Hopstin 1 Million IU Injection (Colistin Sulphate): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Decreased urine output or no urine output
- Swelling of face, lips, or throat
- Difficulty breathing or shortness of breath
- Severe dizziness or fainting
- Tingling or numbness in hands or feet
- Unusual bleeding or bruising
- Seizures
If experiencing severe symptoms, call emergency services immediately.
What is myxitin 1million iu injection used for?
This medicine is a polymyxin antibiotic injection containing colistin sulphate, used to treat serious multidrug-resistant Gram-negative infections. It works by disrupting the bacterial outer membrane, leading to bacterial death. It is given by a healthcare professional and requires monitoring of kidney function.
- Generic Name: Colistin Sulphate (1Million IU)
- Manufacturer: La Renon Healthcare Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 myxitin 1million iu injection के बारे में (Hindi Summary)
उपयोग: यह दवा कोलिस्टिन सल्फेट का इंजेक्शन है, जिसका उपयोग गंभीर और मल्टीड्रग-रेसिस्टेंट ग्राम-नेगेटिव बैक्टीरिया संक्रमणों के इलाज के लिए किया जाता है। यह अस्पताल में डॉक्टर की देखरेख में दी जाती है। यह उन संक्रमणों के लिए दी जाती है जो अन्य एंटीबायोटिक्स से ठीक नहीं हो रहे होते।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में किडनी पर असर, झुनझुनी, चक्कर आना और इंजेक्शन की जगह पर दर्द शामिल हैं। गंभीर दुष्प्रभावों में किडनी फेलियर, सांस लेने में कठिनाई और एलर्जी शामिल हो सकते हैं। किसी भी असामान्य लक्षण पर तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल डॉक्टर या नर्स द्वारा अस्पताल में दी जानी चाहिए। इसे घर पर खुद न लगाएं। अपने डॉक्टर को अपनी सभी दवाओं के बारे में बताएं। किडनी की जांच नियमित रूप से कराते रहें। पेशाब कम आना, सूजन, झुनझुनी या सांस लेने में तकलीफ हो तो तुरंत डॉक्टर से संपर्क करें।
💊 myxitin 1million iu injection Uses & Benefits
[{"condition":"Multidrug-resistant Gram-negative infections","description":"Used to treat serious infections caused by bacteria resistant to multiple other antibiotics, including carbapenem-resistant Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae.","evidence":"Well-established in hospital settings"},{"condition":"Complicated urinary tract infections","description":"Prescribed for severe urinary tract infections caused by multidrug-resistant Gram-negative bacteria when other options are limited.","evidence":"Established"},{"condition":"Ventilator-associated pneumonia","description":"Used in hospitalized patients with pneumonia caused by resistant Gram-negative organisms, often as part of combination therapy.","evidence":"Established"},{"condition":"Bloodstream infections","description":"Administered for bacteremia caused by multidrug-resistant Gram-negative bacteria, usually in combination with other antibiotics.","evidence":"Established"},{"condition":"Intra-abdominal infections","description":"Used in complicated intra-abdominal infections caused by resistant Gram-negative bacteria when other treatments are not suitable.","evidence":"Limited to specific resistant organisms"}]
Off-label uses: [{"condition":"Aerosolized therapy for respiratory infections","description":"Sometimes used off-label via nebulization for treating resistant respiratory infections, though this is not a standard approved route for this product.","evidence":"Limited"},{"condition":"Intraventricular or intrathecal administration for central nervous system infections","description":"Rarely used off-label for treating multidrug-resistant Gram-negative meningitis or ventriculitis when intravenous therapy alone is insufficient.","evidence":"Limited"}]
Primary treatment for: Multidrug-resistant Gram-negative infections
Also treats: Complicated urinary tract infections, Ventilator-associated pneumonia, Bloodstream infections, Intra-abdominal infections
📋 Drug Information
| Generic Name(s) | Colistin Sulphate (1Million IU) |
| Brand Name | myxitin 1million iu injection |
| Manufacturer | La Renon Healthcare Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Cell membrane active agent |
| Route of Administration | Parenteral (intravenous or intramuscular injection) |
| Storage | Store below 25°C, protected from light. Reconstituted solution should be used immediately or stored as directed by the manufacturer. Do not freeze. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Colistin is included in the WHO Model List of Essential Medicines for the treatment of multidrug-resistant Gram-negative infections. It is recommended as part of combination therapy for infections caused by carbapenem-resistant organisms. |
| ICMR Guideline | The Indian Council of Medical Research (ICMR) recommends colistin as a reserve antibiotic for the treatment of infections caused by carbapenem-resistant Gram-negative bacteria, based on culture and sensitivity reports. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine belongs to the polymyxin class of antibiotics. It works by binding to lipopolysaccharides in the outer membrane of Gram-negative bacteria, displacing calcium and magnesium ions. This disrupts the membrane integrity, leading to leakage of intracellular contents and bacterial cell death. It is bactericidal against many Gram-negative organisms, including multidrug-resistant strains.
