carryl mp 60mg/15mg/500mg tablet sr - Gliclazide (60mg) + Pioglitazone (15mg) medicine

carryl mp 60mg/15mg/500mg tablet sr

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🏭 4Care Lifescience Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

What is carryl mp 60mg/15mg/500mg tablet sr used for?

This medicine contains Gliclazide (60mg) + Pioglitazone (15mg) and is used to treat ANTI DIABETIC. Gliclazide: Stimulates insulin secretion from pancreatic beta cells; Pioglitazone: Activates PPAR-ga. Always consult your doctor before use.

  • Generic Name: Gliclazide + Pioglitazone
  • Manufacturer: 4Care Lifescience Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Category C
  • Prescription Required: Yes
💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 carryl mp 60mg/15mg/500mg tablet sr Uses & Benefits

Type 2 diabetes mellitus as adjunct to diet and exercise

Off-label uses: Polycystic ovary syndrome (pioglitazone component)

📋 Drug Information

Generic Name(s)Gliclazide + Pioglitazone
Brand NameAim7 60 XR Tablet
Manufacturer4Care Lifescience Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI DIABETIC
Action ClassSulfonylurea + Thiazolidinedione
Route of AdministrationOral
StorageStore at 20-25°C (68-77°F), protect from moisture and light
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionGliclazide: Rapidly absorbed from GI tract; Pioglitazone: Well absorbed, food delays absorption
DistributionGliclazide: Volume of distribution ~13-24 L; Pioglitazone: Volume of distribution ~0.25 L/kg
Protein BindingGliclazide: 85-97% bound to plasma proteins; Pioglitazone: >99% bound to albumin
MetabolismGliclazide: Hepatic metabolism via CYP2C9; Pioglitazone: Hepatic metabolism via CYP2C8 and CYP3A4
Half-LifeGliclazide: 10-12 hours; Pioglitazone: 3-7 hours
ExcretionGliclazide: Urine (60-70%) and feces (10-20%); Pioglitazone: Feces (55%) and urine (30%)
BioavailabilityGliclazide: ~80%; Pioglitazone: >80%
Onset of ActionGliclazide: 30-60 minutes; Pioglitazone: 2-4 weeks for full effect
Peak Plasma TimeGliclazide: 4-6 hours; Pioglitazone: 2-4 hours
Duration of ActionGliclazide: Up to 24 hours; Pioglitazone: 24 hours

How It Works

Gliclazide: Stimulates insulin secretion from pancreatic beta cells; Pioglitazone: Activates PPAR-gamma receptors, increasing insulin sensitivity

Mechanism Steps

1Gliclazide binds to SUR1 on pancreatic beta cells
2Closes ATP-sensitive potassium channels
3Depolarizes beta cell membrane
4Opens voltage-gated calcium channels
5Increases intracellular calcium
6Stimulates insulin exocytosis
7Pioglitazone activates PPAR-gamma receptors
8Increases transcription of genes involved in glucose and lipid metabolism
9Enhances insulin sensitivity in adipose tissue, muscle, and liver
10Reduces hepatic gluconeogenesis

💡 How to Take carryl mp 60mg/15mg/500mg tablet sr

Follow your doctor's prescription exactly.

⚠️ Side Effects of carryl mp 60mg/15mg/500mg tablet sr

✅ Common Side Effects

Hypoglycemia
Weight gain
Edema
Headache
Nausea
Diarrhea

🚨 Serious Side Effects

Severe hypoglycemia
Hepatotoxicity
Heart failure
Bladder cancer
Fractures

⚠️ Rare Side Effects

Hemolytic anemia
Stevens-Johnson syndrome
Pancreatitis
Macular edema

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major Increased anticoagulant effect and bleeding risk
Miconazole Major Severe hypoglycemia
Fluconazole Major Increased gliclazide levels, hypoglycemia
Rifampin Major Reduced gliclazide efficacy
Gemfibrozil Major Increased pioglitazone levels, risk of toxicity

🚨 Major Interactions

  • Warfarin
  • Miconazole
  • Fluconazole
  • Rifampin
  • Gemfibrozil

⚡ Moderate Interactions

  • NSAIDs
  • ACE inhibitors
  • Beta-blockers
  • Corticosteroids
  • Diuretics

🍷 Alcohol Interaction

May increase risk of hypoglycemia; avoid excessive alcohol

🛡️ Safety & Warnings

🚫 Contraindications

Type 1 diabetes, diabetic ketoacidosis, severe hepatic impairment, severe renal impairment, history of bladder cancer, heart failure (NYHA Class III/IV)

🤱 Lactation Safety

Not recommended; excreted in milk in animal studies

💊 Overdose Management

Monitor blood glucose; administer glucose orally or IV if hypoglycemic; supportive care

⏰ Missed Dose

Take as soon as remembered unless close to next dose; do not double dose

🔄 Substitutes for carryl mp 60mg/15mg/500mg tablet sr

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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