benorgan 5mg syrup

4.6 (14 reviews)

Promethazine (5mg)

🏭 Benmed Pharmaceuticals 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is benorgan 5mg syrup used for?

Avomine (Promethazine) is used to treat GASTRO INTESTINAL. It contains Promethazine (5mg), which Antagonizes histamine H1 receptors; also has anticholinergic, antiemetic, and se. Always consult your doctor before use. Take as prescribed.

Generic Name: Promethazine
Manufacturer: Benmed Pharmaceuticals
Form: Allopathy
Pregnancy Category: C
Prescription Required: Yes

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 benorgan 5mg syrup Uses & Benefits

Nausea and vomiting, Motion sickness, Allergic conditions, Sedation

Off-label uses: Insomnia, Anxiety

📋 Drug Information

Generic Name(s)	Promethazine
Brand Name	Avomine
Manufacturer	Benmed Pharmaceuticals
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	GASTRO INTESTINAL
Action Class	H1 Antihistaminics (First Generation)
Route of Administration	Oral, intramuscular, intravenous, rectal
Storage	Store at room temperature (20-25°C); protect from light.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionWell absorbed orally; peak plasma concentration achieved in 2-3 hours.

DistributionWidely distributed; crosses blood-brain barrier and placenta.

Protein BindingApproximately 93% bound to plasma proteins.

MetabolismHepatic metabolism via CYP2D6; major metabolite is promethazine sulfoxide.

Half-Life10-14 hours

ExcretionPrimarily renal as metabolites; small amount unchanged.

BioavailabilityApproximately 25% due to first-pass metabolism.

Onset of Action20-30 minutes

Peak Plasma Time2-3 hours

Duration of Action4-6 hours

How It Works

Antagonizes histamine H1 receptors; also has anticholinergic, antiemetic, and sedative effects.

Mechanism Steps

1Binds to histamine H1 receptors

2Blocks histamine-mediated effects

3Inhibits vestibular stimulation in the inner ear

💡 How to Take benorgan 5mg syrup

Follow your doctor's prescription exactly.

⚠️ Side Effects of benorgan 5mg syrup

✅ Common Side Effects

Drowsiness
Dizziness
Dry mouth
Blurred vision

🚨 Serious Side Effects

Respiratory depression
Seizures
Extrapyramidal symptoms
Neuroleptic malignant syndrome

⚠️ Rare Side Effects

Agranulocytosis
Leukopenia
Photosensitivity

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

🚨 Major Interactions

CNS depressants (e.g., alcohol, benzodiazepines)
MAO inhibitors

⚡ Moderate Interactions

Anticholinergic drugs
Other antihistamines

ℹ️ Minor Interactions

CYP2D6 substrates

🍽️ Food Interactions

None significant

🍷 Alcohol Interaction

Enhanced CNS depression; avoid concurrent use.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to promethazine, Comatose states, CNS depression, Children <2 years (risk of respiratory depression)

📊 Monitoring Parameters

CNS depression, Respiratory rate, Blood pressure

🤱 Lactation Safety

Excreted in breast milk; use with caution.

💊 Overdose Management

Supportive care; activated charcoal if recent ingestion; treat hypotension and respiratory depression.

⏰ Missed Dose

Take as soon as remembered; skip if near next dose; do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

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🔄 Substitutes for benorgan 5mg syrup

View All

Alternative brands with exact same active ingredient (Promethazine (5mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Happy Patient Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Regular Customer Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Trusted Reviewer Jul 10, 2026