Bestomycin-DS Suspension: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Decreased urine output or swelling
- Difficulty breathing or muscle weakness
- Severe or bloody diarrhea
- Rash, itching, or swelling of face or throat
- Seizures or confusion
- Yellowing of skin or eyes
If experiencing severe symptoms, call emergency services immediately.
What is colirest dry syrup used for?
This medicine is an oral suspension of Colistin Sulphate, an antibiotic used to treat serious infections caused by certain multidrug-resistant Gram-negative bacteria. It works by disrupting the bacterial outer membrane, leading to bacterial death. It is not absorbed significantly from the gut and is typically used under medical supervision.
- Generic Name: Colistin Sulphate
- Manufacturer: Micro Organics Pharmaceuticals India Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 colirest dry syrup के बारे में (Hindi Summary)
उपयोग: यह दवा कोलिस्टिन सल्फेट का मौखिक सस्पेंशन है, जिसका उपयोग कुछ गंभीर संक्रमणों के इलाज के लिए किया जाता है जो मल्टीड्रग-रेसिस्टेंट ग्राम-नेगेटिव बैक्टीरिया के कारण होते हैं। यह दवा बैक्टीरिया की बाहरी झिल्ली को तोड़कर उन्हें मार देती है। यह आमतौर पर डॉक्टर की देखरेख में दी जाती है और सामान्य सर्दी-जुकाम या वायरल संक्रमण के लिए नहीं है। किडनी की बीमारी वाले मरीजों को यह दवा सावधानी से दी जाती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, दस्त, पेट में असहजता, चक्कर आना और हाथ-पैरों में झुनझुनी शामिल हो सकते हैं। गंभीर दुष्प्रभावों में किडनी की समस्या, तंत्रिका संबंधी समस्याएं, और एलर्जी प्रतिक्रियाएं शामिल हैं। यदि आपको पेशाब कम आना, सूजन, मांसपेशियों में कमजोरी, या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। दवा की खुराक खुद से न बदलें और न ही बीच में बंद करें। अपने डॉक्टर को अपनी सभी दवाओं के बारे में बताएं। इलाज के दौरान किडनी की जांच करवाते रहें। पर्याप्त पानी पिएं। शरूर न करें। यदि मांसपेशियों में कमजोरी, सांस लेने में तकलीफ, या पेशाब कम आना हो तो तुरंत डॉक्टर से मिलें।
💊 colirest dry syrup Uses & Benefits
[{"condition":"Multidrug-resistant Gram-negative infections","description":"This medicine is used to treat serious infections caused by multidrug-resistant Gram-negative bacteria, including certain strains of Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae, when other antibiotics are not effective.","evidence":"Well-established"},{"condition":"Healthcare-associated infections","description":"It may be used in hospitalized patients with healthcare-associated infections such as ventilator-associated pneumonia or bloodstream infections caused by susceptible organisms.","evidence":"Established"},{"condition":"Urinary tract infections","description":"In some cases, this medicine may be used for complicated urinary tract infections caused by multidrug-resistant Gram-negative bacteria.","evidence":"Limited"}]
Off-label uses: [{"condition":"Selective decontamination of the digestive tract","description":"In some intensive care settings, oral colistin may be used off-label for selective decontamination of the digestive tract to prevent infections in critically ill patients.","evidence":"Limited"}]
Primary treatment for: Multidrug-resistant Gram-negative infections
Also treats: Healthcare-associated infections, Complicated urinary tract infections
📋 Drug Information
| Generic Name(s) | Colistin Sulphate |
| Brand Name | Bestomycin-DS Suspension |
| Manufacturer | Micro Organics Pharmaceuticals India Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Cell membrane active agent |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep the container tightly closed. Do not freeze. |
| Shelf Life | Not established from the available information. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine contains Colistin Sulphate, which belongs to the polymyxin class of antibiotics. Colistin is a cationic polypeptide that binds to the lipopolysaccharide component of the outer membrane of Gram-negative bacteria. This binding displaces calcium and magnesium ions, destabilizes the membrane, and increases its permeability. As a result, essential intracellular contents leak out, leading to bacterial cell death. Colistin is primarily bactericidal against susceptible Gram-negative organisms, but it is not active against Gram-positive bacteria or anaerobes.
