Ex Spa M 135mg/5mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of face, lips, or throat
- Yellowing of skin or eyes (jaundice)
- Severe abdominal pain or persistent vomiting
- Unusual bleeding or bruising
- Severe drowsiness or confusion
- Seizures or loss of consciousness
- Signs of withdrawal (anxiety, tremors, insomnia) after stopping
If experiencing severe symptoms, call emergency services immediately.
What is ibotris 135mg/5mg tablet used for?
This medicine is a combination of mebeverine (an antispasmodic) and chlordiazepoxide (an anxiolytic) used to treat irritable bowel syndrome (IBS) and functional bowel disorders. It helps relieve abdominal pain, cramps, and anxiety-related gut symptoms. It is usually taken two to three times daily before meals, but the dose must be individualized by a doctor. It can cause drowsiness, so avoid driving and alcohol. Do not use for long periods without medical review.
- Generic Name: Mebeverine (135mg) + Chlordiazepoxide (5mg)
- Manufacturer: Ravenmac Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ibotris 135mg/5mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा मेबेवेरिन और क्लोरडायजेपॉक्साइड का संयोजन है, जिसका उपयोग इरिटेबल बाउल सिंड्रोम (IBS) और अन्य कार्यात्मक आंत्र विकारों में पेट दर्द, ऐंठन और बेचैनी को कम करने के लिए किया जाता है। यह आंतों की मांसपेशियों को आराम देती है और चिंता को कम करती है। इसका सेवन डॉक्टर के निर्देशानुसार ही करें।
साइड इफेक्ट्स: आम दुष्प्रभावों में नींद आना, चक्कर आना, मुंह सूखना, थकान और जी मिचलाना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, रक्त विकार या लीवर की समस्या हो सकती है। यदि सांस लेने में कठिनाई, चेहरे या गले में सूजन, या पीलिया हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। शराब और अन्य नींद लाने वाली दवाओं से बचें। जब तक आपको इसका असर पता न चल जाए, वाहन न चलाएं। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। दवा को बच्चों से दूर रखें।
💊 ibotris 135mg/5mg tablet Uses & Benefits
[{"condition":"Irritable bowel syndrome (IBS)","description":"Relieves abdominal pain, cramping, and discomfort associated with IBS by relaxing gut smooth muscle and reducing anxiety.","evidence":"Well-established for mebeverine; chlordiazepoxide component has limited evidence for IBS but is used for anxiety-related gut symptoms."},{"condition":"Functional bowel disorders","description":"Used to manage symptoms of spasm and anxiety in functional gastrointestinal disorders.","evidence":"Limited; combination use is based on clinical experience."}]
Off-label uses: [{"condition":"Anxiety-associated gastrointestinal symptoms","description":"Sometimes prescribed off-label for patients with anxiety and concurrent gut spasm.","evidence":"Limited"}]
Primary treatment for: Irritable bowel syndrome (IBS)
Also treats: Functional bowel disorders, Anxiety-related gastrointestinal symptoms
📋 Drug Information
| Generic Name(s) | Mebeverine (135mg) + Chlordiazepoxide (5mg) |
| Brand Name | ibotris 135mg/5mg tablet |
| Manufacturer | Ravenmac Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with distinct mechanisms. Mebeverine is a musculotropic antispasmodic that acts directly on the smooth muscle of the gastrointestinal tract. It blocks sodium channels and reduces calcium influx, leading to muscle relaxation and relief of spasms without affecting normal peristalsis. Chlordiazepoxide is a benzodiazepine that enhances the inhibitory effect of gamma-aminobutyric acid (GABA) at GABA-A receptors in the central nervous system, producing anxiolytic, sedative, and muscle relaxant effects. Together, they address both the muscular and psychological components of functional bowel disorders.
Mechanism Steps
💡 How to Take ibotris 135mg/5mg tablet
Strength: Tablet containing Mebeverine 135 mg and Chlordiazepoxide 5 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally two to three times daily, preferably before meals. However, the exact dose and frequency must be individualized by a qualified clinician based on the indication, severity of symptoms, age, and renal and hepatic function. Do not self-adjust the dose. This medicine is intended for short-term use; prolonged use should be reviewed regularly by your doctor. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of chlordiazepoxide, especially drowsiness and cognitive impairment. Use with caution and lower doses may be appropriate. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose adjustment may be necessary. Consult a clinician. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Chlordiazepoxide undergoes hepatic metabolism; dose reduction may be required. Consult a clinician. |
| Maximum Daily Dose | The maximum daily dose should not exceed the prescribed amount. Typically, the maximum recommended dose is one tablet three times daily, but this must be confirmed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ibotris 135mg/5mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Alcohol | Major | |
| Opioids | Major | |
| MAO inhibitors | Major | |
| CNS depressants | Moderate | |
| Oral contraceptives | Moderate | |
| Cimetidine | Moderate | |
| Antacids | Minor | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- Alcohol
- Opioids (e.g., morphine, codeine)
- MAO inhibitors
⚡ Moderate Interactions
- CNS depressants (e.g., barbiturates, sedatives)
- Oral contraceptives
- Cimetidine
🍷 Alcohol Interaction
Alcohol should be completely avoided while taking this medicine. Alcohol enhances the central nervous system depressant effects of chlordiazepoxide, leading to increased drowsiness, dizziness, impaired coordination, and risk of respiratory depression. It may also worsen gastrointestinal symptoms.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to mebeverine, chlordiazepoxide, or any component","Severe liver disease","Severe kidney disease","Myasthenia gravis","Severe respiratory insufficiency","Sleep apnea","Pregnancy (especially first trimester) unless clearly needed","Breastfeeding"]
⚠️ Warnings & Precautions
["May cause drowsiness; avoid driving or operating machinery.","Avoid alcohol and other CNS depressants.","Do not stop abruptly after prolonged use; taper gradually.","Use with caution in elderly and debilitated patients.","May impair memory and cognitive function.","Not recommended for children unless prescribed by a specialist.","May cause dependence with long-term use.","Inform your doctor if you have a history of substance abuse."]
