Arzi 200mg Injection (Dacarbazine): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Fever of 100.4°F (38°C) or higher, chills, or sore throat
- Unusual bleeding or bruising, such as nosebleeds, gum bleeding, or blood in urine or stool
- Yellowing of the skin or eyes, dark urine, or severe abdominal pain
- Shortness of breath, chest pain, or rapid heartbeat
- Swelling of the face, lips, tongue, or throat
- Decreased urine output or swelling in the legs
- Severe headache, confusion, or vision changes
If experiencing severe symptoms, call emergency services immediately.
What is celdaz 200mg injection used for?
This medicine is an injectable chemotherapy drug containing dacarbazine 200 mg. It is used to treat metastatic melanoma and Hodgkin lymphoma by damaging cancer cell DNA. It is given intravenously by a healthcare professional and can cause side effects like nausea, low blood counts, and fatigue.
- Generic Name: Dacarbazine
- Manufacturer: Celon Laboratories Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 celdaz 200mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा डैकार्बाज़ीन 200 मिलीग्राम इंजेक्शन है, जिसका उपयोग कैंसर के इलाज में किया जाता है। यह मुख्य रूप से त्वचा के कैंसर (मेलेनोमा) और हॉजकिन लिंफोमा के इलाज के लिए दी जाती है। यह दवा कैंसर कोशिकाओं के डीएनए को नुकसान पहुंचाकर उनकी वृद्धि को रोकती है। यह इंजेक्शन के रूप में नस के माध्यम से दी जाती है और इसे केवल अस्पताल या कैंसर केंद्र में प्रशिक्षित डॉक्टर या नर्स द्वारा ही लगाया जाता है। इस दवा का सेवन घर पर स्वयं नहीं करना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, भूख न लगना और थकान शामिल हैं। कई रोगियों में रक्त कोशिकाओं की संख्या कम हो सकती है, जिससे संक्रमण, खून बहने या चोट लगने का खतरा बढ़ जाता है। कुछ लोगों को इंजेक्शन लगाने की जगह पर दर्द या जलन हो सकती है। कभी-कभी बुखार, मांसपेशियों में दर्द और कमजोरी भी हो सकती है। गंभीर दुष्प्रभावों में लीवर की समस्या, किडनी की समस्या और एलर्जी प्रतिक्रिया शामिल हैं। कोई भी नया या बिगड़ता लक्षण दिखने पर तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल अस्पताल या कैंसर केंद्र में योग्य डॉक्टर या नर्स द्वारा ही दी जानी चाहिए। इसे घर पर स्वयं न लगाएं। इलाज के दौरान नियमित रूप से खून की जांच करवाएं। बुखार, गले में खराश, असामान्य खून बहना या चोट लगने पर तुरंत डॉक्टर को सूचित करें। संक्रमण से बचने के लिए हाथों की सफाई रखें और भीड़-भाड़ वाली जगहों से बचें। गर्भवती महिलाओं को यह दवा नहीं दी जानी चाहिए। इलाज के दौरान शराब का सेवन न करें। सभी जांच और फॉलो-अप अपॉइंटमेंट समय पर लें।
💊 celdaz 200mg injection Uses & Benefits
[{"condition":"Metastatic malignant melanoma","description":"This medicine is used as a single agent or in combination with other drugs to treat advanced melanoma that has spread to other organs.","evidence":"Well-established"},{"condition":"Hodgkin lymphoma","description":"This medicine is part of combination chemotherapy regimens such as ABVD for the treatment of Hodgkin lymphoma.","evidence":"Well-established"},{"condition":"Soft tissue sarcoma","description":"This medicine may be used in some combination regimens for certain soft tissue sarcomas, though this is less common.","evidence":"Limited"}]
Off-label uses: [{"condition":"Neuroendocrine tumours","description":"This medicine has been used off-label in some neuroendocrine tumours, but evidence is limited and it is not a standard treatment.","evidence":"Limited"},{"condition":"Other solid tumours","description":"Occasionally used in other solid tumours as part of clinical trials or individualised treatment plans.","evidence":"Limited"}]
Primary treatment for: Metastatic malignant melanoma
Also treats: Hodgkin lymphoma, Soft tissue sarcoma
📋 Drug Information
| Generic Name(s) | Dacarbazine |
| Brand Name | Arzi 200mg Injection |
| Manufacturer | Celon Laboratories Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Alkylating agent |
| Route of Administration | Intravenous |
| Storage | Store this medicine in a refrigerator at 2°C to 8°C. Protect from light. Do not freeze. Keep out of reach of children. |
| Shelf Life | The shelf life of this medicine is typically 24 months from the date of manufacture. Refer to the product label for the exact expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is an alkylating agent that works by transferring methyl groups to DNA, leading to the formation of cross-links between DNA strands. These cross-links prevent DNA replication and transcription, which ultimately stops cancer cells from dividing and causes them to die. Because this medicine is cell-cycle non-specific, it can affect cells at any phase of the cell cycle, although rapidly dividing cells are more sensitive.
