What is evachek 2 tablet used for?

This medicine contains Prucalopride 2 mg, a selective serotonin 5-HT4 receptor agonist used to treat chronic constipation in adults. It works by stimulating bowel movements. The usual dose is 2 mg once daily, taken orally. It is available only with a prescription.

Generic Name: Prucalopride (2mg)
Manufacturer: Kelvin Remedies
Form: Allopathy
Pregnancy Category: Consult doctor
Prescription Required: Yes

🇮🇳 evachek 2 tablet के बारे में (Hindi Summary)

उपयोग: यह दवा प्रुकैलोप्राइड 2 मिलीग्राम की गोली है, जिसका उपयोग वयस्कों में दीर्घकालिक कब्ज (क्रोनिक कॉन्स्टिपेशन) के इलाज के लिए किया जाता है। यह आंतों की गति को बढ़ाकर मल त्याग को आसान बनाती है। यह उन रोगियों के लिए है जिन्हें अन्य जुलाब से लाभ नहीं हुआ है। यह दवा केवल डॉक्टर के पर्चे पर मिलती है।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, जी मिचलाना, दस्त और पेट दर्द शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ दिनों में ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन यदि आपको गंभीर दस्त, धड़कन अनियमितता, या एलर्जी के लक्षण जैसे चकत्ते, सूजन या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी स्वास्थ्य समस्याओं और दवाओं के बारे में बताएं। इसे डॉक्टर के बताए अनुसार ही लें। खुराक से अधिक न लें। यदि आपको गंभीर दस्त हो, तो दवा बंद करें और डॉक्टर से मिलें। इसे कमरे के तापमान पर सूखी जगह पर रखें। बच्चों की पहुंच से दूर रखें।

💊 evachek 2 tablet Uses & Benefits

[{"condition":"Chronic constipation","description":"This medicine is used to treat chronic constipation in adults when other laxatives have not provided adequate relief.
It helps to increase the frequency of bowel movements and improves stool consistency.","evidence":"Well-established"},{"condition":"Chronic idiopathic constipation","description":"It is specifically indicated for chronic idiopathic constipation, where no underlying cause is identified.
It improves bowel movement frequency and reduces straining.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Constipation-predominant irritable bowel syndrome (IBS-C)","description":"Sometimes prescribed off-label to improve bowel movement frequency and reduce abdominal discomfort in IBS-C.","evidence":"Limited"},{"condition":"Gastroparesis","description":"May be used off-label to improve gastric emptying in patients with gastroparesis, but evidence is limited.","evidence":"Limited"}]

Primary treatment for: Chronic idiopathic constipation

Also treats: Constipation-predominant irritable bowel syndrome, Gastroparesis

📋 Drug Information

Generic Name(s)	Prucalopride (2mg)
Brand Name	evachek 2 tablet
Manufacturer	Kelvin Remedies
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	GASTRO INTESTINAL
Action Class	Serotonin (5-HT4) receptor agonist-Prokinetic agent
Route of Administration	Oral
Storage	Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep in a dry place, away from moisture and heat. Keep out of reach of children.
Shelf Life	24 months from the date of manufacture.
WHO Guideline	Not established from the available information.
ICMR Guideline	Not established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1

Take this medicine at the same time each day to establish a routine.

2

If you experience nausea, take it with a light meal.

3

Stay well hydrated to help prevent dehydration if diarrhea occurs.

4

Do not stop taking this medicine abruptly without consulting your doctor.

5

Report any persistent or severe side effects to your doctor promptly.

6

Keep a record of your bowel movements to help your doctor assess the effectiveness.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅

Chronic constipation

This medicine is commonly prescribed for this.

Likely Use

❌

Occasional constipation

This medicine is not intended for occasional constipation.

Not Primary

❌

Abdominal pain

This medicine is not a pain reliever; consult your doctor for diagnosis.

Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionThis medicine is rapidly absorbed after oral administration. The absolute bioavailability is approximately 90% in healthy adults. Food does not significantly affect the extent of absorption, but it may slightly delay the time to peak plasma concentration.

DistributionThis medicine is widely distributed throughout the body. The volume of distribution is approximately 567 liters in healthy adults. It is not known to accumulate in any specific tissue.

Protein BindingApproximately 30% of this medicine is bound to plasma proteins, primarily to albumin.

MetabolismThis medicine undergoes extensive metabolism in the liver, primarily by cytochrome P450 enzymes, including CYP3A4 and, to a lesser extent, CYP2D6. Several metabolites are formed, but they are not considered to contribute significantly to the therapeutic effect.

Half-LifeThe elimination half-life of this medicine is approximately 24 hours in healthy adults. In patients with renal impairment, the half-life may be prolonged.

ExcretionThis medicine is excreted primarily in the urine (approximately 60-70% of the dose) and in the feces (approximately 20-30%). A small amount is excreted unchanged in the urine.

BioavailabilityThe absolute bioavailability of this medicine is approximately 90% in healthy adults.

Onset of ActionThe onset of action of this medicine is typically within 2 to 3 hours after oral administration, but the full therapeutic effect on bowel movements may take a few days to become apparent.

Peak Plasma TimeThe peak plasma concentration of this medicine is reached approximately 2 to 3 hours after oral administration in the fasted state. Food may delay the peak by about 1 hour.

Duration of ActionThe duration of action of this medicine is approximately 24 hours, which allows for once-daily dosing.

How It Works

This medicine works by selectively stimulating the serotonin 5-HT4 receptors located in the gastrointestinal tract. When these receptors are activated, they enhance the release of acetylcholine and other neurotransmitters in the enteric nervous system, which leads to increased peristaltic activity and accelerated intestinal transit. This results in more frequent and easier bowel movements. Unlike some other laxatives, this medicine does not act by drawing water into the intestines or by softening the stool; instead, it directly stimulates the muscles of the gut to move contents forward.

Mechanism Steps

1

Binding to 5-HT4 receptors: This medicine binds selectively to serotonin 5-HT4 receptors located on enteric neurons in the gastrointestinal tract.

2

Activation of enteric neurons: Binding stimulates the release of acetylcholine and other excitatory neurotransmitters from enteric neurons.

3

Increased peristalsis: The release of acetylcholine enhances smooth muscle contraction and peristaltic waves, promoting forward movement of intestinal contents.

4

Accelerated transit: As a result, colonic transit time is reduced, leading to more frequent and complete bowel movements.

💡 How to Take evachek 2 tablet

Strength: Prucalopride 2 mg immediate-release tablet

1Take this medicine exactly as prescribed by your doctor.

2Swallow the tablet whole with a glass of water.

3You may take it with or without food.

4Take it at the same time each day to help you remember.

5Do not crush, chew, or break the tablet unless your doctor advises otherwise.

6If you miss a dose, follow the missed dose instructions.

7Do not take more than the prescribed dose.

Dosage Information

Adult Dosage	The usual recommended dose of this medicine for adults is 2 mg taken orally once daily. The dose may be adjusted by your doctor based on your response and tolerability. For patients with severe renal impairment, a lower starting dose may be recommended. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric Dosage	Pediatric dosing is not established from available information. Consult a pediatrician.
Elderly Dosage	Elderly patients (above 65 years) may be more sensitive to the effects of this medicine. The usual adult dose may be used, but caution is advised. Dose must be individualized by a qualified clinician based on renal and hepatic function.
Renal Impairment	For patients with severe renal impairment (creatinine clearance less than 30 mL/min), the recommended dose is 1 mg once daily. For patients with mild to moderate renal impairment, no dose adjustment is necessary. Dose must be individualized by a qualified clinician.
Hepatic Impairment	For patients with severe hepatic impairment (Child-Pugh class C), the recommended dose is 1 mg once daily. For patients with mild to moderate hepatic impairment, no dose adjustment is necessary. Dose must be individualized by a qualified clinician.
Maximum Daily Dose	The maximum recommended daily dose is 2 mg.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With or without food

Take at the same time each day

Food does not significantly affect absorption, but taking it consistently helps with adherence.

