Aflate N 250mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe abdominal pain
- Blood in stool or vomit
- Difficulty breathing or swelling of face/lips/throat
- Persistent diarrhea or vomiting
- Signs of dehydration (dry mouth, reduced urine)
- Yellowing of skin or eyes
If experiencing severe symptoms, call emergency services immediately.
What is Penizar-HS Capsule used for?
This medicine contains pancreatin 250mg, a pancreatic enzyme replacement used to treat exocrine pancreatic insufficiency. It helps digest fats, proteins, and carbohydrates. Take it with meals as prescribed by your doctor.
- Generic Name: Pancreatin (250mg)
- Manufacturer: Panacea Biotec Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 Penizar-HS Capsule के बारे में (Hindi Summary)
उपयोग: यह दवा पैन्क्रियाटिन 250mg टैबलेट है, जिसका उपयोग अग्नाशयी अपर्याप्तता (exocrine pancreatic insufficiency) के इलाज के लिए किया जाता है। यह अग्नाशय द्वारा उत्पादित पाचक एंजाइमों की कमी को पूरा करती है, जिससे भोजन का पाचन और पोषक तत्वों का अवशोषण ठीक से हो पाता है। यह दवा वसा, प्रोटीन और कार्बोहाइड्रेट को तोड़ने में मदद करती है। इसे भोजन के साथ लेना चाहिए। यह दवा पुरानी अग्नाशयशोथ, सिस्टिक फाइब्रोसिस, अग्नाशय कैंसर या अग्नाशय सर्जरी के बाद होने वाली समस्याओं में दी जाती है। इसे डॉक्टर की सलाह के बिना न लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में पेट दर्द, जी मिचलाना, उल्टी, दस्त, कब्ज और पेट फूलना शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ समय में ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन यदि आपको त्वचा पर चकत्ते, खुजली, चेहरे या गले में सूजन, सांस लेने में कठिनाई या गंभीर पेट दर्द हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। गोली को पानी के साथ पूरा निगलें, चबाएं नहीं। इसे हमेशा भोजन के साथ लें। खुराक बदलने से पहले डॉक्टर से सलाह लें। यदि खुराक भूल जाएं, तो याद आते ही ले लें, लेकिन अगली खुराक का समय नजदीक हो तो छोड़ दें। दोहरी खुराक न लें। इसे बच्चों की पहुंच से दूर रखें। सूखी और ठंडी जगह पर स्टोर करें। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें।
💊 Penizar-HS Capsule Uses & Benefits
[{"condition":"Exocrine pancreatic insufficiency (EPI)","description":"This medicine replaces missing pancreatic enzymes to help digest food and absorb nutrients in people with EPI due to chronic pancreatitis, cystic fibrosis, or pancreatic surgery.","evidence":"Well-established"},{"condition":"Chronic pancreatitis","description":"Used to manage malabsorption and steatorrhea associated with chronic pancreatitis by supplementing pancreatic enzymes.","evidence":"Well-established"},{"condition":"Cystic fibrosis","description":"Helps improve fat absorption and nutritional status in patients with cystic fibrosis who have pancreatic insufficiency.","evidence":"Well-established"},{"condition":"Pancreatic cancer","description":"May be used to alleviate symptoms of malabsorption in patients with pancreatic tumors causing ductal obstruction.","evidence":"Limited"},{"condition":"Post-pancreatic surgery","description":"Prescribed after pancreatic resection to compensate for loss of enzyme production.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Celiac disease","description":"Sometimes used off-label to aid digestion in celiac disease, though evidence is limited.","evidence":"Limited"},{"condition":"Irritable bowel syndrome (IBS)","description":"Occasionally prescribed off-label for bloating and gas in IBS, but not routinely recommended.","evidence":"Limited"}]
Primary treatment for: Exocrine pancreatic insufficiency
Also treats: Chronic pancreatitis, Cystic fibrosis, Pancreatic cancer, Post-pancreatic surgery
📋 Drug Information
| Generic Name(s) | Pancreatin (250mg) |
| Brand Name | Penizar-HS Capsule |
| Manufacturer | Panacea Biotec Ltd |
| Packaging / Form | strip of 10 capsules (Allopathy) |
| Therapeutic Class | |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by providing exogenous pancreatic enzymes that mimic the natural digestive enzymes produced by the pancreas. The lipase component breaks down fats into fatty acids and glycerol, amylase breaks down carbohydrates into simple sugars, and protease breaks down proteins into amino acids and peptides. These enzymes are released in the duodenum where they facilitate the digestion and absorption of nutrients, compensating for the deficient endogenous enzyme production.
