Diavas 500mg/2mg/10mg Tablet: Complete Guide To Uses, Side Effects, And Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Rapid breathing, muscle pain, or extreme fatigue (possible lactic acidosis)
- Severe hypoglycemia: confusion, seizures, loss of consciousness
- Signs of allergic reaction: rash, itching, swelling of face, lips, or throat, difficulty breathing
- Yellowing of skin or eyes (jaundice)
- Unusual bleeding or bruising
- Persistent vomiting or severe abdominal pain
- Decreased urine output or swelling in legs
If experiencing severe symptoms, call emergency services immediately.
What is Stator GM 500mg/2mg/10mg Tablet used for?
This medicine is a combination of Metformin and Glimepiride used to treat type 2 diabetes. It lowers blood sugar by reducing glucose production in the liver and increasing insulin release from the pancreas. It is taken orally with meals, usually once or twice daily, as prescribed by a doctor.
- Generic Name: Metformin (500mg) + Glimepiride (2mg)
- Manufacturer: Abbott
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 Stator GM 500mg/2mg/10mg Tablet के बारे में (Hindi Summary)
उपयोग: यह दवा मेटफॉर्मिन और ग्लिमेपिराइड का संयोजन है, जिसका उपयोग टाइप 2 डायबिटीज (मधुमेह) के इलाज में किया जाता है। यह रक्त शर्करा को नियंत्रित करने में मदद करती है जब अकेले मेटफॉर्मिन या ग्लिमेपिराइड से पर्याप्त नियंत्रण नहीं हो पाता। यह लीवर में ग्लूकोज उत्पादन को कम करती है और अग्न्याशय से इंसुलिन के स्राव को बढ़ाती है। इसे भोजन के साथ लेना चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में कम रक्त शर्करा (हाइपोग्लाइसीमिया), मतली, दस्त, पेट की गड़बड़ी और स्वाद में बदलाव शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन तत्काल चिकित्सा की आवश्यकता हो सकती है, जैसे लैक्टिक एसिडोसिस, गंभीर हाइपोग्लाइसीमिया, और एलर्जी प्रतिक्रियाएं। यदि आपको तेजी से सांस लेने, मांसपेशियों में दर्द, अत्यधिक थकान, या चेहरे, होंठ या गले में सूजन का अनुभव हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को अपने डॉक्टर के निर्देशानुसार ही लें। खुराक को स्वयं न बदलें या दवा बंद न करें। इसे हमेशा भोजन के साथ लें ताकि पेट की गड़बड़ी और कम रक्त शर्करा का खतरा कम हो। नियमित रूप से अपने रक्त शर्करा की जांच करें। कम रक्त शर्करा के लिए तुरंत काम करने वाली शर्करा (जैसे ग्लूकोज टैबलेट) अपने पास रखें। शराब से बचें क्योंकि इससे लैक्टिक एसिडोसिस और हाइपोग्लाइसीमिया का खतरा बढ़ सकता है। अपने डॉक्टर को अन्य सभी दवाओं के बारे में बताएं। यदि आपको किडनी या लीवर की समस्या है, या सर्जरी होने वाली है, तो डॉक्टर को सूचित करें।
💊 Stator GM 500mg/2mg/10mg Tablet Uses & Benefits
[{"condition":"Type 2 Diabetes Mellitus","description":"Used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus who are not adequately controlled on metformin or glimepiride alone.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Polycystic Ovary Syndrome (PCOS)","description":"Metformin component may be used off-label to improve insulin sensitivity in PCOS, but the combination with glimepiride is not standard for this indication.","evidence":"Limited"}]
Primary treatment for: Type 2 Diabetes Mellitus
Also treats: Insulin resistance, Metabolic syndrome
📋 Drug Information
| Generic Name(s) | Metformin (500mg) + Glimepiride (2mg) |
| Brand Name | Stator GM 500mg/2mg/10mg Tablet |
| Manufacturer | Abbott |
| Packaging / Form | strip of 10 tablets (Allopathy) |
| Therapeutic Class | |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from moisture and light. Keep in the original container, tightly closed. Do not refrigerate unless specified by the manufacturer. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the packaging. |
| WHO Guideline | Not established from the available information. Guidelines from WHO generally recommend metformin as first-line therapy for type 2 diabetes, but specific recommendations for this fixed-dose combination may vary. |
| ICMR Guideline | Not established from the available information. ICMR guidelines for type 2 diabetes recommend metformin as first-line, with sulfonylureas as add-on therapy. This combination may be used when dual therapy is indicated. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two oral antidiabetic agents with complementary mechanisms. Metformin decreases hepatic glucose production, reduces intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Glimepiride, a sulfonylurea, stimulates insulin release from pancreatic beta cells by binding to ATP-sensitive potassium channels, leading to membrane depolarization and calcium influx. The combined effect lowers blood glucose levels through both insulin-dependent and insulin-independent pathways.
