bipivac 5mg injection - Bupivacaine (5mg) medicine

Bipivac 5mg Injection - Uses, Price, Side Effects

4.4 (14 reviews)

Bupivacaine (5mg)

🏭 Miracalus Pharma Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is bipivac 5mg injection used for?

Bipivac 5mg Injection contains Bupivacaine, a local anesthetic used to numb specific areas of the body during surgery, labor, or dental procedures. It works by blocking nerve signals in the targeted area, providing effective pain relief.

Generic Name: Bupivacaine
Manufacturer: Miracalus Pharma Pvt Ltd
Form: Allopathy
Pregnancy Category: C
Prescription Required: Yes

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 bipivac 5mg injection Uses & Benefits

Spinal anesthesia for lower abdominal, pelvic, and lower limb surgeries; epidural anesthesia; peripheral nerve blocks.

Off-label uses: Intra-articular injection for postoperative pain; intravenous regional anesthesia (Bier block).

📋 Drug Information

Generic Name(s)	Bupivacaine
Brand Name	Anawin Heavy 5mg Injection
Manufacturer	Miracalus Pharma Pvt Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	PAIN ANALGESICS
Action Class	Local anaesthetic (Amides)
Route of Administration	Intrathecal (spinal), epidural, peripheral nerve block.
Storage	Store at 20-25°C; protect from light; do not freeze.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed from the injection site; systemic absorption depends on dose, concentration, and vascularity of the site.

DistributionWidely distributed; highly bound to tissues; crosses the blood-brain barrier and placenta.

Protein BindingApproximately 95% bound to alpha-1-acid glycoprotein.

MetabolismPrimarily hepatic via CYP3A4 and CYP1A2 to pipecoloxylidine and desbutylbupivacaine.

Half-Life2.7 to 3.4 hours in adults; prolonged in neonates and hepatic impairment.

ExcretionRenal excretion of metabolites; less than 5% unchanged.

BioavailabilityNot applicable (administered parenterally); systemic absorption depends on route.

Onset of Action5 to 10 minutes for spinal anesthesia.

Peak Plasma Time15 to 30 minutes after injection.

Duration of Action2 to 4 hours for spinal anesthesia; longer with epinephrine.

How It Works

Blocks sodium channels in nerve cell membranes, inhibiting nerve impulse conduction.

Mechanism Steps

1Bupivacaine binds to the intracellular portion of voltage-gated sodium channels.

2Inhibits sodium influx, preventing depolarization of the nerve membrane.

3Blocks propagation of action potentials along the nerve axon.

💡 How to Take bipivac 5mg injection

Follow your doctor's prescription exactly.

Dosage Timeline

🌅 Morning ✅ ☀️ Afternoon ❌ 🌆 Evening ✅ 🌙 Night ❌

⚠️ Side Effects of bipivac 5mg injection

✅ Common Side Effects

Hypotension
Bradycardia
Nausea
Vomiting
Headache
Back pain

🚨 Serious Side Effects

Cardiac arrest
Arrhythmias
Seizures
Respiratory depression
Anaphylaxis
Spinal hematoma

⚠️ Rare Side Effects

Allergic dermatitis
Methhemoglobinemia
Peripheral nerve injury
Arachnoiditis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Warfarin	Major	Increased bleeding risk
Cimetidine	Moderate	Increased bupivacaine levels
Beta-blockers	Moderate	Reduced clearance of bupivacaine

🚨 Major Interactions

Class I antiarrhythmics
Other local anesthetics
CYP3A4 inhibitors

⚡ Moderate Interactions

Beta-blockers
Calcium channel blockers
Antihypertensives

ℹ️ Minor Interactions

Cimetidine
Ranitidine

🍽️ Food Interactions

No significant food interactions.

🍷 Alcohol Interaction

May increase CNS depression; avoid excessive alcohol.

🛡️ Safety & Warnings

Liver

Low

Kidney

Low

Heart

Moderate

Pregnancy

Category C

🚫 Contraindications

Hypersensitivity to bupivacaine or amide anesthetics, severe hypotension, complete heart block, spinal deformities, infection at injection site.

📊 Monitoring Parameters

Blood pressure, heart rate, respiratory rate, level of anesthesia, CNS status, cardiac monitoring.

🤱 Lactation Safety

Excreted in breast milk in small amounts; use with caution.

💊 Overdose Management

Discontinue injection; administer oxygen, IV fluids, vasopressors; treat seizures with benzodiazepines; manage cardiac toxicity with lipid emulsion therapy.

⏰ Missed Dose

Not applicable; administered by healthcare professional.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

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🔄 Substitutes for bipivac 5mg injection

View All

Alternative brands with exact same active ingredient (Bupivacaine (5mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Regular Customer Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Certified Buyer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Verified User Jul 10, 2026