Emigan Injection (Promethazine 5mg): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or slow, shallow breathing
- Severe drowsiness or unresponsiveness
- High fever with muscle rigidity and confusion
- Irregular heartbeat or palpitations
- Severe allergic reaction with swelling of face, lips, or throat
- Pain, redness, or blistering at injection site
- Yellowing of skin or eyes
If experiencing severe symptoms, call emergency services immediately.
What is histazine 5mg syrup used for?
This medicine is a promethazine injection used to treat allergic reactions, nausea, vomiting, and to provide sedation. It works by blocking histamine and acetylcholine receptors in the body and brain.
- Generic Name: Promethazine (5mg)
- Manufacturer: Angel Laboratories Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 histazine 5mg syrup के बारे में (Hindi Summary)
उपयोग: यह दवा एलर्जी की प्रतिक्रियाओं, मतली, उल्टी और बेचैनी को कम करने के लिए इस्तेमाल की जाती है। यह प्रोमेथाज़ीन का इंजेक्शन है जो अस्पताल में डॉक्टर द्वारा दिया जाता है। यह शरीर में हिस्टामिन नामक पदार्थ को रोककर एलर्जी के लक्षणों को कम करता है और दिमाग को शांत करके नींद लाने में मदद करता है।
साइड इफेक्ट्स: आम दुष्प्रभावों में नींद आना, चक्कर आना, धुंधली दृष्टि, मुँह सूखना और जी मिचलाना शामिल हैं। गंभीर दुष्प्रभावों में सांस लेने में कठिनाई, तेज बुखार, मांसपेशियों में अकड़न और एलर्जी की गंभीर प्रतिक्रिया हो सकती है। किसी भी असामान्य लक्षण को तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल योग्य स्वास्थ्यकर्मी द्वारा ही दी जानी चाहिए। इसे स्वयं न लगाएं। इस दवा को लेने के बाद वाहन चलाने या मशीनरी चलाने से बचें। शराब का सेवन न करें क्योंकि इससे नींद और चक्कर बढ़ सकते हैं। अपनी सभी चिकित्सीय स्थितियों के बारे में डॉक्टर को बताएं।
💊 histazine 5mg syrup Uses & Benefits
[{"condition":"Allergic reactions","description":"Used to treat acute allergic reactions, including urticaria and angioedema, by blocking histamine receptors.","evidence":"Well-established"},{"condition":"Nausea and vomiting","description":"Effective in controlling nausea and vomiting from various causes, including postoperative and chemotherapy-induced nausea.","evidence":"Well-established"},{"condition":"Sedation","description":"Used for preoperative sedation and to relieve apprehension in patients undergoing surgery or procedures.","evidence":"Well-established"},{"condition":"Motion sickness","description":"Can be used to prevent and treat motion sickness, though injectable form is reserved for severe cases.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Migraine headache","description":"Sometimes used in emergency settings to treat acute migraine attacks due to its antiemetic and sedative effects.","evidence":"Limited"},{"condition":"Anxiety","description":"Occasionally used for short-term management of anxiety, but not a first-line treatment.","evidence":"Limited"}]
Primary treatment for: Allergic reactions, nausea and vomiting, sedation
Also treats: Motion sickness, Preoperative anxiety
📋 Drug Information
| Generic Name(s) | Promethazine (5mg) |
| Brand Name | histazine 5mg syrup |
| Manufacturer | Angel Laboratories Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | H1 Antihistaminics (First Generation) |
| Route of Administration | Parenteral (intramuscular or intravenous) |
| Storage | Store at room temperature (15-30°C). Protect from light. Do not freeze. |
| Shelf Life | Not established from the available information. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Promethazine is a phenothiazine derivative that competitively blocks histamine H1 receptors, thereby preventing histamine-mediated allergic responses. It also has anticholinergic effects by blocking muscarinic receptors, which contributes to its antiemetic and sedative properties. Additionally, it acts on the central nervous system by depressing the vomiting center in the medulla oblongata and the chemoreceptor trigger zone. Its sedative effects are thought to be due to its ability to block central H1 receptors and possibly dopamine receptors.
Mechanism Steps
💡 How to Take histazine 5mg syrup
Strength: Injection: 5 mg
Dosage Information
| Adult Dosage | The dosage of this medicine is individualized by a qualified clinician based on the indication, patient's age, weight, renal and hepatic function, and response to therapy. For allergic reactions, a typical adult dose is 12.5 to 25 mg intramuscularly or intravenously, repeated every 4 to 6 hours as needed. For nausea and vomiting, 12.5 to 25 mg may be given. For sedation, 25 to 50 mg may be used. Do not exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. This medicine is contraindicated in children under 2 years of age. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of promethazine, especially sedation, confusion, and anticholinergic effects. Lower doses may be required. Use with caution. |
| Renal Impairment | No specific dosage adjustment is established from available information. Use with caution in patients with renal impairment. |
| Hepatic Impairment | No specific dosage adjustment is established from available information. Use with caution in patients with hepatic impairment. |
| Maximum Daily Dose | The maximum daily dose is determined by the prescribing clinician. Do not exceed the prescribed dose. |
Dosage Timeline
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of histazine 5mg syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Opioids | Major | |
| Benzodiazepines | Major | |
| MAO inhibitors | Major | |
| Tricyclic antidepressants | Moderate | |
| Epinephrine | Moderate | |
| Alcohol | Major |
🚨 Major Interactions
- CNS depressants (e.g., opioids, benzodiazepines, alcohol)
- MAO inhibitors
⚡ Moderate Interactions
- Anticholinergic drugs (e.g., atropine, tricyclic antidepressants)
- Epinephrine
🍷 Alcohol Interaction
Alcohol increases the central nervous system depressant effects of promethazine, leading to enhanced sedation, dizziness, and impaired motor skills. Avoid alcohol while receiving this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to promethazine or other phenothiazines","Comatose patients","Severe respiratory depression","Children under 2 years of age","Patients with asthma or sleep apnea"]
⚠️ Warnings & Precautions
["May impair mental and physical abilities; avoid driving or operating machinery.","Use with caution in elderly patients due to increased risk of confusion and falls.","May cause respiratory depression; use with caution in patients with respiratory conditions.","Avoid use in children under 2 years due to risk of fatal respiratory depression.","May lower seizure threshold; use with caution in patients with seizure disorders.","Can cause photosensitivity; avoid prolonged sun exposure."]
