duphapro 2mg tablet

4.5 (16 reviews)

Prucalopride (2mg)

🏭 Abbott 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 21, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 21, 2026

What is duphapro 2mg tablet used for?

Consticalo 2 Tablet (Prucalopride) is used to treat GASTRO INTESTINAL. It contains Prucalopride (2mg), which Selective serotonin 5-HT4 receptor agonist; enhances gastrointestinal motility b. Always consult your doctor before use. Take as prescribed.

Generic Name: Prucalopride
Manufacturer: Abbott
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 duphapro 2mg tablet Uses & Benefits

Chronic idiopathic constipation; constipation-predominant irritable bowel syndrome (IBS-C).

Off-label uses: Gastroparesis; chronic intestinal pseudo-obstruction.

📋 Drug Information

Generic Name(s)	Prucalopride
Brand Name	Consticalo 2 Tablet
Manufacturer	Abbott
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	GASTRO INTESTINAL
Action Class	Serotonin (5-HT4) receptor agonist-Prokinetic agent
Route of Administration	Oral
Storage	Store at room temperature (20-25°C); protect from moisture and light.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed after oral administration; peak plasma concentration reached within 2-3 hours.

DistributionWidely distributed; volume of distribution approximately 567 L.

Protein BindingApproximately 30% bound to plasma proteins.

MetabolismMetabolized primarily via CYP3A4; minor metabolism via CYP2D6 and CYP2C9.

Half-LifeApproximately 24-30 hours.

ExcretionPrimarily excreted in urine (60-65% as unchanged drug and metabolites) and feces (20-25%).

BioavailabilityApproximately 90%.

Onset of ActionWithin 1-2 hours.

Peak Plasma Time2-3 hours.

Duration of ActionUp to 24 hours.

How It Works

Selective serotonin 5-HT4 receptor agonist; enhances gastrointestinal motility by increasing acetylcholine release from enteric neurons.

Mechanism Steps

1Prucalopride binds to 5-HT4 receptors on enteric neurons.

2Activation of 5-HT4 receptors stimulates adenylate cyclase.

3Increased cAMP levels lead to enhanced acetylcholine release.

💡 How to Take duphapro 2mg tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of duphapro 2mg tablet

✅ Common Side Effects

Headache
Nausea
Diarrhea
Abdominal pain
Flatulence

🚨 Serious Side Effects

Severe diarrhea leading to electrolyte imbalance
Hypersensitivity reactions
Cardiac arrhythmias (rare)

⚠️ Rare Side Effects

QT prolongation
Seizures
Hepatotoxicity

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Ketoconazole	Major	Increased prucalopride exposure due to CYP3A4 inhibition
Rifampin	Major	Decreased prucalopride exposure due to CYP3A4 induction
Atropine	Moderate	Reduced prokinetic effect due to anticholinergic action
Morphine	Moderate	Opposing effects on gastrointestinal motility

🚨 Major Interactions

CYP3A4 inhibitors (e.g., ketoconazole)
CYP3A4 inducers (e.g., rifampin)

⚡ Moderate Interactions

Anticholinergic drugs
Opioid analgesics

ℹ️ Minor Interactions

Metoclopramide
Domperidone

🍽️ Food Interactions

No significant food interactions; may be taken with or without food.

🍷 Alcohol Interaction

No specific interaction; alcohol may worsen gastrointestinal symptoms.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to prucalopride; intestinal obstruction; severe inflammatory bowel disease; renal impairment (CrCl <30 mL/min).

📊 Monitoring Parameters

Bowel movement frequency; renal function; signs of hypersensitivity.

🤱 Lactation Safety

Not recommended; excreted in breast milk in animal studies.

💊 Overdose Management

Supportive care; activated charcoal if recent ingestion; monitor for arrhythmias.

⏰ Missed Dose

Take as soon as remembered; skip if almost time for next dose; do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 21, 2026

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🔄 Substitutes for duphapro 2mg tablet

View All

Alternative brands with exact same active ingredient (Prucalopride (2mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Regular Customer Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Certified Buyer Jul 10, 2026

Effective and reliable. Worked as expected.

Verified User Jul 10, 2026

Found this to be a helpful product. Good results.