costar-ds dry syrup - Colistin Sulphate (25mg/5ml) medicine

costar-ds dry syrup - Uses, Price, Side Effects & Substitutes

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๐Ÿญ Esquire Drug House ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 28, 2026
โš ๏ธ Nephrotoxicity Risk ๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Jun 28, 2026

What is costar-ds dry syrup used for?

Bestomycin-DS Suspension (Colistin Sulphate) is used to treat GASTRO INTESTINAL. It contains Colistin Sulphate (25mg/5ml), which Disrupts bacterial cell membrane by binding to lipopolysaccharides, increasing p. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Colistin Sulphate
  • Manufacturer: Esquire Drug House
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

๐Ÿ’Š costar-ds dry syrup Uses & Benefits

Treatment of acute gastroenteritis caused by susceptible Gram-negative bacteria; intestinal decontamination.

Off-label uses: Selective digestive decontamination in ICU patients

๐Ÿ“‹ Drug Information

Generic Name(s)Colistin Sulphate
Brand NameBestomycin-DS Suspension
ManufacturerEsquire Drug House
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGASTRO INTESTINAL
Action ClassCell membrane active agent
Route of AdministrationOral
StorageStore at room temperature (20-25ยฐC); protect from light and moisture.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionPoorly absorbed from gastrointestinal tract; acts locally in the gut.
DistributionMinimal systemic distribution due to poor absorption; primarily confined to GI tract.
Protein BindingLow (approximately 10-20%)
MetabolismNot significantly metabolized.
Half-LifeNot applicable for oral formulation due to minimal systemic absorption.
ExcretionPrimarily excreted unchanged in feces.
BioavailabilityNegligible (<1%)
Onset of ActionRapid (within hours) for local GI effect.
Peak Plasma TimeNot applicable due to minimal absorption.
Duration of Action6-8 hours (local GI effect)

How It Works

Disrupts bacterial cell membrane by binding to lipopolysaccharides, increasing permeability and causing cell death.

Mechanism Steps

1Colistin binds to lipopolysaccharides in the outer membrane of Gram-negative bacteria.
2Displaces calcium and magnesium ions from the membrane.
3Increases membrane permeability leading to leakage of cytoplasmic contents.

๐Ÿ’ก How to Take costar-ds dry syrup

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of costar-ds dry syrup

โœ… Common Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal pain

๐Ÿšจ Serious Side Effects

  • Neurotoxicity (paresthesias, dizziness)
  • Nephrotoxicity (rare with oral form)

โš ๏ธ Rare Side Effects

  • Allergic reactions
  • Superinfection

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Neuromuscular blocking agents Major Enhanced neuromuscular blockade
Aminoglycosides Major Increased nephrotoxicity and ototoxicity risk
Amphotericin B Major Increased nephrotoxicity risk
Cephalosporins Moderate Possible additive nephrotoxicity
Vancomycin Moderate Increased nephrotoxicity risk
Probiotics Minor Reduced efficacy of probiotics

๐Ÿšจ Major Interactions

  • Neuromuscular blocking agents
  • Aminoglycosides
  • Amphotericin B

โšก Moderate Interactions

  • Cephalosporins
  • Vancomycin

โ„น๏ธ Minor Interactions

  • Probiotics

๐Ÿฝ๏ธ Food Interactions

No significant food interactions.

๐Ÿท Alcohol Interaction

No known interaction.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to colistin or polymyxins.

๐Ÿ“Š Monitoring Parameters

Renal function, stool culture, signs of neurotoxicity (rare).

๐Ÿคฑ Lactation Safety

Not recommended; minimal systemic absorption but safety not established.

๐Ÿ’Š Overdose Management

Gastric lavage; supportive care; monitor renal function.

โฐ Missed Dose

Take as soon as remembered; skip if almost time for next dose; do not double dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 28, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for costar-ds dry syrup

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Alternative brands with exact same active ingredient (Colistin Sulphate (25mg/5ml)):

Medical Note: Always consult your doctor before switching medications.

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