Morease-I Granules: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe abdominal pain with vomiting and inability to pass stool or gas
- Blood in stool or vomit
- Swelling of face, lips, or throat
- Difficulty breathing or chest pain
- Severe dizziness or fainting
- Signs of dehydration (dry mouth, reduced urine output)
If experiencing severe symptoms, call emergency services immediately.
What is matiz-i granules used for?
This medicine is a combination of Mebeverine and Ispaghula used to treat irritable bowel syndrome (IBS). Mebeverine relaxes gut muscles to relieve cramps, while Ispaghula adds bulk to stool to relieve constipation. It is taken orally as granules mixed with water.
- Generic Name: Mebeverine (135mg) + Ispaghula (3.5gm)
- Manufacturer: Tas Med India Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 matiz-i granules के बारे में (Hindi Summary)
उपयोग: यह दवा मेबेवेरिन और इस्पघुला का संयोजन है, जिसका उपयोग इरिटेबल बाउल सिंड्रोम (IBS) में पेट दर्द, ऐंठन, सूजन और कब्ज जैसी समस्याओं के इलाज के लिए किया जाता है। मेबेवेरिन आंतों की मांसपेशियों को आराम देता है, जिससे ऐंठन कम होती है, जबकि इस्पघुला मल को नरम और भारी बनाता है, जिससे कब्ज में राहत मिलती है। इसे पानी या जूस के साथ लेना चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में पेट फूलना, गैस, हल्का पेट दर्द, मतली और सिरदर्द शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ दिनों में ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अगर आपको तेज पेट दर्द, उल्टी, मल त्याग में कठिनाई, चेहरे या गले में सूजन, या सांस लेने में तकलीफ हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे एक गिलास पानी या जूस में मिलाकर तुरंत पिएं। सूखा न लें। दिनभर पर्याप्त पानी पिएं। अन्य दवाओं के साथ लेने से 1-2 घंटे का अंतर रखें। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। शराब न पिएं। चक्कर आने पर वाहन न चलाएं। बच्चों की पहुंच से दूर रखें।
💊 matiz-i granules Uses & Benefits
[{"condition":"Irritable bowel syndrome (IBS)","description":"Relieves abdominal pain, cramping, bloating, and irregular bowel habits associated with IBS.","evidence":"Well-established for mebeverine; ispaghula has good evidence for IBS with constipation."},{"condition":"Functional bowel disorders","description":"Helps manage chronic abdominal discomfort and altered bowel habits not explained by organic disease.","evidence":"Moderate"},{"condition":"Constipation-predominant IBS","description":"The Ispaghula component adds bulk to stool, making it easier to pass, while mebeverine reduces spasm.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Diverticular disease","description":"Sometimes used to relieve symptoms of diverticular disease, though evidence is limited.","evidence":"Limited"},{"condition":"Post-infectious IBS","description":"May be used to manage persistent bowel symptoms after a gastrointestinal infection.","evidence":"Limited"}]
Primary treatment for: Irritable bowel syndrome (IBS)
Also treats: Functional constipation, Diverticular disease, Post-infectious IBS
📋 Drug Information
| Generic Name(s) | Mebeverine (135mg) + Ispaghula (3.5gm) |
| Brand Name | matiz-i granules |
| Manufacturer | Tas Med India Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep the container tightly closed. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary actions. Mebeverine is a musculotropic antispasmodic that acts directly on the smooth muscle of the gastrointestinal tract. It blocks sodium channels and reduces calcium influx, leading to relaxation of the gut muscle and relief of spasm without affecting normal peristalsis. Ispaghula is a bulk-forming laxative derived from plant husk. It absorbs water in the intestine to form a gel, increasing stool bulk and moisture, which stimulates natural bowel movement and reduces constipation.
Mechanism Steps
💡 How to Take matiz-i granules
Strength: Granules containing Mebeverine 135 mg and Ispaghula 3.5 g per sachet.
