Metrogyl Compound 400mg/500mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Seizures or convulsions
- Confusion, drowsiness, or difficulty speaking
- Numbness or tingling in hands or feet
- Severe skin rash with blisters or peeling
- Yellowing of skin or eyes
- Unusual bleeding or bruising
- Persistent high fever
If experiencing severe symptoms, call emergency services immediately.
What is qugyl ds 400mg/500mg tablet used for?
This medicine is a combination of metronidazole and diloxanide furoate used to treat intestinal amoebiasis, including amoebic dysentery and asymptomatic cyst passers. It works by killing both tissue-invasive and luminal forms of the parasite. It is a prescription medicine and must be taken under medical supervision.
- Generic Name: Metronidazole (400mg) + Diloxanide (500mg)
- Manufacturer: RPG Life Sciences Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 qugyl ds 400mg/500mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा मेट्रोनिडाजोल और डाइलोक्सानाइड फ्यूरोएट का संयोजन है, जिसका उपयोग आंतों के अमीबियासिस (अमीबिक पेचिश) और अमीबिक सिस्ट वाहकों के इलाज के लिए किया जाता है। यह आंतों में अमीबा परजीवी को मारती है और दस्त, पेट दर्द, बुखार और मल में खून जैसे लक्षणों में राहत देती है। यह दवा डॉक्टर के पर्चे के बिना नहीं लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में जी मिचलाना, मुँह में धातु जैसा स्वाद, पेट दर्द, भूख न लगना, सिरदर्द और गहरे रंग का पेशाब शामिल हैं। कभी-कभी उल्टी, दस्त या चक्कर आ सकते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन हाथ-पैरों में झनझनाहट, दौरे, भ्रम या त्वचा पर गंभीर दाने हो सकते हैं। ऐसा होने पर तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे भोजन के साथ पूरे गिलास पानी के साथ निगलें। इलाज के दौरान और आखिरी खुराक के 48 घंटे बाद तक शराब न पिएँ, क्योंकि इससे गंभीर प्रतिक्रिया हो सकती है। अगर आपको लीवर या किडनी की बीमारी है, तो डॉक्टर को बताएं। दवा का पूरा कोर्स पूरा करें, भले ही आप बेहतर महसूस करें।
💊 qugyl ds 400mg/500mg tablet Uses & Benefits
[{"condition":"Intestinal amoebiasis (amoebic dysentery)","description":"This medicine treats invasive amoebic infection of the large intestine, helping to relieve bloody diarrhoea, abdominal pain, and fever.","evidence":"Well-established"},{"condition":"Asymptomatic amoebic cyst passers","description":"This medicine is used to clear Entamoeba histolytica cysts from the stool in people who have no symptoms but can spread the infection.","evidence":"Well-established"},{"condition":"Mixed intestinal infections with anaerobic bacteria","description":"The metronidazole component covers susceptible anaerobic bacteria that may accompany amoebic infection.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Giardiasis","description":"Metronidazole alone is used for giardiasis, but the combination with diloxanide is not standard for this indication.","evidence":"Limited"},{"condition":"Trichomoniasis","description":"Metronidazole is effective for trichomoniasis, but the combination product is not typically used because diloxanide is not needed.","evidence":"Limited"}]
Primary treatment for: Intestinal amoebiasis
Also treats: Amoebic dysentery, Asymptomatic amoebic cyst carriage, Mixed anaerobic intestinal infections
📋 Drug Information
| Generic Name(s) | Metronidazole (400mg) + Diloxanide (500mg) |
| Brand Name | qugyl ds 400mg/500mg tablet |
| Manufacturer | RPG Life Sciences Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the pack. |
| WHO Guideline | Not established from the available information. Consult local guidelines for amoebiasis treatment. |
| ICMR Guideline | Not established from the available information. Consult local guidelines for amoebiasis treatment. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two agents with complementary actions. Metronidazole enters susceptible anaerobic organisms and protozoa, where its nitro group is reduced to reactive intermediates that damage DNA and inhibit nucleic acid synthesis, leading to cell death. Diloxanide furoate is a luminal amoebicide that acts on Entamoeba histolytica in the intestinal lumen, killing trophozoites and cysts through an unknown mechanism that may involve inhibition of protein synthesis. Together, they target both tissue-invasive and luminal forms of the parasite.
