E Ova Plus 50mg Tablet: Complete Guide To Uses, Dosage, And Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe pelvic or abdominal pain
- Rapid weight gain or abdominal swelling
- Blurred vision, double vision, or flashes
- Chest pain, shortness of breath, or leg swelling
- Yellowing of skin or eyes, dark urine
- Severe allergic reaction (rash, itching, swelling of face or throat)
- Decreased urine output
- Persistent vomiting or diarrhea
If experiencing severe symptoms, call emergency services immediately.
What is Smartova 50 Combipack used for?
This medicine is a combination of clomiphene 50 mg and coenzyme Q10 75 mg used to induce ovulation in women with ovulatory dysfunction, such as PCOS. It works by stimulating the release of hormones that trigger egg release from the ovaries. Coenzyme Q10 supports egg quality through its antioxidant effects. It is taken orally for five days starting early in the menstrual cycle, under medical supervision.
- Generic Name: Clomiphene (50mg) + Coenzyme Q10 (75mg)
- Manufacturer: Pharmanova India Drugs Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 Smartova 50 Combipack के बारे में (Hindi Summary)
उपयोग: यह दवा क्लोमिफीन 50 मिलीग्राम और कोएंजाइम क्यू10 75 मिलीग्राम का संयोजन है, जिसका उपयोग महिलाओं में ओव्यूलेशन (अंडोत्सर्ग) को प्रेरित करने के लिए किया जाता है। यह उन महिलाओं के लिए है जो गर्भधारण करने की कोशिश कर रही हैं लेकिन उन्हें पीसीओएस, अनियमित मासिक धर्म या अस्पष्ट बांझपन के कारण ओव्यूलेशन में समस्या है। क्लोमिफीन हार्मोन के स्तर को बढ़ाकर अंडाशय को उत्तेजित करता है, जिससे अंडे का उत्पादन और रिलीज होता है। कोएंजाइम क्यू10 एक एंटीऑक्सीडेंट है जो अंडे की गुणवत्ता में सुधार करने में मदद कर सकता है। यह दवा केवल डॉक्टर की सलाह पर ही लेनी चाहिए और इसका सेवन मासिक धर्म चक्र के विशिष्ट दिनों में पांच दिनों तक किया जाता है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में गर्म लहरें (हॉट फ्लैश), मूड स्विंग, स्तन में कोमलता, मतली, पेट फूलना और सिरदर्द शामिल हैं। कुछ महिलाओं को धुंधली दृष्टि या दोहरी दृष्टि जैसी दृश्य गड़बड़ी हो सकती है, जिसके लिए तुरंत डॉक्टर से संपर्क करना चाहिए। ओवेरियन हाइपरस्टिमुलेशन सिंड्रोम एक गंभीर लेकिन दुर्लभ जटिलता है, जिसमें पेट में तेज दर्द, सूजन और वजन में तेजी से वृद्धि हो सकती है। कोएंजाइम क्यू10 आमतौर पर सुरक्षित होता है, लेकिन कभी-कभी पेट की खराबी या अनिद्रा हो सकती है।
सुरक्षा सलाह: इस दवा को अपने डॉक्टर के निर्देशानुसार ही लें, आमतौर पर मासिक धर्म चक्र के एक विशिष्ट दिन से शुरू करके पांच दिनों तक। अपनी मर्जी से खुराक न बढ़ाएं या घटाएं। नियमित जांच, जैसे पेल्विक अल्ट्रासाउंड, कराते रहें। यदि आपको धुंधली दृष्टि या चक्कर आए तो वाहन चलाने से बचें। गर्भावस्था के दौरान इस दवा का सेवन न करें। शराब और अंगूर का जूस न लें। अपने डॉक्टर को अन्य सभी दवाओं और सप्लीमेंट्स के बारे में बताएं। दवा को कमरे के तापमान पर, धूप और नमी से दूर, बच्चों की पहुंच से बाहर रखें।
💊 Smartova 50 Combipack Uses & Benefits