🤱 Lactation Safety
Promethazine is excreted in breast milk and may cause drowsiness in the nursing infant. Consult a doctor before use during breastfeeding.
💊 Overdose Management
Overdose may cause severe drowsiness, coma, seizures, respiratory depression, and hypotension. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if ingestion is recent. Maintain airway, breathing, and circulation. Monitor vital signs and provide symptomatic care.
⏰ Missed Dose
This medicine is usually given as a single dose or as needed in a healthcare setting. If you miss a scheduled dose, contact your healthcare provider for instructions. Do not self-administer an extra dose.
Additional Safety Advice
This medicine should only be administered by a qualified healthcare professional. Do not attempt to self-inject. Inform your doctor about all your medical conditions, especially asthma, sleep apnea, liver disease, or heart problems. Avoid alcohol and other central nervous system depressants while receiving this medicine. Do not drive or operate machinery until you know how this medicine affects you. Report any unusual muscle stiffness, high fever, or confusion immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the sedative, anticholinergic, and hypotensive effects of this medicine. Lower doses are recommended, and close monitoring is advised.
🤰 Pregnancy Planning (TTC)
Consult your doctor if you are planning pregnancy or are pregnant. This medicine should be used during pregnancy only if clearly needed and prescribed by a doctor.
🏥 Post-Surgery Considerations
This medicine may be used for preoperative sedation or postoperative nausea and vomiting. It can increase the risk of respiratory depression when used with other sedatives. Monitor closely after surgery.
🦷 Dental Procedures
This medicine may be used for sedation during dental procedures in some settings. Inform your dentist if you are taking this medicine or have any allergies.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities requiring alertness until the sedative effects of this medicine have worn off. Dizziness and drowsiness may increase the risk of falls or injury.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause significant drowsiness and impair your ability to drive or operate machinery. It is recommended to rest and avoid work until the effects wear off. Inform your employer if your job requires alertness.
🛑 When to Stop This Medicine
This medicine is usually given as a single dose or for a short duration. Do not stop or change the dose without consulting your healthcare provider. If you experience severe side effects, seek immediate medical attention.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended due to the risk of tardive dyskinesia, neuroleptic malignant syndrome, and other serious side effects. It is typically used for short-term management. Regular monitoring of liver function, blood counts, and neurological status is advised if prolonged use is necessary.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another antihistamine that can be used for allergic reactions.
Evidence: Well-establishedA 5-HT3 antagonist used for nausea and vomiting.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not freeze
✅ DO
Protect from light
❌ DON'T
Do not use if solution is discolored or contains particles
✅ DO
Keep out of reach of children
❌ DON'T
Do not store in bathroom
✈️ Traveling with This Medicine
This medicine is administered in a healthcare setting and is not for self-administration during travel. If you are prescribed this medicine for travel, carry it in its original packaging with a copy of your prescription. Store at room temperature and protect from light. Check customs regulations for injectable medications before traveling internationally.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 5 to 20 minutes after injection.
A: The effects typically last for 4 to 12 hours.
A: No, this medicine must be administered by a healthcare professional in a clinical setting.
🤔 Common Patient Concerns
🔄 Substitutes for histazine 5mg syrup
View AllAlternative brands with exact same active ingredient:
-
emigan injectionBiochem Pharmaceutical Industries ₹6.47 59.4% CHEAPER
-
k promex 5mg syrupKumayun Drugs Pvt Ltd ₹15.94 SAME PRICE
-
benorgan 5mg syrupBenmed Pharmaceuticals ₹21.56 35.3% COSTLIER
-
largan syrupSouthshourne Corporation India ₹22.50 41.2% COSTLIER
-
progan syrupThe Pharmed Research Lab Pvt Ltd ₹23.34 46.4% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be self-administered at home.
Fact: This medicine must only be administered by a healthcare professional in a clinical setting. - Myth: This medicine is safe for children under 2 years.
Fact: This medicine is contraindicated in children under 2 years due to risk of fatal respiratory depression.
🔄 Alternative Options
Generic Alternatives
- Promethazine injection
Brand Alternatives
- Phenergan
- Promethegan