angispan - tr 2.5mg capsule - Nitroglycerin (2.5mg) medicine

angispan - tr 2.5mg capsule - Uses, Price, Side Effects & Substitutes

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๐Ÿญ USV Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 27, 2026
๐Ÿคฐ Pregnancy Category C ๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Jun 27, 2026

What is angispan - tr 2.5mg capsule used for?

Angispan - TR 2.5mg Capsule (Nitroglycerin) is used to treat CARDIAC. It contains Nitroglycerin (2.5mg), which Nitroglycerin is converted to nitric oxide (NO) in smooth muscle cells, activati. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Nitroglycerin
  • Manufacturer: USV Ltd
  • Form: Allopathy
  • Pregnancy Category: C
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

๐Ÿ’Š angispan - tr 2.5mg capsule Uses & Benefits

Prophylaxis of angina pectoris, long-term management of chronic stable angina.

Off-label uses: Heart failure (acute decompensated), hypertensive emergencies, anal fissures (topical).

โš–๏ธ Pros & Cons

Benefits

  • โœ… Din mein ek baar lene se angina attacks ka control 24 ghante tak rehta hai.
  • โœ… Blood vessels ko chauda karke heart tak blood flow improve karta hai.
  • โœ… Regular use se seene ke dard ki frequency aur severity kam ho jati hai.

Drawbacks

  • โŒ Sir mein dard (headache) aam hai, khaas kar shuruat mein, par dheere-dheere kam ho jata hai.
  • โŒ BP low ho sakta hai, jisse chakkar ya behoshi jaisi feel ho sakti hai.
  • โŒ Kuch logon ko face aur gale ki redness (flushing) ho sakti hai.

๐Ÿ“‹ Drug Information

Generic Name(s)Nitroglycerin
Brand NameAngispan - TR 2.5mg Capsule
ManufacturerUSV Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassCARDIAC
Action ClassNO Donors
Route of AdministrationOral (sustained-release capsule).
StorageStore at room temperature (20-25ยฐC) in a tight, light-resistant container.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed from the gastrointestinal tract; undergoes extensive first-pass metabolism.
DistributionWidely distributed; volume of distribution approximately 3 L/kg.
Protein BindingApproximately 60% bound to plasma proteins.
MetabolismExtensively metabolized in the liver by glutathione-organic nitrate reductase and possibly by cytochrome P450 enzymes.
Half-Life1-4 minutes (parent drug); active metabolites have longer half-lives.
ExcretionRenal excretion of metabolites; less than 1% excreted unchanged.
BioavailabilityLow due to first-pass metabolism; sustained-release formulation improves bioavailability.
Onset of ActionWithin 30-60 minutes for sustained-release capsule.
Peak Plasma Time2-4 hours for sustained-release formulation.
Duration of ActionUp to 8-12 hours for sustained-release formulation.

How It Works

Nitroglycerin is converted to nitric oxide (NO) in smooth muscle cells, activating guanylate cyclase, increasing cGMP, leading to vasodilation.

Mechanism Steps

1Nitroglycerin is absorbed and undergoes denitration in smooth muscle cells.
2Releases nitric oxide (NO) via enzymatic and non-enzymatic pathways.
3NO activates soluble guanylate cyclase (sGC).

๐Ÿ’ก How to Take angispan - tr 2.5mg capsule

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of angispan - tr 2.5mg capsule

โœ… Common Side Effects

  • Headache
  • Dizziness
  • Lightheadedness
  • Flushing
  • Orthostatic hypotension
  • Tachycardia

๐Ÿšจ Serious Side Effects

  • Severe hypotension
  • Syncope
  • Methemoglobinemia (rare)
  • Paradoxical bradycardia

โš ๏ธ Rare Side Effects

  • Allergic reactions
  • Exfoliative dermatitis
  • Angioedema

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Sildenafil Major Severe hypotension and syncope
Tadalafil Major Severe hypotension and syncope
Vardenafil Major Severe hypotension and syncope
Riociguat Major Severe hypotension
Alcohol Moderate Additive hypotension
Antihypertensives Moderate Increased hypotensive effect
Beta-blockers Moderate Enhanced antianginal effect, risk of bradycardia
Calcium channel blockers Moderate Additive hypotension and vasodilation
Aspirin Moderate Increased antiplatelet effect
Heparin Minor Possible decreased heparin effect
Acetylcysteine Minor Enhanced vasodilation

