Ajaduo 25mg/5mg Tablet: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Nausea, vomiting, or abdominal pain with difficulty breathing (possible ketoacidosis)
- Severe pain, redness, or swelling in the genital or perineal area with fever (possible Fournier's gangrene)
- Fever, chills, burning urination, or blood in urine (possible severe urinary tract infection)
- Swelling of the face, lips, tongue, or throat, or difficulty breathing (possible angioedema)
- Severe abdominal pain radiating to the back with nausea and vomiting (possible pancreatitis)
- Decreased urine output, swelling in legs, or fatigue (possible kidney problems)
- Signs of hypoglycemia such as shakiness, sweating, confusion, or rapid heartbeat
If experiencing severe symptoms, call emergency services immediately.
What is ajaduo 25mg/5mg tablet used for?
This medicine is a combination of empagliflozin and linagliptin used to treat type 2 diabetes. It works by increasing sugar removal through urine and enhancing insulin release. It is taken once daily orally, with or without food, as prescribed by a doctor.
- Generic Name: Empagliflozin + Linagliptin
- Manufacturer: Lupin Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ajaduo 25mg/5mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा टाइप 2 डायबिटीज (मधुमेह) के इलाज के लिए इस्तेमाल की जाती है। यह शरीर में ब्लड शुगर को कंट्रोल करने में मदद करती है। इसमें एम्पाग्लिफ्लोज़िन और लिनाग्लिप्टिन दो दवाएं होती हैं जो मिलकर काम करती हैं। यह दवा खून में शुगर की मात्रा को कम करने के साथ-साथ वजन कम करने में भी मदद कर सकती है। इसे डॉक्टर की सलाह पर ही लें।
साइड इफेक्ट्स: आम दुष्प्रभावों में यूरिन इन्फेक्शन, जननांगों में फंगल इन्फेक्शन, बार-बार पेशाब आना, प्यास लगना और हल्का जी मिचलाना शामिल हैं। कुछ लोगों को सिरदर्द या गले में खराश हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें डायबिटिक कीटोएसिडोसिस, गंभीर यूरिन इन्फेक्शन, किडनी की समस्या, पैन्क्रियाटाइटिस और एलर्जी शामिल हैं। अगर आपको उल्टी, पेट दर्द, सांस लेने में तकलीफ, चेहरे या गले में सूजन, या जननांग क्षेत्र में दर्द और सूजन हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। अपनी मर्जी से डोज न बदलें और न ही दवा बंद करें। दिनभर पर्याप्त पानी पिएं क्योंकि यह दवा पेशाब की मात्रा बढ़ाती है। जननांगों की सफाई का ध्यान रखें ताकि इन्फेक्शन से बचा जा सके। अपने ब्लड शुगर की नियमित जांच करते रहें। अगर आपको किडनी, लिवर, पैन्क्रियास या जननांग इन्फेक्शन की समस्या है तो डॉक्टर को बताएं। शराब का सेवन न करें या बहुत कम करें। सर्जरी से पहले डॉक्टर को इस दवा के बारे में जरूर बताएं। गर्भावस्था या स्तनपान के दौरान इस दवा का इस्तेमाल न करें।
💊 ajaduo 25mg/5mg tablet Uses & Benefits
[{"condition":"Type 2 Diabetes Mellitus","description":"Used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus who are not adequately controlled on empagliflozin or linagliptin alone or other antidiabetic therapies.","evidence":"Well-established"},{"condition":"Type 2 Diabetes with Cardiovascular Disease","description":"Empagliflozin component has shown cardiovascular benefits in patients with type 2 diabetes and established cardiovascular disease.","evidence":"Well-established"},{"condition":"Type 2 Diabetes with Chronic Kidney Disease","description":"Empagliflozin component may slow progression of kidney disease in patients with diabetic nephropathy.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Weight management in type 2 diabetes","description":"Empagliflozin component may cause modest weight loss, but this is not a primary indication.","evidence":"Limited"},{"condition":"Non-alcoholic fatty liver disease","description":"Some studies suggest potential benefit, but not an approved indication.","evidence":"Limited"}]
Primary treatment for: Type 2 Diabetes Mellitus
Also treats: Cardiovascular disease, Chronic kidney disease, Obesity
📋 Drug Information
| Generic Name(s) | Empagliflozin + Linagliptin |
| Brand Name | Ajaduo |
| Manufacturer | Lupin Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI DIABETIC |
| Action Class | SGLT2 inhibitor + DPP-4 inhibitor |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep in the original container, tightly closed. Protect from moisture and light. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. Guidelines from various organizations recommend SGLT2 inhibitors and DPP-4 inhibitors as options for type 2 diabetes management. |
| ICMR Guideline | Not established from the available information. ICMR guidelines for type 2 diabetes may include these classes as treatment options. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antidiabetic agents with complementary mechanisms. Empagliflozin inhibits sodium-glucose co-transporter 2 (SGLT2) in the proximal renal tubules, reducing glucose reabsorption and increasing urinary glucose excretion, thereby lowering blood glucose independently of insulin. Linagliptin inhibits dipeptidyl peptidase-4 (DPP-4) enzyme, increasing the levels of active incretin hormones (GLP-1 and GIP), which stimulate insulin release from pancreatic beta cells and reduce glucagon secretion from alpha cells in a glucose-dependent manner. Together, they improve glycemic control through multiple pathways.
