Mucomix 1gm Injection (Acetylcysteine): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or wheezing
- Swelling of face, lips, or throat
- Severe rash or blistering of skin
- Chest pain or palpitations
- Severe dizziness or fainting
- Yellowing of skin or eyes
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is nacel 1000mg injection used for?
This medicine contains Acetylcysteine 1000mg, used to treat paracetamol overdose and to thin thick mucus in respiratory conditions. It is given as an injection by a healthcare professional.
- Generic Name: Acetylcysteine (1000mg)
- Manufacturer: Celon Laboratories Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nacel 1000mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा एसिटाइलसिस्टीन 1000mg इंजेक्शन के रूप में उपलब्ध है। इसका मुख्य उपयोग पैरासिटामोल की अधिक मात्रा (ओवरडोज) के इलाज में किया जाता है, जिससे लीवर को नुकसान से बचाया जा सके। यह शरीर में ग्लूटाथियोन के स्तर को बढ़ाकर जहरीले पदार्थ को बेअसर करती है। इसके अलावा, यह श्वसन संबंधी बीमारियों जैसे ब्रोंकाइटिस, सिस्टिक फाइब्रोसिस में गाढ़े बलगम को पतला करने में मदद करती है। यह दवा केवल डॉक्टर या नर्स द्वारा अस्पताल में ही दी जाती है। इसे स्वयं न लगाएं।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, पेट खराब होना, चकत्ते, खुजली और बुखार शामिल हैं। कभी-कभी सांस लेने में कठिनाई, चेहरे या गले में सूजन, और रक्तचाप में गिरावट जैसी गंभीर एलर्जी हो सकती है। अस्थमा के रोगियों में घरघराहट हो सकती है। यदि कोई भी दुष्प्रभाव गंभीर हो, तो तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल अस्पताल में डॉक्टर या नर्स द्वारा दी जाती है। इसे स्वयं न लगाएं। यदि आपको एसिटाइलसिस्टीन से एलर्जी है, अस्थमा, लीवर या किडनी की बीमारी है, तो डॉक्टर को बताएं। इंजेक्शन के दौरान आपकी निगरानी की जाएगी। सांस लेने में तकलीफ, सूजन या चक्कर आने पर तुरंत बताएं। शराब न पिएं। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें।
💊 nacel 1000mg injection Uses & Benefits
- [{"condition":"Paracetamol overdose","description":"This medicine is the antidote of choice for paracetamol poisoning.
- It works by replenishing glutathione, which detoxifies the toxic metabolite NAPQI, thereby preventing liver damage.","evidence":"Well-established"},{"condition":"Mucolytic therapy in respiratory conditions","description":"It helps break down thick mucus in conditions like chronic bronchitis, cystic fibrosis, and bronchiectasis, making it easier to clear airways.","evidence":"Well-established"},{"condition":"Contrast-induced nephropathy prevention","description":"Sometimes used off-label to prevent kidney damage caused by contrast dyes used in imaging procedures, due to its antioxidant properties.","evidence":"Limited"},{"condition":"Acetaminophen toxicity in pregnancy","description":"Used to treat paracetamol overdose in pregnant women, as it is considered safe for the fetus when indicated.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Chronic obstructive pulmonary disease (COPD) exacerbations","description":"May be used to reduce mucus viscosity and improve symptoms during exacerbations, though evidence is mixed.","evidence":"Limited"},{"condition":"Infertility in women with polycystic ovary syndrome (PCOS)","description":"Sometimes used to improve ovulation and pregnancy rates, but evidence is insufficient.","evidence":"Insufficient"},{"condition":"Prevention of postoperative pulmonary complications","description":"May be given to reduce mucus plugging after surgery, but routine use is not established.","evidence":"Limited"}]
Primary treatment for: Paracetamol overdose
Also treats: Chronic bronchitis, Cystic fibrosis, Bronchiectasis, Contrast-induced nephropathy
📋 Drug Information
| Generic Name(s) | Acetylcysteine (1000mg) |
| Brand Name | nacel 1000mg injection |
| Manufacturer | Celon Laboratories Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Acetylcysteine -Mucolytic |
| Route of Administration | Parenteral (intravenous infusion or intramuscular injection) |
| Storage | Store at room temperature (15-30°C). Protect from light. Do not freeze. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | The World Health Organization includes acetylcysteine in its Model List of Essential Medicines for the treatment of paracetamol overdose. |
| ICMR Guideline | The Indian Council of Medical Research recommends acetylcysteine as the antidote of choice for paracetamol poisoning. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Acetylcysteine acts primarily by replenishing intracellular glutathione stores. In paracetamol overdose, the toxic metabolite NAPQI accumulates and depletes glutathione, leading to liver cell damage. Acetylcysteine provides cysteine, a precursor for glutathione synthesis, which then conjugates with NAPQI to form a non-toxic compound that is excreted. Additionally, acetylcysteine has antioxidant properties and can directly reduce free radicals. In respiratory conditions, it breaks disulfide bonds in mucus glycoproteins, reducing mucus viscosity and aiding clearance.
