bupicain 5mg injection - Bupivacaine (5mg) medicine

bupicain 5mg injection

4.6 (17 reviews)
๐Ÿญ Themis Medicare Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Aug 22, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Aug 22, 2026

What is bupicain 5mg injection used for?

Anawin Heavy 5mg Injection (Bupivacaine) is used to treat PAIN ANALGESICS. It contains Bupivacaine (5mg), which Blocks sodium channels in nerve cell membranes, inhibiting nerve impulse conduct. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Bupivacaine
  • Manufacturer: Themis Medicare Ltd
  • Form: Allopathy
  • Pregnancy Category: C
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

๐Ÿ’Š bupicain 5mg injection Uses & Benefits

Spinal anesthesia for lower abdominal, pelvic, and lower limb surgeries; epidural anesthesia; peripheral nerve blocks.

Off-label uses: Intra-articular injection for postoperative pain; intravenous regional anesthesia (Bier block).

๐Ÿ“‹ Drug Information

Generic Name(s)Bupivacaine
Brand NameAnawin Heavy 5mg Injection
ManufacturerThemis Medicare Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassPAIN ANALGESICS
Action ClassLocal anaesthetic (Amides)
Route of AdministrationIntrathecal (spinal), epidural, peripheral nerve block.
StorageStore at 20-25ยฐC; protect from light; do not freeze.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed from the injection site; systemic absorption depends on dose, concentration, and vascularity of the site.
DistributionWidely distributed; highly bound to tissues; crosses the blood-brain barrier and placenta.
Protein BindingApproximately 95% bound to alpha-1-acid glycoprotein.
MetabolismPrimarily hepatic via CYP3A4 and CYP1A2 to pipecoloxylidine and desbutylbupivacaine.
Half-Life2.7 to 3.4 hours in adults; prolonged in neonates and hepatic impairment.
ExcretionRenal excretion of metabolites; less than 5% unchanged.
BioavailabilityNot applicable (administered parenterally); systemic absorption depends on route.
Onset of Action5 to 10 minutes for spinal anesthesia.
Peak Plasma Time15 to 30 minutes after injection.
Duration of Action2 to 4 hours for spinal anesthesia; longer with epinephrine.

How It Works

Blocks sodium channels in nerve cell membranes, inhibiting nerve impulse conduction.

Mechanism Steps

1Bupivacaine binds to the intracellular portion of voltage-gated sodium channels.
2Inhibits sodium influx, preventing depolarization of the nerve membrane.
3Blocks propagation of action potentials along the nerve axon.

๐Ÿ’ก How to Take bupicain 5mg injection

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of bupicain 5mg injection

โœ… Common Side Effects

  • Hypotension
  • Bradycardia
  • Nausea
  • Vomiting
  • Headache
  • Back pain

๐Ÿšจ Serious Side Effects

  • Cardiac arrest
  • Arrhythmias
  • Seizures
  • Respiratory depression
  • Anaphylaxis
  • Spinal hematoma

โš ๏ธ Rare Side Effects

  • Allergic dermatitis
  • Methhemoglobinemia
  • Peripheral nerve injury
  • Arachnoiditis

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Class I antiarrhythmics Major Increased risk of cardiac toxicity
CYP3A4 inhibitors Major Increased bupivacaine levels
Beta-blockers Moderate Reduced hepatic clearance
Alcohol Moderate Additive CNS depression

๐Ÿšจ Major Interactions

  • Class I antiarrhythmics
  • Other local anesthetics
  • CYP3A4 inhibitors

โšก Moderate Interactions

  • Beta-blockers
  • Calcium channel blockers
  • Antihypertensives

โ„น๏ธ Minor Interactions

  • Cimetidine
  • Ranitidine

๐Ÿฝ๏ธ Food Interactions

No significant food interactions.

๐Ÿท Alcohol Interaction

May increase CNS depression; avoid excessive alcohol.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to bupivacaine or amide anesthetics, severe hypotension, complete heart block, spinal deformities, infection at injection site.

๐Ÿ“Š Monitoring Parameters

Blood pressure, heart rate, respiratory rate, level of anesthesia, CNS status, cardiac monitoring.

๐Ÿคฑ Lactation Safety

Excreted in breast milk in small amounts; use with caution.

๐Ÿ’Š Overdose Management

Discontinue injection; administer oxygen, IV fluids, vasopressors; treat seizures with benzodiazepines; manage cardiac toxicity with lipid emulsion therapy.

โฐ Missed Dose

Not applicable; administered by healthcare professional.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for bupicain 5mg injection

View All

Alternative brands with exact same active ingredient (Bupivacaine (5mg)):

Medical Note: Always consult your doctor before switching medications.

โญ User Reviews

Trusted Reviewer Jul 10, 2026

Effective and reliable. Worked as expected.

Certified Buyer Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Verified User Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Certified Buyer Jul 10, 2026

Effective and reliable. Worked as expected.

Certified Buyer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

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