Mechanism Steps
💡 How to Take colirest dry syrup
Strength: Colistin Sulphate 25mg/5ml oral suspension
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified clinician based on the type and severity of infection, the patient's kidney function, and other factors. It is typically taken orally, and the frequency and duration depend on the specific indication. Do not self-medicate. Follow your doctor's instructions exactly. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced kidney function and may require dose adjustment. Close monitoring of kidney function is recommended. |
| Renal Impairment | Dose adjustment is required in patients with kidney impairment. The dose should be individualized based on creatinine clearance. Consult a healthcare professional for guidance. |
| Hepatic Impairment | No specific dose adjustment is established for hepatic impairment. Use with caution and monitor liver function. |
| Maximum Daily Dose | Not established from the available information. |
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of colirest dry syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Aminoglycosides | Major | |
| Amphotericin B | Major | |
| Vancomycin | Major | |
| NSAIDs | Major | |
| Neuromuscular blockers | Major | |
| Loop diuretics | Moderate | |
| Cephalosporins | Moderate |
🚨 Major Interactions
- Other nephrotoxic drugs (e.g., aminoglycosides, amphotericin B, vancomycin, NSAIDs)
- Neuromuscular blocking agents (e.g., vecuronium, pancuronium)
⚡ Moderate Interactions
- Loop diuretics (e.g., furosemide)
- Cephalosporins
🍷 Alcohol Interaction
Alcohol may worsen nausea, dizziness, or stomach upset while taking this medicine. It is advisable to avoid alcohol during treatment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to colistin or other polymyxins","Myasthenia gravis (may worsen muscle weakness)","Severe kidney impairment (unless benefits outweigh risks and dose is adjusted)"]
⚠️ Warnings & Precautions
["Use with caution in patients with kidney disease; dose adjustment may be required.","Monitor for signs of neurotoxicity such as numbness, tingling, or muscle weakness.","Avoid concurrent use with other nephrotoxic or neurotoxic drugs.","Not effective against Gram-positive bacteria, fungi, or viruses.","May cause Clostridioides difficile-associated diarrhea; report severe or bloody diarrhea.","Do not use for minor infections or without a prescription."]
🤱 Lactation Safety
It is not known whether colistin is excreted in human breast milk. Because many drugs are excreted in human milk, caution should be exercised when this medicine is administered to a nursing woman. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose of this medicine may increase the risk of kidney damage and nerve toxicity. If you suspect an overdose, seek immediate medical attention. Treatment is supportive and may include monitoring of kidney function and neurological status. There is no specific antidote.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop treatment early, even if you feel better, because incomplete treatment can lead to resistance and relapse. Inform your doctor about all other medicines you are taking, especially other antibiotics, kidney-affecting drugs, or muscle relaxants. Your doctor may order blood tests to monitor kidney function and electrolyte levels during treatment. Drink plenty of fluids unless your doctor advises otherwise. Avoid alcohol while taking this medicine as it may worsen side effects. If you experience muscle weakness, difficulty breathing, or reduced urine output, seek medical help immediately. Keep this medicine out of reach of children and store it as directed on the label.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of kidney damage. Close monitoring of kidney function is recommended.
🤰 Pregnancy Planning (TTC)
Consult your doctor if you are planning pregnancy or are pregnant. The safety of this medicine during pregnancy is not well established.
🏥 Post-Surgery Considerations
If you are scheduled for surgery, inform your surgeon about this medicine. It may interact with anesthesia or other medications.
🦷 Dental Procedures
Inform your dentist about this medicine before any dental procedure. It may interact with other medications used during dental work.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
If you experience muscle weakness or dizziness, avoid strenuous exercise. Consult your doctor before starting any exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue. Avoid driving or operating heavy machinery if you are affected. Take rest as needed.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Stopping early may lead to treatment failure and resistance. Your doctor will decide when to stop based on your response.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of kidney damage and nerve toxicity. Regular monitoring of kidney function and neurological status is recommended. The duration of treatment should be determined by your doctor based on the infection.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the susceptibility of the bacteria, other antibiotics may be used.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are established. Consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid temperature extremes. If traveling across time zones, consult your doctor about dose timing adjustments. Check local customs regulations regarding antibiotics before travel.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The onset of action depends on the type and severity of infection. Your doctor will monitor your response to treatment.
A: No, you should complete the full course as prescribed to prevent resistance and relapse.
A: This medicine can affect kidney function, so regular monitoring is required. Inform your doctor if you have kidney problems.
🤔 Common Patient Concerns
🔄 Substitutes for colirest dry syrup
View AllAlternative brands with exact same active ingredient:
-
wenmycin 25mg/5ml dry syrupWens Drugs India Pvt Ltd ₹27.61 34.6% CHEAPER
-
gd safe dry syrupInd Swift Laboratories Ltd ₹35.77 15.2% CHEAPER
-
harmless plus suspensionHi Tech Pharmaceuticals Pvt Ltd ₹45.50 7.8% COSTLIER
-
gd safe ds dry syrupInd Swift Laboratories Ltd ₹51.50 22.1% COSTLIER
-
colitis 25mg dry syrupAtlantis Formulations Pvt Ltd ₹53.44 26.7% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any infection.
Fact: This medicine is only effective against certain Gram-negative bacteria and is not effective against viruses or Gram-positive bacteria. - Myth: This medicine is safe for everyone.
Fact: This medicine can cause kidney and nerve damage, and it is not suitable for everyone. It should only be used under medical supervision.