bdparib 300 Tablet (Rucaparib): Comprehensive Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Persistent fever, chills, or sore throat (signs of infection)
- Unusual bleeding or bruising
- Shortness of breath or difficulty breathing
- Severe abdominal pain
- Yellowing of skin or eyes (jaundice)
- Decreased urine output
- Severe headache with visual changes
- Swelling of face, lips, or throat
If experiencing severe symptoms, call emergency services immediately.
What is bdparib 300 tablet used for?
This medicine is a PARP inhibitor used to treat ovarian, fallopian tube, primary peritoneal, and prostate cancers with BRCA mutations. It works by blocking DNA repair in cancer cells, leading to cell death. The usual dose is 600 mg twice daily, but dose adjustments are needed for kidney or liver problems.
- Generic Name: Rucaparib
- Manufacturer: BDR Pharmaceuticals Internationals Pvt
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 bdparib 300 tablet के बारे में (Hindi Summary)
उपयोग: यह दवा रुकापारिब नामक सक्रिय तत्व से बनी है और यह 300 मिलीग्राम की गोली के रूप में उपलब्ध है। यह मुख्य रूप से डिम्बग्रंथि कैंसर, फैलोपियन ट्यूब कैंसर, प्राइमरी पेरिटोनियल कैंसर और प्रोस्टेट कैंसर के इलाज में उपयोग की जाती है, खासकर उन रोगियों में जिनके ट्यूमर में बीआरसीए जीन म्यूटेशन होता है। यह पैरप एंजाइम को रोककर कैंसर कोशिकाओं के डीएनए की मरम्मत को बाधित करती है, जिससे कैंसर कोशिकाएं नष्ट हो जाती हैं। यह दवा केवल कैंसर विशेषज्ञ द्वारा ही निर्धारित की जानी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में थकान, मतली, उल्टी, पेट दर्द, भूख में कमी, कब्ज, दस्त और स्वाद में बदलाव शामिल हैं। कुछ रोगियों में एनीमिया, थ्रोम्बोसाइटोपेनिया और न्यूट्रोपेनिया जैसी रक्त संबंधी समस्याएं हो सकती हैं। गंभीर दुष्प्रभावों में मायलोडिस्प्लास्टिक सिंड्रोम या तीव्र माइलॉयड ल्यूकेमिया, गंभीर एलर्जी प्रतिक्रिया और निमोनिया शामिल हैं। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को शुरू करने से पहले अपने डॉक्टर को अपनी सभी चिकित्सीय स्थितियों के बारे में बताएं, विशेष रूप से गुर्दे या यकृत की समस्याएं, रक्त विकार, या पहले कीमोथेरेपी या विकिरण चिकित्सा। नियमित रक्त परीक्षण करवाएं। गर्भावस्था के दौरान इस दवा का उपयोग न करें। स्तनपान कराने वाली महिलाएं इस दवा का उपयोग न करें। अंगूर और अंगूर के रस से बचें। इस दवा को कमरे के तापमान पर सूखी जगह पर रखें।
💊 bdparib 300 tablet Uses & Benefits
[{"condition":"Ovarian cancer","description":"Used as maintenance treatment for adult patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in complete or partial response to platinum-based chemotherapy.","evidence":"Well-established"},{"condition":"BRCA-mutated ovarian cancer","description":"Used for the treatment of adult patients with deleterious BRCA mutation associated with ovarian cancer who have been treated with two or more chemotherapies.","evidence":"Well-established"},{"condition":"Fallopian tube cancer","description":"Indicated for the maintenance treatment of fallopian tube cancer in patients who are in response to platinum-based chemotherapy.","evidence":"Well-established"},{"condition":"Primary peritoneal cancer","description":"Indicated for the maintenance treatment of primary peritoneal cancer in patients who are in response to platinum-based chemotherapy.","evidence":"Well-established"},{"condition":"Prostate cancer","description":"Used for the treatment of adult patients with deleterious BRCA mutation associated with metastatic castration-resistant prostate cancer who have been treated with androgen receptor-directed therapy and a taxane-based chemotherapy.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Pancreatic cancer","description":"Sometimes used off-label in patients with BRCA-mutated pancreatic cancer after other treatments have failed.","evidence":"Limited"},{"condition":"Breast cancer","description":"Occasionally used off-label in BRCA-mutated breast cancer, but not approved for this indication.","evidence":"Limited"}]
Primary treatment for: Ovarian cancer
Also treats: Fallopian tube cancer, Primary peritoneal cancer, Prostate cancer
📋 Drug Information
| Generic Name(s) | Rucaparib |
| Brand Name | Bdparib 300 Tablet |