Mechanism Steps
💡 How to Take Stator GM 500mg/2mg/10mg Tablet
Strength: Tablet containing Metformin 500 mg and Glimepiride 2 mg.
Dosage Information
| Adult Dosage | The usual starting dose of this medicine is one tablet taken once daily with a meal, typically with breakfast. The dose may be adjusted by your doctor based on your blood sugar levels and tolerance. The maximum recommended dose is generally one tablet twice daily, but this must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. Always follow your doctor's prescription. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the effects of this medicine, especially the risk of hypoglycemia and lactic acidosis. The dose should be carefully adjusted by a clinician based on renal function and overall health. Regular monitoring of blood glucose and renal function is recommended. |
| Renal Impairment | Metformin is contraindicated in severe renal impairment (eGFR <30 mL/min/1.73 m²). In mild to moderate renal impairment, dose adjustment or discontinuation may be necessary. Glimepiride should be used with caution; starting dose should be low and titrated slowly. Consult your doctor for personalized dosing. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Metformin may increase the risk of lactic acidosis, and glimepiride may cause hypoglycemia. Dose adjustment may be needed. Consult your doctor. |
| Maximum Daily Dose | The maximum daily dose of this combination is generally one tablet twice daily (i.e., Metformin 1000 mg and Glimepiride 4 mg per day). However, the exact maximum dose must be determined by a qualified clinician based on individual patient factors. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of Stator GM 500mg/2mg/10mg Tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Alcohol | Major | |
| Contrast media | Major | |
| Beta-blockers | Major | |
| Fluconazole | Major | |
| Diuretics | Moderate | |
| Corticosteroids | Moderate | |
| NSAIDs | Moderate | |
| MAO inhibitors | Moderate | |
| Cationic drugs | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Alcohol
- Contrast media (iodinated)
- Beta-blockers
- Cationic drugs (e.g., amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, vancomycin)
- CYP2C9 inhibitors (e.g., fluconazole, miconazole)
⚡ Moderate Interactions
- Diuretics (thiazides, loop)
- Corticosteroids
- Sympathomimetics
- MAO inhibitors
- NSAIDs
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. It increases the risk of lactic acidosis, a rare but serious complication of metformin, and can potentiate the hypoglycemic effect of glimepiride, leading to dangerous low blood sugar. If you consume alcohol, do so only in moderation and with food, and monitor your blood sugar closely.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Type 1 diabetes mellitus","Diabetic ketoacidosis","Severe renal impairment (eGFR
⚠️ Warnings & Precautions
["Risk of lactic acidosis: Rare but serious. Discontinue and seek medical help if symptoms occur.","Hypoglycemia: Can occur, especially with skipped meals, alcohol, or intense exercise. Monitor blood sugar regularly.","Renal impairment: Dose adjustment or discontinuation may be needed. Monitor renal function.","Hepatic impairment: Use with caution; risk of lactic acidosis and hypoglycemia.","Elderly patients: Increased risk of hypoglycemia and renal impairment. Use with caution.","Surgery: Discontinue before surgery and during recovery until renal function is stable.","Alcohol: Avoid due to increased risk of lactic acidosis and hypoglycemia.","Vitamin B12 deficiency: Long-term metformin use may reduce B12 levels. Monitor periodically.","Hemolytic anemia: Rarely, glimepiride can cause hemolytic anemia in patients with G6PD deficiency.","Pregnancy and breastfeeding: Not recommended unless clearly needed. Consult doctor."]
🤱 Lactation Safety
Metformin is excreted in human breast milk in small amounts. Glimepiride is also excreted in breast milk. The combination is not recommended during breastfeeding due to potential risk of hypoglycemia in the infant. Consult your doctor for alternative treatments.
💊 Overdose Management
Overdose can cause severe hypoglycemia and lactic acidosis. Symptoms include shakiness, sweating, confusion, rapid breathing, and abdominal pain. If overdose is suspected, seek emergency medical attention immediately. Treatment includes supportive care, monitoring of blood glucose and electrolytes, and administration of intravenous glucose for hypoglycemia. Hemodialysis may be considered for metformin overdose with lactic acidosis.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure, consult your doctor or pharmacist.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without medical advice. Always take it with meals to reduce stomach upset and lower the risk of low blood sugar. Monitor your blood sugar levels regularly as advised. Carry a fast-acting source of sugar, such as glucose tablets or candy, to treat low blood sugar episodes. Avoid alcohol, as it can increase the risk of lactic acidosis and hypoglycemia. Inform your doctor about all other medicines, supplements, or herbal products you are taking. Tell your doctor if you have kidney or liver problems, or if you are scheduled for surgery or imaging tests with contrast dyes. Do not drive or operate heavy machinery if you experience symptoms of low blood sugar. Keep this medicine out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at increased risk of hypoglycemia, lactic acidosis, and renal impairment. The dose should be started low and titrated slowly. Regular monitoring of blood glucose and renal function is essential. Educate patients and caregivers on recognizing and managing hypoglycemia.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before conception. This combination is generally not recommended during pregnancy. Your doctor may switch you to insulin or other safer alternatives. Good blood sugar control before and during pregnancy is crucial to prevent complications for both mother and baby.