[{"condition":"Ovulatory dysfunction in polycystic ovary syndrome (PCOS)","description":"This medicine is used to induce ovulation in women with PCOS who have irregular or absent menstrual cycles and are trying to conceive.","evidence":"Well-established"},{"condition":"Unexplained infertility","description":"It may be prescribed to stimulate ovulation in women with unexplained infertility to increase the chances of pregnancy.","evidence":"Well-established"},{"condition":"Luteal phase defect","description":"Sometimes used to support ovulation and improve luteal phase in women with short menstrual cycles or low progesterone.","evidence":"Limited"},{"condition":"Male infertility (idiopathic oligospermia or asthenospermia)","description":"In some cases, this medicine is used off-label in men to improve sperm count and motility, though evidence is limited.","evidence":"Limited"}]
Off-label uses: [{"condition":"Male hypogonadism","description":"Rarely used to stimulate testosterone production in men with low testosterone due to secondary hypogonadism.","evidence":"Limited"},{"condition":"Gynecomastia","description":"Occasionally used off-label to treat breast enlargement in men, but not a standard approach.","evidence":"Limited"}]
Primary treatment for: Ovulatory dysfunction
Also treats: Polycystic ovary syndrome (PCOS), Unexplained infertility, Luteal phase defect
📋 Drug Information
| Generic Name(s) | Clomiphene (50mg) + Coenzyme Q10 (75mg) |
| Brand Name | Smartova 50 Combipack |
| Manufacturer | Pharmanova India Drugs Pvt Ltd |
| Packaging / Form | strip of 10 kit (Allopathy) |
| Therapeutic Class | |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture, heat, and direct sunlight. Do not refrigerate unless specified by the manufacturer. Keep in the original container, tightly closed, and out of reach of children. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the packaging. |
| WHO Guideline | Not established from the available information. Clomiphene is widely recognized as a first-line treatment for ovulation induction in anovulatory infertility, but specific WHO recommendations may vary. |
| ICMR Guideline | Not established from the available information. ICMR guidelines for infertility management may include clomiphene as a first-line agent for ovulation induction. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Clomiphene is a selective estrogen receptor modulator that binds to estrogen receptors in the hypothalamus and pituitary gland, blocking the negative feedback of estrogen. This leads to increased secretion of gonadotropin-releasing hormone, which in turn raises follicle-stimulating hormone and luteinizing hormone levels. Higher FSH and LH stimulate ovarian follicular growth and ovulation. Coenzyme Q10 is a fat-soluble antioxidant that participates in mitochondrial electron transport and ATP production. It helps protect cells from oxidative damage and may improve oocyte quality and ovarian function, complementing clomiphene's ovulatory effects.