Grapefruit juice

Avoid

May increase drug levels and risk of side effects.

⏰ What to Do If You Miss a Dose

📌 Less than 12 hours have passed since the missed dose

→ Take the missed dose as soon as you remember.

💡 Continue with your regular schedule.

📌 More than 12 hours have passed since the missed dose

→ Skip the missed dose.

💡 Do not double dose to catch up.

⚠️ Side Effects of evachek 2 tablet

✅ Common Side Effects

Headache (Common (5-10%))

Usually resolves on its own. If persistent or severe, consult your doctor.

Nausea (Common (5-10%))

Take with food to reduce nausea. If it persists, consult your doctor.

Diarrhea (Common (5-10%))

Stay hydrated. If diarrhea is severe or persistent, contact your doctor.

Abdominal pain (Common (5-10%))

Usually mild and transient. If severe, seek medical advice.

Flatulence (Common (1-5%))

Usually resolves with continued use. If bothersome, consult your doctor.

🚨 Serious Side Effects

Severe diarrhea leading to dehydration (Rare (<0.1%))

Stop taking this medicine and seek immediate medical attention if you experience severe diarrhea, dizziness, or reduced urine output.

Irregular heartbeat (Rare (<0.1%))

Seek immediate medical attention if you experience palpitations, chest pain, or fainting.

Allergic reaction (Rare (<0.1%))

Seek emergency help if you notice rash, itching, swelling of the face, lips, or throat, or difficulty breathing.

⚠️ Rare Side Effects

Angioedema

Seek emergency medical care immediately.

QT prolongation

Consult your doctor if you have a history of heart rhythm problems.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug	Severity	Effect
Erythromycin	Major
Ketoconazole	Major
Verapamil	Moderate
Quinidine	Moderate
Cimetidine	Minor

🚨 Major Interactions

Erythromycin
Ketoconazole

⚡ Moderate Interactions

Verapamil
Quinidine

🍷 Alcohol Interaction

Alcohol may increase the risk of dizziness, drowsiness, and gastrointestinal side effects such as nausea and diarrhea. It is advisable to avoid or limit alcohol consumption while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity or allergy to Prucalopride or any component of the tablet","Intestinal obstruction or blockage","Intestinal perforation","Severe inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis)","Toxic megacolon","Severe renal impairment requiring dialysis","History of QT prolongation or congenital long QT syndrome"]

⚠️ Warnings & Precautions

["This medicine may cause diarrhea; monitor for signs of dehydration and electrolyte imbalance.","Use with caution in patients with a history of cardiac arrhythmias or QT prolongation.","Avoid concurrent use with strong CYP3A4 inhibitors.","Use with caution in patients with severe renal impairment; dose adjustment may be needed.","Use with caution in patients with severe hepatic impairment.","Not recommended for use in children and adolescents.","Elderly patients may be more sensitive to the effects of this medicine.","Do not exceed the recommended dose."]

🤱 Lactation Safety

It is not known whether this medicine is excreted in human breast milk. Because many drugs are excreted in human milk, caution should be exercised when this medicine is administered to a nursing woman. Consult your doctor before breastfeeding.

