Dabaz 200 Injection (Dacarbazine 200 mg): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Fever with chills or sore throat
- Unusual bleeding or bruising
- Yellowing of skin or eyes
- Severe abdominal pain or swelling
- Difficulty breathing or swelling of face
- Chest pain or palpitations
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is dacarex 200mg injection used for?
This medicine is a chemotherapy injection containing dacarbazine 200 mg, used to treat metastatic melanoma and Hodgkin lymphoma. It works by damaging cancer cell DNA and is given intravenously by a healthcare professional.
- Generic Name: Dacarbazine (200mg)
- Manufacturer: Alkem Laboratories Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 dacarex 200mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा डैकार्बाज़ीन 200 मिलीग्राम इंजेक्शन के रूप में एक कीमोथेरेपी एजेंट है, जिसका उपयोग मुख्य रूप से मेटास्टेटिक मेलेनोमा और हॉजकिन लिंफोमा के इलाज के लिए किया जाता है। यह कैंसर कोशिकाओं के डीएनए को नुकसान पहुंचाकर उनकी वृद्धि और विभाजन को रोकती है। यह दवा केवल योग्य ऑन्कोलॉजिस्ट की देखरेख में अस्पताल में इंट्रावेनस इन्फ्यूजन द्वारा दी जाती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, भूख न लगना, थकान और रक्त कोशिकाओं की कमी शामिल हैं। गंभीर दुष्प्रभावों में गंभीर एलर्जी, यकृत विषाक्तता और हेपेटिक वेनो-ऑक्लूसिव रोग हो सकते हैं। इंजेक्शन स्थल पर दर्द, लालिमा या सूजन भी हो सकती है। कोई भी असामान्य लक्षण होने पर तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल योग्य स्वास्थ्य पेशेवर द्वारा अस्पताल में ही दी जानी चाहिए। उपचार के दौरान नियमित रूप से रक्त परीक्षण करवाना आवश्यक है। बुखार, ठंड लगना, गले में खराश, असामान्य रक्तस्राव या पीलिया होने पर तुरंत डॉक्टर से संपर्क करें। गर्भावस्था और स्तनपान के दौरान इस दवा का उपयोग न करें। उपचार के दौरान और बाद में प्रभावी गर्भनिरोधक उपाय अपनाएं।
💊 dacarex 200mg injection Uses & Benefits
[{"condition":"Metastatic malignant melanoma","description":"This medicine is used as a single agent or in combination regimens for the treatment of advanced melanoma that has spread to other parts of the body.","evidence":"Well-established"},{"condition":"Hodgkin lymphoma","description":"This medicine is a component of the ABVD chemotherapy regimen (doxorubicin, bleomycin, vinblastine, and dacarbazine) used for treating Hodgkin lymphoma.","evidence":"Well-established"},{"condition":"Soft tissue sarcoma","description":"This medicine may be used in combination with other chemotherapy agents for certain soft tissue sarcomas, though its role is more limited.","evidence":"Limited"}]
Off-label uses: [{"condition":"Neuroendocrine tumors","description":"This medicine has been used off-label in some neuroendocrine tumor regimens, but evidence is limited and it is not a standard first-line option.","evidence":"Limited"},{"condition":"Pheochromocytoma","description":"Rarely, this medicine has been used in combination chemotherapy for malignant pheochromocytoma, but this is not a standard approved indication.","evidence":"Limited"}]
Primary treatment for: Metastatic malignant melanoma
Also treats: Hodgkin lymphoma, Soft tissue sarcoma
📋 Drug Information
| Generic Name(s) | Dacarbazine (200mg) |
| Brand Name | dacarex 200mg injection |
| Manufacturer | Alkem Laboratories Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Alkylating agent |
| Route of Administration | Parenteral (intravenous) |
| Storage | Store this medicine in a refrigerator at 2°C to 8°C (36°F to 46°F). Protect from light. Do not freeze. Once reconstituted, the solution should be used immediately or stored as directed by the pharmacist. Keep out of reach of children. |
| Shelf Life | The shelf life of the unreconstituted product is typically 24 months from the date of manufacture. Refer to the product label for the exact expiry date. Once reconstituted, use immediately. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is an alkylating agent that exerts its anticancer effects by interfering with the structure and function of DNA. After administration, dacarbazine is metabolized in the liver to an active intermediate that methylates DNA, forming cross-links between DNA strands and causing DNA damage. This damage prevents cancer cells from replicating and ultimately leads to cell death. The cytotoxic effect is not specific to cancer cells, which explains many of the side effects on rapidly dividing normal cells such as those in the bone marrow and gastrointestinal tract.
