Colist 1million IU Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Decreased urine output or no urine output
- Difficulty breathing or shortness of breath
- Severe muscle weakness or paralysis
- Seizures or convulsions
- Swelling of face, lips, or throat
- Severe abdominal pain or vomiting blood
- Yellowing of skin or eyes
If experiencing severe symptoms, call emergency services immediately.
What is colisig 1 injection used for?
This medicine is a polymyxin antibiotic injection used to treat serious multidrug-resistant Gram-negative bacterial infections. It works by disrupting the bacterial cell membrane, leading to bacterial death. It is given by healthcare professionals in a hospital setting.
- Generic Name: Colistin Sulphate
- Manufacturer: Signity Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 colisig 1 injection के बारे में (Hindi Summary)
उपयोग: यह दवा कोलिस्टिन सल्फेट का इंजेक्शन है, जिसका उपयोग गंभीर और मल्टीड्रग-रेसिस्टेंट ग्राम-नेगेटिव बैक्टीरिया के संक्रमण के इलाज के लिए किया जाता है। यह अस्पताल में डॉक्टर की देखरेख में दी जाती है। यह निमोनिया, मूत्र मार्ग संक्रमण, रक्त संक्रमण और मेनिनजाइटिस जैसी बीमारियों में प्रभावी है। यह दवा बैक्टीरिया की कोशिका झिल्ली को तोड़कर उन्हें मार देती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में गुर्दे की समस्या, नसों में झनझनाहट, चक्कर आना, मतली, उल्टी और इंजेक्शन की जगह पर दर्द शामिल हैं। गंभीर दुष्प्रभावों में गुर्दे की विफलता, सांस लेने में कठिनाई, दौरे और एलर्जी प्रतिक्रिया हो सकती है। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल अस्पताल में डॉक्टर या नर्स द्वारा दी जानी चाहिए। इसे स्वयं न लगाएं। इलाज के दौरान गुर्दे की कार्यप्रणाली और नसों की निगरानी की जाती है। अगर आपको गुर्दे की बीमारी, मांसपेशियों की कमजोरी या सांस लेने में तकलीफ है तो डॉक्टर को पहले बताएं। इस दवा के साथ शराब न लें। स्तनपान कराने वाली महिलाएं इस दवा का उपयोग न करें।
💊 colisig 1 injection Uses & Benefits
[{"condition":"Multidrug-resistant Gram-negative infections","description":"Used to treat serious infections caused by bacteria such as Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae that are resistant to other antibiotics.","evidence":"Well-established"},{"condition":"Hospital-acquired pneumonia","description":"Effective against ventilator-associated pneumonia and other hospital-acquired lung infections caused by resistant Gram-negative bacteria.","evidence":"Well-established"},{"condition":"Complicated urinary tract infections","description":"Used for severe urinary tract infections caused by multidrug-resistant organisms.","evidence":"Well-established"},{"condition":"Bloodstream infections","description":"Administered for bacteremia caused by resistant Gram-negative bacteria.","evidence":"Well-established"},{"condition":"Meningitis","description":"May be used intrathecally or intraventricularly for Gram-negative meningitis resistant to other antibiotics.","evidence":"Limited"}]
Off-label uses: [{"condition":"Aerosolized therapy for respiratory infections","description":"Sometimes used as inhaled colistin for patients with cystic fibrosis or bronchiectasis colonized with multidrug-resistant Pseudomonas.","evidence":"Limited"},{"condition":"Intraventricular therapy for central nervous system infections","description":"Occasionally used for ventriculitis or meningitis when intravenous therapy alone is insufficient.","evidence":"Limited"}]
Primary treatment for: Multidrug-resistant Gram-negative infections
Also treats: Hospital-acquired pneumonia, Complicated urinary tract infections, Bloodstream infections, Meningitis
📋 Drug Information
| Generic Name(s) | Colistin Sulphate |
| Brand Name | Bestomycin-DS Suspension |
| Manufacturer | Signity Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Cell membrane active agent |
| Route of Administration | Parenteral (intramuscular or intravenous) |
| Storage | Store below 25°C. Protect from light. Do not freeze. Reconstituted solution should be used immediately or stored as directed by the manufacturer. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is a polymyxin antibiotic that works by binding to the lipopolysaccharide component of the outer membrane of Gram-negative bacteria. This binding displaces calcium and magnesium ions, destabilizing the membrane and increasing its permeability. As a result, essential intracellular contents leak out, leading to bacterial cell death. This medicine is bactericidal and concentration-dependent.
Mechanism Steps
💡 How to Take colisig 1 injection
Strength: Colistin sulphate 1 million IU injection
Dosage Information
| Adult Dosage | The dose of this medicine must be individualized by a qualified clinician based on the indication, severity of infection, patient weight, and renal function. Typical adult doses range from 2.5 to 5 mg/kg per day of colistin base activity, divided into 2 to 4 doses, with a loading dose often recommended. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced renal function and are at higher risk of nephrotoxicity. Dose should be adjusted based on renal function. Monitor closely. |
| Renal Impairment | Dose adjustment is required in patients with renal impairment. The dose should be reduced according to creatinine clearance. Consult a clinician for specific dosing. |
| Hepatic Impairment | No specific dose adjustment is established for hepatic impairment. Use with caution. |
| Maximum Daily Dose | The maximum daily dose should not exceed the recommended dose determined by a qualified clinician based on the patient's condition and renal function. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of colisig 1 injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Aminoglycosides | Major | |
| Neuromuscular blocking agents | Major | |
| NSAIDs | Major | |
| Loop diuretics | Moderate | |
| Cyclosporine | Moderate |
🚨 Major Interactions
- Aminoglycosides (e.g., gentamicin, amikacin)
- Neuromuscular blocking agents (e.g., vecuronium)
- Nonsteroidal anti-inflammatory drugs (NSAIDs)
⚡ Moderate Interactions
- Loop diuretics (e.g., furosemide)
- Cyclosporine
🍷 Alcohol Interaction
Alcohol may increase the risk of kidney and liver problems. Avoid alcohol while receiving this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to colistin or any component of the formulation","Myasthenia gravis","Severe renal impairment without appropriate dose adjustment"]
⚠️ Warnings & Precautions
["Nephrotoxicity: Monitor kidney function closely.","Neurotoxicity: May cause dizziness, confusion, or seizures.","Respiratory paralysis: Use with caution in patients with neuromuscular disorders.","Superinfection: May lead to overgrowth of non-susceptible organisms.","Not for intrathecal use unless specifically prepared."]
