Atrapure 25mg/ml Injection (Atracurium): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or shortness of breath after the procedure
- Swelling of face, lips, or throat
- Severe rash or hives
- Chest pain or irregular heartbeat
- Prolonged muscle weakness or inability to move
- Seizures or convulsions
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is arium 25mg/ml injection used for?
This medicine is a non-depolarizing neuromuscular blocker used during surgery to relax muscles. It is given intravenously by anesthesia providers and works by blocking nerve signals to muscles. It is not for home use.
- Generic Name: Atracurium (25mg/ml)
- Manufacturer: Celon Laboratories Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 arium 25mg/ml injection के बारे में (Hindi Summary)
उपयोग: यह दवा एट्राक्यूरियम बेसिलेट 25 मिलीग्राम/मिलीलीटर का इंजेक्शन है, जिसका उपयोग सर्जरी के दौरान मांसपेशियों को ढीला करने के लिए किया जाता है। यह केवल अस्पताल में प्रशिक्षित डॉक्टरों द्वारा दी जाती है। यह दवा मांसपेशियों को पूरी तरह से आराम देती है ताकि सर्जरी आसानी से हो सके। इसे घर पर या बिना डॉक्टर की निगरानी में नहीं लिया जा सकता।
साइड इफेक्ट्स: आम दुष्प्रभावों में चेहरे पर लालिमा, हल्का रक्तचाप कम होना और दिल की धड़कन तेज होना शामिल है। गंभीर दुष्प्रभावों में लंबे समय तक मांसपेशियों का पक्षाघात, एलर्जी, और सांस लेने में कठिनाई हो सकती है। ये सभी प्रभाव अस्पताल में डॉक्टरों की निगरानी में ही होते हैं।
सुरक्षा सलाह: यह दवा केवल अस्पताल में विशेषज्ञ डॉक्टर द्वारा ही दी जानी चाहिए। इस दवा को लेने के बाद आपको कुछ समय तक निगरानी में रखा जाएगा। अपनी सभी दवाओं और एलर्जी की जानकारी डॉक्टर को दें। बिना डॉक्टर की सलाह के इस दवा का उपयोग न करें।
💊 arium 25mg/ml injection Uses & Benefits
[{"condition":"Endotracheal intubation","description":"Facilitates placement of a breathing tube during general anesthesia by relaxing the jaw and throat muscles.","evidence":"Well-established"},{"condition":"Skeletal muscle relaxation during surgery","description":"Provides muscle relaxation to improve surgical access and reduce the need for deep anesthesia.","evidence":"Well-established"},{"condition":"Mechanical ventilation in intensive care","description":"Used for short-term paralysis to facilitate mechanical ventilation in critically ill patients when other measures fail.","evidence":"Well-established"},{"condition":"Adjunct to electroconvulsive therapy","description":"Prevents fractures and muscle injury during electrically induced seizures by modifying motor activity.","evidence":"Established"}]
Off-label uses: [{"condition":"Rapid sequence intubation in emergency department","description":"Sometimes used off-label for emergency intubation when other agents are contraindicated, though succinylcholine is more common.","evidence":"Limited"},{"condition":"Treatment of tetanus-induced muscle spasms","description":"May be used to control severe muscle spasms in tetanus when other measures are inadequate.","evidence":"Limited"}]
Primary treatment for: Surgical muscle relaxation
Also treats: Mechanical ventilation, Endotracheal intubation, Electroconvulsive therapy
📋 Drug Information
| Generic Name(s) | Atracurium (25mg/ml) |
| Brand Name | arium 25mg/ml injection |
| Manufacturer | Celon Laboratories Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Skeletal muscle relaxant- Peripherally acting |
| Route of Administration | Parenteral (intravenous) |
| Storage | Store refrigerated at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light. Once removed from refrigeration, it should be used within a specified period as per manufacturer's instructions. |
| Shelf Life | Refer to the product label for the exact shelf life. Typically 24 months from the date of manufacture when stored under recommended conditions. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is a non-depolarizing neuromuscular blocking agent that competitively antagonizes acetylcholine at nicotinic receptors on the motor endplate of skeletal muscle. By binding to these receptors without activating them, it prevents depolarization and subsequent muscle contraction. This results in flaccid paralysis. The block is reversible by increasing acetylcholine levels (e.g., with neostigmine) or by allowing the drug to be eliminated. Atracurium is unique because it undergoes Hofmann elimination, a spontaneous non-enzymatic degradation at physiological pH and temperature, independent of liver and kidney function.