Mechanism Steps
💡 How to Take myxitin 1million iu injection
Strength: Each vial contains colistin sulphate equivalent to 1 million international units of colistin base activity.
Dosage Information
| Adult Dosage | The dose of this medicine must be individualized by a qualified clinician based on the type and severity of infection, patient weight, and kidney function. Typical adult doses range from 2.5 to 5 mg/kg per day of colistin base activity, divided into 2 to 4 doses, administered intravenously. For intramuscular administration, doses may vary. Renal dose adjustment is required. Always follow the prescribed regimen. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced kidney function and are at higher risk of nephrotoxicity. Dose adjustment based on renal function is necessary. Monitor closely. |
| Renal Impairment | Dose adjustment is required in patients with renal impairment. The dose should be reduced according to creatinine clearance. A loading dose may be given, followed by adjusted maintenance doses. Consult a clinician for specific guidance. |
| Hepatic Impairment | No specific dose adjustment is recommended for hepatic impairment, but monitor liver function. |
| Maximum Daily Dose | The maximum daily dose should not exceed the recommended dose determined by a clinician based on renal function. Typically, the maximum is 5 mg/kg per day of colistin base activity. |
Dosage Timeline
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of myxitin 1million iu injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Aminoglycosides | Major | |
| Amphotericin B | Major | |
| Vancomycin | Major | |
| Neuromuscular blockers | Major | |
| Loop diuretics | Moderate | |
| Cephalosporins | Moderate | |
| Anticholinergics | Minor |
🚨 Major Interactions
- Other nephrotoxic drugs (e.g., aminoglycosides, amphotericin B, vancomycin)
- Neuromuscular blocking agents (e.g., vecuronium, succinylcholine)
⚡ Moderate Interactions
- Loop diuretics (e.g., furosemide)
- Cephalosporins
🍷 Alcohol Interaction
Alcohol may increase the risk of kidney and liver problems. Avoid alcohol while receiving this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to colistin or polymyxin antibiotics","Severe renal impairment without dose adjustment","Myasthenia gravis (may worsen muscle weakness)"]
⚠️ Warnings & Precautions
["Nephrotoxicity: Monitor kidney function closely; dose adjust in renal impairment.","Neurotoxicity: May cause tingling, numbness, dizziness, or seizures; use with caution in patients with neurological disorders.","Neuromuscular blockade: May cause respiratory paralysis; avoid concomitant use with neuromuscular blockers.","Superinfection: Prolonged use may lead to overgrowth of non-susceptible organisms.","Pregnancy and lactation: Use only if clearly needed.","Pediatric use: Safety and efficacy not established in children under 12 years."]
🤱 Lactation Safety
It is not known whether this medicine is excreted in human breast milk. Because many drugs are excreted in human milk, caution should be exercised when administered to a nursing woman.
💊 Overdose Management
Overdose may cause severe nephrotoxicity, neurotoxicity, and neuromuscular blockade. Treatment is supportive and symptomatic. Hemodialysis may be considered to remove the drug in cases of severe toxicity. There is no specific antidote.
