Acetine 1000mg Injection (Acetylcysteine): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or wheezing
- Swelling of face, lips, tongue, or throat
- Severe nausea and vomiting that prevents keeping the medicine down
- Signs of severe allergic reaction such as rash, itching, or hives
- Chest pain or palpitations
- Decreased urine output or dark urine
- Yellowing of skin or eyes (jaundice)
If experiencing severe symptoms, call emergency services immediately.
What is coenac 1000 solution used for?
This medicine contains acetylcysteine 1000mg and is used orally (after dilution) as an antidote for acetaminophen overdose and to loosen thick mucus in respiratory conditions. It works by replenishing glutathione in the liver and breaking down mucus. It must be used under medical supervision.
- Generic Name: Acetylcysteine
- Manufacturer: Koye Pharmaceuticals Pvt ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 coenac 1000 solution के बारे में (Hindi Summary)
उपयोग: यह दवा एसिटिलसिस्टीन 1000mg इंजेक्शन के रूप में उपलब्ध है, लेकिन इसे मुँह से लेने के लिए तैयार किया जाता है। इसका मुख्य उपयोग पैरासिटामोल (एसिटामिनोफेन) की अधिक मात्रा लेने पर लीवर को बचाने के लिए किया जाता है। यह शरीर में ग्लूटाथियोन की मात्रा बढ़ाकर जहरीले पदार्थ को बेअसर करती है। इसके अलावा, यह बलगम को पतला करने में भी मदद करती है, जिससे खांसी में आराम मिलता है। इसका उपयोग डॉक्टर की देखरेख में ही किया जाना चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, पेट खराब होना, और मुँह का स्वाद खराब होना शामिल हैं। कभी-कभी त्वचा पर चकत्ते, खुजली, या बुखार हो सकता है। दमा के रोगियों में सांस लेने में कठिनाई हो सकती है। गंभीर एलर्जी प्रतिक्रिया दुर्लभ है, लेकिन अगर चेहरे, होंठ, या गले में सूजन, सांस लेने में तकलीफ, या चक्कर आएं तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा का उपयोग केवल डॉक्टर की सलाह और देखरेख में करें। इसे स्वयं न लें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से परामर्श करें। दमा के रोगियों को सावधानी बरतनी चाहिए। अन्य दवाओं के साथ लेने से पहले डॉक्टर से पूछें। पर्याप्त पानी पिएं। निर्धारित खुराक से अधिक न लें। एलर्जी के लक्षण दिखने पर तुरंत चिकित्सा सहायता लें।
💊 coenac 1000 solution Uses & Benefits
- [{"condition":"Acetaminophen (paracetamol) overdose","description":"This medicine is used as an antidote to prevent or reduce liver damage caused by acetaminophen overdose.
- It replenishes glutathione, which detoxifies the harmful metabolite NAPQI.","evidence":"Well-established"},{"condition":"Chronic bronchitis with thick mucus","description":"Acetylcysteine helps thin and loosen mucus in the airways, making it easier to cough out.
- However, the injectable formulation is not typically used for this purpose; oral or inhaled forms are preferred.","evidence":"Limited for this formulation"},{"condition":"Cystic fibrosis (adjunct)","description":"May be used to help clear thick mucus in cystic fibrosis patients, but again, other formulations are more commonly used.","evidence":"Limited for this formulation"}]
Off-label uses: [{"condition":"Contrast-induced nephropathy prevention","description":"Some studies suggest acetylcysteine may help prevent kidney damage caused by contrast dyes, but evidence is conflicting and it is not a standard use for this formulation.","evidence":"Conflicting"},{"condition":"Infertility in women with polycystic ovary syndrome","description":"Occasionally used off-label to improve ovulation and pregnancy rates, but not established for this formulation.","evidence":"Limited"}]
Primary treatment for: Acetaminophen (paracetamol) overdose
Also treats: Chronic bronchitis, Cystic fibrosis
📋 Drug Information
| Generic Name(s) | Acetylcysteine |
| Brand Name | Acyline Tablet |
| Manufacturer | Koye Pharmaceuticals Pvt ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Acetylcysteine -Mucolytic |
| Route of Administration | Oral (after appropriate dilution, as directed by a healthcare professional) |
| Storage | Store at room temperature (15-30°C), protected from light and moisture. Do not freeze. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Acetylcysteine acts as a mucolytic by breaking disulfide bonds in mucoproteins, reducing mucus viscosity. As an antidote for acetaminophen overdose, it replenishes hepatic glutathione stores, which are essential for conjugating and detoxifying the toxic metabolite N-acetyl-p-benzoquinone imine (NAPQI). This prevents NAPQI from binding to liver cell proteins and causing necrosis. Additionally, acetylcysteine has antioxidant properties and can scavenge free radicals.
Mechanism Steps
💡 How to Take coenac 1000 solution
Strength: Acetylcysteine 1000mg injection (for oral use after dilution).
