Alphadol 0.25mcg Capsule: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Confusion or altered mental status
- Excessive thirst and frequent urination
- Severe nausea, vomiting, or abdominal pain
- Muscle weakness or bone pain
- Irregular heartbeat or palpitations
- Blood in urine or painful urination
- Yellowing of skin or eyes
If experiencing severe symptoms, call emergency services immediately.
What is alphadol 0.25mcg capsule used for?
Alphadol 0.25mcg capsule contains alfacalcidol, a vitamin D analogue used to treat low calcium levels and bone disease in chronic kidney disease, osteoporosis, and related conditions. It works by increasing calcium absorption and promoting bone health. It requires regular monitoring of calcium levels.
- Generic Name: Alfacalcidol
- Manufacturer: Panacea Biotec Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 alphadol 0.25mcg capsule के बारे में (Hindi Summary)
उपयोग: यह दवा अल्फाकैल्सिडॉल नामक सक्रिय तत्व से बनी है और यह विटामिन डी की श्रेणी में आती है। इसका उपयोग मुख्य रूप से शरीर में कैल्शियम की कमी को पूरा करने, किडनी की बीमारी से जुड़ी हड्डियों की समस्या, ऑस्टियोपोरोसिस, रिकेट्स और ऑस्टियोमलेशिया के इलाज में किया जाता है। यह दवा कैल्शियम के अवशोषण को बढ़ाती है और हड्डियों को मजबूत बनाने में मदद करती है। यह डॉक्टर के परामर्श के बिना नहीं लेनी चाहिए और नियमित रूप से कैल्शियम की जांच करानी चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, कब्ज, सिरदर्द, मुंह सूखना और कमजोरी शामिल हैं। गंभीर दुष्प्रभावों में रक्त में कैल्शियम का स्तर बढ़ना, गुर्दे की पथरी, और दिल की धड़कन में गड़बड़ी हो सकती है। अगर आपको भ्रम, अत्यधिक प्यास, बार-बार पेशाब आना, या मांसपेशियों में कमजोरी महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे पानी के साथ निगलें, चबाएं नहीं। हर दिन एक ही समय पर लेने की कोशिश करें। डॉक्टर समय-समय पर कैल्शियम और किडनी की जांच करेंगे, इसलिए सभी जांचें समय पर कराएं। बिना डॉक्टर की सलाह के अतिरिक्त विटामिन डी या कैल्शियम सप्लीमेंट न लें। अगर आप गर्भवती हैं या स्तनपान करा रही हैं, तो डॉक्टर को बताएं। दवा को बच्चों से दूर, ठंडी और सूखी जगह पर रखें।
💊 alphadol 0.25mcg capsule Uses & Benefits
[{"condition":"Hypocalcaemia","description":"Used to treat low calcium levels in the blood, especially when caused by chronic kidney disease or hypoparathyroidism.","evidence":"Well-established"},{"condition":"Renal osteodystrophy","description":"Helps manage bone disease in people with chronic kidney disease by regulating calcium and phosphate balance.","evidence":"Well-established"},{"condition":"Osteoporosis","description":"Supports bone health and may be used as an adjunct to other treatments to reduce fracture risk.","evidence":"Established"},{"condition":"Rickets and osteomalacia","description":"Treats softening and weakening of bones due to vitamin D deficiency or impaired metabolism.","evidence":"Well-established"},{"condition":"Hypoparathyroidism","description":"Helps maintain normal calcium levels when the parathyroid glands do not produce enough parathyroid hormone.","evidence":"Established"}]
Off-label uses: [{"condition":"Psoriasis","description":"Sometimes used off-label for its effects on skin cell differentiation, but evidence is limited.","evidence":"Limited"},{"condition":"Prevention of corticosteroid-induced osteoporosis","description":"May be considered in some patients, but not a standard first-line approach.","evidence":"Limited"}]
Primary treatment for: Hypocalcaemia
Also treats: Renal osteodystrophy, Osteoporosis, Rickets, Osteomalacia, Hypoparathyroidism
📋 Drug Information
| Generic Name(s) | Alfacalcidol |
| Brand Name | Alphadol |
| Manufacturer | Panacea Biotec Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | VITAMINS MINERALS NUTRIENTS |
| Action Class | Vitamins |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep in the original container, tightly closed, away from moisture and direct sunlight. Do not refrigerate unless specified by the manufacturer. |
| Shelf Life | Typically 24 months from the date of manufacture, but check the expiry date on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Alfacalcidol is a synthetic vitamin D analogue that is converted in the liver by 25-hydroxylation to 1,25-dihydroxyvitamin D3 (calcitriol), the active form of vitamin D. This active metabolite binds to vitamin D receptors in the intestine, bone, kidney, and parathyroid glands. In the intestine, it increases the absorption of calcium and phosphate. In bone, it promotes normal bone mineralization and may stimulate bone formation. In the kidney, it reduces calcium excretion and increases phosphate reabsorption. In the parathyroid glands, it suppresses parathyroid hormone secretion. Together, these actions help normalize calcium and phosphate levels and support healthy bone metabolism.