⏰ Missed Dose
Since this medicine is administered by a healthcare professional, missed doses are unlikely. If a dose is missed, contact your healthcare provider for instructions. Do not attempt to self-administer a double dose.
Additional Safety Advice
This medicine must be given only by a qualified healthcare professional in a hospital or clinic setting. Do not attempt to self-administer this injection. Inform your doctor about all medicines you take, especially other antibiotics, muscle relaxants, and kidney-affecting drugs. Your doctor will monitor your kidney function and may adjust the dose. Report any decrease in urine output, swelling, tingling, weakness, or difficulty breathing immediately. Do not stop treatment early without medical advice, even if you feel better.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of kidney damage from this medicine. Dose adjustment based on renal function is crucial. Monitor closely for signs of neurotoxicity.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss with your doctor. This medicine should be used during pregnancy only if clearly needed. Effective contraception may be advised during treatment.
🏥 Post-Surgery Considerations
This medicine may be used to treat surgical site infections caused by resistant bacteria. Monitor for signs of infection and kidney function.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine. No specific precautions are required, but maintain good oral hygiene.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise during treatment, especially if you experience dizziness or weakness. Light activity may be allowed as tolerated.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital setting, so it may require hospitalization. You should not drive or operate machinery if you feel dizzy or weak.
🛑 When to Stop This Medicine
Do not stop this medicine without your doctor's advice. Stopping early may lead to treatment failure or resistance. Your doctor will decide when to stop based on your clinical response and test results.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of kidney damage and nerve problems. Regular monitoring of kidney function is essential. If used for prolonged periods, watch for signs of superinfection. The duration of therapy is determined by your doctor based on your response.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on susceptibility, other antibiotics like polymyxin B, tigecycline, or ceftazidime-avibactam may be used.
Evidence: Well-establishedCombining colistin with other antibiotics may improve efficacy and reduce resistance.
Evidence: Established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, ensure you are up to date with routine vaccinations as advised by your doctor.
📦 Storage Guide
✅ DO
Store below 25°C, protected from light
❌ DON'T
Do not freeze
✅ DO
Use reconstituted solution immediately
❌ DON'T
Do not store reconstituted solution for long periods
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✈️ Traveling with This Medicine
This medicine is administered in a hospital setting, so travel is not applicable. If you are discharged with a prescription for home infusion, carry the medicine in its original packaging with a copy of your prescription. Store it as directed, and ensure you have enough supply for your trip. Check customs regulations for carrying injectable antibiotics.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within hours after administration, but clinical improvement may take a few days.
A: No, this medicine must be given by a healthcare professional in a hospital or clinic setting.
A: Avoid alcohol and other nephrotoxic drugs. Inform your doctor about all medicines you take.
🤔 Common Patient Concerns
🔄 Substitutes for myxitin 1million iu injection
View AllAlternative brands with exact same active ingredient:
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pmx 1million iu injectionIntas Pharmaceuticals Ltd ₹587.50 34.1% CHEAPER
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unilistin 1million iu injectionUnited Biotech Pvt Ltd ₹731.25 18% CHEAPER
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polymxe 1million iu injectionBharat Serums & Vaccines Ltd ₹769.93 13.6% CHEAPER
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viscostin 1miu injectionVistica Life Sciences ₹777.00 12.8% CHEAPER
-
colisig 1 injectionSignity Pharmaceuticals Pvt Ltd ₹837.73 6% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Colistin is a first-line antibiotic for all infections.
Fact: Colistin is a reserve antibiotic used only for multidrug-resistant Gram-negative infections when other options are limited. - Myth: Colistin can be taken orally for systemic infections.
Fact: Colistin is not absorbed orally and must be given by injection for systemic infections. - Myth: Colistin is safe for everyone.
Fact: Colistin can cause kidney damage and nerve problems, and requires close monitoring.
🔄 Alternative Options
Generic Alternatives
- Colistin sulphate injection 1 million IU
Brand Alternatives
- Colistin 1 MIU injection
- Colistimethate sodium injection