Mebaspa AL Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Slow, shallow breathing or difficulty breathing
- Severe drowsiness or confusion
- Yellowing of skin or eyes, dark urine
- Severe abdominal pain or persistent vomiting
- Signs of allergic reaction: rash, swelling of face/lips/throat
- Unusual bruising or bleeding
- Seizures or tremors
- Worsening anxiety or agitation
If experiencing severe symptoms, call emergency services immediately.
What is mebaspa al tablet used for?
This medicine is a combination of mebeverine (an antispasmodic) and alprazolam (a benzodiazepine) used for short-term relief of irritable bowel syndrome with anxiety. It relaxes gut muscles and calms the mind, but it can cause drowsiness and dependence. It should be taken exactly as prescribed and not stopped suddenly.
- Generic Name: Mebeverine (135mg) + Alprazolam (0.25mg)
- Manufacturer: USV Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 mebaspa al tablet के बारे में (Hindi Summary)
उपयोग: यह दवा मेबेवेरिन और अल्प्राजोलम का संयोजन है। यह मुख्य रूप से चिड़चिड़ा आंत्र सिंड्रोम (IBS) के साथ चिंता के इलाज के लिए अल्पकालिक उपयोग में लाई जाती है। मेबेवेरिन आंतों की मांसपेशियों को आराम देकर पेट की ऐंठन और दर्द को कम करता है, जबकि अल्प्राजोलम मन को शांत करता है और चिंता को कम करता है। यह दवा पेट की ऐंठन, सूजन, गैस, और चिंता से जुड़े लक्षणों में राहत देती है। इसे डॉक्टर के निर्देशानुसार ही लें और इसका लंबे समय तक उपयोग न करें क्योंकि अल्प्राजोलम की लत लग सकती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में नींद आना, चक्कर आना, मुँह सूखना, थकान, और धुंधली दृष्टि शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ दिनों में कम हो जाते हैं। गंभीर दुष्प्रभावों में सांस लेने में कठिनाई, भ्रम, याददाश्त की समस्या, एलर्जी, और लीवर की समस्या के लक्षण जैसे आँखों या त्वचा का पीला पड़ना शामिल हैं। यदि आपको कोई भी असामान्य लक्षण महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। अपनी मर्जी से खुराक न बढ़ाएँ या कम न करें। इस दवा के साथ शराब का सेवन बिल्कुल न करें क्योंकि इससे गंभीर नींद और सांस की समस्या हो सकती है। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन न चलाएँ और मशीनरी न चलाएँ। यदि आप गर्भवती हैं, स्तनपान करा रही हैं, या गर्भधारण की योजना बना रही हैं, तो डॉक्टर को बताएं। इस दवा को अचानक बंद न करें, क्योंकि इससे withdrawal के लक्षण हो सकते हैं। इसे बच्चों और पालतू जानवरों से दूर रखें।
💊 mebaspa al tablet Uses & Benefits
[{"condition":"Irritable bowel syndrome (IBS) with anxiety","description":"This medicine helps relieve abdominal pain, cramping, bloating, and altered bowel habits associated with IBS, while alprazolam addresses anxiety that may worsen gut symptoms.","evidence":"Mebeverine is well-established for IBS; alprazolam is used adjunctively for short-term anxiety, but combination evidence is limited."},{"condition":"Gastrointestinal spasms","description":"Mebeverine relaxes smooth muscle in the gut, reducing spasms and associated discomfort.","evidence":"Well-established for mebeverine."},{"condition":"Anxiety disorders (short-term)","description":"Alprazolam provides rapid relief of anxiety symptoms, but it is intended for short-term use only due to dependence risk.","evidence":"Well-established for alprazolam."}]
Off-label uses: [{"condition":"Stress-related abdominal pain","description":"Sometimes prescribed when anxiety clearly exacerbates gastrointestinal symptoms, though this is not a formal approved indication.","evidence":"Limited"}]
Primary treatment for: Irritable bowel syndrome with anxiety
Also treats: Generalized anxiety disorder, Gastrointestinal spasms, Stress-related abdominal pain
📋 Drug Information
| Generic Name(s) | Mebeverine (135mg) + Alprazolam (0.25mg) |
| Brand Name | mebaspa al tablet |
| Manufacturer | USV Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container, tightly closed. Do not refrigerate. Keep out of reach of children and pets. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. Mebeverine is included in some national guidelines for IBS, but this specific combination is not addressed by WHO guidelines. |
| ICMR Guideline | Not established from the available information. ICMR guidelines for IBS may recommend antispasmodics like mebeverine, but the combination with alprazolam is not specifically recommended. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Mebeverine acts directly on the smooth muscle of the gastrointestinal tract. It blocks sodium channels in the muscle cell membrane, which prevents the influx of sodium and thereby reduces muscle contractility. This leads to relaxation of the gut wall and relief of spasms. Alprazolam binds to the benzodiazepine site on the GABA-A receptor in the brain, enhancing the inhibitory effect of GABA. This increases chloride ion flow into neurons, hyperpolarizing them and reducing their excitability. The result is anxiolytic, sedative, muscle relaxant, and anticonvulsant effects. The combination targets both the gut spasm and the anxiety component that often accompanies IBS.