🏥 Post-Surgery Considerations
This medicine may need to be temporarily discontinued before surgery and during the recovery period, especially if you are not eating or if your kidney function is affected. Your doctor will advise when to restart. Monitor blood sugar closely during this period.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. Dental procedures can cause stress and may affect blood sugar levels. You may need to adjust your medication or meal timing. If you are having a procedure that requires fasting, consult your doctor about dose adjustments.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise can lower blood sugar and increase the risk of hypoglycemia, especially when combined with glimepiride. Check your blood sugar before exercising. If it is below 100 mg/dL, have a small snack first. Carry a fast-acting sugar source during exercise. Avoid intense exercise if your blood sugar is very high or if you have ketones in your urine. Consult your doctor before starting a new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause low blood sugar, which can affect your ability to drive or operate machinery. Do not drive if you feel shaky, dizzy, or confused. Take breaks and have snacks if your work involves physical activity. Inform your employer about your condition and emergency contacts. With proper management, most people can continue their normal work and daily activities.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects, such as lactic acidosis or severe hypoglycemia, seek immediate medical attention. Your doctor may adjust the dose or switch to a different medication. If you are scheduled for surgery or a contrast imaging test, you may need to temporarily stop this medicine as advised by your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine requires regular monitoring of blood glucose, HbA1c, renal function, and vitamin B12 levels. Metformin can cause vitamin B12 deficiency over time, leading to anemia and neuropathy. Glimepiride may cause weight gain and increase the risk of hypoglycemia. Cardiovascular risk may be neutral to beneficial with metformin. Regular follow-up with your doctor is essential to adjust the dose and detect any complications early.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet and exercise are the cornerstone of diabetes management and can reduce the need for medication.
Evidence: Well-establishedDPP-4 inhibitors, SGLT2 inhibitors, or GLP-1 receptor agonists may be alternatives with different side effect profiles.
Evidence: Well-establishedMay be needed if oral agents fail to control blood sugar.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, patients with diabetes are at higher risk of infections, so ensure you are up to date with recommended vaccinations, including influenza, pneumococcal, and hepatitis B vaccines. Consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or moisture. If crossing time zones, consult your doctor about adjusting the timing of doses to maintain blood sugar control. Carry a fast-acting sugar source and your blood glucose monitor. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts lowering blood sugar within a few days, but the full effect may take 1-2 weeks. Your doctor will monitor your HbA1c every 3-6 months to assess long-term control.
A: No, it should be taken with meals to reduce stomach upset and the risk of low blood sugar.
A: Symptoms include shakiness, sweating, confusion, rapid heartbeat, hunger, and dizziness. If you experience these, eat or drink something sugary immediately and inform your doctor.
A: No, do not stop without consulting your doctor. Diabetes is a chronic condition, and stopping medication can cause blood sugar to rise again.
A: The safety of this combination during pregnancy is not well established. Consult your doctor for alternative treatments if you are pregnant or planning to become pregnant.
🤔 Common Patient Concerns
🔄 Substitutes for Stator GM 500mg/2mg/10mg Tablet
View AllAlternative brands with exact same active ingredient:
-
metpride 2 mg/500 mg tabletAlkem Laboratories Ltd ₹8.12 90.6% CHEAPER
-
glynet-m2 tabletZeelab Pharmacy Pvt Ltd ₹9.38 89.1% CHEAPER
-
glimpil mf 2 mg/500 mg tabletPsychotropics India Ltd ₹18.75 78.3% CHEAPER
-
davapride mf 2mg/500mg tablet srDavaindia Generic Pharmacy ₹20.00 76.9% CHEAPER
-
drmet g drmet g2 tablet srDR Best pharmaceuticals Pvt Ltd ₹20.63 76.1% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure diabetes.
Fact: This medicine helps control blood sugar but does not cure diabetes. Lifestyle changes and ongoing medication are usually needed. - Myth: You can stop taking this medicine once your sugar levels are normal.
Fact: Stopping without medical advice can cause blood sugar to rise again. Always consult your doctor before making changes. - Myth: This medicine causes weight gain.
Fact: Metformin may cause slight weight loss, while glimepiride can cause weight gain. The net effect varies. Monitor your weight and discuss with your doctor. - Myth: It is safe to drink alcohol while taking this medicine.
Fact: Alcohol increases the risk of lactic acidosis and hypoglycemia. It is best to avoid alcohol. - Myth: This medicine can be taken on an empty stomach.
Fact: It should be taken with meals to reduce stomach upset and hypoglycemia risk.
🔄 Alternative Options
Generic Alternatives
- Metformin 500 mg + Glimepiride 2 mg tablet (various manufacturers)
Brand Alternatives
- Diavas 500mg/2mg/10mg tablet