Mechanism Steps
💡 How to Take qugyl ds 400mg/500mg tablet
Strength: Immediate-release tablet containing metronidazole 400 mg and diloxanide furoate 500 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally two to three times daily, depending on the severity of the infection and your doctor's assessment. The exact dose and duration must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function. Do not self-adjust the dose. Complete the full course as prescribed. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially neurological effects and liver toxicity. Dose adjustment may be needed based on liver and kidney function. Consult your doctor for individualized dosing. |
| Renal Impairment | In patients with severe kidney impairment, dose adjustment may be necessary. Metronidazole and its metabolites are excreted by the kidneys. Consult your doctor for individualized dosing. |
| Hepatic Impairment | In patients with severe liver disease, dose reduction may be required because metronidazole is metabolised in the liver. Monitor liver function closely. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose is not established from the available information. Dose must be individualized by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of qugyl ds 400mg/500mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Alcohol | Major | |
| Lithium | Major | |
| Disulfiram | Major | |
| Phenytoin | Moderate | |
| Carbamazepine | Moderate | |
| Cimetidine | Moderate | |
| Fluorouracil | Moderate | |
| Antacids | Minor | |
| Oral contraceptives | Minor |
🚨 Major Interactions
- Alcohol
- Warfarin
- Lithium
- Disulfiram
⚡ Moderate Interactions
- Phenytoin
- Carbamazepine
- Cimetidine
- Fluorouracil
🍷 Alcohol Interaction
Do not drink alcohol while taking this medicine and for at least 48 hours after the last dose. Alcohol can trigger a disulfiram-like reaction with flushing, severe nausea, vomiting, headache, and rapid heartbeat. It may also reduce the effectiveness of treatment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to metronidazole, diloxanide, or other nitroimidazole derivatives","First trimester of pregnancy unless clearly needed","Active neurological disorders such as epilepsy or peripheral neuropathy","Severe liver disease","Use of disulfiram within the past two weeks","Alcohol consumption during treatment"]
⚠️ Warnings & Precautions
["Do not consume alcohol during treatment and for at least 48 hours after the last dose.","May cause dizziness or confusion; avoid driving or operating machinery until you know how it affects you.","Prolonged use may cause peripheral neuropathy; report numbness or tingling immediately.","May increase the risk of bleeding if taken with warfarin; monitor INR.","Use with caution in patients with liver disease; dose adjustment may be needed.","Use with caution in patients with kidney disease; dose adjustment may be needed.","May cause dark urine, which is harmless.","Complete the full course as prescribed even if symptoms improve."]
🤱 Lactation Safety
Metronidazole passes into breast milk. Breastfeeding is generally not recommended during treatment and for 24 to 48 hours after the last dose. Diloxanide furoate excretion in breast milk is not well established. Consult your doctor for guidance.
💊 Overdose Management
Overdose of this medicine may cause nausea, vomiting, abdominal pain, dizziness, headache, and in severe cases, seizures or peripheral neuropathy. There is no specific antidote. Treatment is supportive and symptomatic. If overdose is suspected, seek emergency medical care immediately. Do not induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Swallow the tablet whole with a full glass of water and take it with food to reduce stomach upset. Do not drink alcohol while taking this medicine and for at least 48 hours after finishing the course, because a disulfiram-like reaction with severe nausea, vomiting, flushing, and rapid heartbeat can occur. Complete the full course even if you feel better after a few days. Do not share this medicine with anyone else. Inform your doctor if you have liver disease, kidney disease, or a history of blood disorders. Avoid driving or operating heavy machinery if you feel dizzy or confused. Keep this medicine out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to the neurological side effects of metronidazole, such as peripheral neuropathy and confusion. Liver and kidney function should be assessed before starting treatment, and dose adjustment may be needed. Monitor closely for any signs of toxicity.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss this medicine with your doctor. Metronidazole is generally avoided in the first trimester. Use effective contraception during treatment and for at least 48 hours after the last dose. Consult your doctor for preconception counselling.