Mechanism Steps
💡 How to Take arium 25mg/ml injection
Strength: Injection: 25 mg/ml
Dosage Information
| Adult Dosage | The dose of this medicine must be individualized by a qualified clinician based on the indication, patient's weight, age, renal and hepatic function, and response. For endotracheal intubation, a common initial dose is 0.4 to 0.5 mg/kg intravenously, followed by maintenance doses of 0.08 to 0.1 mg/kg as needed. For prolonged procedures, continuous infusion may be used. Dose must be titrated to effect using neuromuscular monitoring. This information is for educational purposes only and does not replace clinical judgment. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician and anesthesiologist for individualized dosing. |
| Elderly Dosage | Elderly patients may have increased sensitivity to neuromuscular blocking agents. Doses should be individualized and titrated carefully with neuromuscular monitoring. |
| Renal Impairment | No dosage adjustment is typically required because atracurium undergoes Hofmann elimination independent of renal function. However, metabolites may accumulate in severe renal impairment; monitor closely. |
| Hepatic Impairment | No dosage adjustment is typically required because atracurium undergoes Hofmann elimination independent of hepatic function. However, monitor closely in severe hepatic disease. |
| Maximum Daily Dose | Not established from the available information. Dosing is individualized and titrated to effect under medical supervision. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of arium 25mg/ml injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Inhalational anesthetics | Major | |
| Aminoglycosides | Major | |
| Magnesium sulfate | Major | |
| Loop diuretics | Moderate | |
| Calcium channel blockers | Moderate | |
| Lithium | Moderate | |
| Corticosteroids | Minor | |
| Azathioprine | Minor |
🚨 Major Interactions
- Inhalational anesthetics (e.g., isoflurane, sevoflurane)
- Aminoglycoside antibiotics (e.g., gentamicin, tobramycin)
- Magnesium sulfate
⚡ Moderate Interactions
- Loop diuretics (e.g., furosemide)
- Calcium channel blockers (e.g., verapamil)
- Lithium
🍷 Alcohol Interaction
Alcohol may enhance the sedative effects of anesthesia and increase the risk of hypotension. Patients should avoid alcohol before surgery and while recovering from anesthesia.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to atracurium or any component of the formulation","Use in patients with a history of anaphylaxis to neuromuscular blocking agents"]
⚠️ Warnings & Precautions
["Should be administered only by experienced clinicians in a setting with immediate access to airway management and resuscitation equipment.","May cause histamine release; use with caution in patients with asthma or cardiovascular disease.","Prolonged use in intensive care may lead to critical illness polyneuropathy.","Dose must be individualized based on patient response and procedure.","Not recommended for use in patients with myasthenia gravis unless absolutely necessary and with extreme caution."]
🤱 Lactation Safety
Not established from the available information. It is unlikely to be present in breast milk in significant amounts due to intravenous use and short half-life, but consult a doctor.
💊 Overdose Management
Overdose leads to prolonged neuromuscular blockade and respiratory paralysis. Management includes continued mechanical ventilation, monitoring of vital signs, and administration of an acetylcholinesterase inhibitor (e.g., neostigmine) once spontaneous recovery begins. There is no specific antidote for atracurium itself; supportive care is essential.
⏰ Missed Dose
This medicine is administered only by healthcare professionals in a controlled setting. Missed doses are not applicable.