🤱 Lactation Safety
Chlordiazepoxide is excreted in breast milk and may cause sedation in the infant. Mebeverine is not known to be excreted in breast milk. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose may cause severe drowsiness, confusion, coma, respiratory depression, and cardiovascular collapse. Seek emergency medical attention immediately. Treatment is supportive and symptomatic. Flumazenil may be used as an antidote for benzodiazepine overdose but should be used with caution. Gastric lavage may be considered if taken recently.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration. Avoid alcohol and other central nervous system depressants while taking this medicine, as they can increase drowsiness and dizziness. Do not drive or operate heavy machinery until you know how this medicine affects you. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Do not use this medicine for longer than prescribed without medical review. Keep out of reach of children. Store at room temperature away from moisture and heat. If you miss a dose, take it as soon as you remember unless it is almost time for the next dose; do not double the dose.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the sedative and cognitive effects of chlordiazepoxide. They may also have reduced liver and kidney function, requiring lower doses. Use with caution and monitor closely for falls, confusion, and excessive drowsiness.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Chlordiazepoxide may not be safe during pregnancy, especially in the first trimester. Your doctor may recommend alternative treatments.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist if you are taking this medicine before surgery. It may interact with anesthetic agents and increase sedation. Your doctor may advise you to stop it temporarily before surgery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may interact with local anesthetics or sedatives used during dental procedures. It may also cause dry mouth, which can affect dental health.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause drowsiness and dizziness. Avoid strenuous exercise or activities requiring alertness until you know how it affects you. If you experience dizziness, stop exercising and consult your doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and dizziness, which may affect your ability to drive, operate machinery, or perform tasks requiring mental alertness. It is advisable to avoid such activities until you know how the medicine affects you. Inform your employer if your job involves safety-sensitive tasks.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor, especially if you have been taking it for more than a few weeks. Abrupt discontinuation can cause withdrawal symptoms such as anxiety, insomnia, and tremors. Your doctor will guide you on tapering the dose gradually.
📅 Long-Term Use Effects
Long-term use of this medicine, particularly the chlordiazepoxide component, can lead to tolerance, dependence, and withdrawal symptoms upon discontinuation. It may also cause cognitive impairment and memory problems. Regular medical review is essential, and the medicine should be used for the shortest duration possible. Monitor for signs of liver toxicity and blood disorders with prolonged use.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help reduce IBS symptoms by identifying trigger foods.
Evidence: Well-establishedYoga, meditation, and cognitive behavioral therapy can reduce anxiety and gut symptoms.
Evidence: Well-establishedMay help restore gut flora balance and reduce symptoms.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information. Consult your doctor regarding any vaccine timing.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from extreme heat or moisture. If crossing time zones, adjust dosing times gradually as advised by your doctor. Do not pack it in checked luggage; keep it in your carry-on bag. Check local customs regulations for controlled substances, as chlordiazepoxide may be regulated.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Mebeverine starts working within 30-60 minutes, while chlordiazepoxide's anxiolytic effect also begins within 30-60 minutes. However, full benefits for IBS may take a few days to weeks.
A: You should inform your doctor about any liver disease. This medicine may need dose adjustment or may not be suitable for you.
A: The safety of this combination during pregnancy is not well established. Consult your doctor before taking it.
🤔 Common Patient Concerns
🔄 Substitutes for ibotris 135mg/5mg tablet
View AllAlternative brands with exact same active ingredient:
-
iboverin 135mg/5mg tabletMac Millon Pharmaceuticals Pvt Ltd ₹60.94 43% CHEAPER
-
meb cz 135mg/5mg tabletLaxian Healthcare ₹70.31 34.2% CHEAPER
-
overspa x 135mg/5mg tabletGreen Bract Lifesciences ₹75.00 29.8% CHEAPER
-
mebinova-plus tabletSchelling Pharma Private Limited ₹82.50 22.8% CHEAPER
-
mebolic c 135mg/5mg tabletNeuracle Lifesciences Pvt Ltd ₹84.38 21.1% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure IBS permanently.
Fact: This medicine helps manage symptoms but does not cure IBS. Lifestyle and dietary changes are also important. - Myth: It is safe to take this medicine for months without a doctor's supervision.
Fact: Prolonged use can lead to dependence and other side effects. Regular medical review is necessary. - Myth: You can drink alcohol while taking this medicine.
Fact: Alcohol increases drowsiness and other CNS effects. It should be avoided.
🔄 Alternative Options
Generic Alternatives
- Mebeverine 135 mg + Chlordiazepoxide 5 mg tablet (generic)
Brand Alternatives
- Ex Spa M 135mg/5mg tablet