Alkacel 2mg Tablet (Melphalan): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Fever, chills, or sore throat that may indicate infection.
- Unusual bleeding or bruising, such as nosebleeds or blood in urine or stool.
- Severe fatigue or shortness of breath.
- Yellowing of the skin or eyes (jaundice).
- Persistent vomiting or diarrhea leading to dehydration.
- Signs of an allergic reaction: rash, itching, swelling of face or throat, difficulty breathing.
If experiencing severe symptoms, call emergency services immediately.
What is alkacel 2mg tablet used for?
This medicine contains melphalan 2 mg, an alkylating chemotherapy agent used to treat multiple myeloma and certain other cancers. It works by damaging DNA in cancer cells, preventing their growth. It is taken orally on an empty stomach, and regular blood tests are essential to monitor for bone marrow suppression.
- Generic Name: Melphalan
- Manufacturer: Celon Laboratories Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 alkacel 2mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा मेल्फलान 2 मिलीग्राम की गोली है, जिसका उपयोग कैंसर के इलाज में किया जाता है। यह मुख्य रूप से मल्टीपल मायलोमा (एक प्रकार का रक्त कैंसर) और कुछ अन्य कैंसर के इलाज के लिए दी जाती है। यह दवा कैंसर कोशिकाओं की वृद्धि को रोकती है और उन्हें नष्ट करने में मदद करती है। यह दवा केवल डॉक्टर के पर्चे पर ही मिलती है और इसे कैंसर रोग विशेषज्ञ की देखरेख में ही लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, भूख न लगना और थकान शामिल हैं। गंभीर दुष्प्रभावों में हड्डी के मज्जा का दबना, जिससे संक्रमण, रक्तस्राव और एनीमिया का खतरा बढ़ जाता है। बाल झड़ना, मुंह के छाले और दस्त भी हो सकते हैं। अगर आपको बुखार, ठंड लगना, गले में खराश, आसानी से चोट लगना या सांस लेने में तकलीफ हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल योग्य कैंसर रोग विशेषज्ञ की देखरेख में ही लेनी चाहिए। नियमित रूप से रक्त परीक्षण कराना आवश्यक है। इस दवा को लेते समय कोई भी लाइव वैक्सीन न लगवाएं। संक्रमण से बचने के लिए भीड़-भाड़ वाली जगहों से बचें। गर्भावस्था के दौरान यह दवा न लें क्योंकि इससे बच्चे को नुकसान हो सकता है। स्तनपान कराने वाली महिलाएं इस दवा का सेवन न करें। दवा को मूल डिब्बे में कमरे के तापमान पर सूखी जगह पर रखें।
💊 alkacel 2mg tablet Uses & Benefits
[{"condition":"Multiple myeloma","description":"Used as part of combination chemotherapy regimens to treat multiple myeloma, a cancer of plasma cells.","evidence":"Well-established"},{"condition":"Ovarian cancer","description":"Sometimes used in the treatment of ovarian cancer, often in combination with other anticancer drugs.","evidence":"Established"},{"condition":"Breast cancer","description":"May be used in certain chemotherapy regimens for breast cancer.","evidence":"Limited"},{"condition":"Polycythemia vera","description":"Occasionally used to manage polycythemia vera, a blood disorder.","evidence":"Limited"}]
Off-label uses: [{"condition":"Amyloidosis","description":"Sometimes used off-label in the treatment of amyloidosis, a rare disease where abnormal proteins build up in organs.","evidence":"Limited"},{"condition":"Multiple sclerosis","description":"Rarely used off-label in high-dose regimens for multiple sclerosis.","evidence":"Limited"}]
Primary treatment for: Multiple myeloma
Also treats: Ovarian cancer, Breast cancer, Polycythemia vera
📋 Drug Information
| Generic Name(s) | Melphalan |
| Brand Name | Alphalan |
| Manufacturer | Celon Laboratories Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Alkylating agent |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Melphalan is included in the WHO Model List of Essential Medicines for the treatment of multiple myeloma and ovarian cancer. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Melphalan is a bifunctional alkylating agent that works by attaching alkyl groups to DNA, leading to cross-linking of DNA strands. This cross-linking prevents DNA replication and transcription, ultimately causing cell death. Because cancer cells divide rapidly, they are more susceptible to the effects of melphalan. However, normal cells that divide quickly, such as those in the bone marrow, hair follicles, and lining of the gastrointestinal tract, can also be affected, leading to side effects.