Mechanism Steps
💡 How to Take celdaz 200mg injection
Strength: This medicine is available as a sterile powder for injection containing 200 mg of dacarbazine. It is reconstituted with sterile water for injection before use.
Dosage Information
| Adult Dosage | The dose of this medicine is determined by your cancer specialist based on your body weight, the type of cancer, and how well you tolerate treatment. A commonly used regimen for malignant melanoma is 200 mg per square meter of body surface area per day for 5 days, repeated every 3 to 4 weeks. For Hodgkin lymphoma, it is used in combination with other medicines at a dose of 375 mg per square meter on days 1 and 15 of a 28-day cycle. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric oncologist. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially bone marrow suppression and liver toxicity. Dose adjustments may be necessary based on kidney and liver function. Close monitoring is recommended. |
| Renal Impairment | Patients with kidney impairment may require dose reduction. This medicine and its metabolites are excreted in the urine, so impaired kidney function can lead to increased drug levels and toxicity. Monitor kidney function closely and adjust dose as needed. |
| Hepatic Impairment | Patients with liver impairment may require dose reduction because this medicine is metabolised in the liver. Liver function should be monitored closely, and dose adjustments may be necessary. |
| Maximum Daily Dose | The maximum daily dose of this medicine is not fixed and depends on the treatment protocol. It should not exceed the dose determined by your oncologist. For educational reference, a common single-day dose is 200 mg per square meter of body surface area. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of celdaz 200mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Live vaccines | Major | |
| Phenytoin | Major | |
| Warfarin | Major | |
| Ciprofloxacin | Moderate | |
| Ketoconazole | Moderate | |
| Other myelosuppressive agents | Moderate | |
| Grapefruit juice | Minor | |
| Alcohol | Minor |
🚨 Major Interactions
- Live vaccines
- Phenytoin
- Warfarin
⚡ Moderate Interactions
- CYP1A2 inhibitors (e.g., ciprofloxacin, fluvoxamine)
- CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
- Other myelosuppressive agents
🍷 Alcohol Interaction
Alcohol should be avoided while receiving this medicine because it can worsen nausea, vomiting, and liver toxicity. It may also increase the risk of stomach bleeding and interfere with the body's ability to fight infections.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe hypersensitivity to dacarbazine or any component of the formulation","Severe bone marrow suppression","Pregnancy","Breastfeeding","Live vaccine administration during treatment"]
⚠️ Warnings & Precautions
["This medicine should only be administered by a qualified healthcare professional in a hospital setting.","Bone marrow suppression is common and can be severe. Regular blood counts are essential.","This medicine can cause severe nausea and vomiting. Premedication with antiemetics is recommended.","Avoid live vaccines during treatment.","Both men and women should use effective contraception during treatment and for a period afterwards.","Do not breastfeed while receiving this medicine.","Avoid alcohol during treatment.","Report any signs of infection, bleeding, or jaundice immediately.","This medicine may cause photosensitivity; avoid sun exposure and use sunscreen.","Long-term use may increase the risk of secondary malignancies."]
🤱 Lactation Safety
It is not known whether this medicine passes into breast milk. Because of the potential for serious adverse reactions in a nursing infant, breastfeeding should be discontinued during treatment and for a period after treatment as advised by the doctor.
💊 Overdose Management
Overdose of this medicine can cause severe bone marrow suppression, nausea, vomiting, and liver toxicity. There is no specific antidote. Treatment is supportive and symptomatic, including blood transfusions, antiemetics, and monitoring of blood counts and liver function. In case of suspected overdose, seek immediate medical attention.
⏰ Missed Dose
If you miss a scheduled dose of this medicine, contact your treatment centre as soon as possible. Do not try to catch up on your own. Your doctor will advise you on the next steps.
Additional Safety Advice
This medicine must only be given by a qualified healthcare professional in a hospital or cancer centre. You should not handle or administer this medicine yourself. Before each dose, your doctor will check your blood counts, liver function, and kidney function. Tell your doctor immediately if you develop a fever, sore throat, unusual bleeding, or bruising, as these may be signs of a low blood cell count. Avoid close contact with people who have infections, and practice good hand hygiene. This medicine can harm an unborn baby, so both men and women should use effective contraception during treatment and for some time afterwards. Do not breastfeed while receiving this medicine. Avoid alcohol because it can worsen nausea and liver stress. Do not receive any live vaccines without your doctor's approval. Keep all appointments for blood tests and follow-up visits. If you miss a scheduled dose, contact your treatment centre as soon as possible; do not try to catch up on your own.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to the side effects of this medicine, particularly bone marrow suppression, liver toxicity, and kidney toxicity. Dose adjustments may be necessary based on organ function. Close monitoring is recommended.