Dosage Information
| Adult Dosage | The dose of this medicine must be individualized by a qualified clinician based on the indication, patient's age, weight, renal and hepatic function, and severity of the condition. For acetaminophen overdose, a common regimen involves an initial oral loading dose of 140 mg/kg, followed by 70 mg/kg every 4 hours for 17 doses. However, this is for educational purposes only and must not be used for self-medication. Always follow the prescribed dose and schedule. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing. |
| Elderly Dosage | Elderly patients may require dose adjustment based on renal and hepatic function. Consult a doctor for individualized dosing. |
| Renal Impairment | No specific dose adjustment is established for renal impairment, but use with caution and monitor renal function. |
| Hepatic Impairment | No specific dose adjustment is established for hepatic impairment, but use with caution and monitor liver function. |
| Maximum Daily Dose | The maximum daily dose must be determined by a qualified clinician based on the indication and patient factors. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of coenac 1000 solution
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Nitroglycerin | Major | |
| Activated charcoal | Major | |
| Cough suppressants | Moderate | |
| Tetracycline | Moderate | |
| Penicillin | Moderate |
🚨 Major Interactions
- Nitroglycerin
- Activated charcoal
⚡ Moderate Interactions
- Cough suppressants
- Antibiotics (e.g., tetracycline, penicillin)
🍷 Alcohol Interaction
Alcohol may increase the risk of liver damage, especially in the context of acetaminophen overdose. Avoid alcohol while receiving this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to acetylcysteine or any component of the formulation","Not for use in patients with active peptic ulcer disease without medical supervision"]
⚠️ Warnings & Precautions
["Use with caution in patients with asthma due to risk of bronchospasm.","May cause nausea and vomiting; ensure adequate hydration.","Do not use if solution is discolored or contains particles.","Administer orally only after proper dilution as directed by a healthcare professional.","Avoid concurrent use with nitroglycerin due to risk of severe hypotension.","Monitor for signs of anaphylaxis during administration."]
🤱 Lactation Safety
Acetylcysteine is distributed into breast milk. Consult a doctor before use during breastfeeding; potential risks and benefits must be weighed.
💊 Overdose Management
Overdose of acetylcysteine may cause nausea, vomiting, and diarrhea. There is no specific antidote. Treatment is supportive and symptomatic. In case of accidental overdose, seek immediate medical attention.
⏰ Missed Dose
If a dose is missed, take it as soon as remembered unless it is almost time for the next dose. Do not double the dose to catch up. Consult your doctor for specific instructions.
Additional Safety Advice
This medicine must be used only under medical supervision. Do not self-administer; it is intended for clinical use in a controlled setting. If you are pregnant or breastfeeding, inform your doctor before use, as the benefits and risks must be weighed. Patients with asthma should be monitored closely because acetylcysteine can cause bronchospasm. Avoid combining with other medications without consulting a doctor, especially cough suppressants, antibiotics, or nitroglycerin. Drink plenty of fluids unless otherwise directed. Do not exceed the prescribed dose. If you experience rash, swelling, or difficulty breathing, seek emergency medical help immediately. Store as directed and keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to side effects such as nausea and dizziness. Dose adjustment may be needed based on renal and hepatic function. Monitor closely.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before using this medicine. It should be used during pregnancy only if clearly needed.
🏥 Post-Surgery Considerations
If you have recently had surgery, inform your surgeon and anesthesiologist about this medicine. It may interact with other medications used during surgery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine. No specific precautions are typically required, but it is important for your dentist to know your medication history.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
If you experience dizziness or fatigue after taking this medicine, avoid strenuous exercise until you know how it affects you.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or nausea in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is advisable to rest if you feel unwell.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor, especially if it was prescribed for acetaminophen overdose. For mucolytic use, stop if symptoms worsen or if you experience severe side effects, and consult your doctor.
📅 Long-Term Use Effects
Long-term use of acetylcysteine is generally well-tolerated. However, prolonged use may lead to gastrointestinal discomfort. Regular monitoring of liver and kidney function is advised if used for extended periods. There is no evidence of serious long-term toxicity when used appropriately.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help loosen mucus naturally.
Evidence: Well-establishedHelps clear mucus from airways.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are known. However, consult your doctor before receiving any vaccine while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging along with a copy of your prescription. Store it at room temperature, away from direct sunlight and moisture. If traveling across time zones, adjust dosing schedule as advised by your doctor. Check customs regulations for carrying prescription medicines. Always keep it in your carry-on luggage if flying.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: For mucus clearance, it may take 1-2 hours to notice effects. For acetaminophen overdose, it starts working immediately to protect the liver.
A: Yes, taking it with food can reduce stomach upset.
A: Consult your doctor; use only if clearly needed.
🤔 Common Patient Concerns
🔄 Substitutes for coenac 1000 solution
View AllAlternative brands with exact same active ingredient:
-
acetine 1000mg injectionHealth Biotech Limited ₹27.00 77.1% CHEAPER
-
mucosys 1000mg injectionUnited Biotech Pvt Ltd ₹110.63 6.1% CHEAPER
-
mucyst 1000mg injectionNeon Laboratories Ltd ₹115.78 1.7% CHEAPER
-
nacel 1000mg injectionCelon Laboratories Ltd ₹119.70 1.6% COSTLIER
-
mucomelt 1000mg injectionVenus Remedies Ltd ₹122.36 3.9% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Acetylcysteine is only for cough.
Fact: It is also a life-saving antidote for acetaminophen overdose. - Myth: It can be self-administered.
Fact: It must be used under medical supervision, especially for overdose.
🔄 Alternative Options
Generic Alternatives
- Acetylcysteine 1000mg injection (generic)
Brand Alternatives
- Acetine 1000mg injection