Mechanism Steps
💡 How to Take alphadol 0.25mcg capsule
Strength: Alfacalcidol 0.25 microgram immediate-release capsule
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is individualized by a qualified clinician based on the indication, severity of the condition, and the patient's calcium and renal function. For hypocalcaemia and renal osteodystrophy, a common starting dose is 0.25 micrograms once daily, which may be adjusted up to 1 microgram daily. For osteoporosis, doses typically range from 0.25 to 1 microgram daily. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Regular monitoring of serum calcium is essential to guide dose adjustments. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine and are at higher risk of hypercalcaemia. Start with a lower dose and monitor calcium levels closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with renal impairment, alfacalcidol can be used but requires careful monitoring of calcium and phosphate levels. Dose adjustment may be necessary. It is often used in chronic kidney disease patients, but under close supervision. |
| Hepatic Impairment | In patients with hepatic impairment, the conversion of alfacalcidol to its active form may be reduced. Dose adjustment and close monitoring are recommended. Consult a hepatologist. |
| Maximum Daily Dose | The maximum daily dose is typically 1 microgram, but it may be higher in some cases under strict medical supervision. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of alphadol 0.25mcg capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Thiazide diuretics | Major | |
| Digoxin | Major | |
| Vitamin D supplements | Major | |
| Calcium supplements | Moderate | |
| Corticosteroids | Moderate | |
| Anticonvulsants | Moderate | |
| Cholestyramine | Moderate | |
| Orlistat | Minor | |
| Mineral oil | Minor |
🚨 Major Interactions
- Thiazide diuretics
- Digoxin and other cardiac glycosides
- Vitamin D supplements or analogues
- Calcium-containing antacids or supplements
⚡ Moderate Interactions
- Corticosteroids
- Anticonvulsants (phenytoin, phenobarbital)
- Cholestyramine
🍷 Alcohol Interaction
Alcohol may affect calcium metabolism and increase the risk of bone loss. It is advisable to limit alcohol consumption while taking this medicine. Excessive alcohol intake can also worsen the underlying condition being treated.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypercalcaemia (high blood calcium levels)","Hypervitaminosis D (excess vitamin D)","Known hypersensitivity to alfacalcidol or any component of the capsule","Hyperphosphataemia (high phosphate levels) in some cases","Severe renal impairment without monitoring"]
⚠️ Warnings & Precautions
["Monitor serum calcium and phosphate regularly to avoid hypercalcaemia.","Use with caution in patients with a history of kidney stones.","Avoid concurrent use of other vitamin D supplements unless prescribed.","Patients with sarcoidosis may be more sensitive to vitamin D effects.","Elderly patients may be more prone to hypercalcaemia.","Inform your doctor if you are taking digoxin or thiazide diuretics.","Do not exceed the prescribed dose.","If hypercalcaemia occurs, stop the medicine and consult your doctor immediately."]