🏥 Post-Surgery Considerations
If you have recently had surgery, inform your surgeon and anaesthesiologist that you are taking this medicine. Metronidazole can interact with other medications used during surgery. It may also affect liver function, which can influence anaesthesia. Do not restart this medicine after surgery without your doctor's advice.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. Metronidazole can interact with medications used during dental work, and it may increase bleeding risk if you are on blood thinners. Your dentist may advise postponing non-urgent procedures until you complete the course.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise if you feel weak, dizzy, or fatigued. Light activity such as walking is fine if you feel up to it. Do not exercise if you have a fever or severe abdominal pain. Consult your doctor before resuming intense workouts.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, confusion, or fatigue in some people. Avoid driving or operating heavy machinery until you know how it affects you. If your work involves physical exertion, take adequate rest. Inform your employer if you need time off to recover from the infection.
🛑 When to Stop This Medicine
Do not stop this medicine before completing the full course, even if you feel better. Stopping early can lead to relapse and may promote resistance. If you experience serious side effects such as seizures, severe rash, or numbness, stop the medicine and seek immediate medical attention. Always consult your doctor before stopping.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of peripheral neuropathy, liver toxicity, and blood disorders. It should only be used for the prescribed duration. If prolonged therapy is necessary, your doctor may monitor your liver function, blood counts, and neurological status. Do not use this medicine for longer than prescribed without medical supervision.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A longer-acting nitroimidazole that may be used as an alternative for amoebiasis.
Evidence: Well-establishedA luminal amoebicide that can be used for asymptomatic cyst passers.
Evidence: ModerateEssential supportive care for diarrhoea to prevent dehydration.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There is no specific vaccine interaction established for this medicine. However, if you are due for any live vaccines, inform your doctor, as the infection and treatment may affect your immune response. Complete your treatment before scheduling non-urgent vaccinations.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from moisture and direct sunlight. If travelling across time zones, adjust your dosing schedule gradually in consultation with your doctor. Do not pack it in checked luggage; keep it in your hand baggage. Check customs regulations for carrying prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Symptomatic improvement may begin within 24 to 48 hours, but you must complete the full course as prescribed.
A: Yes, take it with food to reduce stomach upset and nausea.
A: Take it as soon as you remember if less than half the dosing interval has passed. Otherwise, skip it and continue with your regular schedule. Do not double dose.
A: No, avoid alcohol completely during treatment and for at least 48 hours after the last dose to prevent a severe reaction.
A: It is generally avoided in the first trimester unless clearly needed. Consult your doctor for individualized advice.
🤔 Common Patient Concerns
🔄 Substitutes for qugyl ds 400mg/500mg tablet
View AllAlternative brands with exact same active ingredient:
-
aristogyl plus tabletAristo Pharmaceuticals Pvt Ltd ₹11.45 44.9% COSTLIER
-
ameebee df 400mg/500mg tabletTOSC International Pvt Ltd ₹13.00 64.6% COSTLIER
-
metroken forte 400mg/500mg tabletKentreck Laboratories Pvt Ltd ₹14.00 77.2% COSTLIER
-
metrodil m 400mg/500mg tabletOyster Labs Ltd ₹16.88 113.7% COSTLIER
-
acrogyl df 400mg/500mg tabletAcron Pharmaceuticals ₹17.81 125.4% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken for any type of diarrhoea.
Fact: This medicine is specifically for amoebic infections. It is not effective for viral or bacterial diarrhoea unless susceptible anaerobes are involved. - Myth: You can stop taking this medicine once you feel better.
Fact: You must complete the full course to ensure the parasite is fully cleared and to prevent relapse. - Myth: Alcohol is safe while taking this medicine.
Fact: Alcohol can cause a severe disulfiram-like reaction and must be avoided during treatment and for 48 hours after.
🔄 Alternative Options
Generic Alternatives
- Metronidazole 400 mg + Diloxanide furoate 500 mg tablet (various manufacturers)
Brand Alternatives
- Metrogyl Compound 400mg/500mg Tablet