Morease Tablet (Mebeverine 135mg): Complete Guide to Uses, Dosage, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or black, tarry stools
- Severe or worsening abdominal pain
- Chest pain, palpitations, or difficulty breathing
- Swelling of face, lips, or throat
- Yellowing of skin or eyes (jaundice)
- Difficulty passing urine
- Severe dizziness or fainting
If experiencing severe symptoms, call emergency services immediately.
What is mebirin tablet used for?
This medicine is an antispasmodic used to relieve abdominal pain and cramps in irritable bowel syndrome (IBS). It works by relaxing the muscles in the gut. The usual dose is 135 mg three times a day before meals.
- Generic Name: Mebeverine (135mg)
- Manufacturer: Zeelab Pharmacy Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 mebirin tablet के बारे में (Hindi Summary)
उपयोग: यह दवा पेट की ऐंठन, दर्द और असुविधा को कम करने के लिए इस्तेमाल की जाती है, खासकर इरिटेबल बाउल सिंड्रोम (IBS) में। यह आंतों की मांसपेशियों को आराम देकर काम करती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, चक्कर आना, सिरदर्द और मुंह सूखना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी, दिल की धड़कन में बदलाव या गंभीर पेट दर्द हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी स्वास्थ्य समस्याओं और दवाओं के बारे में बताएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें। शराब न पिएं। चक्कर आ सकते हैं, इसलिए वाहन चलाने से बचें।
💊 mebirin tablet Uses & Benefits
- [{"condition":"Irritable Bowel Syndrome (IBS)","description":"Relieves abdominal pain, cramps, bloating, and discomfort associated with IBS.
- It helps normalize bowel habits but is not a cure.","evidence":"Well-established"},{"condition":"Functional Bowel Disorders","description":"Used to treat abdominal cramps and pain in conditions where no organic cause is found.","evidence":"Moderate"},{"condition":"Gastrointestinal Spasms","description":"Helps relax smooth muscles in the gut to relieve spasm-related pain.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Biliary Dyskinesia","description":"Sometimes used to relieve pain from biliary tract spasms, but evidence is limited.","evidence":"Limited"},{"condition":"Ureteric Spasms","description":"Occasionally used for ureteric colic, but not a standard treatment.","evidence":"Limited"}]
Primary treatment for: Irritable Bowel Syndrome (IBS)
Also treats: Functional Bowel Disorders, Gastrointestinal Spasms
📋 Drug Information
| Generic Name(s) | Mebeverine (135mg) |
| Brand Name | mebirin tablet |
| Manufacturer | Zeelab Pharmacy Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Anti-spasmodics (IBD) |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by directly relaxing the smooth muscle cells in the gastrointestinal tract. It achieves this by blocking sodium channels in the muscle cell membrane, which prevents the influx of sodium ions and thereby reduces muscle contraction. Additionally, it may affect calcium movement, further contributing to muscle relaxation. This action is selective for the gut, so it does not cause widespread muscle relaxation or affect the heart muscle at therapeutic doses. By relaxing the gut muscles, it relieves spasms and the associated pain and discomfort.
Mechanism Steps
💡 How to Take mebirin tablet
Strength: Mebeverine 135 mg immediate-release tablet
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one 135 mg tablet taken three times a day, preferably 20 minutes before meals. However, the dose may be adjusted by your doctor based on your condition and response. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine. Use with caution and follow your doctor's advice. |
| Renal Impairment | No specific dose adjustment is recommended for patients with renal impairment, but use with caution. |
| Hepatic Impairment | No specific dose adjustment is recommended for patients with hepatic impairment, but use with caution. |
| Maximum Daily Dose | The maximum recommended daily dose is 405 mg (three 135 mg tablets). |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of mebirin tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Anticholinergic drugs | Moderate | |
| Beta-blockers | Moderate | |
| Alcohol | Minor |
⚡ Moderate Interactions
- Anticholinergic drugs (e.g., atropine, hyoscyamine)
- Beta-blockers (e.g., propranolol)
🍷 Alcohol Interaction
Alcohol may increase the central nervous system side effects of this medicine, such as dizziness and drowsiness. It is advisable to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to Mebeverine or any component of the tablet","Paralytic ileus (intestinal obstruction)","Severe heart block or arrhythmias","Children under 12 years of age (unless prescribed)"]
⚠️ Warnings & Precautions
["Use with caution in patients with heart block or arrhythmias.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol while taking this medicine.","Consult your doctor if symptoms persist or worsen.","Do not exceed the recommended dose.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding."]