Mechanism Steps
💡 How to Take ajaduo 25mg/5mg tablet
Strength: Tablet containing empagliflozin 25 mg and linagliptin 5 mg.
Dosage Information
| Adult Dosage | The recommended dose is one tablet of empagliflozin 25 mg and linagliptin 5 mg taken orally once daily, with or without food. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No dose adjustment is required based on age alone. However, elderly patients may be more susceptible to volume depletion and renal impairment. Monitor renal function and hydration status closely. |
| Renal Impairment | Empagliflozin: Not recommended if eGFR is less than 30 mL/min/1.73 m2. Linagliptin: No dose adjustment is required for renal impairment. However, the combination should be used with caution in patients with renal impairment. Consult your doctor for dose adjustments. |
| Hepatic Impairment | Empagliflozin: No dose adjustment is required for mild to moderate hepatic impairment; not recommended in severe hepatic impairment. Linagliptin: No dose adjustment is required for hepatic impairment. Consult your doctor for individual recommendations. |
| Maximum Daily Dose | Empagliflozin 25 mg and linagliptin 5 mg once daily. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ajaduo 25mg/5mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Insulin | Major | |
| Sulfonylureas | Major | |
| Diuretics | Moderate | |
| ACE inhibitors | Moderate | |
| ARBs | Moderate | |
| Rifampicin | Moderate | |
| Carbamazepine | Moderate | |
| Phenytoin | Moderate | |
| Phenobarbital | Moderate | |
| Digoxin | Minor |
🚨 Major Interactions
- Insulin or insulin secretagogues (e.g., sulfonylureas)
- Diuretics
- ACE inhibitors or ARBs
⚡ Moderate Interactions
- Rifampicin
- Carbamazepine, phenytoin, phenobarbital
🍷 Alcohol Interaction
Alcohol may increase the risk of lactic acidosis and ketoacidosis, and can also cause hypoglycemia. It is advisable to limit or avoid alcohol while taking this medicine. If you choose to drink, do so in moderation and monitor your blood sugar closely.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to empagliflozin, linagliptin, or any component of the formulation","Type 1 diabetes mellitus","Diabetic ketoacidosis","Severe renal impairment (eGFR < 30 mL/min/1.73 m2) for empagliflozin component","Pregnancy and breastfeeding"]
⚠️ Warnings & Precautions
["Risk of diabetic ketoacidosis: May occur even with normal blood glucose levels. Monitor for symptoms.","Risk of volume depletion: May cause dehydration and hypotension. Monitor fluid status.","Risk of urinary tract infections: Maintain hygiene and hydration.","Risk of genital fungal infections: Keep area clean and dry.","Risk of Fournier's gangrene: Rare but serious. Seek immediate care if symptoms occur.","Risk of pancreatitis: Monitor for severe abdominal pain.","Risk of hypoglycemia when used with insulin or sulfonylureas: Dose adjustment may be needed.","Risk of acute kidney injury: Monitor renal function.","Not recommended in patients with severe hepatic impairment.","May need to be temporarily discontinued before surgery."]
🤱 Lactation Safety
Not established from the available information. This medicine is not recommended during breastfeeding. Consult your doctor for alternative treatments.
