celdach 100mg injection

4.6 (15 reviews)

Oxaliplatin (100mg)

🏭 Celon Laboratories Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is celdach 100mg injection used for?

Acoxal 50 Injection (Oxaliplatin) is used to treat ANTI NEOPLASTICS. It contains Oxaliplatin (100mg), which Forms platinum-DNA adducts, inhibiting DNA replication and transcription, leadin. Always consult your doctor before use. Take as prescribed.

Generic Name: Oxaliplatin
Manufacturer: Celon Laboratories Ltd
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 celdach 100mg injection Uses & Benefits

Metastatic colorectal cancer (adjuvant and advanced), Adjuvant treatment of stage III colon cancer

Off-label uses: Pancreatic cancer, Gastric cancer, Hepatocellular carcinoma

📋 Drug Information

Generic Name(s)	Oxaliplatin
Brand Name	Acoxal 50 Injection
Manufacturer	Celon Laboratories Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	ANTI NEOPLASTICS
Action Class	Platinum compounds-Anticancer
Route of Administration	Intravenous infusion (over 2-6 hours).
Storage	Store at 20-25°C; protect from light; do not freeze.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionIntravenously administered, complete bioavailability.

DistributionWidely distributed into tissues; volume of distribution ~440 L.

Protein Binding>90% bound to plasma proteins, mainly albumin and gamma-globulins.

MetabolismNon-enzymatic biotransformation to active metabolites (dichloro-, monochloro-, and diaquo-DACH platinum).

Half-LifeApproximately 10-25 minutes (parent); 24-48 hours (active metabolites).

ExcretionRenal excretion (50% as unchanged drug and metabolites within 48 hours).

Bioavailability100% (intravenous).

Onset of ActionRapid; within minutes of infusion.

Peak Plasma TimeImmediately after infusion.

Duration of ActionPlatinum levels persist for weeks; clinical effects last through treatment cycles.

How It Works

Forms platinum-DNA adducts, inhibiting DNA replication and transcription, leading to cell death.

Mechanism Steps

1Oxaliplatin enters cells via passive diffusion and active transport.

2Undergoes non-enzymatic activation to form reactive platinum species.

3Platinum species bind to DNA, forming intrastrand and interstrand crosslinks.

💡 How to Take celdach 100mg injection

Follow your doctor's prescription exactly.

⚠️ Side Effects of celdach 100mg injection

✅ Common Side Effects

Peripheral neuropathy
Nausea/vomiting
Diarrhea
Myelosuppression (neutropenia, thrombocytopenia)
Fatigue

🚨 Serious Side Effects

Severe neurotoxicity (ataxia, dysarthria)
Anaphylaxis
Acute renal failure
Interstitial lung disease

⚠️ Rare Side Effects

Hemolytic uremic syndrome
Pancreatitis
Hepatic veno-occlusive disease

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Warfarin	Major	Increased INR and bleeding risk.
Aminoglycosides	Major	Increased nephrotoxicity.
Cisplatin	Major	Additive neurotoxicity.
NSAIDs	Moderate	Increased risk of bleeding.
Loop diuretics	Moderate	Increased nephrotoxicity.

🚨 Major Interactions

Warfarin
Nephrotoxic drugs (e.g., aminoglycosides)
Neurotoxic drugs (e.g., cisplatin)

⚡ Moderate Interactions

Anticoagulants
NSAIDs
Loop diuretics

ℹ️ Minor Interactions

Antacids
Cimetidine

🍽️ Food Interactions

No significant food interactions (IV administration).

🍷 Alcohol Interaction

No known interaction.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to oxaliplatin, Severe renal impairment (CrCl <30 mL/min), Pregnancy, Lactation

📊 Monitoring Parameters

CBC with differential, Liver function tests, Renal function (creatinine, BUN), Neurologic exam for peripheral neuropathy

🤱 Lactation Safety

Contraindicated; excreted in breast milk.

💊 Overdose Management

Supportive care; no specific antidote; monitor for myelosuppression and neurotoxicity.

⏰ Missed Dose

Do not double dose; consult physician for rescheduling.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

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🔄 Substitutes for celdach 100mg injection

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Alternative brands with exact same active ingredient (Oxaliplatin (100mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Trusted Reviewer Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Verified User Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.