Mechanism Steps
💡 How to Take nacel 1000mg injection
Strength: Injection: 1000mg in a single-use vial.
Dosage Information
| Adult Dosage | The dosage of this medicine is individualized by a qualified clinician based on the indication, patient weight, and clinical status. For paracetamol overdose, a common regimen is 150 mg/kg intravenously over 15 minutes, followed by 50 mg/kg over 4 hours, then 100 mg/kg over 16 hours. For mucolytic use, doses may range from 200 mg to 1000 mg given once or twice daily. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced renal or hepatic function, so doses should be adjusted accordingly. No specific dose adjustments are established, but close monitoring is recommended. |
| Renal Impairment | No specific dose adjustments are established for renal impairment. However, since acetylcysteine is excreted renally, caution is advised in patients with severe renal impairment. Monitor renal function. |
| Hepatic Impairment | No specific dose adjustments are established for hepatic impairment. However, in patients with severe liver disease, the half-life may be prolonged. Use with caution and monitor liver function. |
| Maximum Daily Dose | The maximum daily dose depends on the indication. For paracetamol overdose, the total dose over 20 hours is 300 mg/kg. For mucolytic use, the maximum daily dose is typically 1000 mg. Dose must be individualized by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nacel 1000mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Nitroglycerin | Major | |
| Activated charcoal | Moderate | |
| Cough suppressants | Moderate | |
| Antibiotics (oral) | Moderate |
🚨 Major Interactions
- Nitroglycerin
- Activated charcoal
⚡ Moderate Interactions
- Cough suppressants
- Antibiotics (e.g., tetracycline, penicillin)
🍷 Alcohol Interaction
Alcohol should be avoided while receiving this medicine, as it can increase the risk of liver damage and may worsen the condition being treated. In paracetamol overdose, alcohol consumption can further deplete glutathione and increase hepatotoxicity.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to acetylcysteine or any component of the formulation","Use with caution in patients with asthma due to risk of bronchospasm"]
⚠️ Warnings & Precautions
["Administer only under medical supervision.","Monitor for anaphylactic reactions during infusion.","Use with caution in patients with asthma; have bronchodilators available.","Avoid concurrent use with nitroglycerin due to risk of severe hypotension.","In paracetamol overdose, treatment should be started as soon as possible, ideally within 8-10 hours of ingestion.","Do not use if the solution is discolored or contains particles.","Inform your doctor if you are pregnant or breastfeeding."]
🤱 Lactation Safety
Acetylcysteine is excreted in breast milk in small amounts. It is generally considered safe during breastfeeding, but consult your doctor to weigh the benefits and risks.
💊 Overdose Management
Overdose of acetylcysteine is unlikely to cause serious harm due to its wide therapeutic index. However, excessive doses may cause nausea, vomiting, and diarrhea. Treatment is supportive and symptomatic. In case of accidental overdose, contact a poison control center or seek medical attention immediately.