| Manufacturer | BDR Pharmaceuticals Internationals Pvt |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | |
| Action Class | Anticancer-others |
| Route of Administration | Oral |
| Storage | Store at room temperature between 20°C and 25°C (68°F and 77°F). Keep the container tightly closed in a dry place. Protect from moisture and light. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is a poly (ADP-ribose) polymerase (PARP) inhibitor. It works by blocking the activity of PARP enzymes, which are involved in repairing single-strand breaks in DNA. Cancer cells with defects in homologous recombination repair, such as those with BRCA mutations, rely heavily on PARP to repair their DNA. When PARP is inhibited, these cancer cells accumulate DNA damage, leading to cell cycle arrest and apoptosis. This medicine has been shown to inhibit PARP-1, PARP-2, and PARP-3, and its cytotoxic effects may involve both catalytic inhibition and trapping of PARP-DNA complexes.
Mechanism Steps
💡 How to Take bdparib 300 tablet
Strength: 300 mg immediate-release tablet
Dosage Information
| Adult Dosage | The recommended dose of this medicine is 600 mg taken orally twice daily, with or without food. The dose may be adjusted based on individual patient factors such as renal or hepatic impairment, and the occurrence of adverse reactions. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is recommended for elderly patients based on age alone. However, elderly patients may be more sensitive to the effects of this medicine and should be monitored closely. |
| Renal Impairment | For patients with moderate renal impairment (creatinine clearance 30-59 mL/min), the dose should be reduced to 500 mg twice daily. For patients with severe renal impairment (creatinine clearance less than 30 mL/min), the dose should be reduced to 400 mg twice daily. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | For patients with moderate hepatic impairment (Child-Pugh class B), the dose should be reduced to 500 mg twice daily. For patients with severe hepatic impairment (Child-Pugh class C), the dose should be reduced to 400 mg twice daily. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose is 1200 mg (600 mg twice daily). |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of bdparib 300 tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Fluoxetine | Major | |
| Paroxetine | Major | |
| Quinidine | Major | |
| Ketoconazole | Major | |
| Clarithromycin | Major | |
| Ritonavir | Major | |
| Rifampicin | Major | |
| Carbamazepine | Major | |
| Phenytoin | Major | |
| Warfarin | Minor |
🚨 Major Interactions
- Strong CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)
- Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir)
- Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine, phenytoin)
⚡ Moderate Interactions
- Moderate CYP2D6 inhibitors (e.g., duloxetine, terbinafine)
- Moderate CYP3A4 inhibitors (e.g., aprepitant, diltiazem, verapamil)
🍷 Alcohol Interaction
Alcohol may increase the risk of liver problems and drowsiness. It is advisable to avoid or limit alcohol consumption while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to rucaparib or any component of the formulation","Pregnancy","Breastfeeding","Severe hepatic impairment","Severe renal impairment"]
⚠️ Warnings & Precautions
["Myelodysplastic syndrome/acute myeloid leukaemia: This medicine may cause MDS/AML, which can be fatal. Monitor blood counts regularly.","Embryo-fetal toxicity: This medicine can cause fetal harm. Use effective contraception during treatment and for at least 6 months after the last dose.","Hepatic impairment: Dose adjustment is recommended for patients with moderate to severe hepatic impairment.","Renal impairment: Dose adjustment is recommended for patients with moderate to severe renal impairment.","Drug interactions: Avoid concomitant use with strong CYP2D6 inhibitors, strong CYP3A4 inhibitors, and strong CYP3A4 inducers.","Photosensitivity: This medicine may cause photosensitivity. Avoid prolonged sun exposure and use sunscreen.","Pneumonitis: Cases of pneumonitis have been reported. Monitor for respiratory symptoms."]
