prozyl f syrup - Furazolidone (50mg) + Metronidazole (100mg) medicine

Amcidal Suspension: Complete Medicine Guide

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🏭 Acron Pharmaceuticals 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 29, 2026
🤰 Pregnancy Category Not recommended. This medicine is contraindicated in pregnancy due to potential risk to the fetus. Consult your doctor for alternative treatments. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for giardiasis and amoebiasis; limited for other uses.
Reviewed by
SaathiMed Expert Panel | Oct 29, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Seizures or confusion
  • Numbness or tingling in hands or feet
  • Yellowing of skin or eyes
  • Difficulty breathing or swelling of face
  • Unusual bleeding or bruising

If experiencing severe symptoms, call emergency services immediately.

What is prozyl f syrup used for?

This medicine is a combination of furazolidone and metronidazole used to treat certain intestinal infections like giardiasis and amoebiasis. It works by killing the parasites and bacteria causing the infection. It should be taken exactly as prescribed and alcohol must be avoided.

  • Generic Name: Furazolidone (50mg) + Metronidazole (100mg)
  • Manufacturer: Acron Pharmaceuticals
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 prozyl f syrup के बारे में (Hindi Summary)

उपयोग: यह दवा फ्यूराज़ोलिडोन और मेट्रोनिडाज़ोल का संयोजन है, जिसका उपयोग पेट और आंतों के कुछ संक्रमणों जैसे जियार्डिया और अमीबियासिस के इलाज के लिए किया जाता है। यह कीटाणुओं और परजीवियों को मारकर काम करती है। इसे डॉक्टर के निर्देशानुसार ही लें और शराब का सेवन बिल्कुल न करें।

साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त, सिरदर्द और मुंह में धातु जैसा स्वाद शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें तंत्रिका संबंधी समस्याएं, दौरे और एलर्जी प्रतिक्रियाएं हो सकती हैं। कोई भी असामान्य लक्षण होने पर तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। उपचार के दौरान और अंतिम खुराक के 48 घंटे बाद तक शराब न पिएं। यदि आपको लीवर या किडनी की समस्या है या आप खून पतला करने वाली दवाएं ले रहे हैं तो डॉक्टर को बताएं। बिना सलाह के दवा न रोकें।

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 prozyl f syrup Uses & Benefits

[{"condition":"Giardiasis","description":"Treatment of diarrhea and intestinal infection caused by Giardia lamblia.","evidence":"Well-established"},{"condition":"Amoebiasis","description":"Treatment of intestinal amoebiasis caused by Entamoeba histolytica.","evidence":"Well-established"},{"condition":"Bacterial diarrhea","description":"May be used for certain bacterial causes of diarrhea, but only when prescribed.","evidence":"Limited"}]

Off-label uses: [{"condition":"Helicobacter pylori eradication","description":"Sometimes included in combination regimens, but not a standard first-line option.","evidence":"Limited"}]

Primary treatment for: Giardiasis

Also treats: Amoebiasis, Bacterial diarrhea

📋 Drug Information

Generic Name(s)Furazolidone (50mg) + Metronidazole (100mg)
Brand Nameprozyl f syrup
ManufacturerAcron Pharmaceuticals
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGASTRO INTESTINAL
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep the bottle tightly closed. Do not refrigerate unless specified.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always prescribe this medicine only when there is a confirmed or strongly suspected protozoal infection.
2
Instruct patients to avoid alcohol completely during and for 48 hours after treatment.
3
Warn patients about the possibility of dark urine, which is harmless.
4
Monitor for neurological symptoms if treatment exceeds 10 days.
5
Consider alternative agents in patients with liver or kidney impairment.
6
Advise patients to take the medicine with food to reduce gastrointestinal upset.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Chronic diarrhea
This medicine is commonly prescribed for parasitic diarrhea.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionFurazolidone is poorly absorbed from the gastrointestinal tract, with most of the drug remaining in the gut lumen. Metronidazole is well absorbed orally, reaching peak plasma concentrations within 1 to 2 hours.
DistributionMetronidazole distributes widely into body tissues and fluids, including cerebrospinal fluid, saliva, and breast milk. Furazolidone's distribution is limited due to poor absorption.
Protein BindingMetronidazole is less than 20% bound to plasma proteins. Furazolidone binding is not well established.
MetabolismMetronidazole is metabolized in the liver by oxidation and glucuronidation. Furazolidone is partially metabolized in the liver and gut.
Half-LifeThe elimination half-life of metronidazole is approximately 8 hours in adults with normal liver function. The half-life of furazolidone is not well established.
ExcretionMetronidazole and its metabolites are excreted primarily in the urine. Furazolidone is excreted mainly in the feces.
BioavailabilityMetronidazole has a bioavailability of approximately 80% or higher. Furazolidone's bioavailability is low due to poor absorption.
Onset of ActionThe onset of action for the combination is not precisely established, but symptomatic improvement in diarrheal illnesses may begin within 24 to 48 hours.
Peak Plasma TimeMetronidazole reaches peak plasma concentrations in 1 to 2 hours. Furazolidone's peak plasma time is not well established.
Duration of ActionThe duration of action depends on the dosing schedule and the treated infection. Metronidazole's effects persist for several hours after each dose.