Mechanism Steps
💡 How to Take dacarex 200mg injection
Strength: This medicine is available as a sterile powder for injection containing 200 mg of dacarbazine per vial.
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified clinician based on the type of cancer, stage, patient's overall health, and response to treatment. For metastatic melanoma, a common regimen is 200 to 250 mg per square meter of body surface area per day for 5 days, repeated every 3 to 4 weeks. For Hodgkin lymphoma, it is used in combination with other agents in the ABVD regimen at a dose of 375 mg per square meter on days 1 and 15 of a 28-day cycle. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric oncologist. |
| Elderly Dosage | Elderly patients may be more susceptible to the toxic effects of this medicine, particularly bone marrow suppression and liver toxicity. Dose selection should be cautious, and close monitoring of blood counts and organ function is recommended. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Dose adjustments may be necessary in patients with renal impairment. Close monitoring of renal function is advised. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | Dose adjustments may be necessary in patients with hepatic impairment due to increased risk of toxicity. Liver function should be monitored closely. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum daily dose is not fixed and depends on the specific treatment protocol. It must be determined by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of dacarex 200mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Live vaccines | Major | |
| Warfarin | Moderate | |
| Phenytoin | Major | |
| Ciprofloxacin | Moderate | |
| Rifampin | Moderate |
🚨 Major Interactions
- Live vaccines
- Other myelosuppressive agents
- Phenytoin
⚡ Moderate Interactions
- Warfarin
- CYP1A2 inhibitors (e.g., ciprofloxacin, fluvoxamine)
- CYP1A2 inducers (e.g., rifampin, smoking)
🍷 Alcohol Interaction
Alcohol may increase the risk of liver toxicity and worsen side effects such as nausea and fatigue. It is advisable to avoid alcohol during treatment with this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe hypersensitivity to dacarbazine or any component of the formulation","Severe bone marrow suppression","Active serious infection","Pregnancy (unless potential benefit justifies risk)","Breastfeeding"]
⚠️ Warnings & Precautions
["This medicine should be administered only under the supervision of a qualified oncologist.","Bone marrow suppression is common and can be severe; regular blood counts are mandatory.","Hepatic veno-occlusive disease is a rare but potentially fatal complication; monitor liver function.","Avoid live vaccines during treatment.","Effective contraception is required for both men and women during treatment and for a period after.","Do not breastfeed while receiving this medicine.","Inform your doctor of all other medicines you are taking, including over-the-counter products.","This medicine may impair your ability to drive or operate machinery; use caution."]
🤱 Lactation Safety
It is not known whether dacarbazine is excreted in human milk. Because of the potential for serious adverse reactions in nursing infants, breastfeeding should be discontinued during treatment with this medicine.
💊 Overdose Management
There is no specific antidote for overdose with this medicine. Overdose may cause severe bone marrow suppression, nausea, vomiting, and other toxicities. Management should be supportive and symptomatic, with close monitoring of blood counts and organ function. In case of suspected overdose, seek immediate medical attention.
⏰ Missed Dose
This medicine is administered by a healthcare professional in a clinical setting. If you miss an appointment for your dose, contact your oncology team as soon as possible to reschedule. Do not attempt to self-administer or double the dose.
Additional Safety Advice
This medicine must only be administered by a qualified healthcare professional in a clinical setting equipped to manage chemotherapy-related complications. Regular blood tests are essential to monitor your blood cell counts, liver function, and kidney function before and during treatment. Inform your doctor immediately if you develop fever, chills, sore throat, unusual bleeding or bruising, persistent vomiting, or yellowing of the eyes or skin. Avoid contact with people who have active infections, and practice good hand hygiene. This medicine can harm an unborn baby, so effective contraception is required for both men and women during treatment and for a period after the last dose. Do not receive any live vaccines without consulting your oncologist. Do not breastfeed while receiving this medicine. Always inform any healthcare provider treating you that you are receiving this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to the toxic effects of this medicine, especially bone marrow suppression and liver toxicity. Close monitoring and dose adjustments are recommended.