Mechanism Steps
💡 How to Take Smartova 50 Combipack
Strength: Each tablet contains clomiphene 50 mg and coenzyme Q10 75 mg in an immediate-release oral tablet.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet (clomiphene 50 mg + coenzyme Q10 75 mg) taken orally once daily for five consecutive days, starting on day 2, 3, 4, or 5 of the menstrual cycle, or as directed by your fertility specialist. If ovulation does not occur, your doctor may increase the dose to 100 mg (two tablets) daily for five days in the next cycle. The maximum recommended dose is 150 mg per day for five days. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and response to treatment. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | This medicine is not intended for use in postmenopausal women. Safety and efficacy in elderly patients have not been established. Use in women over 65 is not recommended. |
| Renal Impairment | Not established from the available information. Caution is advised in patients with renal impairment. Dose adjustment may be necessary based on clinical judgment. |
| Hepatic Impairment | Not established from the available information. This medicine is contraindicated in patients with liver disease. Use with caution in patients with mild hepatic impairment, and monitor liver function closely. |
| Maximum Daily Dose | The maximum recommended daily dose is 150 mg of clomiphene (three tablets) for five days per cycle. Coenzyme Q10 maximum daily dose is not established; typical supplemental doses range from 75 mg to 200 mg per day. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of Smartova 50 Combipack
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Hormonal contraceptives | Major | |
| Tamoxifen | Major | |
| Thyroid hormones | Moderate | |
| Antidiabetic drugs | Moderate | |
| Cimetidine | Moderate | |
| Paracetamol | Minor | |
| Antacids | Minor | |
| Grapefruit juice | Moderate | |
| Alcohol | Moderate |
🚨 Major Interactions
- Warfarin
- Hormonal contraceptives
- Tamoxifen
⚡ Moderate Interactions
- Thyroid hormones
- Antidiabetic drugs
- Cimetidine
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can increase the risk of liver problems and may worsen side effects such as dizziness, mood changes, and nausea. Chronic alcohol use may also reduce the effectiveness of clomiphene and coenzyme Q10.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to clomiphene, coenzyme Q10, or any component of the formulation","Pregnancy or suspected pregnancy","Liver disease or abnormal liver function tests","Abnormal uterine bleeding of undetermined cause","Ovarian cysts (except those due to polycystic ovary syndrome)","History of blood clots (thrombophlebitis, deep vein thrombosis, pulmonary embolism)","Breastfeeding"]
⚠️ Warnings & Precautions
["This medicine should only be used under the supervision of a fertility specialist or gynecologist.","Visual disturbances may occur; stop the medicine and consult your doctor immediately if you experience blurred vision or double vision.","Ovarian hyperstimulation syndrome (OHSS) is a rare but serious complication; report rapid weight gain, abdominal swelling, or pelvic pain.","Long-term use may increase the risk of ovarian tumors; use the lowest effective dose for the shortest duration.","Inform your doctor if you have a history of liver disease, kidney disease, or blood clots.","Avoid alcohol and grapefruit juice while taking this medicine.","Use effective contraception if you are not trying to conceive, as this medicine may harm a developing fetus.","Do not drive or operate machinery if you experience dizziness or visual changes."]
🤱 Lactation Safety
Not established from the available information. It is not known whether clomiphene or coenzyme Q10 passes into breast milk. Breastfeeding is not recommended while taking this medicine unless specifically approved by your doctor.
💊 Overdose Management
Overdose of this medicine may cause severe nausea, vomiting, hot flashes, abdominal pain, visual disturbances, and ovarian hyperstimulation. If you suspect an overdose, seek emergency medical attention immediately. Treatment is supportive and symptomatic, with close monitoring of vital signs and ovarian status. There is no specific antidote.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember, unless it is almost time for your next dose. If it is more than half the dosing interval, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up. If you miss multiple doses, contact your doctor for advice.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, usually once daily for five days starting on a specific day of your menstrual cycle. Do not increase or decrease the dose without medical advice. You should have regular check-ups, including pelvic examination and ultrasound, to monitor ovarian response. Avoid driving or operating heavy machinery if you experience blurred vision or dizziness. Inform your doctor if you are pregnant or suspect you might be pregnant, as this medicine should not be used during pregnancy. Use effective contraception if you are not trying to conceive, unless your doctor advises otherwise. Avoid alcohol while taking this medicine, as it may worsen side effects and affect liver function. Tell your doctor about all other medicines, supplements, and herbal products you are taking, especially hormonal treatments. Store this medicine at room temperature, away from moisture and direct sunlight, and keep it out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
This medicine is not intended for use in postmenopausal women. Safety and efficacy in elderly patients have not been established. Use in women over 65 is not recommended.
🤰 Pregnancy Planning (TTC)
This medicine is used to help you conceive. If you are planning pregnancy, take it exactly as prescribed. Once pregnancy is confirmed, stop the medicine immediately and consult your doctor. Do not take this medicine if you are already pregnant, as it may harm the developing baby.
