoring of blood sugar, kidney function, and liver function is necessary. Some patients may experience a gradual loss of effectiveness over time, requiring dose adjustment or addition of other medicines. Long-term use has not been shown to cause cancer or other serious diseases.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
First-line medicine for type 2 diabetes, often used alone or with gliclazide.
Evidence: Well-establishedOral medicines that increase insulin release when blood sugar is high, with lower risk of hypoglycemia.
Evidence: Well-establishedOral medicines that lower blood sugar by increasing glucose excretion in urine.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, maintain up-to-date vaccinations, especially for influenza and pneumonia, as infections can worsen blood sugar control.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C).
❌ DON'T
Do not refrigerate.
✅ DO
Keep in the original container.
❌ DON'T
Do not transfer to unmarked containers.
✅ DO
Keep away from direct sunlight and moisture.
❌ DON'T
Do not store in the bathroom.
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. If crossing time zones, consult your doctor about adjusting the timing of your dose to maintain blood sugar control. Store at room temperature and avoid exposure to direct sunlight or moisture. Check customs regulations for carrying prescription medicines to your destination.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts lowering blood sugar within 2-3 hours, but it may take several weeks to see the full effect on your overall blood sugar control.
A: This medicine is not recommended for severe kidney disease. Your doctor may adjust the dose or choose a different medicine based on your kidney function.
A: Immediately consume fast-acting sugar like glucose tablets, fruit juice, or candy. If symptoms persist or you lose consciousness, seek emergency medical help.
🤔 Common Patient Concerns
🔄 Substitutes for glicla 60mg tablet
View AllAlternative brands with exact same active ingredient:
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glicazide xr 60 tabletZeelab Pharmacy Pvt Ltd ₹20.00 47% CHEAPER
-
davaindia gliclazide 60mg tablet erDavaindia Generic Pharmacy ₹24.00 36.4% CHEAPER
-
danavish gliclazide 60mg tablet mrDanavish Healthcare ₹42.00 11.4% COSTLIER
-
Fordib 60mg Tablet MRMandar Pharmaceuticals Pvt Ltd ₹42.19 11.9% COSTLIER
-
StayHappi Gliclazide 60mg TabletSarvagunaushdhi Pvt Ltd ₹44.06 16.8% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure diabetes.
Fact: This medicine helps control blood sugar but does not cure diabetes. It must be continued as prescribed. - Myth: You can stop taking this medicine once your blood sugar is normal.
Fact: Stopping this medicine without medical advice can cause blood sugar to rise again. Always consult your doctor before stopping. - Myth: This medicine is safe for everyone with diabetes.
Fact: This medicine is not suitable for people with type 1 diabetes, severe kidney or liver disease, or during pregnancy and breastfeeding.
🔄 Alternative Options
Generic Alternatives
- Gliclazide 60 mg extended-release tablet
Brand Alternatives
- Avazide 60mg Tablet XR