ajaduo 25mg/5mg tablet - Uses, Price, Side Effects & Substitutes
What is ajaduo 25mg/5mg tablet used for?
Ajaduo (Empagliflozin + Linagliptin) is used to treat ANTI DIABETIC. It contains Empagliflozin (25mg) + Linagliptin (5mg), which Empagliflozin: inhibits SGLT2 in renal proximal tubule, reducing glucose reabsor. Always consult your doctor before use. Take as prescribed.
- Generic Name: Empagliflozin + Linagliptin
- Manufacturer: Lupin Ltd
- Form: Allopathy
- Pregnancy Category: C
- Prescription Required: Yes
๐ ajaduo 25mg/5mg tablet Uses & Benefits
Type 2 diabetes mellitus as adjunct to diet and exercise
Off-label uses: None established
๐ Drug Information
| Generic Name(s) | Empagliflozin + Linagliptin |
| Brand Name | Ajaduo |
| Manufacturer | Lupin Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI DIABETIC |
| Action Class | SGLT2 inhibitor + DPP-4 inhibitor |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF), protect from moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Empagliflozin: inhibits SGLT2 in renal proximal tubule, reducing glucose reabsorption; Linagliptin: inhibits DPP-4, increasing incretin levels (GLP-1, GIP), enhancing insulin secretion and reducing glucagon
Mechanism Steps
๐ก How to Take ajaduo 25mg/5mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of ajaduo 25mg/5mg tablet
โ Common Side Effects
- Urinary tract infections
- Genital mycotic infections
- Nasopharyngitis
- Headache
- Arthralgia
๐จ Serious Side Effects
- Diabetic ketoacidosis
- Acute kidney injury
- Hypoglycemia (when used with insulin/SU)
- Pancreatitis
- Hypersensitivity reactions
โ ๏ธ Rare Side Effects
- Fournier's gangrene
- Angioedema
- Stevens-Johnson syndrome
- Bullous pemphigoid
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Insulin | Major | Increased risk of hypoglycemia |
| Sulfonylureas | Major | Increased risk of hypoglycemia |
| Loop diuretics | Major | Additive diuretic effect, risk of volume depletion |
| ACE inhibitors | Moderate | Additive blood pressure lowering |
| NSAIDs | Moderate | Reduced antihypertensive effect, risk of acute kidney injury |
| Corticosteroids | Moderate | Hyperglycemic effect may reduce efficacy |
๐จ Major Interactions
- Insulin
- Sulfonylureas
- Loop diuretics
โก Moderate Interactions
- ACE inhibitors
- ARBs
- NSAIDs
- Corticosteroids
โน๏ธ Minor Interactions
- Beta-blockers
- Calcium channel blockers
๐ฝ๏ธ Food Interactions
Food delays absorption of empagliflozin but not clinically significant; linagliptin unaffected
๐ท Alcohol Interaction
May increase risk of hypoglycemia
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Severe renal impairment (eGFR <30), end-stage renal disease, dialysis, history of serious hypersensitivity reaction, diabetic ketoacidosis
๐ Monitoring Parameters
Blood glucose, HbA1c, renal function (eGFR), electrolytes, blood pressure, signs of volume depletion
๐คฑ Lactation Safety
Not recommended; unknown if excreted in human milk
๐ Overdose Management
Supportive care; monitor blood glucose, electrolytes, and renal function; hemodialysis unlikely to remove empagliflozin
โฐ Missed Dose
Take as soon as remembered unless almost time for next dose; do not double dose