🏥 Post-Surgery Considerations
Not established from the available information. If you are planning surgery, inform your surgeon and doctor about this medicine. It may need to be stopped before surgery due to the risk of blood clots.
🦷 Dental Procedures
Not established from the available information. Inform your dentist if you are taking this medicine. No specific precautions are known, but maintain good oral hygiene.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe while taking this medicine. However, if you experience dizziness, visual changes, or severe pelvic pain, avoid strenuous activity and consult your doctor. High-impact exercises may increase the risk of ovarian torsion in women with enlarged ovaries.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, visual changes, or mood swings, which can affect your ability to drive or operate machinery. Avoid driving if you experience these symptoms. Most women can continue their normal daily activities, but it is important to attend regular monitoring appointments, which may require time off work.
🛑 When to Stop This Medicine
Stop taking this medicine and contact your doctor immediately if you experience visual disturbances, severe pelvic pain, rapid weight gain, or signs of an allergic reaction. Do not stop the medicine without consulting your doctor, as abrupt discontinuation may affect your treatment plan. If you become pregnant, stop the medicine and inform your doctor right away.
📅 Long-Term Use Effects
Long-term use of clomiphene beyond 6 cycles is generally not recommended due to potential risks of ovarian hyperstimulation and possible increased risk of ovarian tumors. Regular monitoring of liver function and ovarian status is advised. Coenzyme Q10 is generally safe for long-term use, but its effects on fertility may take several months to manifest. Always consult your doctor before extending treatment.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
An aromatase inhibitor that may be used as an alternative for ovulation induction, especially in PCOS.
Evidence: Well-establishedInsulin sensitizer that can improve ovulation in women with PCOS, often used in combination with clomiphene.
Evidence: Well-establishedInjectable hormones used for ovulation induction when oral agents fail.
Evidence: Well-establishedWeight loss, diet, and exercise can improve ovulation and fertility naturally.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information. There are no known interactions between this medicine and vaccines. However, consult your doctor before receiving any vaccine while on fertility treatment.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. Store at room temperature and protect from direct sunlight. If crossing time zones, continue taking the medicine at the same time each day as prescribed; consult your doctor if adjustments are needed. Check customs regulations for carrying prescription medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Ovulation typically occurs 5 to 10 days after the last dose of this medicine. It may take 1 to 3 cycles to achieve ovulation.
A: No, this is a prescription medicine and must only be taken under the supervision of a qualified doctor.
A: Stop the medicine immediately and contact your doctor right away, as visual disturbances can be a sign of a serious side effect.
A: Yes, clomiphene can increase the chance of multiple pregnancies, including twins, because it may stimulate more than one egg to mature.
A: Yes, it is commonly prescribed for ovulation induction in women with PCOS, but only under medical supervision.
🤔 Common Patient Concerns
🔄 Substitutes for Smartova 50 Combipack
View AllAlternative brands with exact same active ingredient:
-
e ova plus 50mg tabletKoye Pharmaceuticals Pvt ltd ₹327.19 18% CHEAPER
-
clomeva nc 50mg tabletVIVO Life Science ₹399.00 SAME PRICE
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine guarantees pregnancy.
Fact: This medicine induces ovulation but does not guarantee pregnancy. Many factors affect fertility. - Myth: This medicine is safe to take without monitoring.
Fact: It requires regular monitoring by a doctor to avoid serious complications like ovarian hyperstimulation. - Myth: Coenzyme Q10 in this medicine is just a vitamin and has no effect.
Fact: Coenzyme Q10 is an antioxidant that may improve egg quality and support mitochondrial function, though evidence is still evolving. - Myth: This medicine can be taken for as long as you want.
Fact: Treatment cycles are limited, usually to 3-6 cycles, because long-term use may increase risks.
🔄 Alternative Options
Generic Alternatives
- Clomiphene citrate 50 mg tablet
- Coenzyme Q10 75 mg capsule
Brand Alternatives
- e ova plus 50mg tablet