🤱 Lactation Safety
Alfacalcidol may pass into breast milk. Use with caution and only if prescribed by a doctor. Monitor the infant for signs of hypercalcaemia if the mother is on high doses.
💊 Overdose Management
Overdose can cause severe hypercalcaemia, leading to nausea, vomiting, dehydration, confusion, and cardiac arrhythmias. Treatment includes stopping the medicine, intravenous fluids, and medications to lower calcium levels (such as calcitonin or bisphosphonates). Seek emergency medical attention immediately if overdose is suspected.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not take more or less than the recommended dose. Swallow the capsule whole with a glass of water, with or without food, but try to take it at the same time each day. Your doctor will order regular blood tests to check your calcium, phosphate, and kidney function. Keep all follow-up appointments. Avoid taking extra vitamin D or calcium supplements unless your doctor specifically tells you to, as this can increase the risk of high calcium levels. Tell your doctor if you have a history of kidney stones, heart disease, or sarcoidosis. If you are pregnant, planning to become pregnant, or breastfeeding, inform your doctor before taking this medicine. Do not share this medicine with anyone else, even if they have similar symptoms. Store the capsules in their original container at room temperature, away from moisture and direct sunlight. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of hypercalcaemia and should be monitored closely. Lower starting doses may be appropriate.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor. Adequate vitamin D is important, but high doses of alfacalcidol should be avoided unless prescribed.
🏥 Post-Surgery Considerations
After surgery, inform your surgeon about this medicine. Monitoring of calcium levels may be necessary, especially if you are unable to eat normally.
🦷 Dental Procedures
Inform your dentist about this medicine. No specific precautions are usually needed, but maintain good oral hygiene.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
If you experience dizziness or muscle weakness due to hypercalcaemia, avoid strenuous exercise and consult your doctor. Otherwise, regular low-impact exercise is beneficial for bone health.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine generally does not affect your ability to work. However, if you experience side effects like dizziness or confusion, avoid driving or operating heavy machinery until you feel better.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience signs of hypercalcaemia, your doctor may advise temporarily stopping the medicine. Always follow medical advice.
📅 Long-Term Use Effects
Long-term use requires regular monitoring of calcium, phosphate, and kidney function. Prolonged hypercalcaemia can lead to kidney stones, nephrocalcinosis, and soft tissue calcification. Adherence to monitoring and dose adjustments helps prevent these complications. Periodic assessment of bone health is also recommended.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another active vitamin D analogue that may be used instead.
Evidence: Well-establishedVitamin D3 supplement for deficiency states.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are established. Continue routine vaccinations as per schedule.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid temperature extremes. If traveling across time zones, maintain your dosing schedule as close to usual as possible; consult your doctor for specific advice. Store away from direct sunlight and moisture. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: It may take several weeks to see full effects on calcium levels and bone health.
A: Inform your doctor about all medicines, especially thiazide diuretics, digoxin, and calcium supplements.
A: Take it as soon as you remember, but skip if it's almost time for the next dose. Do not double dose.
🤔 Common Patient Concerns
🔄 Substitutes for alphadol 0.25mcg capsule
View AllAlternative brands with exact same active ingredient:
-
vitalpha soft gelatin capsuleKarnataka Antibiotics & Pharmaceuticals Ltd ₹59.68 46.9% CHEAPER
-
decalcid 0.25mcg tabletEast West Pharma ₹61.51 45.3% CHEAPER
-
alphadol-c soft gelatin capsulePanacea Biotec Ltd ₹115.88 3.1% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Alphadol is a calcium supplement.
Fact: Alphadol is a vitamin D analogue that helps your body absorb calcium; it is not a calcium supplement itself. - Myth: You can take alphadol without monitoring.
Fact: Regular blood tests for calcium are essential to prevent serious side effects. - Myth: Alphadol works immediately.
Fact: It may take several weeks to see full benefits.
🔄 Alternative Options
Generic Alternatives
- Alfacalcidol 0.25mcg capsule (various manufacturers)
Brand Alternatives
- Alphadol 0.25mcg capsule (Panacea Biotec Ltd)