Flagyl 400 Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe allergic reaction with swelling of the face, lips, or throat, or difficulty breathing.
- Seizures or convulsions.
- Numbness, tingling, or burning in the hands or feet.
- Unusual bruising or bleeding, fever, or sore throat.
- Severe abdominal pain, especially with nausea and vomiting.
- Yellowing of the skin or eyes, or dark urine.
- Confusion, disorientation, or difficulty speaking.
- Sudden vision changes or loss of vision.
If experiencing severe symptoms, call emergency services immediately.
What is unimegyl 400mg tablet used for?
This medicine contains metronidazole 400 mg, an antibiotic used to treat anaerobic bacterial and protozoal infections such as bacterial vaginosis, trichomoniasis, amoebiasis, and giardiasis. It works by damaging microbial DNA. It is taken orally, usually two to three times daily with food. Alcohol must be strictly avoided during and for 48 hours after treatment.
- Generic Name: Metronidazole (400mg)
- Manufacturer: Torrent Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 unimegyl 400mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा मेट्रोनिडाजोल 400 मिलीग्राम युक्त एक एंटीबायोटिक टैबलेट है। इसका उपयोग एनारोबिक बैक्टीरिया और कुछ परजीवियों के कारण होने वाले संक्रमणों के इलाज के लिए किया जाता है, जैसे बैक्टीरियल वेजिनोसिस, ट्राइकोमोनिएसिस, अमीबiasis, और जिआर्डiasis। यह दवा संक्रमण पैदा करने वाले सूक्ष्मजीवों के डीएनए को नष्ट करके उन्हें मरने में मदद करती है। इसे डॉक्टर के निर्देशानुसार भोजन के साथ लेना चाहिए। इस दवा को लेते समय और आखिरी खुराक के 48 घंटे बाद तक शराब का सेवन बिल्कुल न करें, क्योंकि इससे गंभीर प्रतिक्रिया हो सकती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, मुँह में धातु जैसा स्वाद, सिरदर्द, और पेट में असुविधा शामिल हैं। कुछ लोगों को भूख न लगना, दस्त, या कब्ज हो सकती है। पेशाब का रंग गहरा हो सकता है, जो आमतौर पर हानिरहित होता है। दुर्लभ मामलों में गंभीर एलर्जी, रक्त विकार, हाथ-पैरों में झुनझुनी, या दौरे पड़ सकते हैं। यदि आपको कोई असामान्य लक्षण महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें, भोजन के साथ लेना बेहतर है ताकि पेट की परेशानी कम हो। इलाज के दौरान और आखिरी खुराक के 48 घंटे बाद तक शराब न पिएं। कोर्स पूरा करें, भले ही आप बेहतर महसूस करने लगें। यदि आपको लीवर, किडनी, रक्त, या तंत्रिका तंत्र की कोई बीमारी है, तो डॉक्टर को बताएं। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। दवा को बच्चों की पहुंच से दूर रखें।
💊 unimegyl 400mg tablet Uses & Benefits
- [{"condition":"Bacterial vaginosis","description":"This medicine is effective against the anaerobic bacteria that cause bacterial vaginosis, helping to restore the normal vaginal flora and relieve symptoms such as discharge and odour.","evidence":"Well-established"},{"condition":"Trichomoniasis","description":"It is a first-line treatment for trichomoniasis, a sexually transmitted infection caused by Trichomonas vaginalis.