🤱 Lactation Safety
It is not known whether this medicine passes into breast milk. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose may cause severe anticholinergic symptoms such as blurred vision, dry mouth, difficulty urinating, and rapid heartbeat. In case of overdose, seek immediate medical attention. Treatment is supportive and symptomatic.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Before taking this medicine, inform your doctor if you have any heart conditions, especially heart block or arrhythmias, as this medicine may affect heart rhythm. Also, tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding. This medicine may cause dizziness; avoid driving or operating heavy machinery until you know how it affects you. Do not drink alcohol while taking this medicine, as it may increase drowsiness and dizziness. Take this medicine exactly as prescribed. Do not crush or chew the tablet; swallow it whole with a glass of water. If you miss a dose, take it as soon as you remember, but skip it if it's almost time for your next dose. Do not double the dose. Keep this medicine out of reach of children. Store it at room temperature, away from moisture and direct sunlight. Do not use it after the expiry date.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the side effects of this medicine, especially dizziness and low blood pressure. Use with caution and monitor closely.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. The safety of this medicine during pregnancy is not well established.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may interact with certain anesthetic agents.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It is generally safe, but your dentist should be aware of all medications you take.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause dizziness. Avoid strenuous exercise or activities that require balance until you know how it affects you. If you feel dizzy during exercise, stop and rest.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It should not significantly impact your ability to work if you are not experiencing side effects.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or your symptoms worsen, contact your doctor immediately. Your doctor will advise you on whether to stop or adjust the dose.
📅 Long-Term Use Effects
Long-term use of this medicine is generally considered safe when taken as prescribed. However, regular monitoring by your doctor is recommended to ensure it remains effective and to check for any rare side effects. It is not habit-forming. If you have been taking it for a long time, do not stop suddenly without consulting your doctor.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help reduce IBS symptoms by eliminating trigger foods.
Evidence: Well-establishedTechniques like yoga, meditation, and counseling can help manage stress-related IBS symptoms.
Evidence: ModerateMay help restore healthy gut bacteria and reduce symptoms.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. You can receive vaccinations as usual.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it in a cool, dry place away from direct sunlight. If crossing time zones, continue taking it at your usual times as much as possible, but do not double doses. Check local customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 1 to 2 hours after taking a dose. However, you may need to take it regularly for a few days to notice a significant improvement in your symptoms.
A: It can interact with certain medicines like anticholinergics and beta-blockers. Always inform your doctor about all medicines you are taking.
A: The safety of this medicine during pregnancy is not well established. Consult your doctor before taking it if you are pregnant or planning to become pregnant.
A: Common side effects include nausea, dizziness, headache, and dry mouth. These are usually mild and temporary.
A: It is advisable to avoid alcohol as it may increase drowsiness and dizziness.
🤔 Common Patient Concerns
🔄 Substitutes for mebirin tablet
View AllAlternative brands with exact same active ingredient:
-
mebrin 135mg tabletPsycormedies ₹50.63 68.8% COSTLIER
-
libure 135mg tabletAamorb Pharmaceuticals Pvt Ltd ₹69.50 131.7% COSTLIER
-
gatoverine 135mg tabletCmg Biotech Pvt Ltd ₹85.00 183.3% COSTLIER
-
mebaspa tabletUSV Ltd ₹87.42 191.4% COSTLIER
-
mebespa 135mg tabletTaurus Laboratories Pvt Ltd ₹87.42 191.4% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a painkiller for any type of pain.
Fact: It is specifically for abdominal cramps and pain related to gut spasms, not for general pain. - Myth: It can cure IBS permanently.
Fact: It helps manage symptoms but does not cure IBS. Lifestyle and diet changes are also important. - Myth: It is safe to take without a prescription.
Fact: It is a prescription medicine and should only be taken under a doctor's supervision.
🔄 Alternative Options
Generic Alternatives
- Mebeverine 135 mg tablet
Brand Alternatives
- Colospa
- Mebaspa
- Duspatalin