celplat 10mg injection
What is celplat 10mg injection used for?
Blastolem 50mg Injection (Cisplatin) is used to treat ANTI NEOPLASTICS. It contains Cisplatin (10mg), which Cisplatin forms intrastrand and interstrand DNA crosslinks, inhibiting DNA repli. Always consult your doctor before use. Take as prescribed.
- Generic Name: Cisplatin
- Manufacturer: Celon Laboratories Ltd
- Form: Allopathy
- Pregnancy Category: D
- Prescription Required: Yes
๐ celplat 10mg injection Uses & Benefits
Testicular cancer, ovarian cancer, bladder cancer, head and neck cancer, lung cancer, cervical cancer, melanoma, lymphoma
Off-label uses: Esophageal cancer, gastric cancer, hepatocellular carcinoma, osteosarcoma
๐ Drug Information
| Generic Name(s) | Cisplatin |
| Brand Name | Blastolem 50mg Injection |
| Manufacturer | Celon Laboratories Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Platinum compounds-Anticancer |
| Route of Administration | Intravenous infusion |
| Storage | Store at 20-25ยฐC; protect from light; do not refrigerate |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Cisplatin forms intrastrand and interstrand DNA crosslinks, inhibiting DNA replication and transcription, leading to apoptosis
Mechanism Steps
๐ก How to Take celplat 10mg injection
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of celplat 10mg injection
โ Common Side Effects
- Nausea
- Vomiting
- Nephrotoxicity
- Myelosuppression
- Ototoxicity
- Electrolyte disturbances
๐จ Serious Side Effects
- Acute renal failure
- Severe myelosuppression
- Anaphylaxis
- Neurotoxicity
- Hepatotoxicity
โ ๏ธ Rare Side Effects
- Hemolytic uremic syndrome
- Pancreatitis
- SIADH
- Cardiotoxicity
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Aminoglycosides | Major | Increased nephrotoxicity and ototoxicity |
| Loop diuretics | Major | Increased nephrotoxicity |
| Warfarin | Moderate | Increased anticoagulant effect |
| Phenytoin | Moderate | Decreased phenytoin levels |
๐จ Major Interactions
- Aminoglycosides
- Loop diuretics
- Nephrotoxic drugs
- Ototoxic drugs
- Myelosuppressive agents
โก Moderate Interactions
- Anticoagulants
- Phenytoin
- Methotrexate
- Bleomycin
โน๏ธ Minor Interactions
- Antihistamines
- Antiemetics
๐ฝ๏ธ Food Interactions
No significant food interactions
๐ท Alcohol Interaction
Avoid alcohol; may increase hepatotoxicity and dehydration risk
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to cisplatin or platinum compounds, severe renal impairment, myelosuppression, pregnancy, lactation
๐ Monitoring Parameters
Renal function (BUN, creatinine), electrolytes (Mg, K, Ca), complete blood count, audiometry, liver function tests
๐คฑ Lactation Safety
Contraindicated; excreted in breast milk
๐ Overdose Management
Supportive care; hemodialysis may be considered; monitor renal function, electrolytes, and hearing
โฐ Missed Dose
Do not double dose; contact physician immediately
๐จโโ๏ธ Reviewed by Expert
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Medical Note: Always consult your doctor before switching medications.