Mechanism Steps
💡 How to Take Penizar-HS Capsule
Strength: Tablet, 250mg
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 1 to 2 tablets taken with each meal or snack, but the exact dose depends on the severity of pancreatic insufficiency and the fat content of the diet. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is required for elderly patients, but individualization by a clinician is recommended based on renal and hepatic function. |
| Renal Impairment | No dose adjustment is required for renal impairment as this medicine acts locally in the gastrointestinal tract. |
| Hepatic Impairment | No dose adjustment is required for hepatic impairment as this medicine acts locally in the gastrointestinal tract. |
| Maximum Daily Dose | The maximum daily dose should not exceed the amount prescribed by your doctor. Typically, doses are adjusted based on the number of meals and snacks. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of Penizar-HS Capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Antacids | Major | |
| Proton pump inhibitors | Moderate | |
| H2 blockers | Moderate | |
| Iron supplements | Minor |
🚨 Major Interactions
- Antacids containing calcium carbonate or magnesium hydroxide
⚡ Moderate Interactions
- Proton pump inhibitors (e.g., omeprazole)
- H2 blockers (e.g., ranitidine)
🍷 Alcohol Interaction
Alcohol may worsen pancreatitis and reduce the effectiveness of this medicine. It is advisable to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to pancreatin or any component of the formulation","Acute pancreatitis","Acute exacerbation of chronic pancreatitis"]
⚠️ Warnings & Precautions
["Do not crush or chew the tablet; swallow whole.","Take with meals and snacks.","Avoid concomitant use with antacids; separate by 2 hours.","Monitor for signs of allergic reaction.","Use with caution in patients with gout or hyperuricemia.","Consult doctor before use in pregnancy or breastfeeding."]
🤱 Lactation Safety
Not established from the available information. Consult your doctor before use while breastfeeding.
💊 Overdose Management
Overdose of this medicine is unlikely to cause serious harm due to its local action. However, if you suspect an overdose, contact your doctor or poison control center immediately. Symptoms may include nausea, vomiting, or diarrhea. Treatment is supportive.
⏰ Missed Dose
If you miss a dose, take it with your next meal if remembered within 1 hour. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Swallow the tablet whole with plenty of water; do not crush or chew unless your doctor advises otherwise. Always take it with meals or snacks to help with digestion. Do not change the dose without consulting your doctor. If you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose. Keep this medicine out of reach of children. Store it at room temperature, away from moisture and heat. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Also, tell your doctor about all other medicines you are taking, especially antacids, as they may affect how this medicine works.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of this medicine. Regular monitoring of renal and hepatic function is advised. No specific dose adjustment is usually required.
🤰 Pregnancy Planning (TTC)
Consult your doctor before planning pregnancy if you are taking this medicine. The safety of this medicine during pregnancy is not well established.
🏥 Post-Surgery Considerations
This medicine may be prescribed after pancreatic surgery to aid digestion. Follow your surgeon's instructions regarding dosing and timing.
🦷 Dental Procedures
No specific precautions are needed for dental procedures. Inform your dentist about all medicines you are taking.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
No specific exercise restrictions are associated with this medicine. However, if you feel unwell or experience abdominal pain, avoid strenuous exercise and consult your doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine does not usually affect your ability to drive or operate machinery. However, if you experience dizziness or nausea, avoid these activities until you feel better.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or allergic reactions, stop immediately and seek medical help.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe when taken as prescribed. However, high doses may rarely cause fibrosing colonopathy, especially in children with cystic fibrosis. Regular monitoring of nutritional status and symptoms is recommended. Consult your doctor for periodic reviews.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Eating a low-fat diet can help manage symptoms of pancreatic insufficiency.
Evidence: Well-establishedFat-soluble vitamin supplements may be needed to prevent deficiencies.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, consult your doctor before receiving any live vaccines if you are immunocompromised.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from moisture. If traveling across time zones, take it with meals as usual. Check customs regulations for carrying prescription medicines. Always carry enough supply for the duration of your trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 30 minutes to 1 hour after ingestion, as it begins to digest food in the duodenum.
A: No, it should be taken with meals or snacks to be effective.
A: Pediatric dosing is not established. Consult a pediatrician.
🤔 Common Patient Concerns
🔄 Substitutes for Penizar-HS Capsule
View AllAlternative brands with exact same active ingredient:
-
aflate n 250mg tabletDigmedi Pvt Ltd ₹50.00 89.8% CHEAPER
-
enzar-hs capsuleTorrent Pharmaceuticals Ltd ₹867.32 77% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure pancreatitis.
Fact: This medicine does not cure pancreatitis; it only replaces missing enzymes to aid digestion. - Myth: You can take this medicine without food.
Fact: This medicine should be taken with meals to be effective. - Myth: This medicine is safe for everyone.
Fact: It is contraindicated in acute pancreatitis and in people allergic to pancreatin.
🔄 Alternative Options
Generic Alternatives
- Pancreatin 250mg tablet