How It Works

This medicine works through two complementary mechanisms. Furazolidone is reduced by bacterial and protozoal enzymes to reactive intermediates that damage DNA and other cellular components. Metronidazole enters susceptible organisms and is reduced to nitro radical anions that cause DNA strand breakage and inhibit nucleic acid synthesis. The combination disrupts essential microbial functions, leading to cell death.

Mechanism Steps

1
Entry into microorganism: Both furazolidone and metronidazole penetrate susceptible protozoa and bacteria.
2
Reductive activation: Furazolidone is reduced by microbial enzymes, and metronidazole is reduced by ferredoxin-like proteins in anaerobic organisms.
3
DNA damage: The reduced intermediates bind to DNA, causing strand breakage and inhibiting synthesis.
4
Cell death: The cumulative damage leads to microbial cell death.

💡 How to Take prozyl f syrup

Strength: Each 5 mL of suspension contains furazolidone 50 mg and metronidazole 100 mg.

1Shake the bottle well before each use.
2Measure the dose accurately using the provided measuring cup or spoon.
3Take with food to reduce stomach upset.
4Swallow the suspension; do not chew.
5Drink a full glass of water after taking.
6Wash the measuring cup after each use.

Dosage Information

Adult DosageThe usual adult dose of this medicine is determined by the prescribing doctor based on the specific infection being treated. It is typically taken orally, often in divided doses. The exact dose and duration must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-medicate.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the side effects of this medicine. Dose adjustment may be necessary based on renal and hepatic function. Consult a doctor.
Renal ImpairmentDose adjustment may be required in patients with renal impairment. Consult a doctor for individualized dosing.
Hepatic ImpairmentDose adjustment may be required in patients with hepatic impairment. Consult a doctor for individualized dosing.
Maximum Daily DoseNot established from the available information. The maximum daily dose must be determined by a qualified clinician.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Alcohol
Avoid
Can cause disulfiram-like reaction.
Tyramine-rich foods
Limit
Furazolidone is a weak MAO inhibitor.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of prozyl f syrup

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food to reduce nausea. If it persists, consult your doctor.
Metallic taste (Common (5-10%))
Usually temporary. Chewing sugar-free gum or rinsing mouth may help.
Headache (Common (5-10%))
Rest and stay hydrated. Consult doctor if severe or persistent.
Dark urine (Common (5-10%))
This is harmless and resolves after treatment. Stay hydrated.

🚨 Serious Side Effects

Peripheral neuropathy (Rare (<0.1%))
Report numbness, tingling, or weakness to your doctor immediately.
Seizures (Rare (<0.1%))
Seek emergency medical attention if seizures occur.
Blood disorders (Rare (<0.1%))
Report unusual bruising, bleeding, or fatigue to your doctor.

⚠️ Rare Side Effects

Hypersensitivity reactions
Seek immediate medical help if rash, swelling, or difficulty breathing occurs.
Liver toxicity
Report yellowing of eyes or skin, dark urine, or abdominal pain to your doctor.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Alcohol Major
Lithium Major
Phenytoin Moderate
Cimetidine Moderate
Antacids Minor

🚨 Major Interactions

  • Alcohol
  • Warfarin
  • Lithium

⚡ Moderate Interactions

  • Phenytoin
  • Cimetidine

🍷 Alcohol Interaction

Alcohol must be strictly avoided during treatment with this medicine and for at least 48 hours after the last dose. Combining alcohol with metronidazole can cause a disulfiram-like reaction characterized by severe nausea, vomiting, flushing, headache, and rapid heartbeat. Furazolidone may also interact with alcohol and tyramine-rich foods due to its weak monoamine oxidase inhibiting properties.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to furazolidone, metronidazole, or other nitroimidazoles","Pregnancy","Breastfeeding","Children under 1 year of age","Severe liver disease","Severe kidney disease","Alcohol consumption during treatment"]

⚠️ Warnings & Precautions

["Avoid alcohol during and for 48 hours after treatment.","May cause peripheral neuropathy with prolonged use.","Use with caution in patients with liver or kidney impairment.","May interact with blood thinners; monitor INR.","Do not use for longer than prescribed without medical supervision.","May cause dark urine, which is harmless.","Furazolidone is a weak MAO inhibitor; avoid tyramine-rich foods."]

