coenac 1000 solution

4.6 (13 reviews)

Acetylcysteine (1000mg)

🏭 Koye Pharmaceuticals Pvt ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is coenac 1000 solution used for?

Acyline Tablet (Acetylcysteine) is used to treat PAIN ANALGESICS. It contains Acetylcysteine (1000mg), which Reduces mucus viscosity by breaking disulfide bonds; also acts as a precursor to. Always consult your doctor before use. Take as prescribed.

Generic Name: Acetylcysteine
Manufacturer: Koye Pharmaceuticals Pvt ltd
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 coenac 1000 solution Uses & Benefits

Mucolytic in respiratory conditions (COPD, cystic fibrosis, bronchitis), acetaminophen overdose

Off-label uses: Prevention of contrast-induced nephropathy, treatment of pulmonary fibrosis

📋 Drug Information

Generic Name(s)	Acetylcysteine
Brand Name	Acyline Tablet
Manufacturer	Koye Pharmaceuticals Pvt ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	PAIN ANALGESICS
Action Class	Acetylcysteine -Mucolytic
Route of Administration	Oral, intravenous (for overdose), inhalation
Storage	Store at room temperature (20-25°C), protect from moisture
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed after oral administration

DistributionDistributes widely into body tissues and fluids

Protein Binding50-83%

MetabolismHepatic, primarily deacetylation to cysteine

Half-Life5.6 hours (adults), 11 hours (neonates)

ExcretionRenal (primarily as inactive metabolites)

Bioavailability6-10% (oral, due to extensive first-pass metabolism)

Onset of ActionRapid (within 1 hour for mucolytic effect)

Peak Plasma Time1-3 hours

Duration of Action4-6 hours

How It Works

Reduces mucus viscosity by breaking disulfide bonds; also acts as a precursor to glutathione, providing antioxidant effects

Mechanism Steps

1Acetylcysteine is deacetylated to cysteine in the liver

2Cysteine is a precursor for glutathione synthesis

3Glutathione conjugates with reactive metabolites of acetaminophen, preventing hepatotoxicity

💡 How to Take coenac 1000 solution

Follow your doctor's prescription exactly.

⚠️ Side Effects of coenac 1000 solution

✅ Common Side Effects

Nausea
Vomiting
Rash
Fever
Drowsiness

🚨 Serious Side Effects

Anaphylactoid reaction
Bronchospasm
Stevens-Johnson syndrome
Seizures

⚠️ Rare Side Effects

Hepatotoxicity
Metabolic acidosis
Hypotension

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Nitroglycerin	Major	Increased hypotension and headache
Carbamazepine	Major	Decreased carbamazepine levels
Warfarin	Moderate	Increased INR and bleeding risk
Chloroquine	Moderate	Decreased chloroquine efficacy
Activated charcoal	Minor	Reduced acetylcysteine absorption
Tetracyclines	Minor	Decreased tetracycline absorption if taken simultaneously

🚨 Major Interactions

Nitroglycerin
Carbamazepine

⚡ Moderate Interactions

Warfarin
Chloroquine

ℹ️ Minor Interactions

Activated charcoal
Tetracyclines

🍽️ Food Interactions

None known

🍷 Alcohol Interaction

May increase risk of hepatotoxicity; avoid concurrent use

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to acetylcysteine, severe asthma (relative), peptic ulcer disease (relative)

📊 Monitoring Parameters

Liver function tests (in overdose), respiratory status, signs of hypersensitivity

🤱 Lactation Safety

Excreted in breast milk in small amounts; considered compatible with breastfeeding

💊 Overdose Management

Supportive care; monitor for anaphylactoid reactions, seizures, and metabolic acidosis

⏰ Missed Dose

Take as soon as remembered; if close to next dose, skip missed dose and resume regular schedule

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

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🔄 Substitutes for coenac 1000 solution

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Alternative brands with exact same active ingredient (Acetylcysteine (1000mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Happy Patient Jul 10, 2026

Effective and reliable. Worked as expected.

Trusted Reviewer Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Regular Customer Jul 10, 2026