Aldezol DF 400mg/500mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Seizures or confusion
- Numbness or tingling in hands or feet
If experiencing severe symptoms, call emergency services immediately.
What is ameebee df 400mg/500mg tablet used for?
This medicine is a combination of metronidazole and diloxanide furoate used to treat intestinal amoebiasis (amoebic dysentery). It works by killing the parasite in both the gut wall and the gut lumen. It is a prescription medicine and must be taken exactly as directed by your doctor.
- Generic Name: Metronidazole + Diloxanide
- Manufacturer: TOSC International Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ameebee df 400mg/500mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा मेट्रोनिडाजोल और डाइलोक्सानाइड फ्यूरोएट का संयोजन है, जिसका उपयोग आंतों के अमीबियासिस (अमीबिक पेचिश) के इलाज के लिए किया जाता है। यह परजीवी को आंतों की दीवार और आंतों के लुमेन दोनों में मारती है। यह एक प्रिस्क्रिप्शन दवा है और इसे डॉक्टर के निर्देशानुसार ही लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, मुँह में धातु जैसा स्वाद, पेट दर्द, सिरदर्द और चक्कर आना शामिल हैं। कुछ लोगों का पेशाब गहरा पीला या लाल हो सकता है, जो हानिकारक नहीं है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अगर आपको त्वचा पर चकत्ते, सूजन, साँस लेने में कठिनाई, या हाथ-पैरों में झुनझुनी महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे भोजन के बाद पानी के साथ पूरा निगलें, चबाएँ नहीं। दवा लेते समय और आखिरी खुराक के 48 घंटे बाद तक शराब न पिएँ, क्योंकि इससे गंभीर प्रतिक्रिया हो सकती है। अगर आप गर्भवती हैं, स्तनपान करा रही हैं, या आपको लीवर या किडनी की बीमारी है, तो डॉक्टर को बताएं। पूरा कोर्स पूरा करें, बीच में न छोड़ें।
💊 ameebee df 400mg/500mg tablet Uses & Benefits
- [{"condition":"Intestinal amoebiasis (amoebic dysentery)","description":"This medicine is used to treat infection of the large intestine caused by Entamoeba histolytica, a parasite that causes bloody diarrhoea, abdominal pain, and fever.
- The combination targets both tissue-invading and luminal parasites.","evidence":"Well-established"},{"condition":"Amoebic liver abscess (as part of combination therapy)","description":"This medicine may be used along with other medicines to treat amoebic liver abscess, although metronidazole alone is often sufficient.
- Diloxanide helps clear intestinal carriage.","evidence":"Established"},{"condition":"Giardiasis (as an alternative)","description":"Metronidazole component is effective against Giardia lamblia, but the combination is not typically first-line for giardiasis alone.","evidence":"Limited"},{"condition":"Trichomoniasis (as an alternative)","description":"Metronidazole is highly effective for trichomoniasis, but the combination with diloxanide is not standard for this infection.","evidence":"Limited"}]
Off-label uses: [{"condition":"Bacterial vaginosis","description":"Metronidazole alone is sometimes used, but the combination with diloxanide is not standard and may not be appropriate.","evidence":"Limited"},{"condition":"Rosacea","description":"Metronidazole has anti-inflammatory effects and is used topically for rosacea, but oral combination is not recommended for this purpose.","evidence":"Limited"}]
Primary treatment for: Intestinal amoebiasis
Also treats: Amoebic liver abscess, Giardiasis, Trichomoniasis
📋 Drug Information
| Generic Name(s) | Metronidazole + Diloxanide |
| Brand Name | Aldezol DF 400mg/500mg Tablet |
| Manufacturer | TOSC International Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Antiprotozoal |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C. Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two agents with complementary mechanisms. Metronidazole is a nitroimidazole that enters susceptible microorganisms and is reduced by ferredoxin-like electron transport proteins in anaerobic conditions. The reduced products form reactive intermediates that bind to DNA, causing strand breakage and inhibiting nucleic acid synthesis, which leads to cell death. Diloxanide furoate is a luminal amoebicide that acts primarily in the intestinal lumen. It is hydrolysed to diloxanide, which is thought to interfere with the parasite's energy metabolism and protein synthesis, although the exact mechanism is not fully understood. Together, they eliminate both invasive and luminal forms of Entamoeba histolytica.