Mechanism Steps
💡 How to Take mebaspa al tablet
Strength: Each tablet contains mebeverine hydrochloride 135 mg and alprazolam 0.25 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally one to three times daily, depending on the severity of symptoms and the doctor's assessment. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and response to treatment. Do not exceed the prescribed dose. This medicine is intended for short-term use only, typically not exceeding 4 weeks, because of the risk of dependence with alprazolam. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) are more sensitive to the effects of alprazolam, especially drowsiness, dizziness, and impaired coordination. The starting dose should be lower, and the dose should be titrated slowly. Use with caution and monitor closely for falls and cognitive impairment. |
| Renal Impairment | Mebeverine: No specific dose adjustment established. Alprazolam: Use with caution in renal impairment; metabolites may accumulate. Dose reduction may be necessary. Consult a clinician for individualized dosing. |
| Hepatic Impairment | Mebeverine: Avoid in severe hepatic impairment. Alprazolam: Use with caution in mild to moderate hepatic impairment; reduce dose. Contraindicated in severe hepatic impairment. |
| Maximum Daily Dose | The maximum recommended daily dose is 3 tablets (mebeverine 405 mg + alprazolam 0.75 mg) per day, but the exact maximum must be determined by a qualified clinician based on individual patient factors. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of mebaspa al tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Moderate | |
| Opioids | Major | |
| Ketoconazole | Major | |
| Rifampin | Major | |
| Carbamazepine | Major | |
| Fluoxetine | Moderate | |
| Antacids | Minor | |
| Cimetidine | Minor | |
| Oral contraceptives | Moderate | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- CNS depressants (e.g., opioids, alcohol, barbiturates)
- CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir, clarithromycin)
- CYP3A4 inducers (e.g., carbamazepine, rifampin, St. John's wort)
⚡ Moderate Interactions
- Antihypertensives
- Oral contraceptives
- Antacids
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine. Both alprazolam and alcohol are central nervous system depressants. Together, they can cause severe drowsiness, dizziness, impaired judgment, respiratory depression, coma, and even death. Even small amounts of alcohol can intensify these effects.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to mebeverine, alprazolam, or any component of the formulation","Myasthenia gravis","Severe hepatic impairment","Narrow-angle glaucoma","Severe respiratory insufficiency","Sleep apnea syndrome","Pregnancy (especially first trimester) and breastfeeding","Children under 18 years of age"]
⚠️ Warnings & Precautions
["This medicine can cause physical and psychological dependence. Use for the shortest duration possible.","Do not stop abruptly after prolonged use; taper gradually under medical supervision.","Avoid alcohol and other CNS depressants.","May impair ability to drive or operate machinery.","Use with caution in elderly patients due to increased sensitivity to benzodiazepines.","Use with caution in patients with hepatic or renal impairment.","May cause paradoxical reactions such as increased anxiety, agitation, or mania.","Not recommended for patients with a history of substance abuse."]
🤱 Lactation Safety
Mebeverine: Not established from the available information; caution advised. Alprazolam: Excreted in breast milk and may cause sedation, poor feeding, and weight loss in the infant. Breastfeeding is not recommended while taking this medicine.
💊 Overdose Management
Overdose of this medicine can cause severe drowsiness, confusion, respiratory depression, coma, and death. If overdose is suspected, seek emergency medical attention immediately. Treatment is supportive and may include gastric lavage if within 1-2 hours of ingestion, administration of activated charcoal, and flumazenil (a benzodiazepine antagonist) for severe CNS depression. However, flumazenil should be used with caution as it can precipitate seizures in dependent patients. Monitor vital signs, airway, and breathing continuously.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose. If you are unsure, consult your doctor or pharmacist.
