colisig 1 injection

4.4 (15 reviews)

Colistin Sulphate (1Million IU)

🏭 Signity Pharmaceuticals Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 23, 2026

⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 23, 2026

What is colisig 1 injection used for?

Bestomycin-DS Suspension (Colistin Sulphate) is used to treat GASTRO INTESTINAL. It contains Colistin Sulphate (1Million IU), which Disrupts bacterial cell membrane by binding to lipopolysaccharides, increasing p. Always consult your doctor before use. Take as prescribed.

Generic Name: Colistin Sulphate
Manufacturer: Signity Pharmaceuticals Pvt Ltd
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 colisig 1 injection Uses & Benefits

Treatment of acute gastroenteritis caused by susceptible Gram-negative bacteria; intestinal decontamination.

Off-label uses: Selective digestive decontamination in ICU patients

📋 Drug Information

Generic Name(s)	Colistin Sulphate
Brand Name	Bestomycin-DS Suspension
Manufacturer	Signity Pharmaceuticals Pvt Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	GASTRO INTESTINAL
Action Class	Cell membrane active agent
Route of Administration	Oral
Storage	Store at room temperature (20-25°C); protect from light and moisture.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionPoorly absorbed from gastrointestinal tract; acts locally in the gut.

DistributionMinimal systemic distribution due to poor absorption; primarily confined to GI tract.

Protein BindingLow (approximately 10-20%)

MetabolismNot significantly metabolized.

Half-LifeNot applicable for oral formulation due to minimal systemic absorption.

ExcretionPrimarily excreted unchanged in feces.

BioavailabilityNegligible (<1%)

Onset of ActionRapid (within hours) for local GI effect.

Peak Plasma TimeNot applicable due to minimal absorption.

Duration of Action6-8 hours (local GI effect)

How It Works

Disrupts bacterial cell membrane by binding to lipopolysaccharides, increasing permeability and causing cell death.

Mechanism Steps

1Colistin binds to lipopolysaccharides in the outer membrane of Gram-negative bacteria.

2Displaces calcium and magnesium ions from the membrane.

3Increases membrane permeability leading to leakage of cytoplasmic contents.

💡 How to Take colisig 1 injection

Follow your doctor's prescription exactly.

⚠️ Side Effects of colisig 1 injection

✅ Common Side Effects

Nausea
Vomiting
Diarrhea
Abdominal pain

🚨 Serious Side Effects

Neurotoxicity (paresthesias, dizziness)
Nephrotoxicity (rare with oral form)

⚠️ Rare Side Effects

Allergic reactions
Superinfection

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Neuromuscular blocking agents	Major	Enhanced neuromuscular blockade
Aminoglycosides	Major	Increased nephrotoxicity and ototoxicity risk
Amphotericin B	Major	Increased nephrotoxicity risk
Cephalosporins	Moderate	Possible additive nephrotoxicity
Vancomycin	Moderate	Increased nephrotoxicity risk
Probiotics	Minor	Reduced efficacy of probiotics

🚨 Major Interactions

Neuromuscular blocking agents
Aminoglycosides
Amphotericin B

⚡ Moderate Interactions

Cephalosporins
Vancomycin

ℹ️ Minor Interactions

Probiotics

🍽️ Food Interactions

No significant food interactions.

🍷 Alcohol Interaction

No known interaction.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to colistin or polymyxins.

📊 Monitoring Parameters

Renal function, stool culture, signs of neurotoxicity (rare).

🤱 Lactation Safety

Not recommended; minimal systemic absorption but safety not established.

💊 Overdose Management

Gastric lavage; supportive care; monitor renal function.

⏰ Missed Dose

Take as soon as remembered; skip if almost time for next dose; do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 23, 2026

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🔄 Substitutes for colisig 1 injection

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Alternative brands with exact same active ingredient (Colistin Sulphate (1Million IU)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Regular Customer Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Verified User Jul 10, 2026

Effective and reliable. Worked as expected.