🤰 Pregnancy Planning (TTC)
This medicine can harm an unborn baby. Both men and women should use effective contraception during treatment and for a period afterwards. If you are planning to become pregnant, discuss with your doctor before starting treatment. Pregnancy should be avoided during treatment and for at least 6 months after the last dose for women, and 3 months for men.
🏥 Post-Surgery Considerations
If you have recently had surgery, inform your surgeon and oncologist before receiving this medicine. It can affect wound healing and increase the risk of bleeding and infection. Your treatment may need to be delayed until you have recovered from surgery.
🦷 Dental Procedures
Inform your dentist that you are receiving this medicine before any dental procedure. This medicine can increase the risk of bleeding and infection. Your dentist may recommend delaying non-urgent procedures until your blood counts have recovered. Good oral hygiene is important to prevent infections.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While receiving this medicine, your energy levels may be low, and your blood counts may be reduced. Avoid strenuous exercise or activities that carry a risk of injury or bleeding. Gentle walking, stretching, or yoga may be beneficial, but consult your doctor before starting any exercise programme. If you feel dizzy or short of breath, stop and rest.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause fatigue, nausea, and low blood counts, which may affect your ability to work or perform daily activities. You may need to take time off work during treatment cycles. Driving may be unsafe if you feel dizzy or fatigued. Avoid operating heavy machinery. Discuss your work schedule with your employer and doctor to make necessary adjustments.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your oncologist. Treatment is usually continued for a set number of cycles or until the cancer progresses or side effects become unmanageable. If you experience severe side effects, your doctor may reduce the dose or delay treatment. Always follow your doctor's advice regarding when to stop.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of secondary cancers, bone marrow suppression, and organ toxicity. Regular monitoring of blood counts, liver function, and kidney function is essential. Some patients may experience persistent fatigue or neuropathy. Long-term follow-up with your oncologist is recommended to detect any late effects early.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Medicines that boost the immune system to fight cancer, such as checkpoint inhibitors, are used for melanoma.
Evidence: Well-establishedMedicines that target specific genetic mutations in cancer cells, such as BRAF inhibitors for melanoma.
Evidence: Well-establishedUsed for localised tumours or palliative care.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided during treatment with this medicine because they can cause serious infections. Inactivated vaccines may be given, but their effectiveness may be reduced due to immunosuppression. Consult your doctor before receiving any vaccine.
📦 Storage Guide
✅ DO
Store in a refrigerator at 2°C to 8°C
❌ DON'T
Do not freeze
✅ DO
Protect from light
❌ DON'T
Do not expose to direct sunlight
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep out of reach of children
❌ DON'T
Do not store at room temperature for prolonged periods
✈️ Traveling with This Medicine
If you need to travel while receiving this medicine, carry it in its original packaging with the prescription label clearly visible. Keep a copy of your prescription and a letter from your doctor explaining the medical need for the medicine. This medicine should be stored in a refrigerator at 2°C to 8°C; use a cool bag or arrange with your treatment centre for proper storage during travel. Check the customs regulations of your destination country regarding carrying prescription medicines. Plan your travel around your treatment schedule to avoid missing doses. Inform your doctor before travelling so they can provide necessary documentation and advice.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working immediately at the cellular level, but clinical response may take several weeks to months. Your doctor will monitor your progress with regular scans and blood tests.
A: No, this medicine must be given by a healthcare professional in a hospital or cancer centre. It is not available for self-administration.
A: Your doctor will prescribe anti-sickness medicines. Take them as directed. If nausea persists, contact your healthcare team.
A: Yes, but you should avoid close contact with anyone who has an infection. Practice good hand hygiene. This medicine does not spread through casual contact.
A: No, this medicine can harm an unborn baby. Both men and women should use effective contraception during treatment and for a period afterwards as advised by the doctor.
🤔 Common Patient Concerns
🔄 Substitutes for celdaz 200mg injection
View AllAlternative brands with exact same active ingredient:
-
dacarba 200mg injectionChandra Bhagat Pharma Pvt Ltd ₹238.09 37.8% CHEAPER
-
dacarzine 200mg injectionKhandelwal Laboratories Pvt Ltd ₹246.09 35.7% CHEAPER
-
dt care 200mg injectionCriticare Laboratories Pvt Ltd ₹328.13 14.2% CHEAPER
-
daczin 200mg injectionCadila Pharmaceuticals Ltd ₹373.00 2.5% CHEAPER
-
dacarex 200mg injectionAlkem Laboratories Ltd ₹382.13 0.1% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken as a pill.
Fact: This medicine is only available as an intravenous injection and must be given by a healthcare professional. - Myth: This medicine is safe to take during pregnancy.
Fact: This medicine can harm an unborn baby and is not recommended during pregnancy. - Myth: You can stop taking this medicine whenever you feel better.
Fact: You must complete the full course as prescribed by your oncologist. Stopping early can reduce effectiveness.
🔄 Alternative Options
Generic Alternatives
- Dacarbazine 200 mg injection
Brand Alternatives
- Arzi 200mg injection