๐Ÿšจ Major Interactions

  • Sildenafil
  • Tadalafil
  • Vardenafil
  • Riociguat

โšก Moderate Interactions

  • Alcohol
  • Antihypertensives
  • Beta-blockers
  • Calcium channel blockers
  • Aspirin

โ„น๏ธ Minor Interactions

  • Heparin
  • Acetylcysteine

๐Ÿฝ๏ธ Food Interactions

High-fat meals may delay absorption.

๐Ÿท Alcohol Interaction

Additive vasodilation and hypotension.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to nitrates, severe anemia, increased intracranial pressure, concurrent use with PDE-5 inhibitors or riociguat, constrictive pericarditis, pericardial tamponade, hypertrophic obstructive cardiomyopathy.

๐Ÿ“Š Monitoring Parameters

Blood pressure, heart rate, relief of angina symptoms, tolerance development.

๐Ÿคฑ Lactation Safety

Unknown; caution advised.

Additional Safety Advice

Alcohol

Alcohol se BP aur girega aur chakkar aane ka khatra badhega, isliye peene se bachein.

Pregnancy

Doctor se bina poche pregnancy mein na lein, kyunki iske effect unborn baby par clear nahi hain.

Driving

Shuru ke kuch dino mein chakkar ya dizziness aa sakti hai, isliye gadi chalane se pehle dekhen ki aapko kaise feel ho raha hai.

Liver

Liver ki bimari ho to doctor ko batayein, dose adjustment ki zaroorat ho sakti hai.

Kidney

Kidney patients ke liye generally safe hai, lekin doctor se ek baar zaroor consult karein.

Diet & Lifestyle

Low-salt diet lein, processed aur tala hua khana kam karein, aur roz halki walking karein. Omega-3 (jaise fish, flaxseed) heart ke liye faydemand hai.

๐Ÿ’Š Overdose Management

Supportive care; elevate legs to improve venous return; administer fluids; if severe, use vasopressors (e.g., phenylephrine). Avoid epinephrine.

โฐ Missed Dose

Take as soon as remembered unless close to next dose; do not double dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 27, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for angispan - tr 2.5mg capsule

View All

Alternative brands with exact same active ingredient (Nitroglycerin (2.5mg)):

Medical Note: Always consult your doctor before switching medications.

โ“ Frequently Asked Questions

Q: What is angispan - tr 2.5mg capsule used for (ke fayde)?

A: Ye capsule angina pectoris (seene ka dard) ko rokne ke liye diya jata hai. Ye dawai regular use se heart tak blood flow badhakar dard ke attacks ko control karti hai.

Q: Is angispan - tr 2.5mg capsule safe to use in pregnancy?

A: Pregnancy mein iska use tab hi kiya jata hai jab doctor ko clearly fayda nuksan se zyada lage. Bina doctor ki salah ke ise pregnancy mein na lein.

Q: What are the side effects (nuksan) of angispan - tr 2.5mg capsule?

A: Aam side effects mein sir dard, chakkar, garmi lagna ya face ka laal hona (flushing), aur BP ka low hona shamil hai. Ye aksar shuruat mein hote hain aur dheere-dheere kam ho jate hain.

Q: How to take angispan - tr 2.5mg capsule (Khali pet ya khane ke baad)?

A: Is capsule ko khali pet ya khane ke baad le sakte hain, lekin har roz ek hi time par lein. Pura glass water ke saath nigal lein, ise chew ya crush na karein.

Q: Can I take angispan - tr 2.5mg capsule with alcohol?

A: Nahi, alcohol is dawai ke saath nahi lena chahiye. Alcohol BP ko aur gira sakta hai jisse chakkar, behoshi ya serious problems ho sakti hain.

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