🤰 Pregnancy Planning (TTC)
This medicine can cause fetal harm. Both men and women should use effective contraception during treatment and for a period after the last dose. If you are planning pregnancy, consult your oncologist for guidance.
🏥 Post-Surgery Considerations
This medicine may affect wound healing and increase the risk of infections after surgery. Inform your surgeon that you are receiving this medicine. Timing of surgery should be discussed with your oncology team.
🦷 Dental Procedures
This medicine can increase the risk of bleeding and infections after dental procedures. Inform your dentist that you are receiving this medicine. Your dentist may recommend postponing non-urgent procedures until your blood counts recover.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise may be beneficial, but fatigue and low blood counts can increase the risk of injury or infection. Consult your doctor before starting any exercise program. Avoid strenuous activities if you have low blood counts.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue, nausea, and increased risk of infections, which can affect your ability to work. Discuss with your employer about flexible hours or remote work options. Avoid operating heavy machinery if you feel dizzy or tired.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your oncologist. Treatment duration is determined by your response and tolerance. If you experience severe side effects, your doctor may adjust the dose or switch to another treatment.
📅 Long-Term Use Effects
Long-term effects of this medicine may include secondary malignancies, infertility, and organ toxicity. Regular follow-up with your oncologist is essential to monitor for any late effects. Report any new symptoms or health changes promptly.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
For melanoma, immunotherapy drugs such as checkpoint inhibitors may be an alternative or complementary approach.
Evidence: Well-establishedFor melanoma with specific mutations, targeted therapies may be used.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided during treatment with this medicine due to the risk of serious infections. Inactivated vaccines may be given, but their effectiveness may be reduced. Consult your oncologist before receiving any vaccine.
📦 Storage Guide
✅ DO
Store in a refrigerator at 2°C to 8°C
❌ DON'T
Do not freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not store at room temperature for extended periods
✈️ Traveling with This Medicine
This medicine is administered in a hospital setting, so travel is not applicable for its administration. However, if you are traveling after treatment, carry a copy of your prescription and medical records. Store the medicine as directed by your pharmacist. If you need to travel with the medicine, ensure it is kept in its original packaging and stored at the recommended temperature. Check customs regulations for carrying injectable medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The effects on cancer cells begin soon after administration, but clinical response may take several weeks to become evident. Your doctor will monitor your progress with regular scans and tests.
A: This medicine may cause fatigue or dizziness. It is advisable to arrange for someone else to drive you home after treatment.
A: This medicine can be present in body fluids. It is recommended to avoid close contact with pregnant women, especially during and shortly after infusion. Consult your doctor for specific guidance.
🤔 Common Patient Concerns
🔄 Substitutes for dacarex 200mg injection
View AllAlternative brands with exact same active ingredient:
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dacarba 200mg injectionChandra Bhagat Pharma Pvt Ltd ₹238.09 37.7% CHEAPER
-
dacarzine 200mg injectionKhandelwal Laboratories Pvt Ltd ₹246.09 35.6% CHEAPER
-
dt care 200mg injectionCriticare Laboratories Pvt Ltd ₹328.13 14.1% CHEAPER
-
daczin 200mg injectionCadila Pharmaceuticals Ltd ₹373.00 2.4% CHEAPER
-
celdaz 200mg injectionCelon Laboratories Ltd ₹382.60 0.1% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken at home.
Fact: This medicine must be administered by a healthcare professional in a clinical setting. - Myth: This medicine has no side effects.
Fact: This medicine can cause significant side effects, including bone marrow suppression and liver toxicity. - Myth: This medicine can cure all cancers.
Fact: This medicine is effective only for specific types of cancer and is used under the guidance of an oncologist.
🔄 Alternative Options
Generic Alternatives
- Dacarbazine 200 mg injection
Brand Alternatives
- Dabaz 200 injection