axonrich tablet - Alpha Lipoic Acid (100mg) + L-Methyl Folate Calcium (1000mcg) medicine

axonrich tablet

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🏭 Primus Remedies Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

What is axonrich tablet used for?

This medicine contains Alpha Lipoic Acid (100mg) + L-Methyl Folate Calcium (1000mcg) and is used to treat NEURO CNS. Alpha Lipoic Acid acts as a potent antioxidant, scavenging free radicals and regenerating other anti. Always consult your doctor before use.

  • Generic Name: Alpha Lipoic Acid + L-Methyl Folate Calcium
  • Manufacturer: Primus Remedies Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 axonrich tablet Uses & Benefits

Diabetic neuropathy, peripheral neuropathy, cognitive decline, folate deficiency, hyperhomocysteinemia.

Off-label uses: Alzheimer's disease, multiple sclerosis, chronic fatigue syndrome.

📋 Drug Information

Generic Name(s)Alpha Lipoic Acid + L-Methyl Folate Calcium
Brand NameAxonrich Tablet
ManufacturerPrimus Remedies Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassNEURO CNS
Action ClassNeuroprotective Agent, Antioxidant, Vitamin Supplement
Route of AdministrationOral
StorageStore at room temperature (20-25°C), protect from light and moisture.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionAlpha Lipoic Acid: Rapidly absorbed from GI tract; L-Methyl Folate: Well absorbed as active folate form.
DistributionAlpha Lipoic Acid: Widely distributed, crosses blood-brain barrier; L-Methyl Folate: Distributed to tissues, crosses blood-brain barrier.
Protein BindingAlpha Lipoic Acid: ~80-90% bound to plasma proteins; L-Methyl Folate: ~60-70% bound.
MetabolismAlpha Lipoic Acid: Hepatic metabolism via reduction and conjugation; L-Methyl Folate: Metabolized to other folate forms in cells.
Half-LifeAlpha Lipoic Acid: ~30 minutes; L-Methyl Folate: ~3-4 hours.
ExcretionAlpha Lipoic Acid: Renal (80-90% as metabolites); L-Methyl Folate: Renal and fecal.
BioavailabilityAlpha Lipoic Acid: ~30% (oral); L-Methyl Folate: ~100% (as active folate).
Onset of ActionAlpha Lipoic Acid: Within 1-2 hours; L-Methyl Folate: Within 1-2 hours.
Peak Plasma TimeAlpha Lipoic Acid: 1-2 hours; L-Methyl Folate: 1-3 hours.
Duration of ActionAlpha Lipoic Acid: 4-6 hours; L-Methyl Folate: 8-12 hours.

How It Works

Alpha Lipoic Acid acts as a potent antioxidant, scavenging free radicals and regenerating other antioxidants; L-Methyl Folate provides active folate for methylation and neurotransmitter synthesis.

Mechanism Steps

1Alpha Lipoic Acid is reduced to dihydrolipoic acid in cells.
2Dihydrolipoic acid regenerates other antioxidants like glutathione, vitamin C, and vitamin E.
3Alpha Lipoic Acid chelates metal ions, reducing oxidative stress.
4L-Methyl Folate provides methyl groups for homocysteine remethylation to methionine.
5Methionine is used for neurotransmitter synthesis (e.g., dopamine, serotonin).
6Reduced homocysteine levels protect against neurotoxicity and vascular damage.

💡 How to Take axonrich tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of axonrich tablet

✅ Common Side Effects

Nausea
Vomiting
Diarrhea
Headache
Skin rash

🚨 Serious Side Effects

Hypoglycemia
Allergic reactions
Seizures (rare)

⚠️ Rare Side Effects

Insulin autoimmune syndrome
Anaphylaxis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major Increased bleeding risk due to antioxidant effects
Antidiabetic agents Major Enhanced hypoglycemic effect
Methotrexate Major Reduced efficacy of methotrexate
Thyroid hormones Moderate Possible altered thyroid function
Antacids Moderate Reduced absorption of folate
Oral contraceptives Moderate Reduced folate levels
Vitamin B12 Minor Synergistic effect on homocysteine metabolism
Iron supplements Minor Possible reduced absorption of iron
Zinc supplements Minor Possible reduced absorption of zinc

🚨 Major Interactions

  • Warfarin
  • Antidiabetic agents
  • Chemotherapy drugs (e.g., methotrexate)

⚡ Moderate Interactions

  • Thyroid hormones
  • Antacids
  • Oral contraceptives

🍷 Alcohol Interaction

Alcohol may reduce folate levels and increase oxidative stress; avoid excessive alcohol.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to any component, pernicious anemia (due to folate supplementation masking B12 deficiency).

🤱 Lactation Safety

L-Methyl Folate is safe; Alpha Lipoic Acid: Limited data, use with caution.

💊 Overdose Management

Supportive care; no specific antidote; monitor for hypoglycemia and gastrointestinal symptoms.

⏰ Missed Dose

Take as soon as remembered unless near next dose; skip if close to next dose; do not double.

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