bevacirel 400mg injection - Bevacizumab (400mg) medicine

Bevacirel 400mg Injection - Uses, Price, Side Effects

4.4 (9 reviews)

Bevacizumab (400mg)

🏭 Reliance Life Sciences 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 21, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 21, 2026

What is bevacirel 400mg injection used for?

Bevacirel 400mg Injection contains Bevacizumab, a monoclonal antibody that inhibits vascular endothelial growth factor (VEGF), thereby preventing angiogenesis in tumors. It is used to treat various cancers including colorectal, lung, and renal cell carcinoma. It is administered intravenously under medical supervision.

Generic Name: Bevacizumab
Manufacturer: Reliance Life Sciences
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 bevacirel 400mg injection Uses & Benefits

Metastatic colorectal cancer, non-small cell lung cancer, glioblastoma, renal cell carcinoma, ovarian cancer, cervical cancer.

Off-label uses: Age-related macular degeneration (intravitreal), diabetic retinopathy, other solid tumors.

📋 Drug Information

Generic Name(s)	Bevacizumab
Brand Name	Avastin
Manufacturer	Reliance Life Sciences
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	ANTI NEOPLASTICS
Action Class	Vascular endothelial growth factor (VEGF) inhibitor
Route of Administration	Intravenous infusion.
Storage	Store at 2-8°C (36-46°F). Do not freeze. Protect from light.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionSlow absorption after subcutaneous administration; intravenous administration results in complete bioavailability.

DistributionDistributes primarily in plasma and extracellular fluid; limited penetration into certain tissues.

Protein BindingNo significant protein binding (monoclonal antibody).

MetabolismMetabolized by proteolytic degradation into small peptides and amino acids.

Half-LifeApproximately 20 days (range 11-50 days).

ExcretionNot excreted renally; eliminated via intracellular catabolism.

Bioavailability100% (intravenous).

Onset of ActionWithin days to weeks.

Peak Plasma TimeAt end of intravenous infusion.

Duration of ActionSeveral weeks.

How It Works

Bevacizumab binds to vascular endothelial growth factor (VEGF), preventing its interaction with VEGF receptors on endothelial cells, thereby inhibiting angiogenesis.

Mechanism Steps

1Bevacizumab binds to circulating VEGF-A.

2Prevents VEGF-A from interacting with VEGFR-1 and VEGFR-2 on endothelial cells.

3Inhibits VEGF receptor dimerization and activation.

💡 How to Take bevacirel 400mg injection

Follow your doctor's prescription exactly.

Dosage Timeline

🌅 Morning ✅ ☀️ Afternoon ❌ 🌆 Evening ✅ 🌙 Night ❌

⚠️ Side Effects of bevacirel 400mg injection

✅ Common Side Effects

Hypertension
Fatigue
Diarrhea
Nausea
Headache
Proteinuria
Epistaxis

🚨 Serious Side Effects

Gastrointestinal perforation
Hemorrhage
Arterial thromboembolism
Wound dehiscence
Congestive heart failure
Reversible posterior leukoencephalopathy syndrome

⚠️ Rare Side Effects

Osteonecrosis of the jaw
Nephrotic syndrome
Pulmonary hypertension
Ovarian failure

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Warfarin	Major	Increased bleeding risk
Cisplatin	Moderate	Increased nephrotoxicity
Anthracyclines	Moderate	Increased cardiotoxicity

🚨 Major Interactions

Sunitinib
Anthracyclines
Alkylating agents

⚡ Moderate Interactions

Anticoagulants
Antiplatelet agents
NSAIDs

ℹ️ Minor Interactions

ACE inhibitors
Diuretics

🍽️ Food Interactions

No significant food interactions.

🍷 Alcohol Interaction

No known interaction.

🛡️ Safety & Warnings

Liver

Moderate

Kidney

Moderate

Heart

Low

Pregnancy

Category A

🚫 Contraindications

Hypersensitivity to bevacizumab or any excipients; untreated CNS metastases; recent surgery or wound healing complications; severe bleeding disorders.

📊 Monitoring Parameters

Blood pressure, urine protein, signs of bleeding, wound healing, infusion reactions.

🤱 Lactation Safety

Not recommended; excreted in human milk? Unknown, but potential for harm.

💊 Overdose Management

No specific antidote; manage symptoms and monitor for adverse effects.

⏰ Missed Dose

Administer as soon as possible; do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 21, 2026

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🔄 Substitutes for bevacirel 400mg injection

View All

Alternative brands with exact same active ingredient (Bevacizumab (400mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Regular Customer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Verified User Jul 10, 2026

Effective and reliable. Worked as expected.

Happy Patient Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.