🤱 Lactation Safety

Not recommended. Metronidazole is excreted in breast milk and may affect the infant. Consult your doctor for alternatives.

💊 Overdose Management

Overdose may cause nausea, vomiting, dizziness, and potentially seizures. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not share it with others. Avoid alcohol completely during treatment and for at least 48 hours after the last dose, as it can cause a disulfiram-like reaction with metronidazole. Inform your doctor if you have liver or kidney problems, or if you are taking blood thinners. Do not use this medicine for longer than recommended without medical supervision. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more susceptible to side effects such as dizziness and peripheral neuropathy. Use with caution and monitor closely.

🤰 Pregnancy Planning (TTC)

This medicine is contraindicated in pregnancy. If you are planning pregnancy, consult your doctor for alternative treatments.

🏥 Post-Surgery Considerations

Consult your surgeon before taking this medicine after surgery, as it may interact with other medications.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine, as it may interact with certain anesthetics or antibiotics.

💚 Lifestyle Tips for Better Results

🏃
Drink plenty of fluids to stay hydrated, especially if you have diarrhea.
🥗
Wash your hands thoroughly before eating and after using the toilet.
😴
Avoid sharing food and utensils to prevent spreading infection.
💧
Eat a bland diet until diarrhea resolves.
🧘
Get plenty of rest to help your body recover.

🏋️ Exercise Considerations

Avoid strenuous exercise if you are feeling weak or dehydrated due to diarrhea. Gradually resume activities as you recover.

🥗 Diet Recommendations

Eat bland, easy-to-digest foods like bananas, rice, applesauce, and toast.
Avoid spicy, greasy, or heavy meals.
Stay well hydrated with oral rehydration solutions.
Avoid alcohol and caffeine.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or fatigue. Avoid driving or operating heavy machinery until you know how it affects you. Take time off if you feel unwell.

🛑 When to Stop This Medicine

Do not stop this medicine before completing the full course, even if you feel better. Stopping early may lead to treatment failure or resistance. Consult your doctor if you experience severe side effects.

📅 Long-Term Use Effects

Long-term use of this medicine may increase the risk of peripheral neuropathy and blood disorders. It should only be used for the prescribed duration. Regular monitoring may be required if prolonged therapy is necessary.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Oral rehydration therapy

Essential for managing dehydration from diarrhea.

Evidence: Well-established
Probiotics

May help restore gut flora, but evidence is limited.

Evidence: Limited

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions are established. Consult your doctor for routine vaccinations.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from direct sunlight. If traveling across time zones, adjust dosing times gradually as advised by your doctor. Check customs regulations for carrying prescription medicines. Always keep it in your hand luggage.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old man with persistent diarrhea after a camping trip
He was diagnosed with giardiasis and prescribed this medicine. He took it as directed with food and avoided alcohol. His symptoms improved within three days, and he completed the full course. He reported a metallic taste but no other issues.
💡 Lesson: Taking the medicine with food and completing the full course is important for recovery.
👤 A 28-year-old woman with amoebiasis
She experienced nausea and dark urine while on this medicine. Her doctor reassured her that these were expected side effects. She was advised to stay hydrated and avoid alcohol. She recovered fully after treatment.
💡 Lesson: Common side effects like dark urine are harmless, but patients should be informed to prevent anxiety.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Symptomatic improvement may begin within 24 to 48 hours, but the full course must be completed as prescribed.

Q: Can I take this medicine with food?

A: Yes, taking it with food helps reduce stomach upset.

Q: What should I do if I miss a dose?

A: Take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for prozyl f syrup

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken for any diarrhea.
    Fact: It is only effective for specific infections and should not be used for viral or non-infectious diarrhea.
  • Myth: It is safe to drink alcohol while taking this medicine.
    Fact: Alcohol can cause a serious reaction and must be avoided.

🔄 Alternative Options

Generic Alternatives

  • Furazolidone + Metronidazole suspension

📊 Comparison with Similar Medicines

[{"medicine":"Metronidazole alone","difference":"Single agent, may be less effective for some mixed infections."},{"medicine":"Tinidazole","difference":"Longer half-life, simpler dosing, but not available as suspension."}]

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