- Sexual partners should also be treated to prevent reinfection.","evidence":"Well-established"},{"condition":"Amoebiasis (amoebic dysentery)","description":"This medicine is used to treat intestinal and extra-intestinal amoebiasis caused by Entamoeba histolytica, helping to clear the parasite and resolve symptoms such as bloody diarrhoea and abdominal pain.","evidence":"Well-established"},{"condition":"Giardiasis","description":"It is a preferred treatment for giardiasis, an intestinal infection caused by Giardia lamblia, which leads to diarrhoea, bloating, and malabsorption.","evidence":"Well-established"},{"condition":"Anaerobic bacterial infections","description":"This medicine is used for a range of anaerobic infections, including intra-abdominal infections, pelvic infections, skin and soft tissue infections, and brain abscesses, often in combination with other antibiotics.","evidence":"Well-established"},{"condition":"Helicobacter pylori eradication","description":"It is a component of combination regimens used to eradicate Helicobacter pylori, the bacterium associated with peptic ulcers and gastric cancer.","evidence":"Well-established"},{"condition":"Surgical prophylaxis","description":"This medicine may be used before certain colorectal or gynaecological surgeries to prevent postoperative anaerobic infections.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Rosacea","description":"Topical or oral metronidazole is sometimes used off-label for inflammatory rosacea, although the oral form is not approved for this indication in many countries.","evidence":"Limited"},{"condition":"Crohn's disease","description":"Metronidazole has been studied as an off-label treatment for perianal Crohn's disease and for preventing recurrence after surgery, but evidence is limited and it is not a standard first-line therapy.","evidence":"Limited"},{"condition":"Bacterial overgrowth in the small intestine","description":"It may be used off-label for small intestinal bacterial overgrowth, but other antibiotics are generally preferred.","evidence":"Limited"}]
Primary treatment for: Anaerobic bacterial and protozoal infections
Also treats: Bacterial vaginosis, Trichomoniasis, Amoebiasis, Giardiasis, Intra-abdominal infections, Pelvic inflammatory disease, Helicobacter pylori infection
📋 Drug Information
| Generic Name(s) | Metronidazole (400mg) |
| Brand Name | unimegyl 400mg tablet |
| Manufacturer | Torrent Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | 5-Nitroimidazole (Antiprotozoal & Antibacterial) |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | Typically 24 to 36 months from the date of manufacture, depending on the manufacturer. Check the expiry date on the packaging. |
| WHO Guideline | The World Health Organization includes metronidazole in its essential medicines list and recommends it for the treatment of amoebiasis, giardiasis, trichomoniasis, and bacterial vaginosis. Specific regimens should follow national guidelines. |
| ICMR Guideline | The Indian Council of Medical Research recommends metronidazole for the treatment of amoebiasis, giardiasis, trichomoniasis, and anaerobic infections. It is also included in standard treatment guidelines for bacterial vaginosis and Helicobacter pylori eradication. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by entering susceptible anaerobic bacteria and protozoa, where it is reduced by ferredoxin-like electron transport proteins to form reactive nitro radical anions. These reactive metabolites bind to and damage microbial DNA, causing strand breakage and inhibiting nucleic acid synthesis. This leads to rapid loss of helical structure, impaired replication, and eventual cell death. Because the activation occurs only in low-oxygen environments, the medicine is selectively toxic to anaerobic organisms and has little effect on human cells or aerobic bacteria.