💊 Overdose Management

There is limited information on overdose with this medicine. In case of overdose, symptomatic and supportive treatment should be initiated. Monitor for signs of excessive gastrointestinal effects such as severe diarrhea, dehydration, and electrolyte imbalance. Contact a poison control center or emergency department immediately.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Before taking this medicine, tell your doctor if you have any heart problems, kidney disease, liver disease, or if you are pregnant or planning to become pregnant. This medicine may interact with other medicines, so provide your doctor with a complete list of all medications you are taking, including over-the-counter products and herbal supplements. Do not start or stop any medicine without consulting your doctor. Take this medicine exactly as prescribed. Do not take more than the recommended dose. If you miss a dose, follow the missed dose instructions provided by your doctor. Store this medicine at room temperature, away from moisture and heat. Keep it out of reach of children. If you experience severe diarrhea, stop taking this medicine and contact your doctor immediately. Regular follow-up with your doctor is important to monitor your response to treatment.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the effects of this medicine, particularly regarding dehydration from diarrhea. Close monitoring is advised. Dose adjustment may be necessary based on renal function.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. It should be used during pregnancy only if clearly needed. Discuss the risks and benefits with your healthcare provider.

🏥 Post-Surgery Considerations

This medicine may be used after surgery to promote bowel movements, but only under the guidance of your surgeon. It is important to follow your surgeon's instructions regarding when to resume oral intake and medications.

🦷 Dental Procedures

This medicine does not typically interfere with dental procedures. However, inform your dentist about all medications you are taking, including this one.

💚 Lifestyle Tips for Better Results

🏃

Maintain a high-fiber diet with plenty of fruits, vegetables, and whole grains.

🥗

Drink adequate water throughout the day to stay hydrated.

😴

Engage in regular physical activity to promote bowel regularity.

💧

Establish a regular toilet routine, preferably after meals.

🧘

Avoid delaying bowel movements when you feel the urge.

🌞

Manage stress through relaxation techniques as stress can worsen constipation.

🏋️ Exercise Considerations

Regular exercise is encouraged as it can help improve bowel motility. However, if you experience dizziness or fatigue, avoid strenuous activities until you feel better. Stay hydrated during exercise.

🥗 Diet Recommendations

Include high-fiber foods such as beans, lentils, and whole grains.

Eat plenty of fresh fruits and vegetables.

Stay well hydrated by drinking water and other fluids.

Limit processed foods and foods high in fat and sugar.

Consider probiotic-rich foods like yogurt to support gut health.

💼 Impact on Daily Work & Life

This medicine is unlikely to affect your ability to drive or operate machinery. However, if you experience dizziness or fatigue, avoid these activities until you feel well. It should not interfere with your daily work routine.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or if your symptoms do not improve, your doctor may advise you to stop. Always follow your doctor's guidance.

📅 Long-Term Use Effects

Long-term use of this medicine has been studied for up to 24 months in clinical trials and appears to be generally well-tolerated. However, regular monitoring by your doctor is recommended to assess efficacy and any potential side effects. If you experience persistent diarrhea or other concerning symptoms, your doctor may adjust the dose or discontinue treatment.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Dietary fiber supplementation

Increasing dietary fiber can help relieve constipation in some individuals.

Evidence: Well-established

Osmotic laxatives

Polyethylene glycol or lactulose can be used as alternatives.

Evidence: Well-established

Biofeedback therapy

For patients with pelvic floor dysfunction, biofeedback can be effective.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, consult your doctor before receiving any vaccine while on this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from moisture. If crossing time zones, continue taking it at your usual time or adjust gradually as advised by your doctor. Check local customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 52-year-old woman with chronic constipation for over 5 years

She had tried various laxatives with limited success. Her doctor prescribed this medicine 2 mg once daily. After 3 days, she noticed more regular bowel movements and less straining. She experienced mild nausea initially, which subsided after a week. She emphasizes taking it at the same time each day.

💡 Lesson: Consistency and patience are key; side effects often diminish with continued use.

👤 A 68-year-old man with chronic constipation and mild renal impairment

He was started on 1 mg daily due to his kidney function. Within a week, his bowel movements improved significantly. He reported no side effects. He advises others to follow their doctor's dose adjustments carefully.

💡 Lesson: Dose adjustment based on kidney function is important for safety and efficacy.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts working within a few hours, but the full effect on bowel movements may take 2 to 3 days. It may take up to a week to experience the maximum benefit.

Q: Can I take this medicine with other laxatives?