⏰ Missed Dose
This medicine is administered by a healthcare professional, so missed doses are unlikely. If a dose is missed during a scheduled infusion, the healthcare provider will adjust the regimen accordingly. Do not attempt to self-administer.
Additional Safety Advice
This medicine is given only by a healthcare professional in a hospital or clinic setting. Do not attempt to self-administer. Inform your doctor if you are allergic to acetylcysteine or have asthma, liver disease, or kidney disease. Your doctor will monitor you for allergic reactions during and after the infusion. If you experience wheezing, chest tightness, or swelling, tell your nurse or doctor immediately. Do not take any other medicines without consulting your doctor, as interactions may occur. Alcohol should be avoided as it can increase the risk of liver damage. If you are pregnant or breastfeeding, discuss the risks and benefits with your doctor. Keep all follow-up appointments for monitoring.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced liver and kidney function, so doses should be adjusted and monitored closely. They may be more susceptible to side effects like hypotension and allergic reactions.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before receiving this medicine. It is generally considered safe when needed, but the benefits and risks should be discussed.
🏥 Post-Surgery Considerations
This medicine may be used after surgery to prevent mucus plugging. Follow your doctor's instructions regarding its use and monitoring.
🦷 Dental Procedures
No specific precautions for dental procedures. Inform your dentist if you are receiving this medicine.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
If you are receiving this medicine for a respiratory condition, avoid strenuous exercise until your symptoms improve. Consult your doctor before resuming exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital setting, so it may require a hospital stay. After treatment, you may feel tired or dizzy; avoid driving or operating machinery until you feel normal. Consult your doctor about when you can resume work.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. It is given under medical supervision, and the duration is determined by your condition. If you experience severe side effects, inform your doctor immediately.
📅 Long-Term Use Effects
Long-term effects of acetylcysteine are not well established as it is typically used short-term. In chronic conditions like cystic fibrosis, long-term use may be prescribed under medical supervision. Monitoring of liver and kidney function is recommended with prolonged use.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Available for mucolytic use, but not for paracetamol overdose.
Evidence: Well-established for mucolytic useCan be used for respiratory conditions with thick mucus.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are known. However, if you are receiving this medicine for an acute condition, discuss vaccination timing with your doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate or freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not store in direct sunlight
✈️ Traveling with This Medicine
This medicine is administered in a hospital setting, so travel advice is not applicable. If you are traveling after treatment, carry a copy of your prescription and medical records. Store any remaining medication as directed. Consult your doctor before traveling if you have ongoing treatment.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The medicine starts working immediately after intravenous administration. For paracetamol overdose, it begins protecting the liver right away. For mucus clearance, effects may be seen within 1-2 hours.
A: No, this is an injectable form and must be given by a healthcare professional. Oral forms are available but are different products.
A: It is considered safe when clearly needed, especially for paracetamol overdose. Consult your doctor to weigh benefits and risks.
🤔 Common Patient Concerns
🔄 Substitutes for nacel 1000mg injection
View AllAlternative brands with exact same active ingredient:
-
acetine 1000mg injectionHealth Biotech Limited ₹27.00 77.4% CHEAPER
-
mucosys 1000mg injectionUnited Biotech Pvt Ltd ₹110.63 7.6% CHEAPER
-
mucyst 1000mg injectionNeon Laboratories Ltd ₹115.78 3.3% CHEAPER
-
coenac 1000 solutionKoye Pharmaceuticals Pvt ltd ₹117.77 1.6% CHEAPER
-
mucomelt 1000mg injectionVenus Remedies Ltd ₹122.36 2.2% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Acetylcysteine is only for cough.
Fact: It is primarily used for paracetamol overdose and also as a mucolytic. - Myth: It can be taken orally for any condition.
Fact: The injection form is given intravenously under medical supervision. - Myth: It is safe to self-administer.
Fact: It must be administered by a healthcare professional.
🔄 Alternative Options
Generic Alternatives
- Acetylcysteine injection
Brand Alternatives
- Mucomix 1gm injection