Mechanism Steps
💡 How to Take unimegyl 400mg tablet
Strength: This medicine is available as an immediate-release tablet containing 400 mg of metronidazole.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 400 mg taken two to three times daily, depending on the infection being treated. For bacterial vaginosis, a common regimen is 400 mg twice daily for 7 days. For trichomoniasis, a single 2 g dose or a 7-day course may be used. For amoebiasis, the dose is often 400-800 mg three times daily for 5-10 days. For anaerobic infections, 400 mg three times daily is typical. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially neurological effects. Dose adjustment may be needed based on liver and kidney function. Consult a doctor for personalised dosing. |
| Renal Impairment | Dose adjustment is generally not required in mild to moderate renal impairment. In severe renal impairment, caution is advised and dose reduction may be considered. Consult a doctor for personalised dosing. |
| Hepatic Impairment | In patients with severe liver disease, the dose of this medicine may need to be reduced because metronidazole is metabolised in the liver. Monitor liver function and adjust dose as advised by a clinician. |
| Maximum Daily Dose | The maximum recommended daily dose is 2 g (2000 mg) for most indications, but higher doses may be used in specific situations under medical supervision. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of unimegyl 400mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Alcohol | Major | |
| Lithium | Major | |
| Disulfiram | Major | |
| Phenytoin | Moderate | |
| Cimetidine | Moderate | |
| Carbamazepine | Moderate | |
| Cyclosporine | Moderate | |
| Fluorouracil | Moderate | |
| Tacrolimus | Moderate |
🚨 Major Interactions
- Warfarin
- Alcohol
- Lithium
- Disulfiram
- Phenytoin
⚡ Moderate Interactions
- Cimetidine
- Carbamazepine
- Cyclosporine
- Fluorouracil
- Tacrolimus
🍷 Alcohol Interaction
Alcohol must be strictly avoided while taking this medicine and for at least 48 hours after the last dose. Combining alcohol with metronidazole can cause a disulfiram-like reaction characterised by flushing, severe nausea, vomiting, headache, and rapid heartbeat. This reaction can be dangerous and requires immediate medical attention if it occurs.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to metronidazole or other nitroimidazole derivatives","First trimester of pregnancy for certain indications, unless clearly needed","Use of disulfiram within the past two weeks","Alcohol consumption during and for 48 hours after therapy","Severe liver disease with caution","Central nervous system disorders with caution"]
⚠️ Warnings & Precautions
["Avoid alcohol during treatment and for at least 48 hours after the last dose.","May cause peripheral neuropathy, especially with prolonged use. Report numbness or tingling.","May cause seizures, particularly in patients with a history of seizures or CNS disease.","Can cause dark urine, which is harmless.","May increase the risk of bleeding in patients taking warfarin.","Can cause superinfections such as oral thrush or vaginal yeast infections.","Use with caution in patients with liver disease; dose reduction may be needed.","May interfere with certain laboratory tests, including liver enzyme tests.","Do not use for viral infections such as the common cold.","Complete the full course as prescribed to prevent resistance."]
🤱 Lactation Safety
Metronidazole passes into breast milk and may affect the nursing infant. Some guidelines recommend avoiding breastfeeding during treatment and for 12-24 hours after a single dose, or for 48 hours after a multiple-dose regimen. Consult your doctor for personalised advice.
💊 Overdose Management
Overdose of this medicine may cause nausea, vomiting, abdominal pain, headache, dizziness, and in severe cases, seizures and peripheral neuropathy. There is no specific antidote. Treatment is supportive and symptomatic. If overdose is suspected, seek immediate medical attention. Activated charcoal may be considered if the patient presents early. Monitor vital signs and neurological status.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, with a full glass of water, and preferably with food to reduce stomach upset. Do not drink alcohol while taking this medicine and for at least 48 hours after finishing the course, because a severe reaction with flushing, nausea, vomiting, and rapid heartbeat can occur. Complete the full course even if you start feeling better after a few days, as stopping early can allow the infection to return and may lead to resistance. Inform your doctor if you have liver disease, kidney disease, a blood disorder, or a nervous system condition before starting this medicine. Tell your doctor about all other medicines you are taking, especially blood thinners such as warfarin, lithium, and anticonvulsants. Avoid driving or operating heavy machinery if you feel dizzy or confused. If you are pregnant, planning pregnancy, or breastfeeding, speak to your doctor before using this medicine. Keep this medicine out of the reach of children and store it in its original packaging.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the neurological side effects of this medicine, such as dizziness, confusion, and peripheral neuropathy. Dose adjustment may be needed based on liver and kidney function. Regular monitoring is advised. Consult a doctor for personalised dosing.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before taking this medicine. It should be used during pregnancy only when clearly needed. If you become pregnant while taking this medicine, inform your doctor immediately.