Mechanism Steps
💡 How to Take ameebee df 400mg/500mg tablet
Strength: Each tablet contains metronidazole 400 mg and diloxanide furoate 500 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally two to three times a day, depending on the severity of the infection and your doctor's assessment. The exact dose and duration must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function. Do not self-adjust the dose. Always follow your doctor's prescription. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially neurological effects. Dose adjustment may be necessary based on liver and kidney function. Consult your doctor for appropriate dosing. |
| Renal Impairment | In patients with severe renal impairment, dose adjustment may be required. Metronidazole is removed by dialysis, so a supplemental dose may be needed after dialysis. Consult your doctor for specific guidance. |
| Hepatic Impairment | In patients with severe liver disease, metronidazole metabolism may be reduced, leading to increased drug levels. Dose reduction may be necessary. Consult your doctor for appropriate dosing. |
| Maximum Daily Dose | The maximum daily dose should not exceed 2400 mg of metronidazole and 3000 mg of diloxanide furoate, but the exact limit depends on the indication and must be determined by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ameebee df 400mg/500mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Alcohol | Major | |
| Disulfiram | Major | |
| Lithium | Major | |
| Phenytoin | Moderate | |
| Carbamazepine | Moderate | |
| Cimetidine | Moderate | |
| Fluorouracil | Moderate | |
| Antacids | Minor | |
| Oral contraceptives | Minor |
🚨 Major Interactions
- Warfarin
- Alcohol
- Disulfiram
- Lithium
⚡ Moderate Interactions
- Phenytoin
- Carbamazepine
- Cimetidine
- Fluorouracil
🍷 Alcohol Interaction
Alcohol must be strictly avoided while taking this medicine and for at least 48 hours after the last dose. Combining alcohol with metronidazole can cause a disulfiram-like reaction characterised by severe nausea, vomiting, flushing, headache, and rapid heartbeat. This reaction can be dangerous and requires immediate medical attention if it occurs.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to metronidazole, diloxanide, or any component of the formulation","First trimester of pregnancy","Breastfeeding without medical advice","Severe liver disease","Severe kidney disease","Use of disulfiram within the past two weeks","Alcohol consumption during treatment"]
⚠️ Warnings & Precautions
["Avoid alcohol during and for 48 hours after treatment.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Inform your doctor if you have liver or kidney disease.","May cause dark urine, which is harmless.","Do not use for longer than prescribed without medical supervision.","Report any numbness or tingling in hands or feet immediately.","May interact with blood thinners; inform your doctor if you take warfarin.","Not recommended for children under 12 years unless prescribed by a doctor.","Use with caution in elderly patients.","Complete the full course to prevent relapse."]
🤱 Lactation Safety
Metronidazole is excreted in breast milk. Breastfeeding should be avoided during treatment and for 12-24 hours after the last dose to allow the drug to clear from milk. Diloxanide furoate excretion in breast milk is not known. Consult your doctor for guidance.
💊 Overdose Management
Overdose of this medicine may cause nausea, vomiting, abdominal pain, headache, dizziness, and in severe cases, seizures or peripheral neuropathy. If you suspect an overdose, seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if ingestion is recent. Monitor vital signs and neurological status.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as your doctor prescribes. Swallow the tablet whole with a full glass of water, preferably after a meal to reduce stomach upset. Do not chew or crush the tablet. Avoid drinking alcohol while taking this medicine and for at least 48 hours after the last dose, because it can cause severe nausea, vomiting, flushing, and rapid heartbeat. Inform your doctor if you have liver or kidney problems, or if you are pregnant, planning pregnancy, or breastfeeding. Do not share this medicine with others, even if they have similar symptoms. Keep it out of reach of children. Store in a cool, dry place away from direct sunlight. Complete the full course even if you feel better after a few days. If you miss a dose, take it as soon as you remember, but if it is almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to the neurological side effects of metronidazole, such as peripheral neuropathy and dizziness. Dose adjustment may be needed based on liver and kidney function. Regular monitoring is advised.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. Metronidazole should be avoided during the first trimester. Use effective contraception during treatment and for at least 48 hours after the last dose.
🏥 Post-Surgery Considerations
If you have recently undergone surgery, inform your surgeon and anaesthesiologist that you are taking this medicine. It may interact with other medications used during surgery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It may interact with certain antibiotics or anaesthetics used during dental work.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause dizziness or fatigue. Avoid strenuous exercise or activities requiring alertness until you know how the medicine affects you.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is advisable to take rest if you feel unwell.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Complete the full course as prescribed, even if you feel better. If you experience severe side effects, contact your doctor immediately for advice.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended unless prescribed by a doctor. Prolonged use of metronidazole can rarely cause peripheral neuropathy, which may be irreversible. Regular monitoring of liver function and blood counts may be needed if used for extended periods. Always consult your doctor before taking this medicine for more than the prescribed duration.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another nitroimidazole with similar efficacy but longer half-life, allowing shorter courses.
Evidence: Well-establishedA luminal amoebicide used as an alternative for intestinal amoebiasis.
Evidence: Established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are due for a vaccine, inform your doctor that you are taking this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When travelling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from extreme heat or moisture. If crossing time zones, adjust your dosing schedule gradually to maintain even intervals. Keep it in your carry-on luggage to avoid loss. Check customs regulations for prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 2-3 days, but it is important to complete the full course as prescribed.
A: Yes, take it with food to reduce stomach upset.
A: Take it as soon as you remember, but if it is almost time for the next dose, skip the missed dose and continue with your regular schedule.
🤔 Common Patient Concerns
🔄 Substitutes for ameebee df 400mg/500mg tablet
View AllAlternative brands with exact same active ingredient:
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qugyl ds 400mg/500mg tabletRPG Life Sciences Ltd ₹7.90 39.2% CHEAPER
-
aristogyl plus tabletAristo Pharmaceuticals Pvt Ltd ₹11.45 11.9% CHEAPER
-
metroken forte 400mg/500mg tabletKentreck Laboratories Pvt Ltd ₹14.00 7.7% COSTLIER
-
metrodil m 400mg/500mg tabletOyster Labs Ltd ₹16.88 29.8% COSTLIER
-
acrogyl df 400mg/500mg tabletAcron Pharmaceuticals ₹17.81 37% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any type of diarrhoea.
Fact: This medicine is specifically for amoebic dysentery and certain protozoal infections. It is not effective for viral or bacterial diarrhoea. - Myth: You can stop taking this medicine once you feel better.
Fact: You must complete the full course to prevent relapse and resistance. - Myth: Alcohol is safe while taking this medicine.
Fact: Alcohol can cause a severe reaction and must be avoided completely.
🔄 Alternative Options
Generic Alternatives
- Metronidazole + Diloxanide Furoate tablets from other manufacturers
Brand Alternatives
- Aldezol DF 400mg/500mg Tablet