💊 Overdose Management
In case of overdose, seek immediate medical attention. Treatment should be symptomatic and supportive. Monitor blood glucose, renal function, and vital signs. There is no specific antidote. Hemodialysis may be considered for empagliflozin removal, but linagliptin is not significantly removed by dialysis.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without consulting your healthcare provider. Stay well hydrated by drinking plenty of water throughout the day, as this medicine increases urine output. Maintain good genital hygiene to reduce the risk of infections. Check your blood sugar levels regularly as advised. Inform your doctor if you have a history of kidney disease, liver disease, pancreatitis, or genital infections. Avoid excessive alcohol consumption, as it can increase the risk of lactic acidosis and ketoacidosis. If you are scheduled for surgery or a procedure, inform your doctor that you are taking this medicine, as it may need to be temporarily stopped. Do not use this medicine if you are pregnant or planning to become pregnant. If you experience symptoms of ketoacidosis such as nausea, vomiting, stomach pain, tiredness, or difficulty breathing, seek emergency medical help immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to volume depletion, hypotension, and renal impairment. Monitor renal function and hydration status closely. No dose adjustment is required based on age alone, but individualization is important.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy. If you are planning to become pregnant, consult your doctor to switch to a safer alternative. Effective contraception should be used while taking this medicine. Discuss your diabetes management plan with your healthcare provider before conception.
🏥 Post-Surgery Considerations
This medicine may need to be temporarily discontinued before surgery due to the risk of ketoacidosis and volume depletion. Inform your surgeon and anesthesiologist that you are taking this medicine. Follow your doctor's instructions regarding when to restart.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. There are no specific contraindications for dental procedures, but maintain good oral hygiene as diabetes can increase the risk of gum disease. If you are scheduled for a procedure requiring sedation, inform the dentist about your diabetes medicines.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise is beneficial for diabetes management, but if you take this medicine, be cautious about dehydration during intense workouts. Drink plenty of water before, during, and after exercise. Monitor your blood sugar levels, especially if you also take insulin or sulfonylureas, as exercise can increase the risk of hypoglycemia. Consult your doctor before starting a new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue in some people, especially if dehydration occurs. If you experience these symptoms, avoid driving or operating heavy machinery until you feel better. Otherwise, it should not significantly impact your daily work life. Take it at the same time each day to maintain consistency.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as ketoacidosis, severe allergic reactions, or kidney problems, your doctor may advise you to stop. If you become pregnant or plan to become pregnant, consult your doctor immediately for alternative treatment.
📅 Long-Term Use Effects
Long-term use of this medicine may help maintain blood sugar control and reduce the risk of diabetes-related complications. However, it may also increase the risk of urinary tract infections, genital fungal infections, and rarely, kidney problems. Regular monitoring of renal function, blood sugar, and HbA1c is essential. Some patients may experience modest weight loss. Long-term safety data for the combination is limited, but both components have been used individually for many years.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet and exercise are cornerstone treatments for type 2 diabetes and can complement medicine.
Evidence: Well-establishedOften the first-line treatment for type 2 diabetes.
Evidence: Well-establishedDepending on individual needs, other combinations may be suitable.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, patients with diabetes should stay up to date with recommended vaccinations, including influenza and pneumococcal vaccines, as they are at higher risk of infections.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry your medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, continue taking your dose at the same local time as much as possible, but consult your doctor for specific advice. Carry enough supply for your entire trip and consider a backup supply in case of delays. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts lowering blood sugar within a few hours, but the full effect may take several days to weeks. Your doctor will monitor your HbA1c every 3-6 months to assess effectiveness.
A: This medicine may not be suitable for patients with severe kidney impairment. Your doctor will check your kidney function before and during treatment. The linagliptin component does not require dose adjustment for kidney disease, but empagliflozin may need to be avoided if your kidney function is very low.
A: Mild side effects like urinary tract infections or genital fungal infections are common. Maintain hygiene and hydration. If you experience severe symptoms like difficulty breathing, severe abdominal pain, or swelling of the face, seek immediate medical attention.
A: No, diabetes is a chronic condition. Stopping medication without consulting your doctor can lead to high blood sugar and complications. Always consult your doctor before making any changes.
🤔 Common Patient Concerns
🔄 Substitutes for ajaduo 25mg/5mg tablet
View AllAlternative brands with exact same active ingredient:
-
glyxambi 25mg/5mg tabletBoehringer Ingelheim ₹669.00 212.3% COSTLIER
-
tiptengio 25mg/5mg tabletCipla Ltd ₹768.70 258.8% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure diabetes.
Fact: This medicine helps control blood sugar but does not cure diabetes. Lifestyle modifications and ongoing treatment are essential. - Myth: This medicine causes weight gain.
Fact: Empagliflozin may cause modest weight loss, not weight gain. - Myth: You can stop taking this medicine once your sugar levels are normal.
Fact: Diabetes is a chronic condition. Stopping medication without consulting your doctor can lead to serious complications.
🔄 Alternative Options
Generic Alternatives
- Empagliflozin + Linagliptin
Brand Alternatives
- Ajaduo 25mg/5mg Tablet