Mechanism Steps
💡 How to Take alkacel 2mg tablet
Strength: 2 mg immediate-release tablet
Dosage Information
| Adult Dosage | The dose of this medicine is individualized based on the condition being treated, the patient's response, and other factors. For multiple myeloma, a typical oral dose may range from 6 to 10 mg per day for 7 to 10 days, followed by a rest period, but this varies widely. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Always follow your oncologist's instructions exactly. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric oncologist. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of melphalan, especially bone marrow suppression. Dose adjustments may be necessary based on kidney function and overall health. Close monitoring is required. |
| Renal Impairment | In patients with renal impairment, dose reduction may be necessary. Monitor kidney function closely. Consult your doctor for specific dosing. |
| Hepatic Impairment | In patients with hepatic impairment, use with caution. Dose adjustment may be needed. Monitor liver function tests. |
| Maximum Daily Dose | The maximum daily dose varies by indication and is determined by the treating oncologist. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of alkacel 2mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Live vaccines | Major | |
| Cyclosporine | Major | |
| Nalidixic acid | Major | |
| Warfarin | Moderate | |
| Phenytoin | Moderate | |
| Cimetidine | Moderate |
🚨 Major Interactions
- Live vaccines
- Cyclosporine
- Nalidixic acid
⚡ Moderate Interactions
- Warfarin
- Phenytoin
- Cimetidine
🍷 Alcohol Interaction
Alcohol may increase the risk of stomach irritation and liver toxicity. It is advisable to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to melphalan or any component of the formulation","Pregnancy","Breastfeeding","Severe bone marrow suppression","Active uncontrolled infection"]
⚠️ Warnings & Precautions
["Bone marrow suppression: May cause severe myelosuppression; monitor blood counts regularly.","Immunosuppression: May increase risk of infections; avoid live vaccines.","Secondary malignancies: May increase risk of secondary cancers.","Renal impairment: Dose adjustment may be needed.","Hepatic impairment: Use with caution.","Pregnancy: Contraindicated; use effective contraception.","Breastfeeding: Discontinue nursing.","Handling: Avoid direct contact with broken tablets; wash hands after handling."]
🤱 Lactation Safety
It is not known whether melphalan is excreted in human milk. Because of the potential for serious adverse reactions in nursing infants, breastfeeding should be discontinued during treatment.
💊 Overdose Management
Overdose may cause severe bone marrow suppression, nausea, vomiting, and diarrhea. There is no specific antidote. Treatment is supportive, including blood transfusions, antibiotics, and hydration. Seek immediate medical attention if overdose is suspected.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time.
Additional Safety Advice
This medicine must only be taken under the supervision of a qualified oncologist. Regular blood tests are essential to monitor your blood cell counts, liver function, and kidney function. Do not receive any live vaccines while taking this medicine. Avoid contact with people who have infections. Use effective contraception to prevent pregnancy during treatment and for some time after, as this medicine can harm an unborn baby. Do not breastfeed while taking this medicine. Handle the tablets with care; wash your hands after touching them. Store in the original container at room temperature, away from moisture and heat. Do not crush or chew the tablets; swallow them whole with water. If you miss a dose, do not double the next dose; follow your doctor's instructions.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to bone marrow suppression and other side effects. Close monitoring and dose adjustments may be necessary.
🤰 Pregnancy Planning (TTC)
This medicine is contraindicated during pregnancy. Women of childbearing potential should use effective contraception during treatment and for at least 6 months after. Men should also use contraception during treatment and for 3 months after. Consult your doctor if you are planning pregnancy.
🏥 Post-Surgery Considerations
This medicine may impair wound healing and increase the risk of infection after surgery. Inform your surgeon that you are taking this medicine. Your doctor may recommend temporarily stopping it before surgery.
🦷 Dental Procedures
This medicine can increase the risk of bleeding and infection during dental procedures. Inform your dentist that you are taking this medicine. Your dentist may recommend postponing non-urgent procedures until your blood counts recover.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Mild to moderate exercise may be beneficial, but avoid strenuous activities if you feel fatigued or have low blood counts. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue, dizziness, or nausea, which can affect your ability to drive or operate machinery. Avoid driving if you feel unwell. You may need to take time off work during treatment. Discuss with your employer about flexible arrangements.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your oncologist. Stopping early may allow the cancer to return. If you experience severe side effects, your doctor may adjust the dose or temporarily stop treatment.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of secondary cancers, bone marrow suppression, and organ toxicity. Regular monitoring of blood counts, liver, and kidney function is essential. Discuss any long-term concerns with your oncologist.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the cancer type, other chemotherapy drugs or combinations may be used.
Evidence: Well-establishedFor multiple myeloma, targeted therapies such as proteasome inhibitors or immunomodulatory drugs may be options.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided during treatment with this medicine due to the risk of infection. Inactivated vaccines may be given, but their effectiveness may be reduced. Consult your doctor before any vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, consult your doctor about adjusting the dosing schedule. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The therapeutic effects develop over weeks as cancer cells are gradually destroyed. Your doctor will monitor your response with regular tests.
A: It is best taken on an empty stomach, at least 1 hour before or 2 hours after a meal, as food can reduce its absorption.
A: Take it as soon as you remember if it is less than half the dosing interval. If more than half has passed, skip the dose and continue with your regular schedule. Do not double dose.
🤔 Common Patient Concerns
🔄 Substitutes for alkacel 2mg tablet
View AllAlternative brands with exact same active ingredient:
-
alkeran 2mg tabletGlaxo SmithKline Pharmaceuticals Ltd ₹362.32 85.5% CHEAPER
-
melfalax 2mg tabletGLS Pharma Ltd. ₹2,335.00 6.6% CHEAPER
-
alphalan 2mg tabletNatco Pharma Ltd ₹2,700.00 8% COSTLIER
-
melphaz 2mg tabletZuvius Life Sciences ₹2,900.00 16% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Melphalan is safe for everyone.
Fact: Melphalan is a powerful chemotherapy drug with serious side effects and is not suitable for everyone, especially pregnant women. - Myth: You can stop taking melphalan when you feel better.
Fact: You must complete the full course as prescribed by your doctor. Stopping early can allow the cancer to return. - Myth: Melphalan does not interact with other medicines.
Fact: Melphalan can interact with several medicines, including live vaccines and warfarin. Always inform your doctor about all medicines you take.
🔄 Alternative Options
Generic Alternatives
- Melphalan 2 mg tablet
Brand Alternatives
- Alkacel 2mg Tablet