🤱 Lactation Safety
It is not known whether this medicine is present in human milk. Because of the potential for serious adverse reactions in breastfed infants, women should not breastfeed during treatment and for at least 2 weeks after the last dose.
💊 Overdose Management
There is no specific antidote for overdose with this medicine. In case of overdose, discontinue the medicine and initiate general supportive measures. Monitor vital signs and observe the patient for any signs of toxicity. Contact a poison control center for further guidance.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Before starting this medicine, inform your doctor about all your medical conditions, especially any kidney or liver problems, blood disorders, or if you have previously had chemotherapy or radiation therapy. Your doctor will perform regular blood tests to monitor your blood counts and liver function. Do not start or stop any other medicine without consulting your oncologist, as this medicine can interact with many drugs. Avoid grapefruit and grapefruit juice while taking this medicine, as it can increase the levels of the medicine in your body. Use effective contraception during treatment and for at least six months after the last dose if you are a woman of childbearing potential, and for at least three months if you are a man. Do not breastfeed while taking this medicine. If you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. Store this medicine at room temperature, away from moisture and heat. Keep it out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to side effects such as fatigue, blood count abnormalities, and liver enzyme elevations. Close monitoring is recommended. No specific dose adjustment is recommended based on age alone.
🤰 Pregnancy Planning (TTC)
This medicine can cause fetal harm. Women of childbearing potential should use effective contraception during treatment and for at least 6 months after the last dose. Men with female partners of childbearing potential should use effective contraception during treatment and for at least 3 months after the last dose. Discuss pregnancy planning with your doctor before starting treatment.
🏥 Post-Surgery Considerations
If you are planning to undergo surgery, inform your surgeon and oncologist that you are taking this medicine. It may need to be temporarily stopped before surgery due to the risk of bleeding and infection. Follow your doctor's instructions regarding when to resume.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. Due to the risk of bleeding and infection, your dentist may recommend precautions or consult with your oncologist before proceeding.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise is generally encouraged, but you should listen to your body and avoid strenuous activities if you feel fatigued or unwell. Consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue, dizziness, or nausea, which can affect your ability to drive or operate machinery. Avoid driving if you feel unwell. Discuss with your employer about any necessary accommodations. Most patients can continue their daily activities with some adjustments.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your oncologist. Treatment may be stopped if the cancer progresses, if unacceptable side effects occur, or based on your doctor's assessment. Your doctor will guide you on when and how to stop.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML). Regular monitoring of blood counts is essential. Other long-term effects may include persistent fatigue, blood count abnormalities, and liver enzyme elevations. Patients should be monitored for these effects and discuss any concerns with their oncologist.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Enrollment in clinical trials for new therapies may be an option.
Evidence: VariesFocuses on symptom relief and quality of life.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided while taking this medicine due to the risk of infection. Inactivated vaccines may be given, but their effectiveness may be reduced. Consult your doctor before receiving any vaccinations.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. Check the laws of your destination country regarding prescription medicines. If crossing time zones, consult your doctor about adjusting the dosing schedule. Store the medicine at room temperature and avoid leaving it in hot or humid places.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working gradually. It may take several weeks to months to see its full effect, depending on the type and stage of cancer.
A: Yes, you can take this medicine with or without food. However, avoid grapefruit and grapefruit juice as they can increase the levels of the medicine.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, this medicine can cause fetal harm. Women of childbearing potential should use effective contraception during treatment and for at least 6 months after the last dose.
A: No, you should not breastfeed during treatment and for at least 2 weeks after the last dose because of the potential for serious adverse reactions in the infant.
🤔 Common Patient Concerns
🔄 Substitutes for bdparib 300 tablet
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure all types of cancer.
Fact: This medicine is only approved for specific cancers with certain genetic mutations and is not a cure for all cancers. - Myth: This medicine causes hair loss like traditional chemotherapy.
Fact: Hair loss is not a common side effect of this medicine, unlike traditional chemotherapy. - Myth: You can stop taking this medicine once you feel better.
Fact: This medicine should be taken exactly as prescribed. Stopping without consulting your doctor can lead to cancer progression.
🔄 Alternative Options
Generic Alternatives
- Rucaparib
Brand Alternatives
- Rubraca