🏥 Post-Surgery Considerations
This medicine may be used before or after certain surgeries to prevent or treat anaerobic infections. Follow your surgeon's instructions carefully. Inform your surgical team if you are taking this medicine, as it may interact with other medications used during surgery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It may interact with other medications used during dental work. There is no need to stop the medicine unless advised by your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause dizziness or confusion in some people. Avoid strenuous exercise or activities that require mental alertness if you feel unsteady. Light exercise such as walking is generally safe if you feel well. Consult your doctor before starting any new exercise routine while on this medicine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, confusion, or headaches in some people. Avoid driving or operating heavy machinery if you experience these symptoms. Most people can continue their normal daily activities, but take precautions if you feel unwell. Inform your employer if you need to take time off due to severe side effects.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Complete the full course as prescribed, even if you feel better. If you experience serious side effects such as seizures, severe allergic reactions, or peripheral neuropathy, stop the medicine and seek immediate medical attention. Your doctor will advise you on whether to continue or switch to an alternative treatment.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of peripheral neuropathy, which can cause numbness, tingling, or pain in the hands and feet. It may also lead to blood disorders such as low white cell count. Prolonged therapy should be monitored with regular blood tests and liver function tests. If you experience any neurological symptoms, contact your doctor immediately. Long-term use should only be under strict medical supervision.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another nitroimidazole antibiotic with a longer half-life, allowing less frequent dosing for some infections.
Evidence: Well-establishedA nitroimidazole antibiotic used for similar indications, with a longer half-life.
Evidence: Well-establishedMay help restore healthy gut and vaginal flora, especially after antibiotic treatment.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you are due for a vaccination, inform your doctor that you are taking this medicine. There is no need to delay vaccination unless advised by your doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When travelling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature, away from direct sunlight and moisture. If you are crossing time zones, adjust your dosing schedule to maintain even intervals, but consult your doctor for specific advice. Keep enough supply for your entire trip. Check customs regulations for carrying prescription medicines in your destination country. Avoid alcohol throughout your trip while taking this medicine.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24 to 48 hours, but it is important to complete the full course as prescribed to ensure the infection is fully cleared.
A: No, you must strictly avoid alcohol during treatment and for at least 48 hours after the last dose, as it can cause a severe reaction with flushing, nausea, vomiting, and rapid heartbeat.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: It should be used during pregnancy only when clearly needed, as advised by your doctor. Consult your doctor for personalised advice.
A: Yes, taking it with food or milk is recommended to reduce stomach upset and nausea.
🤔 Common Patient Concerns
🔄 Substitutes for unimegyl 400mg tablet
View AllAlternative brands with exact same active ingredient:
-
Tosgyl 400mg TabletTOSC International Pvt Ltd ₹5.63 3.9% CHEAPER
-
unimezol 400 mg tabletTorrent Pharmaceuticals Ltd ₹6.30 7.5% COSTLIER
-
metropen 400mg tabletPfizer Ltd ₹6.94 18.4% COSTLIER
-
neuzol 400mg tabletNeutec Healthcare Pvt Ltd ₹6.97 18.9% COSTLIER
-
metron forte 400mg tabletAlkem Laboratories Ltd ₹7.73 31.9% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any type of infection.
Fact: This medicine is only effective against anaerobic bacteria and certain protozoa. It does not treat viral infections or aerobic bacterial infections. - Myth: You can stop taking this medicine as soon as you feel better.
Fact: You must complete the full course as prescribed to ensure the infection is fully cleared and to prevent resistance. - Myth: It is safe to drink alcohol while taking this medicine.
Fact: Alcohol must be strictly avoided because it can cause a severe disulfiram-like reaction. - Myth: This medicine is safe to take during pregnancy without any risk.
Fact: It should be used during pregnancy only when clearly needed, as advised by a doctor.
🔄 Alternative Options
Generic Alternatives
- Metronidazole 400 mg tablet
Brand Alternatives
- Metrogyl 400
- Flagyl 400
- Metron 400
- Aristogyl 400