A: You should consult your doctor before combining this medicine with other laxatives, as it may increase the risk of diarrhea and dehydration.

Q: Is this medicine habit-forming?

A: No, this medicine is not known to be habit-forming.

Q: What should I do if I experience severe diarrhea?

A: Stop taking this medicine and contact your doctor immediately. Severe diarrhea can lead to dehydration and electrolyte imbalance.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

Can I take this medicine long-term?
Will it affect my kidney function?
Can I drive after taking this medicine?
Does it interact with my blood pressure medicine?
What if I miss a dose?
Can I drink alcohol while taking this?

🔄 Substitutes for evachek 2 tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

Myth: This medicine is a laxative.
Fact: This medicine is not a laxative; it is an enterokinetic agent that stimulates bowel movements by acting on serotonin receptors.
Myth: This medicine can be taken for occasional constipation.
Fact: This medicine is prescribed for chronic constipation and should not be used for occasional constipation without medical advice.
Myth: This medicine is safe for children.
Fact: This medicine is not recommended for children and adolescents; safety and efficacy have not been established.

🔄 Alternative Options

Generic Alternatives

Prucalopride 2 mg tablet

Brand Alternatives

Resolor
Motegrity

📊 Comparison with Similar Medicines

[{"medicine":"This medicine (Prucalopride)","class":"5-HT4 receptor agonist","primary_use":"Chronic constipation","route":"Oral","common_side_effects":"Headache, nausea, diarrhea"},{"medicine":"Lubiprostone","class":"Chloride channel activator","primary_use":"Chronic constipation, IBS-C","route":"Oral","common_side_effects":"Nausea, diarrhea, headache"},{"medicine":"Linaclotide","class":"Guanylate cyclase-C agonist","primary_use":"Chronic constipation, IBS-C","route":"Oral","common_side_effects":"Diarrhea, abdominal pain, flatulence"}]

Evaquik 2mg Tablet (Prucalopride): Comprehensive Medicine Guide

When to Call Your Doctor IMMEDIATELY

What is evachek 2 tablet used for?

🇮🇳 evachek 2 tablet के बारे में (Hindi Summary)

💊 evachek 2 tablet Uses & Benefits

📋 Drug Information

👨‍⚕️ Doctor's Practical Tips

🔍 Is This Medicine Right for Your Symptom?

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

How It Works

Mechanism Steps

💡 How to Take evachek 2 tablet

Dosage Information

Dosage Timeline

🍽️ Food Timing Guide

⏰ What to Do If You Miss a Dose

⚠️ Side Effects of evachek 2 tablet

✅ Common Side Effects

🚨 Serious Side Effects

⚠️ Rare Side Effects

🔬 Drug Interactions

🚨 Major Interactions

⚡ Moderate Interactions

🍷 Alcohol Interaction

🔎 Check Your Other Medicines

🛡️ Safety & Warnings

🚫 Contraindications

⚠️ Warnings & Precautions

🤱 Lactation Safety

💊 Overdose Management

⏰ Missed Dose

Additional Safety Advice

👴 Special Considerations for Elderly

💡 For Patients Above 65

🤰 Pregnancy Planning (TTC)

🏥 Post-Surgery Considerations

🦷 Dental Procedures

💚 Lifestyle Tips for Better Results

🏋️ Exercise Considerations

🥗 Diet Recommendations

💼 Impact on Daily Work & Life

🛑 When to Stop This Medicine

📅 Long-Term Use Effects

🌿 Non-Medicine Approaches

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

📦 Storage Guide

✅ DO

❌ DON'T

✅ DO

❌ DON'T

✅ DO

❌ DON'T

✈️ Traveling with This Medicine

💰 Cost Analysis & Savings

👥 Real Patient Stories

💬 Questions Patients Often Ask

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

🔄 Substitutes for evachek 2 tablet

🛑 Myths vs. Facts

🔄 Alternative Options

Generic Alternatives

Brand Alternatives

📊 Comparison with Similar Medicines

😊 Was this information helpful?

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