Additional Safety Advice
This medicine must only be administered by a qualified anesthesia provider or critical care specialist in a hospital or surgical setting equipped with immediate airway management and resuscitation facilities. Continuous monitoring of neuromuscular function, heart rate, blood pressure, oxygen saturation, and body temperature is mandatory during use. This medicine should never be used outside a properly equipped medical facility. Inform your medical team if you have a history of asthma, allergies, neuromuscular disorders such as myasthenia gravis, or cardiovascular disease. Do not attempt to move or drive yourself after receiving this medicine; full recovery of muscle strength must be confirmed before discharge. Always tell your doctor about all medicines you take, especially antibiotics, anti-seizure drugs, and magnesium-containing products, as these can interact with this medicine. Keep a record of any allergic reactions to medicines and share it with your healthcare provider before any procedure.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have increased sensitivity to neuromuscular blocking agents. Doses should be individualized and titrated carefully with neuromuscular monitoring.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, inform your doctor before any procedure. This medicine is used only when clearly needed during pregnancy, and the benefits must outweigh the risks.
🏥 Post-Surgery Considerations
After surgery, you will be monitored until full muscle strength returns. Follow your surgeon's instructions for recovery, including activity restrictions and follow-up appointments.
🦷 Dental Procedures
This medicine is not typically used for dental procedures unless they are performed under general anesthesia in a hospital setting. Inform your dentist if you have received this medicine recently.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
After receiving this medicine, you should not engage in any strenuous activity until fully recovered and cleared by your doctor. Muscle weakness may persist for some time.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
You should not drive or operate machinery for at least 24 hours after receiving this medicine or as advised by your doctor. You may need to take time off work to recover from surgery and anesthesia.
🛑 When to Stop This Medicine
This medicine is stopped by the healthcare provider once the procedure is complete or when muscle relaxation is no longer needed. Do not attempt to stop or adjust it yourself.
📅 Long-Term Use Effects
Long-term effects are not typically seen with short-term use. Prolonged use in intensive care may be associated with critical illness polyneuropathy and muscle weakness. Monitoring and rehabilitation may be required.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Cisatracurium, vecuronium, or rocuronium may be used depending on the clinical situation.
Evidence: Well-establishedIn some procedures, adequate muscle relaxation can be achieved with deep anesthesia alone.
Evidence: Established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not applicable. This medicine is used acutely in a hospital setting and does not interact with vaccines.
📦 Storage Guide
✅ DO
Store refrigerated at 2°C to 8°C
❌ DON'T
Do not freeze
✅ DO
Protect from light
❌ DON'T
Do not use if solution is discolored or contains particles
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✈️ Traveling with This Medicine
This medicine is administered only in a hospital setting and is not for self-administration. If you are traveling after a procedure, ensure you have a copy of your medical records and discharge summary. Carry your prescription and any relevant medical documents. Inform your travel insurance provider about your recent procedure. Do not attempt to travel immediately after receiving this medicine; wait until fully recovered and cleared by your doctor.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 1 to 2 minutes after intravenous injection.
A: The muscle relaxation typically lasts 20 to 35 minutes, but this can vary.
A: Yes, it is often preferred in kidney disease because it is eliminated independently of kidney function.
A: Yes, reversal agents such as neostigmine can be used, but they are not always necessary as the drug wears off on its own.
🤔 Common Patient Concerns
🔄 Substitutes for arium 25mg/ml injection
View AllAlternative brands with exact same active ingredient:
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atb 25mg/ml injectionCachet Pharmaceuticals Pvt Ltd ₹75.62 40.2% CHEAPER
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atrager 25mg/ml injectionZydus Cadila ₹100.83 20.2% CHEAPER
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crimat 25mg/ml injectionMiracalus Pharma Pvt Ltd ₹118.00 6.6% CHEAPER
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atracade 25mg/ml injectionBharat Serums & Vaccines Ltd ₹120.20 4.9% CHEAPER
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Artacil 25mg/ml InjectionNeon Laboratories Ltd ₹120.70 4.5% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Atracurium is a painkiller.
Fact: Atracurium is a muscle relaxant and has no pain-relieving properties. - Myth: Atracurium can be taken at home.
Fact: Atracurium must only be given in a hospital setting by trained professionals. - Myth: Atracurium is safe for everyone.
Fact: Atracurium can cause serious side effects and is contraindicated in some patients.
🔄 Alternative Options
Generic Alternatives
- Atracurium besylate
Brand Alternatives
- Atrapure 25mg/ml injection