amitop m 5mg/1500mcg tablet - Uses, Price, Side Effects & Substitutes
What is amitop m 5mg/1500mcg tablet used for?
Amnurite 10 Tablet SR (Amitriptyline + Methylcobalamin) is used to treat NEURO CNS. It contains Amitriptyline (5mg) + Methylcobalamin (1500mcg), which Amitriptyline: Inhibits reuptake of serotonin and norepinephrine; Methylcobalami. Always consult your doctor before use. Take as prescribed.
- Generic Name: Amitriptyline + Methylcobalamin
- Manufacturer: Tas Med India Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ amitop m 5mg/1500mcg tablet Uses & Benefits
Depression, neuropathic pain, diabetic neuropathy, fibromyalgia
Off-label uses: Migraine prophylaxis, chronic pain, insomnia, anxiety disorders
๐ Drug Information
| Generic Name(s) | Amitriptyline + Methylcobalamin |
| Brand Name | Amnurite 10 Tablet SR |
| Manufacturer | Tas Med India Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Tricyclic antidepressant + Vitamin B12 analogue |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC, protect from light and moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Amitriptyline: Inhibits reuptake of serotonin and norepinephrine; Methylcobalamin: Coenzyme for myelin synthesis and nerve regeneration
Mechanism Steps
๐ก How to Take amitop m 5mg/1500mcg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of amitop m 5mg/1500mcg tablet
โ Common Side Effects
- Dry mouth
- Drowsiness
- Dizziness
- Constipation
- Blurred vision
- Weight gain
- Urinary retention
๐จ Serious Side Effects
- QT prolongation
- Arrhythmias
- Seizures
- Serotonin syndrome
- Suicidal thoughts
- Agranulocytosis
โ ๏ธ Rare Side Effects
- Hepatotoxicity
- Paralytic ileus
- Bone marrow suppression
- Allergic reactions
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | Hypertensive crisis, serotonin syndrome |
| CYP2D6 inhibitors | Major | Increased amitriptyline toxicity |
| CYP3A4 inhibitors | Major | Increased amitriptyline levels |
| CYP1A2 inhibitors | Major | Increased amitriptyline levels |
| Other serotonergic drugs | Major | Serotonin syndrome |
| Anticholinergics | Major | Additive anticholinergic effects |
| CNS depressants | Major | Enhanced sedation |
| Anticoagulants | Moderate | Increased anticoagulant effect |
| Antihypertensives | Moderate | Additive hypotension |
| Sympathomimetics | Moderate | Hypertension, arrhythmias |
| Thyroid medications | Moderate | Increased cardiac effects |
| Quinolones | Moderate | Increased risk of QT prolongation |
| Cimetidine | Minor | Increased amitriptyline levels |
| Methylphenidate | Minor | Increased amitriptyline levels |
| Oral contraceptives | Minor | Reduced amitriptyline efficacy |
๐จ Major Interactions
- MAOIs
- CYP2D6 inhibitors
- CYP3A4 inhibitors
- CYP1A2 inhibitors
- Other serotonergic drugs
- Anticholinergics
- CNS depressants
โก Moderate Interactions
- Anticoagulants
- Antihypertensives
- Sympathomimetics
- Thyroid medications
- Quinolones
โน๏ธ Minor Interactions
- Cimetidine
- Methylphenidate
- Oral contraceptives
๐ฝ๏ธ Food Interactions
Grapefruit juice may increase amitriptyline levels; high-fiber foods may reduce absorption
๐ท Alcohol Interaction
Increased CNS depression; avoid alcohol
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Recent MI, concurrent MAOI use, narrow-angle glaucoma, urinary retention, hypersensitivity
๐ Monitoring Parameters
ECG, liver function, serum drug levels, mental status, blood pressure
๐คฑ Lactation Safety
Amitriptyline excreted in milk; use with caution. Methylcobalamin safe.
๐ Overdose Management
Activated charcoal, supportive care, physostigmine for anticholinergic symptoms, sodium bicarbonate for arrhythmias
โฐ Missed Dose
Take as soon as remembered unless near next dose; skip if close to next dose. Do not double.