aristogyl plus tablet - Uses, Price, Side Effects & Substitutes
What is aristogyl plus tablet used for?
Aristogyl Plus Tablet (Metronidazole + Diloxanide) is used to treat GASTRO INTESTINAL. It contains Metronidazole (400mg) + Diloxanide (500mg), which Metronidazole: Enters microbial cells, reduced to toxic compounds that damage DN. Always consult your doctor before use. Take as prescribed.
- Generic Name: Metronidazole + Diloxanide
- Manufacturer: Aristo Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ aristogyl plus tablet Uses & Benefits
Intestinal amebiasis (acute and chronic), amebic liver abscess, giardiasis, trichomoniasis, bacterial vaginosis, anaerobic infections.
Off-label uses: Crohn's disease, Rosacea, Periodontitis
๐ Drug Information
| Generic Name(s) | Metronidazole + Diloxanide |
| Brand Name | Aristogyl Plus Tablet |
| Manufacturer | Aristo Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Antiprotozoal + Amebicide |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Metronidazole: Enters microbial cells, reduced to toxic compounds that damage DNA; Diloxanide: Directly kills trophozoites of Entamoeba histolytica by inhibiting protein synthesis.
Mechanism Steps
๐ก How to Take aristogyl plus tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of aristogyl plus tablet
โ Common Side Effects
- Nausea
- Metallic taste
- Headache
- Dry mouth
- Diarrhea
- Abdominal cramps
๐จ Serious Side Effects
- Peripheral neuropathy
- Seizures
- Encephalopathy
- Stevens-Johnson syndrome
- Pancreatitis
โ ๏ธ Rare Side Effects
- Pseudomembranous colitis
- Hepatotoxicity
- Leukopenia
- QT prolongation
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Disulfiram | Major | Psychotic reactions |
| Lithium | Major | Increased lithium toxicity |
| Phenytoin | Major | Increased phenytoin levels |
| Cimetidine | Major | Increased metronidazole levels |
| Alcohol | Moderate | Disulfiram-like reaction |
| Oral contraceptives | Moderate | Reduced contraceptive efficacy |
| Cyclosporine | Moderate | Increased cyclosporine levels |
| Tacrolimus | Moderate | Increased tacrolimus levels |
| Fluorouracil | Moderate | Increased fluorouracil toxicity |
| Antacids | Minor | Reduced absorption of metronidazole |
| Cholestyramine | Minor | Reduced absorption of metronidazole |
| Phenobarbital | Minor | Decreased metronidazole levels |
๐จ Major Interactions
- Warfarin
- Disulfiram
- Lithium
- Phenytoin
- Cimetidine
โก Moderate Interactions
- Alcohol
- Oral contraceptives
- Cyclosporine
- Tacrolimus
- Fluorouracil
โน๏ธ Minor Interactions
- Antacids
- Cholestyramine
- Phenobarbital
๐ฝ๏ธ Food Interactions
Avoid alcohol and alcohol-containing foods; food may delay absorption but not extent.
๐ท Alcohol Interaction
Disulfiram-like reaction (nausea, vomiting, headache, flushing) with alcohol.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to metronidazole, diloxanide, or nitroimidazoles; first trimester of pregnancy (unless essential); active neurological disorders; blood dyscrasias.
๐ Monitoring Parameters
Liver function tests, renal function, CBC, neurological status.
๐คฑ Lactation Safety
Metronidazole excreted in breast milk; avoid or discontinue breastfeeding.
๐ Overdose Management
Symptomatic and supportive; induce vomiting or gastric lavage; monitor for neurotoxicity.
โฐ Missed Dose
Take as soon as remembered unless near next dose; do not double dose.