Additional Safety Advice
Take this medicine exactly as prescribed. Do not increase the dose or take it more often than directed. Avoid alcohol completely while taking this medicine, as it can dangerously increase drowsiness and respiratory depression. Do not drive or operate heavy machinery until you know how this medicine affects you. Do not stop taking this medicine suddenly, especially if you have been on it for more than a few weeks, as this can cause withdrawal symptoms such as anxiety, insomnia, and tremors. Keep this medicine in a secure place away from children and pets, as it can be harmful if taken accidentally. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Tell your doctor about all other medications, supplements, and herbal products you are taking. Do not share this medicine with anyone else, even if they have similar symptoms.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at increased risk of side effects from alprazolam, including excessive sedation, confusion, falls, and fractures. The starting dose should be lower, and the dose should be titrated slowly. Regular monitoring for cognitive impairment and gait instability is recommended. Mebeverine is generally well tolerated, but caution is advised in those with liver or kidney impairment.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy, especially in the first trimester, due to the risk of congenital malformations associated with alprazolam. If you are planning to become pregnant, consult your doctor to discuss alternative treatments. Do not stop the medicine abruptly without medical advice. Effective contraception should be used while taking this medicine.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. Alprazolam can interact with anesthetic agents and increase sedation. Your doctor may advise you to stop the medicine temporarily before surgery to avoid complications. Do not resume without medical clearance.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. Alprazolam may increase drowsiness and interact with sedatives used in dentistry. Your dentist may adjust the dose of local anesthetics or sedatives accordingly. It is important to avoid driving yourself home after dental work if you have taken this medicine.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause drowsiness and dizziness, which may impair your coordination. Avoid activities that require mental alertness, such as driving or operating machinery, until you know how the medicine affects you. Light to moderate exercise like walking or yoga is generally safe, but listen to your body and avoid overexertion.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and dizziness, which may affect your ability to perform tasks that require alertness, such as driving, operating machinery, or making important decisions. It is advisable to avoid these activities until you know how the medicine affects you. Inform your employer if your job involves such tasks. The sedative effect may also impact your productivity, so plan your dose timing accordingly, such as taking it at bedtime if once daily.
🛑 When to Stop This Medicine
You should not stop this medicine without consulting your doctor. If you have been taking it for more than a few weeks, your doctor will likely recommend a gradual tapering schedule to prevent withdrawal symptoms such as anxiety, insomnia, and tremors. If you experience severe side effects or an allergic reaction, seek immediate medical attention. Your doctor will determine the appropriate duration of treatment based on your condition and response.
📅 Long-Term Use Effects
Long-term use of this medicine, particularly the alprazolam component, can lead to tolerance, dependence, and withdrawal symptoms upon discontinuation. Cognitive effects such as memory problems and decreased attention may occur. Mebeverine is generally safe for long-term use, but the combination should be used for the shortest duration possible. Regular review by a doctor is essential to assess the need for continued therapy and to monitor for side effects.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Helps manage anxiety and stress that worsen IBS symptoms.
Evidence: Well-established for anxiety and IBS.Reduces fermentable carbohydrates that trigger IBS symptoms.
Evidence: Well-established for IBS.May help restore gut flora balance and reduce symptoms.
Evidence: Emerging evidence.Natural antispasmodic that may relieve abdominal pain.
Evidence: Some evidence for IBS.💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled to receive a live vaccine, inform your doctor about all medications you are taking. Generally, this medicine does not affect vaccination schedules.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not share with others
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. Check the laws of your destination country regarding benzodiazepines, as some countries have strict regulations. If crossing time zones, adjust dosing times gradually to maintain consistent intervals, but consult your doctor for specific advice. Store at room temperature and protect from light and moisture.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Mebeverine starts relieving gut spasms within 30-60 minutes, while alprazolam's calming effect also begins within 30-60 minutes. However, full benefits for IBS may take a few days of regular use.
A: You should inform your doctor about any liver disease. This medicine may need dose adjustment or may be contraindicated in severe liver disease.
A: Elderly patients are more sensitive to alprazolam's effects, such as drowsiness and dizziness. Lower doses and close monitoring are recommended.
A: Take it as soon as you remember if it's not almost time for your next dose. If it is, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, you should not stop this medicine suddenly, especially if you have been taking it for more than a few weeks. Your doctor will guide you on a gradual tapering plan to avoid withdrawal symptoms.
🤔 Common Patient Concerns
🔄 Substitutes for mebaspa al tablet
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a permanent cure for IBS.
Fact: This medicine provides symptomatic relief but does not cure IBS. Lifestyle and dietary changes are also important. - Myth: It is safe to take this medicine for months.
Fact: Alprazolam can cause dependence and withdrawal; long-term use is not recommended. - Myth: You can drink alcohol while taking this medicine.
Fact: Alcohol increases the risk of severe sedation and respiratory depression. It should be avoided completely. - Myth: You can stop this medicine abruptly without any problems.
Fact: Abrupt discontinuation can cause withdrawal symptoms. Always taper under medical supervision.
🔄 Alternative Options
Generic Alternatives
- Mebeverine 135 mg + Alprazolam 0.25 mg tablet
Brand Alternatives
- Mebaspa AL Tablet