Promethazine 25mg Tablet: Complete Guide
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of face, lips, or throat
- Severe drowsiness or confusion
- Fast, irregular, or pounding heartbeat
- Yellowing of skin or eyes
- Unusual bleeding or bruising
- Seizures
- Severe abdominal pain
If experiencing severe symptoms, call emergency services immediately.
What is avomine tablet used for?
This medicine is an antihistamine used to prevent and treat nausea, vomiting, and motion sickness. It also relieves allergy symptoms such as runny nose and itching. It works by blocking histamine and suppressing the vomiting centre in the brain.
- Generic Name: Promethazine
- Manufacturer: Abbott
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 avomine tablet के बारे में (Hindi Summary)
उपयोग: यह दवा उल्टी, जी मिचलाना और मोशन सिकनेस (यात्रा के दौरान होने वाली उल्टी) को रोकने और इलाज के लिए इस्तेमाल की जाती है। यह एलर्जी के लक्षणों जैसे नाक बहना, छींक आना और खुजली को भी कम करती है। यह दवा दिमाग में उल्टी केंद्र को शांत करके और हिस्टामिन नामक पदार्थ को रोककर काम करती है। इसका सेवन डॉक्टर के बताए अनुसार ही करें।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में नींद आना, चक्कर आना, धुंधली दृष्टि, मुँह सूखना और कब्ज शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। कभी-कभी गंभीर एलर्जी, रक्त विकार या दिल की धड़कन में गड़बड़ी हो सकती है। अगर कोई असामान्य लक्षण दिखे तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। खुद से मात्रा न बढ़ाएँ। इस दवा को लेने के बाद गाड़ी चलाने या मशीन चलाने से बचें क्योंकि इससे नींद आ सकती है। शराब का सेवन न करें। अगर आप गर्भवती हैं, स्तनपान करा रही हैं या कोई अन्य दवा ले रही हैं तो डॉक्टर को बताएं। बच्चों की पहुंच से दूर रखें।
💊 avomine tablet Uses & Benefits
[{"condition":"Motion sickness","description":"Prevents and treats nausea, vomiting, and dizziness associated with travel.","evidence":"Well-established"},{"condition":"Nausea and vomiting","description":"Used to control nausea and vomiting from various causes, including surgery and chemotherapy.","evidence":"Well-established"},{"condition":"Allergic rhinitis","description":"Relieves sneezing, runny nose, and itching due to allergies.","evidence":"Well-established"},{"condition":"Urticaria","description":"Reduces itching and hives associated with allergic skin reactions.","evidence":"Well-established"},{"condition":"Insomnia","description":"Sometimes used for short-term management of insomnia due to its sedative effects.","evidence":"Limited"}]
Off-label uses: [{"condition":"Anxiety","description":"Occasionally used for short-term relief of anxiety due to its calming effects.","evidence":"Limited"},{"condition":"Migraine","description":"May be used to treat migraine-associated nausea and vomiting.","evidence":"Limited"}]
Primary treatment for: Motion sickness
Also treats: Nausea and vomiting, Allergic rhinitis, Urticaria
📋 Drug Information
| Generic Name(s) | Promethazine |
| Brand Name | Avomine |
| Manufacturer | Abbott |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | H1 Antihistaminics (First Generation) |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Promethazine is a first-generation antihistamine of the phenothiazine class. It works by competitively blocking histamine H1 receptors, which reduces allergic symptoms. It also penetrates the central nervous system and acts on the vomiting centre in the medulla oblongata to prevent nausea and vomiting. Additionally, it has anticholinergic and sedative properties, which contribute to its calming effects.