🤱 Lactation Safety
It is not known whether this medicine passes into breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or the medicine, taking into account the importance of the medicine to the mother.
💊 Overdose Management
Overdose may cause severe nephrotoxicity, neurotoxicity, and respiratory paralysis. Treatment is supportive and symptomatic. Hemodialysis may be considered to remove the drug in cases of severe toxicity. Contact a poison control center immediately.
⏰ Missed Dose
If you miss a dose, contact your healthcare provider immediately. Do not attempt to self-administer a double dose. Your provider will determine the appropriate action based on your dosing schedule.
Additional Safety Advice
This medicine must only be given by a healthcare professional in a hospital or clinic setting. Do not attempt to self-administer. Your kidney function, urine output, and neurological status will be monitored closely during treatment. Inform your doctor if you have any kidney disease, muscle weakness, or breathing problems before receiving this medicine. Avoid taking other medicines that can harm the kidneys, such as aminoglycosides or nonsteroidal anti-inflammatory drugs, unless specifically approved by your doctor. Do not breastfeed while receiving this medicine, as it may pass into breast milk and affect the baby. Use effective contraception during treatment and for a period after, as advised by your doctor. If you miss a dose, contact your healthcare provider immediately; do not try to catch up on your own. Keep all follow-up appointments for blood tests and monitoring.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of kidney and nerve toxicity. Dose adjustment based on renal function is essential. Monitor closely for any adverse effects.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before starting this medicine. It should be used during pregnancy only if clearly needed. Use effective contraception during treatment.
🏥 Post-Surgery Considerations
This medicine may be used to treat surgical site infections caused by resistant bacteria. Inform your surgeon if you are on this medicine before any surgery.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine. No specific precautions are established, but maintain good oral hygiene.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise during treatment, especially if you experience muscle weakness or fatigue. Consult your doctor before resuming any exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue. Avoid driving or operating heavy machinery until you know how it affects you. You may need to take time off work during treatment, especially if hospitalized.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Stopping early may lead to incomplete treatment and bacterial resistance. Your doctor will determine the appropriate duration based on your infection.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of kidney damage and nerve damage. Regular monitoring of kidney function and neurological status is essential. Prolonged use may also lead to bacterial resistance. Use only for the prescribed duration and follow up with your doctor for any persistent symptoms.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on susceptibility, other antibiotics like polymyxin B or newer beta-lactams may be used.
Evidence: Well-establishedCombining with other antibiotics may enhance efficacy and reduce resistance.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, ensure you are up to date with routine vaccinations as advised by your doctor.
📦 Storage Guide
✅ DO
Store below 25°C in a dry place.
❌ DON'T
Do not freeze the vial.
✅ DO
Keep in original container until use.
❌ DON'T
Do not use if the solution is discolored or contains particles.
✅ DO
Protect from light.
❌ DON'T
Do not store in bathroom cabinet.
✈️ Traveling with This Medicine
This medicine is typically administered in a hospital setting and is not for self-administration during travel. If you are prescribed this medicine for outpatient use, carry it in its original packaging with the prescription label. Carry a copy of your prescription and a letter from your doctor explaining the medical need. Store it as directed, away from direct sunlight and extreme temperatures. Check with the airline and destination country about regulations for carrying injectable antibiotics. Do not pack it in checked luggage; keep it in your carry-on. If you need to travel with this medicine, ensure you have enough supply and arrange for administration by a healthcare professional at your destination.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 1 to 2 hours after administration, but clinical improvement may take a few days.
A: No, this medicine is given by injection only. It is not absorbed orally.
A: Pediatric dosing is not established. Consult a pediatrician for individualized dosing.
🤔 Common Patient Concerns
🔄 Substitutes for colisig 1 injection
View AllAlternative brands with exact same active ingredient:
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pmx 1million iu injectionIntas Pharmaceuticals Ltd ₹587.50 29.9% CHEAPER
-
unilistin 1million iu injectionUnited Biotech Pvt Ltd ₹731.25 12.7% CHEAPER
-
polymxe 1million iu injectionBharat Serums & Vaccines Ltd ₹769.93 8.1% CHEAPER
-
viscostin 1miu injectionVistica Life Sciences ₹777.00 7.2% CHEAPER
-
myxitin 1million iu injectionLa Renon Healthcare Pvt Ltd ₹891.56 6.4% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Colistin is a first-line antibiotic for all infections.
Fact: Colistin is reserved for multidrug-resistant Gram-negative infections due to its toxicity. - Myth: Colistin can be taken orally for systemic infections.
Fact: Colistin is not absorbed orally and must be given by injection for systemic infections. - Myth: Colistin is safe for everyone.
Fact: Colistin can cause kidney and nerve damage and is contraindicated in certain conditions.
🔄 Alternative Options
Generic Alternatives
- Colistin sulphate injection (generic)
Brand Alternatives
- Colist 1million IU injection