Dosage Information
| Adult Dosage | The usual adult dose is one sachet (containing Mebeverine 135 mg and Ispaghula 3.5 g) mixed with a full glass of water or juice, taken once or twice daily, or as directed by your doctor. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is required, but use with caution due to increased risk of swallowing difficulties and constipation. Consult your doctor. |
| Renal Impairment | No specific dose adjustment is established. Use with caution in severe kidney disease. |
| Hepatic Impairment | No specific dose adjustment is established. Use with caution in severe liver disease. |
| Maximum Daily Dose | The maximum recommended daily dose is two sachets (Mebeverine 270 mg and Ispaghula 7 g). Do not exceed without medical advice. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of matiz-i granules
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Moderate | |
| Digoxin | Moderate | |
| Lithium | Moderate | |
| Antidiabetic drugs | Moderate | |
| Iron supplements | Minor | |
| Antacids | Minor |
🚨 Major Interactions
- Oral medications in general
- Antidiabetic drugs
⚡ Moderate Interactions
- Warfarin
- Digoxin
- Lithium
🍷 Alcohol Interaction
Alcohol may worsen stomach irritation and abdominal discomfort. It is advisable to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to mebeverine, ispaghula, or any ingredient","Suspected or confirmed intestinal obstruction","Severe inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis)","Difficulty swallowing","Severe constipation with impaction"]
⚠️ Warnings & Precautions
["Always take with a full glass of water to prevent choking or blockage.","Do not take at the same time as other medicines; separate by 1-2 hours.","Use with caution in elderly patients and those with swallowing difficulties.","Consult doctor if symptoms persist beyond 2 weeks.","Avoid alcohol while taking this medicine.","Do not exceed the prescribed dose."]
🤱 Lactation Safety
It is not known whether mebeverine passes into breast milk. Ispaghula is not absorbed and is likely safe. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose may cause severe abdominal pain, bloating, or diarrhea. Seek immediate medical attention. Treatment is supportive and symptomatic.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Mix the granules with a full glass of water or juice and drink immediately. Do not take it dry. Drink plenty of fluids throughout the day to help the Ispaghula component work properly. Do not take this medicine within 1-2 hours of other medicines, as Ispaghula can reduce the absorption of other drugs. Avoid alcohol while taking this medicine, as it may worsen stomach irritation. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before use. Do not drive or operate heavy machinery if you feel dizzy. Keep out of reach of children. Store in a cool, dry place away from direct sunlight. Do not use after the expiry date. If symptoms persist beyond 2 weeks or worsen, contact your doctor.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more prone to constipation and swallowing difficulties. Use with caution and ensure adequate hydration.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before starting or continuing this medicine. Alternative treatments may be considered.
🏥 Post-Surgery Considerations
Consult your doctor before using this medicine after surgery, especially abdominal surgery, as it may affect bowel function.
🦷 Dental Procedures
No specific precautions. Inform your dentist about all medicines you are taking.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
No specific exercise restrictions. However, if you experience dizziness, avoid strenuous activities until you feel better.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness in some people. Avoid driving or operating heavy machinery if affected. Otherwise, it should not significantly impact daily activities.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience severe side effects or no improvement after 2 weeks, contact your doctor for reassessment.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe for IBS management. However, prolonged use of bulk-forming laxatives like Ispaghula may rarely lead to dependency or electrolyte imbalances. Regular follow-up with your doctor is recommended to assess symptom control and adjust treatment.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Low-FODMAP diet can help manage IBS symptoms.
Evidence: Well-establishedYoga, meditation, and counseling can reduce IBS flare-ups.
Evidence: ModerateMay help restore gut flora balance in some patients.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No known interactions with vaccines. Continue routine vaccinations as scheduled.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store it in a cool, dry place away from direct sunlight. If traveling across time zones, continue with your regular schedule as much as possible. For air travel, keep it in your carry-on luggage. Check customs regulations for prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Mebeverine starts relieving spasm within 30-60 minutes, while Ispaghula may take 12-24 hours to produce a bowel movement. Full benefits for IBS may take 1-2 weeks.
A: Separate this medicine from other oral drugs by at least 1-2 hours to avoid absorption interference.
A: Consult your doctor before use. The safety of mebeverine in pregnancy is not well established.
🤔 Common Patient Concerns
🔄 Substitutes for matiz-i granules
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a painkiller for any type of pain.
Fact: It is specifically for abdominal pain and cramps related to IBS and functional bowel disorders. - Myth: It can be taken without water.
Fact: It must be taken with a full glass of water to prevent choking and ensure proper action. - Myth: It is safe to take with all other medicines at the same time.
Fact: It can interact with other medicines; separate by at least 1-2 hours.
🔄 Alternative Options
Generic Alternatives
- Mebeverine + Ispaghula granules (generic)
Brand Alternatives
- Morease-I Granules