Mechanism Steps
💡 How to Take avomine tablet
Strength: 25 mg immediate-release tablet
Dosage Information
| Adult Dosage | The usual adult dose for nausea and vomiting is 12.5 to 25 mg every 4 to 6 hours as needed, not to exceed 100 mg per day. For motion sickness, 25 mg is taken 30 to 60 minutes before travel. For allergic conditions, 12.5 to 25 mg is taken at bedtime or as directed. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. This medicine is contraindicated in children under 2 years of age. |
| Elderly Dosage | Elderly patients are more sensitive to the sedative and anticholinergic effects. Start with a lower dose and monitor closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | No specific dosage adjustments are established. Use with caution in renal impairment. Consult a doctor. |
| Hepatic Impairment | Use with caution in hepatic impairment. Dose adjustment may be necessary. Consult a doctor. |
| Maximum Daily Dose | 100 mg per day for adults. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of avomine tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Alcohol | Major | |
| Opioids | Major | |
| MAO inhibitors | Major | |
| Tricyclic antidepressants | Moderate | |
| Epinephrine | Moderate | |
| Antacids | Minor | |
| Lithium | Minor |
🚨 Major Interactions
- CNS depressants (e.g., alcohol, opioids, benzodiazepines)
- MAO inhibitors
⚡ Moderate Interactions
- Anticholinergic drugs (e.g., atropine, tricyclic antidepressants)
- Epinephrine
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can significantly increase drowsiness, dizziness, and the risk of accidental injury. It can also enhance the sedative effects on the central nervous system.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to promethazine or other phenothiazines","Comatose patients","Patients with lower respiratory tract symptoms including asthma","Children under 2 years of age","Patients with narrow-angle glaucoma","Patients with prostatic hypertrophy or bladder neck obstruction"]
⚠️ Warnings & Precautions
["May impair mental and physical abilities; avoid driving or operating machinery.","Use with caution in elderly patients due to increased risk of confusion and falls.","Avoid alcohol and other CNS depressants.","May cause photosensitivity; use sun protection.","Do not use for prolonged periods without medical supervision.","Consult doctor if pregnant or breastfeeding."]
🤱 Lactation Safety
Promethazine is excreted in breast milk and may cause drowsiness in the nursing infant. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose may cause severe drowsiness, coma, seizures, and respiratory depression. Seek emergency medical attention immediately. Treatment is supportive and symptomatic. There is no specific antidote.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose. Avoid driving or operating machinery until you know how this medicine affects you, as it can cause significant drowsiness. Do not drink alcohol while taking this medicine, as it can increase drowsiness and dizziness. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Keep this medicine out of reach of children. Store it at room temperature, away from moisture and heat. If you have any pre-existing conditions like asthma, glaucoma, or prostate problems, tell your doctor before taking this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the sedative and anticholinergic effects of this medicine. Use with caution and lower doses may be needed. Monitor for confusion and falls.
🤰 Pregnancy Planning (TTC)
Consult your doctor before taking this medicine if you are planning to become pregnant or are pregnant. The safety of this medicine during pregnancy is not well established.
🏥 Post-Surgery Considerations
This medicine may be used for post-operative nausea and vomiting, but it can interact with other medications used during surgery. Inform your surgeon and anesthesiologist if you are taking this medicine.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it can interact with sedatives or anesthetics used during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause drowsiness and dizziness, which can affect your coordination. Avoid strenuous exercise or activities requiring alertness until you know how it affects you.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause significant drowsiness, affecting your ability to work, drive, or operate machinery. It is advisable to avoid these activities until you know how it affects you. Inform your employer if your job requires alertness.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or your condition worsens, contact your doctor immediately.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to tolerance, dependence, and tardive dyskinesia. Regular monitoring by a doctor is recommended. It should not be used for prolonged periods without medical supervision.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Sitting in the front seat, focusing on the horizon, and avoiding reading can help.
Evidence: Well-establishedMay help reduce nausea in some people.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it in a cool, dry place away from direct sunlight. If crossing time zones, adjust dosing times as advised by your doctor. Check customs regulations for carrying prescription medicines. For motion sickness, take the dose 30 to 60 minutes before travel.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 20 minutes after oral administration.
A: It can be taken with or without food, but taking it with food may reduce stomach upset.
A: It can interact with several medications, especially CNS depressants and MAO inhibitors. Always inform your doctor about all medicines you are taking.
🤔 Common Patient Concerns
🔄 Substitutes for avomine tablet
View AllAlternative brands with exact same active ingredient:
-
promet 25mg injectionLupin Ltd ₹2.81 95.6% CHEAPER
-
phenamin 25mg injectionIntas Pharmaceuticals Ltd ₹3.52 94.5% CHEAPER
-
promipen 25mg injectionMorepen Laboratories Ltd ₹5.24 91.7% CHEAPER
-
premagan injectionShine Pharmaceuticals Ltd ₹5.93 90.7% CHEAPER
-
prothadus 25mg injectionGerman Remedies ₹6.09 90.4% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is safe for everyone.
Fact: It is not safe for people with certain conditions like asthma, glaucoma, or prostate problems. - Myth: You can drive after taking this medicine.
Fact: This medicine causes drowsiness and impairs alertness; driving should be avoided. - Myth: It is not addictive.
Fact: It has low potential for dependence, but prolonged use should be avoided.
🔄 Alternative Options
Generic Alternatives
- Promethazine 25 mg tablet
Brand Alternatives
- Avomine tablet